News for hackers. Stuff that matters.
Re:Ozempic drug supresses desire to smoke, drink and more by ramraj07 on Friday May 19, 2023 @09:57PM (#36008738)
For a long time we have known the existence of a network of hormones controlling our apetite on the gut brain axis, with names like ghrelin, leptin, glp-1, orexin, somatostatin, list goes on [1]. Issue was the network was tres complicé and hard to perturb without getting the opposite effect than what we wanted. Finally with glp-1, sglt2 and pcsk9 inhibition we are starting to be able to correct in the right way.

To answer your question, yeah turns out it was never about will power. Some people just had hormone drive to be healthier than others and finally we can pharmacologically start to level the field.

1. https://www.cell.com/cell/pdf/S0092-8674(14)01503-7.pdf

Re:Ozempic drug supresses desire to smoke, drink and more by yieldcrv on Friday May 19, 2023 @10:38PM (#36008912)
can we do this for working out and exercise?

I’m lean but dont do that and can recognize the benefits. It would be cool if we could pharmacologically make that appealing too.

What if we could just continually swap in states.

Executive work mode, ah it feels so good to think and focus.

Empath mode, ah it feels so good to build relationships.

Brolic mode, ah it feels so good to think about working out, and actually work out!

Re:Ozempic drug supresses desire to smoke, drink and more by Red_Leaves_Flyy on Friday May 19, 2023 @11:11PM (#36009031)
Do you want to live in the world of we happy few? This is what you’re suggesting with your rose colored glasses. What would really happen is companies would get the drug legalized so they can pump into their employees.
Re:Ozempic drug supresses desire to smoke, drink and more by yieldcrv on Friday May 19, 2023 @11:21PM (#36009081)
Then some people would feel there is a lopsided power dynamic in their choice to take them.

In the meantime I would like that choice from a purely self preservation interest in being good at other bodily health and resource appropriations

Re:Ozempic drug supresses desire to smoke, drink and more by Earw0rm on Saturday May 20, 2023 @03:03AM (#36009956)
Find the right exercise/workout for you and it'll be its own reward.

Shouldn't take more than a bit of caffeine to get you moving at that point.

As to empath mode, you've just described MDMA. But it'd be nice if there were something a little less intense. That you could take weekly without frying your brain & was mild enough for family/work social situations. (And no, alcohol doesn't fit the bill).

Re:Ozempic drug supresses desire to smoke, drink and more by yieldcrv on Saturday May 20, 2023 @02:43PM (#36014482)
> Find the right exercise/workout for you and it'll be its own reward.

appreciate the perspective but I want to be like the people that feel pulled to "find" it at all.

Re:Ozempic drug supresses desire to smoke, drink and more by Earw0rm on Saturday May 20, 2023 @05:24PM (#36015753)
That's not so easy, but also not as hard as you think. Won't take a lot of time on any one thing to see if it clicks for you. Pick a couple of activities, do each from absolute beginner level, twice a week for four weeks. Once if you're pushed for time. Keep the one that sucks less after a month. You don't need to hear the voice of God to download the Couch to 5K running app, grab a basic weights set and watch a few vids on simple exercises, or sign up for a local yoga or spin session.

The high can be way better than you'd believe possible before you try. Or if you don't believe personal anecdote.. /something/ must be keeping all those people coming back to it at considerable expense, hassle and time.

Re:Ozempic drug supresses desire to smoke, drink and more by nebulousthree on Sunday May 21, 2023 @01:30AM (#36018282)
The pleasure of working out only becomes obvious after you've built the habit to do so. You'll know you've built the habit when it starts to feel bad when you don't work out on a day you're normally supposed to. It's pretty similar to a drug addiction.
Re:Ozempic drug supresses desire to smoke, drink and more by yieldcrv on Sunday May 21, 2023 @03:16PM (#36023892)
yeah I want a drug induced version of that where I can't feel satisfied until I figure out that I need to exercise

but its pretty clear what I'm asking I don't have to keep re-explaining that, for thanks for chiming in.

