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Re:The Cause of Depression Is Probably Not What You Think by likeabbas on Thursday January 26, 2023 @11:07AM (#34533528)
There's no single cause and no single cure which is why it's so hard.

I moved cities at 10 years old, and was bullied and isolated during the entirety of Middle School. Ever since then, I've always had negative and depressive thoughts lurking around. It's just my normal.

A psychiatrist helped me understand that those formative years are when your cortex is developing. The cortex learns through repetition, and during those years I was having constant sadness and suffering events. So, my emotional intelligence learned to be that way and that's why I've suffered ever since.

If I'm not pro active in thinking about being happy or doing active things, I default to being depressed. After almost 20 years, I'm still suffering.

A side effect of being isolated during those years is my social skills have taken longer to develop. I didn't have a true batch of friends until college, but now I've lost all of them.

Re:The Cause of Depression Is Probably Not What You Think by exo-pla-net on Thursday January 26, 2023 @11:33AM (#34533950)
Your brain cannot "learn" to be sad. You can, however, learn maladaptive schemata: fundamental ways of viewing the world and oneself that can help a child get through adverse periods (like bullying and ostracization), but which are ultimately maladaptive and inaccurate in adulthood.

You might have come to believe, for instance, that you're fundamentally "different" or "unlovable", and that you can't expect to be socially accepted or loved.

These core beliefs, these schemata, are difficult but possible to change. Schema Therapy has had empirical success at doing so.

The subjective experience of changing a maladaptive schema is like teleporting from a miserable planet to a strange but much happier, more loving planet. You can be (much) happier than you think; you're just stranded on a miserable planet, one that would make anybody sad.

I'd suggest checking out Reinventing Your Life by Jeffrey Young: it provides the tools you need to get to that happier planet, where you can feel safer and loved and accepted.

Re:The Cause of Depression Is Probably Not What You Think by likeabbas on Thursday January 26, 2023 @11:44AM (#34534157)
> Your brain cannot "learn" to be sad.

This is ~equivocally~ unequivocally false. The portion of the brain that develops emotional intelligence forms during your formative years and can learn to be put in a depressive mindset.

* https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984129/

* https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132040/

> Humans are likely the most emotionally regulated creatures on earth. Compared to other animal species, we can modulate and modify emotional reactions and experiences, even very intense ones, through a large and sophisticated emotion regulation repertoire that includes skills of distraction, reappraisal, language, prediction, social interaction, suppression, and more.1–5 At times, these skills require effort, and at other times, they seem reflexive and automatic. But what are some of the variables in this sophisticated emotion regulation repertoire? The parent of any toddler or even adolescent can attest to the very slow development of emotion regulation processes. This slow development has been documented in empirical research, which also notes the large individual differences from one person’s ability or style of emotion regulation to another’s. Evolutionarily speaking, this slow development of emotion regulation ability in childhood that culminates in an exquisite ability in adulthood points to the benefits of a slow-maturing emotion regulation system. Indeed, humans are not only a highly emotionally regulated species, but they are slowly developing in general, relative to other species, 6 with a prolonged period of immaturity. Phylogenetically, slow development may confer benefits through an extended period of neural plasticity—a feature of a developing neural system that heightens its ability to learn from the environment. If so, then humans may owe their sophisticated emotion regulation skills to the “extension” of childhood that has evolved in us. The nature, chronicity, and quality of environmental inputs during these periods of plasticity, in particular those from close relationships (e.g., parents, friends, teachers), in large part determine emotion regulation functioning in adulthood.7 Thus, adult brain and behavioral function in this regard can be conceptualized as a historical reflection of what was experienced during development. To fully appreciate individual differences in adult emotion regulation skills, then, it is helpful to understand how the brain develops.

Re:The Cause of Depression Is Probably Not What You Think by ASalazarMX on Thursday January 26, 2023 @11:59AM (#34534456)
> during your formidable years

I had to lookup "formidable" in case it was a specialized term, but I think it's a typo. Nevertheless, I like it better this way.

Re:The Cause of Depression Is Probably Not What You Think by likeabbas on Thursday January 26, 2023 @12:01PM (#34534515)
Definitely a typo. Thanks
Re:The Cause of Depression Is Probably Not What You Think by yowlingcat on Thursday January 26, 2023 @12:14PM (#34534747)
First of all, the phrase "emotional intelligence" is a pop-psychology invention created by Daniel Goleman which has no clinically meaningful use. There's a big difference between emotional intelligence and emotional regulation.

There's also a difference between traumatic experiences (such as you moving somewhere new at 10 and struggling with isolation and being bullied) and how you may have psychologically adapted to these situations. But nothing you've mentioned implies that your brain can "learn to be put into a depressive mindset" -- it's more the case that strenuous challenges that haven't been addressed, or moved past, or evolved from, will continue to cause problems until work is gradually done to address them.

I have always felt it's similar to musculoskeletal issues. You can do a lot of damage to your lower back by sitting at a desk all day, or to your wrists by typing at an angle that causes repetitive strain. That damage can be "mitigated" in different ways -- medication, surgery, physical rehabilitation. While the last one is most difficult, it's also the most effective because you're training the mind-muscle connection at the point where it's fragility is causing and compounding structural damage.

Even as people get older, until they reach very old age, it's rare for these kinds of MSK problems to occur in ways that cannot be unwound by adherence to physical therapy and a good exercise regimen. I think the same is true for our minds. As you mention in an earlier comment, if you do something that makes you happy, you feel happy for that time before drifting back to depression. But that in and of itself may be the point -- if you are constantly doing things which make you happy, it may not be immediate, but eventually you can re-orient your brain you being default-happy with depressive episodes rather than the other way around. That doesn't make it easy, of course, nor is there a one time fix.

Re:The Cause of Depression Is Probably Not What You Think by likeabbas on Thursday January 26, 2023 @12:36PM (#34535227)
> But nothing you've mentioned implies that your brain can "learn to be put into a depressive mindset" -- it's more the case that strenuous challenges that haven't been addressed, or moved past, or evolved from, will continue to cause problems until work is gradually done to address them.

What is the practical difference between saying "learnt to be put in a depressive mindset" and "psychologically adapted to these situations"? Psychiatrists don't need to be so technical when explaining the differences to people. I'm only framing the conversation in a colloquial manner such that non-psych majors will understand them. In some manner I've "learned" to be in a depressive mindset. And, through repetition, I can "un-learn" it.

> Even as people get older, until they reach very old age, it's rare for these kinds of MSK problems to occur in ways that cannot be unwound by adherence to physical therapy and a good exercise regimen... if you are constantly doing things which make you happy, it may not be immediate, but eventually you can re-orient your brain you being default-happy with depressive episodes rather than the other way around.

I'm not disputing this. The times where I am the happiest is when I'm in my routine of working out and playing tennis. But when I get out of my routine, I fall back into the depressive habits. It's hard to stay consistent. Maybe if I stay consistent for long enough, my default will not be depressed. But I have yet to be consistent for long enough to reach that point.

Re:The Cause of Depression Is Probably Not What You Think by mensetmanusman on Thursday January 26, 2023 @05:34PM (#34539855)
Emotional intelligence is another way of saying that you have the ability to read the room, which clearly many people (and very many of the technical people I interact with) did not have great ability for (which results in a lot of cringe-worthy moments).
Re:The Cause of Depression Is Probably Not What You Think by skissane on Thursday January 26, 2023 @06:08PM (#34540170)
If you want to talk about “ability to read the room”, correct terminology to use (recognised by researchers) is “social cognition”, “theory of mind”, “nonverbal communication” - unlike those terms, “emotional intelligence” is a fringe theory which has failed to win acceptance
[dead]
Re:The Cause of Depression Is Probably Not What You Think by likeabbas on Thursday January 26, 2023 @11:57AM (#34534430)
Practically, what is the difference between emotional state and consistently emotionally regulating into a depressive mindset? I'm not a psychiatrist and I don't care what the precise terminology is. In layman's terms, what I've stated is correct.
[dead]
Re:The Cause of Depression Is Probably Not What You Think by likeabbas on Thursday January 26, 2023 @12:30PM (#34535089)
Nothing I've said is incorrect. I'm just using colloquial language to describe the issue.

You are just being an asshole by trying to show off your technical knowledge in the subject, which is not helping anyone.

Re:The Cause of Depression Is Probably Not What You Think by incognito_robot on Thursday January 26, 2023 @11:24AM (#34533801)
It is uncanny how much this mimics my own experience.

Was bullied between ages 11-16. Grew a a social circle in high school, which started fragmenting once everyone went off to university. I rarely if ever see any of them anymore.

Before the bullying, I was aparently happy and excited for most things (according to siblings). After it I have always been the low energy serious guy.

20 years on I feel an intense need for human connection, but no matter how much I try I never seem to be able to cultivate any kind of lasting relationship with others.

Re:The Cause of Depression Is Probably Not What You Think by likeabbas on Thursday January 26, 2023 @11:29AM (#34533885)
I believe we find it hard to keep relationships because we take criticism/rejection harder than others. My (former) friends would say that I have no trouble burning bridges with anyone. Any time I’ve found myself embarrassed or hurt by someone else, I’ve pushed them out of my life. This definitely comes from how I handled people in my formative years
Re:The Cause of Depression Is Probably Not What You Think by UncleOxidant on Thursday January 26, 2023 @04:24PM (#34539050)
Yep, because we have very negative associations with criticism. In addition to being bullied, we tended to move a lot when I was a kid. So it became easy to just leave and start over somewhere else - I think I even started to look forward to being able to start over. I remember as a kid playing with other kids and after a bit just disappearing and hearing them in the distance say "hey, where did he go?" - I'd often do this. Much later I came to realize that this was some kind of avoidance and that it wasn't the norm. I think that I expected even amicable play situations to eventually lead to being bullied and I think that's why I'd just ghost people.
Re:The Cause of Depression Is Probably Not What You Think by waboremo on Thursday January 26, 2023 @05:27PM (#34539783)
For me this was Rejection Sensitivity Dysphoria, linked to ADHD but of course that itself has a lot of overlap with the anxiety/depression realm.

It's a pretty messed up condition to deal with, especially because even the mere perception of potentially being rejected can cause disproportionate reactions.

Re:The Cause of Depression Is Probably Not What You Think by msrenee on Thursday January 26, 2023 @07:24PM (#34540847)
I need to do some reading on that, but it seems superficially similar to the behavior of someone with borderline personality disorder. However, I think of borderline including becoming attached or infatuated with a new person abnormally quickly and then rejecting them just as fast. I'd be curious if there's some neurological overlap or if it's a different distortion of "normal" human behavior with a different cause. Or if those are one in the same.
Re:The Cause of Depression Is Probably Not What You Think by waboremo on Friday January 27, 2023 @05:09PM (#34552581)
Late reply but ADHD and Borderline get mixed up a lot, especially in women. For a very long time the only people who would get the ADHD labels were extremely hyperactive boys.

More recently people after seeking specialists (not just general doctors) are getting diagnosed as ADHD (inattentive usually) and these meds are having positive impact whereas their previous diagnosis of borderline or bipolar weren't. Buzzfeed News did an article about it but I can't find the link.

This isn't to say ADHD and BPD can't co-exist! Their co-existence however would probably project itself in more extreme ways due to BPD being more consistent and overt in the display of instabilities and self-harm. BPD would sort of override a lot of ADHD symptoms due to not being extreme enough. Someone with ADHD might feel like their friends don't like them due to not replying to text messages, but will be fine if told otherwise. If the same happened to a BPD they would convince themselves that their friends are lying and deep down want to abandon them, and would likely take action in the form of either self-harm or being mean to those friends.

But you can see how there is a bit of overlap when it comes to self-image and how untreated ADHD that permeates can start looking a lot like BPD.

Re:The Cause of Depression Is Probably Not What You Think by zeroonetwothree on Thursday January 26, 2023 @11:35AM (#34533968)
Depression often develops in adolescence so I think we should be a bit skeptical with the 'correlation is not causation' going on with these examples.
Re:The Cause of Depression Is Probably Not What You Think by com2kid on Thursday January 26, 2023 @11:42AM (#34534112)
> but no matter how much I try I never seem to be able to cultivate any kind of lasting relationship with others.