Re:Ozempic drug supresses desire to smoke, drink and more by bevesce- on Tuesday May 23, 2023 @09:50AM (#36044273)
I've been doing calisthenics 3 times a week since 2019. When I skip a day I feel enormous amount of guilt and I can't sleep when the night comes. Still, I don't like every moment of doing the exercises and I have a feeling of time being wasted by tending to my body instead of doing something with my family, cooking for them or being creative. What's more doing the workout eats a huge amount of my will power and leaves me unwilling to do any other chore for that day.
Re:Ozempic drug supresses desire to smoke, drink and more by ImPostingOnHN on Sunday May 21, 2023 @03:35PM (#36024056)
close the feedback loop enough to get the dopamine rush each time:

- aim to either meet or exceed the previous workout, and consider that a success

- count reps so you can increase them 1 at a time until you're ready to increase weight

- for cardio, increase difficulty (incline/speed) until you're ready to increase distance

- set a longer term goal, too, like a body weight bench press or a 10 minute mile

- after doing this for a while, you might notice some differences in your appearance, which can be its own motivator

Re:Ozempic drug supresses desire to smoke, drink and more by kika on Saturday May 20, 2023 @04:25PM (#36015240)
Empath mode is oxytocin injection. Joking? Or not?
Re:Ozempic drug supresses desire to smoke, drink and more by tick_tock_tick on Friday May 19, 2023 @10:43PM (#36008931)
> yeah turns out it was never about will power.

What a completely silly take away. It's like nature vs nurture it's not 100% one thing only.

Re:Ozempic drug supresses desire to smoke, drink and more by beebmam on Friday May 19, 2023 @11:16PM (#36009054)
Free will has not been shown to exist. Everything is nature.
Re:Ozempic drug supresses desire to smoke, drink and more by leroy-is-here on Friday May 19, 2023 @11:20PM (#36009076)
Reality does not need to be peer-reviewed to be true.
Re:Ozempic drug supresses desire to smoke, drink and more by pasquinelli on Friday May 19, 2023 @11:51PM (#36009226)
how could you separate actually will power from the illusion of will power?
Re:Ozempic drug supresses desire to smoke, drink and more by 0cVlTeIATBs on Saturday May 20, 2023 @12:15AM (#36009322)
You know the conversation has strayed once you start debating epistemology.
Re:Ozempic drug supresses desire to smoke, drink and more by AndrewKemendo on Saturday May 20, 2023 @08:39AM (#36011428)
This is the opposite of straying it’s actually a real conversation
Re:Ozempic drug supresses desire to smoke, drink and more by ChainOfFools on Sunday May 21, 2023 @01:43AM (#36018337)
What's that old quote, you're not getting somewhere until you're going nowhere
Re:Ozempic drug supresses desire to smoke, drink and more by rblatz on Saturday May 20, 2023 @02:48AM (#36009896)
I always thought that it’s uncertain if free will exists, but you have to behave as if it does otherwise the world falls into chaos.
Re:Ozempic drug supresses desire to smoke, drink and more by mensetmanusman on Saturday May 20, 2023 @10:06PM (#36017361)
That's just what the people with free will power tell those without.
Re:Ozempic drug supresses desire to smoke, drink and more by imtringued on Saturday May 20, 2023 @06:09AM (#36010631)
People talk about willpower but they ignore social influences like children learning habits from their parents or simply being forced by their parents to become obese (all it takes is a portion size that is slightly too big and demanding that you eat the full plate). No amount of willpower is going to end that unless you want to blame children for not running away from home.
Re:Ozempic drug supresses desire to smoke, drink and more by fatnoah on Monday May 22, 2023 @11:56AM (#36033069)
> People talk about willpower but they ignore social influences like children learning habits from their parents or simply being forced by their parents to become obese

As a very young child, my family was probably on the upper end of poor. "Treats" were rare and food was not anything to be wasted at all. I'm almost 50 now, and it's virtually impossible for me to throw away food. I have to have an inner monologue conversation with myself about whether I really need to finish my portion and whether it's OK to discard it. Needless to say, despite being very physically active, my weight has challenged me my entire life.

As a parent, I'm irrationally proud of my child for being able to stop eating when they're full, even if it's ice cream or a treat. That's actually helped me get over throwing food away (a little bit, at least)