I used to run a startup focused on this, here is what I learned:

Time. The answer is time. Research shows there are two ways long term bonds are formed, shared adversity[1], or lots of time spent together. General rule of thumb for relationship building:

1. 10 hours together is someone you know 2. 100 hours together is a good acquittance. 3. 1000 hours together is a good friend and a relationship that can now last a long time

This is why activities such as football watching (3*18, 54 hours a year, 2 years and you now have the beginnings of a good friends circle), or weekly poker matches (2 hours, almost 100 hours in a year) are so effective at building relationships.

Interpersonal hobbies with lots of down time, like rock climbing or playing in a band, accelerate this process greatly.

For people with kids, weekly play dates, or a weekly rotated dinner hosting.

Friendship is literally grinding hours, when we are young it is easy, studying and hanging out get those hours in, but when we get older, we have to be purposeful about it.

[1] Military boot camps are an example of this, so are the various culture wars. If you make people feel they are part of an oppressed group, preferably while isolating them from society at large, you will forms a cohesive group that acts together and one where everyone feels connected to each other. "Both sides" of the political spectrum do this, once you learn to spot it you start seeing it everywhere.

Re:The Cause of Depression Is Probably Not What You Think by takk309 on Thursday January 26, 2023 @02:28PM (#34537399)
I can't agree more on the shared adversity. My three main hobbies are rock climbing, hockey, and cycling. With climbing you have to battle against yourself and your limits. Good partners will support you in those pursuits. Add in the fact that your life is literally in someone else's hands when they belay you, it is a quick path to trust. Add in the down time, as stated above, and you will make true friends. Going on a week long climbing trip with a small group will stack up quality hours fast.

Hockey is different but you still have a team working towards a goal, literally! With a good group of people, good as in nice people, not skilled, you win and lose as a team. Plus the on bench and locker room time means you get to know one another over time.

Cycling is different for me, it is a solo experience and as a result I don't have any friends in that world.

Re:The Cause of Depression Is Probably Not What You Think by geph2021 on Thursday January 26, 2023 @03:00PM (#34537878)

   Cycling is different for me, it is a solo experience and as a result I don't have any friends in that world.
I guess it depends where you live, but usually there are cycling clubs or bike stores that have organized group rides. Riding with a group is an incredible way to enjoy longer rides while socializing, and it's safer.

I started cycling and was amazed at how social it was (albeit living in a town with a sizable cycling community). In my youth I was a swimmer, and although there is a lot of shared experience/adversity and friendship on any sports team, there's a lot less socializing that can be done while your head is underwater!

Re:The Cause of Depression Is Probably Not What You Think by takk309 on Thursday January 26, 2023 @06:56PM (#34540591)
I choose to do it solo, for the most part. I enjoy the solitude. I have been mountain biking more and that has been more group rides.
Re:The Cause of Depression Is Probably Not What You Think by hirvi74 on Friday January 27, 2023 @12:21AM (#34542796)
> Plus the on bench and locker room time means you get to know one another over time.

It's so lonely being a goalie sometimes. We never get any bench chat except for the short intermissions.

Re:The Cause of Depression Is Probably Not What You Think by spidersouris on Thursday January 26, 2023 @03:49PM (#34538619)
> Research shows...

Do you have any references in mind?

Re:The Cause of Depression Is Probably Not What You Think by com2kid on Thursday January 26, 2023 @04:52PM (#34539406)
When running my startup I did a deep dive into the psychology behind friendship and relationship building, but I haven't kept track of any of the references since then.
Re:The Cause of Depression Is Probably Not What You Think by citilife on Thursday January 26, 2023 @05:36PM (#34539874)
I recommend people try to go to Church -- even if you're not exceptionally religious (you can even tell them that, I've never seen anyone mind; though they may try to convince you).

It's an easy place to meet 30-40 people in a day, everyone there has different interests and comes from different walks of life. If you attend for a few weeks you'll often start attending lunch together, meeting out at some activities, etc. Plus, all you have to do is show up. People at a church tend to be outgoing, at least some of them are. Someone is bound to reach out to you if you sit there and drink a coffee.

Re:The Cause of Depression Is Probably Not What You Think by PuppyTailWags on Thursday January 26, 2023 @06:20PM (#34540260)
I would offer some hesitations to offer Church without knowing too much about someone or without caveats. Lots of people have religious trauma from being sexually assaulted/abused by church members or religious leaders, being ostracized for being LGBTQ or even just not performing gender strongly enough, or from being autistic/ADHD/a weirdo. When religion is good, it's a great pin to community building and mutual aid. When religion is bad it's a nightmare.
Re:The Cause of Depression Is Probably Not What You Think by codemonkey-zeta on Thursday January 26, 2023 @06:34PM (#34540389)
Eh, just steer clear of hardcore churches and you'll be good. Mormon, Jehovah's Witness, Catholic, Orthodox, Baptist are going to be too intense for a first-time churchgoer, but plenty of other Protestant churches are very liberal. Hell my Lutheran church in Massachusetts even had a gay minister. There are so many liberal protestant sects it will make your head spin, to the point that recommending someone try going to church these days (especially with all the polarizing, isolating events of the last decade) is probably solid advice if they're seeking community.
Re:The Cause of Depression Is Probably Not What You Think by amanaplanacanal on Thursday January 26, 2023 @07:39PM (#34540975)
From what I can see Unitarians welcome all the weirdos (saying this as a weirdo myself). My local church has Zen meditation groups, Wiccan circles, and specifically LGBT hangouts.
Re:The Cause of Depression Is Probably Not What You Think by smeej on Thursday January 26, 2023 @09:07PM (#34541600)
Ironically I spent a few years looking in all those places before ending up Catholic.

Everybody else "tolerated" the heck out of my gender-bewildered, 'spergie self from the messed up family, but it was the Catholics who finally showed me a love that would actually sacrifice something for my sake. Up until then, I sincerely believed "love" was like "Santa Claus" - a nice story you tell children, but nobody actually believes when they grow up.

Are there some Catholics who wouldn't know love if it came back from the dead? Absolutely. But there are others who stake their lives and well-being on the belief that love is at the center of everything, and wow are they worth meeting.

Re:The Cause of Depression Is Probably Not What You Think by galaxyLogic on Tuesday January 31, 2023 @11:28AM (#34597276)
Love is great but it's even better if you can put it in action. Love without acting to try to help others, is that love really?

There are lots of suffering in the world caused by systemic factors. If you think all that matters is that God loves YOU and EVERYBODY then you will probably not spend much time thinking about the systemic causes of suffering, and how to alleviate them.

The thing about religion is it mostly advocates keeping the status quo as is. Religion doesn't demand that you use your brain does it? Whereas if you are serious about making the world a better place then you MUST use your brain.

I know, there is something called Liberation Theology:

https://www.religion-online.org/article/an-evangelical-theol...

"...central biblical doctrines is that God is on the side of the poor and the oppressed. Tragically, evangelical theology has largely ignored this doctrine"

Re:The Cause of Depression Is Probably Not What You Think by PuppyTailWags on Friday January 27, 2023 @08:38AM (#34545819)
I agree there are plenty of liberal churches. I'm merely saying that "go to church" isn't without caveats. You have to have some consideration about ensuring they go to a church that won't make their mental health worse, or that the advice you're giving doesn't come off as totally bone-headed (suggesting church to someone who was raped by a minister is obviously cruel, for example).
Re:The Cause of Depression Is Probably Not What You Think by vagrantJin on Friday January 27, 2023 @01:52AM (#34543378)
> ...being ostracized for being LGBT...sexual trauma...autism

Right...

Re:The Cause of Depression Is Probably Not What You Think by boppo1 on Thursday January 26, 2023 @06:23PM (#34540297)
I have considered this, however I'm agnostic asymptotically approaching atheist. It's not really important to me and I don't care to talk about it, but I really wouldn't want to lie about it.
Re:The Cause of Depression Is Probably Not What You Think by freshpots on Friday January 27, 2023 @01:27AM (#34543243)
I recommend volunteering with an organization you want to support or a group that does various things in your community. You'll find like minded people in no time that want to serve others. No faith needed.
Re:The Cause of Depression Is Probably Not What You Think by SpikeDad on Thursday January 26, 2023 @10:28PM (#34542114)
As long as you don't mind supporting evil organizations and being subject to continuous prostilitizing. I find it difficult to believe that someone who is depressed needs to hear that they're a sinner heading to hell unless they accept whatever precepts the particular church is pushing.
Re:The Cause of Depression Is Probably Not What You Think by ekam on Thursday January 26, 2023 @10:55PM (#34542257)
Not even a christian but painting all churches as "evil organizations" is super inflammatory and unfair
Re:The Cause of Depression Is Probably Not What You Think by iosystem on Friday January 27, 2023 @12:15AM (#34542760)
Evil is subjective. Some people think churches are evil while others think the opposite.
Re:The Cause of Depression Is Probably Not What You Think by ekam on Friday January 27, 2023 @12:42AM (#34542947)
Some churches have done evil things, others have immensely benefitted their community. Arguments that uniformly paint independent groups of people with a broad stroke of immorality are usually irrational because people aren't monoliths and don't behave a single way, especially churches which are operated in a decentralized and independent fashion (eg my small city has 50+ churches, all operated by separate groups). OP's comment is just as irrational as the people who say "all women are x, all minorities/white people are y, etc. The fact that some people may subscribe to these irrational beliefs is neither here nor there.
Re:The Cause of Depression Is Probably Not What You Think by freshpots on Friday January 27, 2023 @01:26AM (#34543234)
Irrational is one who believes in things without evidence, aka faith.
Re:The Cause of Depression Is Probably Not What You Think by nostromo123 on Friday January 27, 2023 @09:57AM (#34546720)
Well, if you want to go down that road, someone's belief that they identify as a woman despite being xy is also irrational...
Re:The Cause of Depression Is Probably Not What You Think by citilife on Friday January 27, 2023 @11:27AM (#34547834)
> As long as you don't mind supporting evil organizations and being subject to continuous prostilitizing.

lol really? Define evil. I view evil as anything that leads to disorder in the world (death, destruction, etc); churches do not do that - they often build people up, build in the community, etc.

> I find it difficult to believe that someone who is depressed needs to hear that they're a sinner heading to hell unless they accept whatever precepts the particular church is pushing.

I'm fairly certain 99% of them preach the opposite?

They'll say "here are all the bad things we do", "we are saved because we attempt to do good and believe in God [or if christian - Jesus sacrificed himself for all people, living and dead]"

Christians really preach self-reflection and atonement - aka be humble. Frankly, the world can use more of that.

Re:The Cause of Depression Is Probably Not What You Think by tempnow987 on Thursday January 26, 2023 @11:54PM (#34542618)
This is not a bad suggestion. HN folks tend to be "anti" - I think that also is in part isolating. So many / most gatherings of folks don't meet the HN purity / behavior / etc standards (church groups / political groups etc).

As a note I went to church every sunday growing up - my parents (not religious) did it for exactly the reasons you described. Because we weren't religious there are some things that aren't a good fit even if its with other kids (confirmation meetings - I was very reasonably asked not to attend after asking questions because I was confused about the whole thing). There is a wide range of religious orthodoxy as well - plenty of mellower denominations.

Re:The Cause of Depression Is Probably Not What You Think by freshpots on Friday January 27, 2023 @01:24AM (#34543220)
I recommend volunteering in your city/town with an organization unaffiliated with religion if you're not religious. It saves that awkward conversation and gets straight to the point of both meeting new people and finding a place where you can feel like you're helping others. Like the Lion's Club International.
Re:The Cause of Depression Is Probably Not What You Think by freehorse on Thursday January 26, 2023 @06:35PM (#34540399)
Friendships do involve a lot of time grinding, but is it just time the force that forms a friendship? Or what you see actually comes the other way around, meaning that people who "bond well" tend to spend more time together?

While indeed time is important, it does not mean that merely spending time with somebody creates a friendship between you. It is more the quality of the time than time itself and, sadly, often our lives do not make quality easy to find. Especially regarding "hobbies and interests", personally I have found that relationships formed just through them tend to be more superficial and lasting less than relationships which are formed in a multitude of contexts and circumstances rather than simply spending time on one interest. They are good ways to meet new people, but for me an analogue of watching football together 2 or 10 hours per week and not other common context has never really worked out.

I like the approach of this blog post bellow on this. I think that especially the part of sharing life struggles together to be quite important.

https://billmei.net/blog/friendship

Re:The Cause of Depression Is Probably Not What You Think by com2kid on Friday January 27, 2023 @01:43AM (#34543322)
Quality time is important, for certain.

That blog's point to ask for help to create connections is a classic technique, super effective as well. Neighbors asking to borrow small things from each other is a great example of this bit of psychology in action.

Re:The Cause of Depression Is Probably Not What You Think by spaceman_2020 on Friday January 27, 2023 @12:50AM (#34543001)
Curious what your startup was. I feel this is one of the world’s biggest problems (chronic loneliness) that doesn’t get enough attention.
Re:The Cause of Depression Is Probably Not What You Think by com2kid on Friday January 27, 2023 @01:41AM (#34543308)
* * *
Re:The Cause of Depression Is Probably Not What You Think by snthpy on Friday January 27, 2023 @01:47AM (#34543351)
Your point about shared adversity is so interesting to me. I was on a "ferry" (it was really a kind of speedboat or something) from Belize to Honduras that got caught in a tropical storm. The waves were terrible, people vomiting everywhere, then the engine overheated and cut out, we had to search for life vests and eventually found some and put them on. They managed to revive the engine but the whole trip took 5 hours instead of two. It was a pretty frightening experience.

Anyway, even though I only spent a couple of hours with my fellow passengers on that boat, I felt more bonded to them than most people I met in almost a year backpacking and stayed in touch with them for a long time on Facebook.

So interesting that that's some kind of inbuilt thing. Like the OP, I also struggle making friends otherwise like which makes this more curious to me.

Re:The Cause of Depression Is Probably Not What You Think by jvm___ on Thursday January 26, 2023 @11:45AM (#34534179)
Same. Insulting nicknames from elementary into highschool. Same 15 boys due to small classes at private Christian school.

Married the first girl who showed me positive attention. I didn't know what a friend for me was, so we're married but not friends.

The hope for you is that I found a group through a local running group. They posted on Facebook and we run weekly. They added me to the group chat last year and it's been amazing having people to chat with and go on runs with.

Going home to someone who you can't have a conversation with is hard though.

Trite advice that worked for me. Find a group of people who do the thing you like as a way to make friends. This group was started by someone just looking to not run alone in town.

I can picture in my head walking up to the running group meetup for the first time, it honestly feels like a new birth after being friendless from grade 7 til age 40+.

Re:The Cause of Depression Is Probably Not What You Think by ryanwaggoner on Thursday January 26, 2023 @04:18PM (#34538985)
I wasn’t bullied, but I was a homeschool kid who ended up at a private Christian school and then married the first girl who showed me any interest. We finally divorced after two decades of struggle. The entire 3-4 year period of my marriage finally collapsing under its own weight came with several beautiful bright spots: I went to therapy, I had several life-changing experiences with psychedelics, and I found a group of incredibly good friends in similar situations. It’s mindblowing the difference that a few good friends can make.
Re:The Cause of Depression Is Probably Not What You Think by jvm___ on Friday January 27, 2023 @07:01PM (#34553494)
1000%

Same experiences with psychedelics, haha.

Re:The Cause of Depression Is Probably Not What You Think by theGnuMe on Thursday January 26, 2023 @11:58AM (#34534453)
People develop a set of psychological defense mechanisms to the bullying that work at the time but can be maladaptive later. Maybe you were bullied because the bullies found your happy excitement upsetting to their feelings and wanted you to feel the way they feel. This is not uncommon. I'm sorry that happened to you. But it sounds like you are finding the time to reflect on your past.

As for relationships, the "one simple trick" for human connection and relationships is that there is no trick, you have to continuously put the work in. It helps if you find activities that you want to do and make friends there. A lot of people find satisfaction in helping other people, so volunteering can be one way to meet new people.

You might face constant rejection at first but you are not unlovable. But if you are nice and kind to others and help others people will value that and think of you in the future.

At some point you will reach critical mass and things will get easier.

Re:The Cause of Depression Is Probably Not What You Think by vbezhenar on Thursday January 26, 2023 @12:02PM (#34534534)
I'm in a similar situation. Best friends I've found are when I actively played WoW and attended raids. I didn't kept them though but that was nice time and probably I had best interactions at that time. I'm trying to replicate that time but WoW changed and its audience changed, I don't feel like I fit there anymore.
Re:The Cause of Depression Is Probably Not What You Think by PuppyTailWags on Thursday January 26, 2023 @03:05PM (#34537947)
I found out that part of the issue with creating lasting relationships with others is that it actually takes a lot of effort to maintain relationships. It's not like a dating game where if you have a good dialogue on day 1 and then another good dialogue on day 2 their disposition changes. It's much more nuanced and much more specific on individual-to-individual interactions over months or years. Remembering common events to talk about regularly, responding and being responded to, birthdays, holiday celebrations, mutual activities, organizing intimate setting (think "potluck at X's house") socialization, the list goes on and on about the wide variety of behaviors.

If you're struggling, I found graythorn's various assessment resources super helpful, as it systematizes aspects of relationship building that most people find intuitive. Things like "what level of friendship am I with this person" and "assessment on expressing needs and support" were helpful to me. Although these guides are specifically towards autistics, so keep that in mind when you try them.

Re:The Cause of Depression Is Probably Not What You Think by citboin on Thursday January 26, 2023 @06:11PM (#34540205)
Googling “ graythorn assessment resources” gives us nothing useful. Please post more detail.
Re:The Cause of Depression Is Probably Not What You Think by PuppyTailWags on Thursday January 26, 2023 @06:21PM (#34540278)
https://linktr.ee/Gray.Thorn

Contexts to the links is the tiktok account https://www.tiktok.com/@graythornian

Re:The Cause of Depression Is Probably Not What You Think by Traubenfuchs on Thursday January 26, 2023 @04:01PM (#34538776)
> It is uncanny how much this mimics my own experience.

A significant amount of people damaged exactly like that run around. It‘s nothing noteworthy nor exceptional. And there is no recognized cure for us.

My pet theory is that through either nature or nurture, we are permanently damaged individuals that won‘t ever experience what we perceive as the normal, healthy social life and mental states. Our brains are permanently altered to our detriment.

Connecting to your anecdote: I am 30 and my mom still mentions what a lively and happy child I was. I wish she wouldn‘t, because it hurts to hear about the potential I squandered, lost or had stolen.

Re:The Cause of Depression Is Probably Not What You Think by ryanwaggoner on Thursday January 26, 2023 @04:20PM (#34539013)
There are no magic bullets, but the research on psychedelics and depression are encouraging.
Re:The Cause of Depression Is Probably Not What You Think by Traubenfuchs on Thursday January 26, 2023 @05:08PM (#34539585)
The only time I managed to acquire psylocobin was on an island where a big rave was happening. A hippie guy sold me magic mushroom pills. I was too scared to take it in this atmosphere and wanted to take the pills home. To leave the island, one had to walk through nipple-high water. The pills in my wallet melted away in the water.

Maybe some other day.

Re:The Cause of Depression Is Probably Not What You Think by bnjms on Friday January 27, 2023 @12:48AM (#34542987)
If you are in the US mushroom spores can be found in head-shops and grown easily enough. If you have friends who smoke weed they will likely know someone who knows how to get mushrooms.

Raves are fun enough as it is. You made the right choice.

Re:The Cause of Depression Is Probably Not What You Think by imiric on Thursday January 26, 2023 @05:51PM (#34540027)
> I wish she wouldn‘t, because it hurts to hear about the potential I squandered, lost or had stolen.

I think this negative mentality doesn't help. The sooner you try to live life to the best of your abilities with the cards you've been dealt, the sooner you'll feel better about your present and future. We can't change the past, but we can choose to accept it and move on.

Re:The Cause of Depression Is Probably Not What You Think by sammalloy on Thursday January 26, 2023 @06:01PM (#34540112)
> we are permanently damaged individuals that won‘t ever experience what we perceive as the normal, healthy social life and mental states. Our brains are permanently altered to our detriment.

Pretty much all of the available evidence says otherwise. Look into neuroplasticity, developing healthy habits, and exposing yourself to people and situations that are far different than your comfort zone. I’m not the same person I was 20 years ago, and I’m not the person I was ten years ago. If you’re not busy growing, you’re busy dying. Change is the one thing we can count on to improve ourselves. But you have to accept it and get on with it. There are some people out there who have great difficulty changing and growing. Best to confront that now rather than later. Challenge yourself every day, and at the end of a year you’ll look back and laugh at your old self who said they were permanently damaged. Everyone has their unique way of doing this. For me, it’s going to nature and immersing myself in it every day and trying to find the beauty in all things. Find your own way.

Re:The Cause of Depression Is Probably Not What You Think by Pigo on Thursday January 26, 2023 @11:38AM (#34534031)
This reminds me of how long it took me to notice a pattern in my relationships. When I look back, it's so obvious that I was picking a certain kind of person, and behaving in a certain kind of way, that would lead to the same conclusion. But it didn't feel like I was repeating the same story over and over again just to satisfy some malformed part of my psyche. I can't rewire something so deep in me that even effects who I'm attracted to. All I can do is be aware of it, and course correct.
Re:The Cause of Depression Is Probably Not What You Think by csours on Thursday January 26, 2023 @11:24AM (#34533807)
It seems likely that depression is also not a single disease.
Re:The Cause of Depression Is Probably Not What You Think by mathematicaster on Thursday January 26, 2023 @11:10AM (#34533584)
Thank you for sharing this.
Re:The Cause of Depression Is Probably Not What You Think by likeabbas on Thursday January 26, 2023 @11:49AM (#34534263)
Any time. I wish every child could have rich formative years so they can avoid long lasting emotional pain.
Re:The Cause of Depression Is Probably Not What You Think by dmd on Thursday January 26, 2023 @11:54AM (#34534374)
> There's no single cause and no single cure which is why it's so hard.

My neurologist once said to me "any time you see the phrase 'multiple mechanisms of X' in a medical journal, that's code for 'we have no fucking clue'".

Re:The Cause of Depression Is Probably Not What You Think by ASalazarMX on Thursday January 26, 2023 @12:06PM (#34534616)
> I didn't have a true batch of friends until college, but now I've lost all of them.

I think losing college friends is inevitable. People get jobs, move, marry, change, etc. Clutching to the friends when life was much simpler might not work now.

The solution would be making more social ties with neighbors, family, acquaintances, hobbyists, etc., and try to find new friendships/relationships within them.

Re:The Cause of Depression Is Probably Not What You Think by spiffytech on Thursday January 26, 2023 @12:07PM (#34534630)
> There's no single cause and no single cure which is why it's so hard.

This is exactly right. I'm at the tail end of a long depressive journey that wasn't caused by self-beliefs, distorted thoughts, trauma, etc. Nearly every depression treatment I sought had zero effect.

My problems came about because I had undiagnosed and unappreciated neurological + genetic conditions that created stacking debuffs that made ordinary SWE jobs tax my executive function and deplete my neurotransmitters, eventually leaving me personally and professionally debilitated.

Because I suffered the symptoms for so long before identifying the causes, neurologically I seemed to have entered a new attractor (in dynamical systems terms). I couldn't recover by just discontinuing what brought me there; my neurology kept gravitating towards the new steady-state. (A good chunk of this is black-box reverse engineering what helped me recover)

I've only gotten better by radically changing my circumstances, identifying a crucial supplement, and undergoing a medical procedure.

The eye-opening part of the journey was understanding that because depression is defined by a set of symptoms, receiving a diagnosis doesn't tell you anything at all about what's wrong with you. It only confirms you have a problem at all.

Re:The Cause of Depression Is Probably Not What You Think by trevwilson on Thursday January 26, 2023 @12:20PM (#34534865)
> identifying a crucial supplement, and undergoing a medical procedure

Would you feel comfortable sharing some specifics on what these were for you?

Re:The Cause of Depression Is Probably Not What You Think by spiffytech on Thursday January 26, 2023 @12:30PM (#34535095)
I remarked on the supplement in another comment.

The medical procedure was TMS - I spent ~6 weeks coming in every weekday, had my head strapped into a magnet helmet, and the magnets stimulate the parts of the brain associated with depression. I understand it to be vaguely like jump-starting an engine with a dead battery.

I just had my last session yesterday, and I see huge changes from December.

Crucually, I underwent TMS in 2019 and saw almost no change. At that time, I was still in the abravise career situation, and wasn't on the supplement, so my hypothesis is TMS had very limited benefit because I didn't have sufficient quantities of neurotransmitters for stimulation to do anything, and any possible benefit was being immediately eroded by the circumstances that created my problems in the first place.

I also had undiagnosed autism (which came with hardcoded limitations I'd been treating as personal preferences or bad attitude), and ADHD (which I was diagnosed with as a kid, but didn't understand how it manifests as an adult). Both of these tax executive function (neurotransmitters) heavily, and the MTHFR mutation handicapped how much executive function I had to go around in the first place. My particular neurodiverse needs appear to be at odds with the typical SWE work environment, so every day I was powering through my special needs, until my brain couldn't take it anymore and simply gave out.

Re:The Cause of Depression Is Probably Not What You Think by petemir on Thursday January 26, 2023 @07:30PM (#34540914)
Could you share how ADHD affected you as an adult? I am in a semi-burnt-out situation where I just cannot seem to focus on responsibilities anymore (it was always like that, it just got worse) and wanted to get a diagnosis on that. Sadly, there seems to be a long wait list, so until that happens anecdata is all I get :).
Re:The Cause of Depression Is Probably Not What You Think by spiffytech on Thursday January 26, 2023 @08:35PM (#34541396)
Apologies for the rambling. In the words of Blaise Pascal, it's long because I didn't have the time to make it shorter...

A big one for me is that staying focused on work responsibilities for 40 hours every week is really hard. Whatever my natural interest in the subject matter, it's exhausted much sooner than that. So I have to spend all day saying 'yes' to things I'm not interested in, while saying 'no' to everything else I'd rather be doing.

That sounds like a mundane attitude problem - ADHD problems can sound like ordinary problems (we're only human!), but the big difference is how unrealistic it is to "power through" problems, and what happens when we ignore them. We're fighting a brain that works differently at a physical level; your conscious mind can only do so much about that.

Choosing where your attention goes (either activating focus or breaking off focus) drains executive function, and the neurotransmitters that power it. ADHD brains are known to consume executive function more often, and to draw deeper from it. We have something like a 25% penalty towards available executive function. So an ADHD brain can easily run out of steam in circumstances a neurotypical person can sail through.

Brain scans show that ADHD brains use an inefficient subsystem to maintain focus, and also never stop daydreaming, so there's constant noise running in our heads. Maintaining focus is just plain harder for us. https://www.additudemag.com/current-research-on-adhd-breakdo...

Meds can help with this, but they don't "fix" ADHD; they only help us manage our symptoms to varying degrees.

In my childhood my ADHD was obvious because I was physically hyperactive - I was bouncing off the walls. When I got older and calmed down, I figured I'd somehow grown out of ADHD or something. I learned that you never grow out of it. Some of the symptoms were things I didn't know were ADHD, like my relationship with time. As for the hyperactivity, in adulthood turns from external to internal - your mind can't stop running.

For burnout symptoms specifically, ADHD can play its own role there. Online ADHD communities talk about "ADHD burnout". I haven't seen research about it, but its cousin, "autistic burnout" has early research, and they share the same root cause: "executive function depletion" caused by trying to power through neurological needs. Your brain just can't make chemicals as fast as you're using them up, and eventually you run out. An important distinction between burnout and depression: burnout tends to affect only work, while your mood is normal off-hours. Depression affects everything. Executive function depletion looks more like depression, despite the "burnout" moniker.

Executive function controls your ability to exercise willpower and take action, as well as your ability to regulate your emotions. If your brain runs out of the chemicals that make this work, these two things will fall apart. The only solution appears to be to remove yourself from the circumstance that overtaxes your executive function, then wait days / weeks for your neurology to recover. If it takes longer, you have additional factors in play.

Anecdotally, a lot of ADHD people find it challenging to keep normal jobs, and eventually find themselves in less traditional career paths where they can follow their mind's natural whims instead of struggling against them all day.

Another important ADHD thing for me is that ADHD brains often only have two ways of perceiving time: "now" and "not now". This is a component of time blindness, but I like to call it "the eternal now". Whatever I'm experiencing right now is the only thing that exists. If I'm happy, I'm happy with my whole being. Or sad. Or angry. I don't do well with delayed gratification because all I know is what this moment feels like - the future is irrelevant. Doing unpleasant work for "those moments that make it all worthwhile" - that doesn't exist for me. A brief moment in the past or future doesn't do anything for what I feel right now.

One more thing: ADHD people wind up relying heavily on routines and habits. Literally any amount of friction can stop you from initiating tasks, so any way to remove friction, avoid making decisions, or otherwise delegate willpower and memory to your environment becomes crucial just to function like a normal person. Three examples: 1) I reliably get my dishes into the dishwasher now that we have a clean/dirty sticker, because figuring out whether it's dirty was enough friction that I just left dishes on the counter. 2) I've heard several people say they actually vacuum once they got a cordless vacuum, because handling the cord was enough friction to discourage them from vacuuming at all. 3) I rely heavily on calendar/task reminders to get anything done. I can forget an important todo in seconds, so it has to make it into my phone.

It's worth noting that my ADHD won't be your ADHD experience. ADHD isn't a single, atomic condition - it's a collection of abnormalities that are so tightly intertwined that we can't tell where each starts and ends, so we have to treat them as one big lump of symptoms. There are six widely-recognized scientific models for what ADHD does to the mind, because that's the kind of complexity we're dealing with. That means each of us will have different limitations.

You may find it worth googling "spoon theory" - it's a mental model of how much energy you have that neurodiverse people find useful for understanding and planning their day-to-day experience. I also recommend the podcasts ADHD Nerds and Translating ADHD.

Re:The Cause of Depression Is Probably Not What You Think by petemir on Friday January 27, 2023 @03:00AM (#34543737)
That's a lot of great information, it will take me some time to grasp it :), thank you very much for your time!
Re:The Cause of Depression Is Probably Not What You Think by smn1234 on Thursday January 26, 2023 @12:15PM (#34534770)
which supplement helped you most ?
Re:The Cause of Depression Is Probably Not What You Think by spiffytech on Thursday January 26, 2023 @12:24PM (#34534954)
I have a genetic mutation called MTHFR C677T, which means my body doesn't process vitamin B9 with the necessary efficiency. B9 is upstream of regulating the quantities of monoamine neurotransmitters the brain synthesizes (serotonin, dopamine, and norepinepherine).

(Not everyone with an MTHFR mutation experiences symptoms. For a long time I didn't. Best guess is my body changed after a period of intense stress.)

I take L-Methylfolate 15mg, which bypasses my digestion and provides my body with the processed materials directly.

The brand name for this is Deplin, which requires a prescription. I just switched to over-the-counter L-Methylfolate - it remains to be seen if it's as effective.

Fun fact: once I started taking Deplin, I had to come off of all my traditional antidepressants. They were at max dosage and having no effect, but once my brain was flooded with neurotransmitters, all the antidepressant side effects kicked in, including (perversely) amplifying depression symptoms.

Re:The Cause of Depression Is Probably Not What You Think by bnjms on Thursday January 26, 2023 @05:46PM (#34539983)
How did you find out about the MTHFR mutation? How was it tested for?
Re:The Cause of Depression Is Probably Not What You Think by spiffytech on Thursday January 26, 2023 @05:55PM (#34540056)
I took a mail-in genetic test from Genomind. I didn't understand the significance of the result until I was coincidentally prescribed Deplin and mentioned the mood change to my ADHD coach, who connected the dots.

Having a concrete scientific explanation for the empirical result I was seeing was a great confidence booster, bolstered some hypotheses I had, and helped me identify next steps in my journey.

Re:The Cause of Depression Is Probably Not What You Think by kayodelycaon on Thursday January 26, 2023 @06:39PM (#34540436)
I have the same MTHFR mutation. Deplin really helped with some serious short-memory issues. Can’t speak for the depression aspect since I’m bipolar. Too much noise to signal.

Over the counter should be identical. I only prefer the prescription because it’s regulated and less likely to be fake. :)

Re:The Cause of Depression Is Probably Not What You Think by slv77 on Friday January 27, 2023 @08:33AM (#34545763)
TMG (betaine) utilizes an alternate methylation pathway and for me was life changing.
Re:The Cause of Depression Is Probably Not What You Think by resters on Thursday February 02, 2023 @07:11AM (#34625476)
I'm curious if you noticed any other health changes/improvements after starting L-Methylfolate.
Re:The Cause of Depression Is Probably Not What You Think by spiffytech on Thursday February 02, 2023 @11:05AM (#34628493)
I didn't notice anything else, but the mood impact was all I was paying attention to.
Re:The Cause of Depression Is Probably Not What You Think by TurkishPoptart on Thursday January 26, 2023 @04:46PM (#34539314)
>My problems came about because I had undiagnosed and unappreciated neurological + genetic conditions that created stacking debuffs that made ordinary SWE jobs tax my executive function and deplete my neurotransmitters, eventually leaving me personally and professionally debilitated.

I love how you used "stacking debuffs" here. That made me smile.

Re:The Cause of Depression Is Probably Not What You Think by hi41 on Thursday January 26, 2023 @12:21PM (#34534878)
I can relate to your comment a lot. I went through many years of isolation during my childhood resulting in poor social skills. After so many years my thoughts are continually negative. Like you, I too don’t have any friends. I am unable to break the cycle of loneliness. When I try my interactions are awkward which makes me self-conscious and I withdraw.
Re:The Cause of Depression Is Probably Not What You Think by vervez on Thursday January 26, 2023 @12:27PM (#34535031)
Thanks for sharing and i'm happy to be your friend :)
Re:The Cause of Depression Is Probably Not What You Think by agumonkey on Thursday January 26, 2023 @12:29PM (#34535075)
It would be interesting to know what phases our brains go through that 'settle' emotional / social reflexes.

I had a strange life due to pre-wired issues, until 30 when a few traumatic event (including a first relationship that was as positive as negative) completely altered my reality. I was very surprising to say the least how one day you cannot exist socially (total shut-in with obsessive painful thoughts on a daily basis), and the next one you see colors and friendliness everywhere. Deep in your guts, something that really lifts your mind, imagination and heart solidly, not just a philosophical understanding.

I had a year of socially vibrant emotions but gradually went back to my old self (avoidant) but I still remember that my reality is somehow altered and very far from what others can experience or what is healthy.

If anybody has resources to read or places to monitor I'll be glad to know.

ps: I have a ton of questions regarding the neurology of the perception of "the self" and others for the lack of better terms. if any neuroscientist has time to waste, my email is in my profile, feel free to spam.

Re:The Cause of Depression Is Probably Not What You Think by missingrib on Thursday January 26, 2023 @10:51PM (#34542236)
I don't have much to add except that I've also experienced brief but seismic shifts in my perspective and my view on social interactions. It's been surreal to say the least, and in both of these different states I had a hard time seeing how I ever could have been in the other one.
Re:The Cause of Depression Is Probably Not What You Think by kodah on Thursday January 26, 2023 @03:57PM (#34538725)
Same thing, ish, here. I don't know if my experience is anecdotal but this gets easier with age. I can hypothesize that I did a lot of unpacking and that my experiences today are much more net positive, thus drifting my "default state" farther from a depressive mindset. Mushrooms helped, but I'd recommend anyone looking into mushrooms, or psychedelics in general, to be cognizant that dealing with trauma in a trip can either be really great or really terrifying. You also are largely not in the driver's seat when dealing with trauma in a trip and fighting it will make things worse. The latter being a lesson I've learned many times over at this point.
Re:The Cause of Depression Is Probably Not What You Think by UncleOxidant on Thursday January 26, 2023 @04:14PM (#34538938)
Bullying is such a detrimental thing to experience. It has lifelong consequences. It's good to see that schools in the US are taking it more seriously than they used to. In the past the attitude from adults seemed to be that experiencing bullying would make you tougher. Now we know better.

I know that I personally still suffer the effects of bullying some 40 to 50 years later - for example, I tend to withdraw from any conflict/confrontation in the work setting misinterpreting even constructive conflict/criticism as being directed at me personally. When I was a kid playing with other kids I tended to withdraw and disappear even in situations where there was no bullying because I came to expect it would happen. And I see that I withdraw similarly in the workplace. In that sense the bullying from many years ago has negatively impacted my career and mental health (anxiety, panic attacks and a bit of paranoia as I'm always expecting the worst from other people).

Re:The Cause of Depression Is Probably Not What You Think by charlieflowers on Thursday January 26, 2023 @06:34PM (#34540390)
> It's good to see that schools in the US are taking it more seriously than they used to.

It's nothing but lip service. Bullying is largely the result of several quite obvious system design flaws. 30 kids to one adult is going to result in a Lord of the Flies culture, and that culture will get worse as you scale to additional 30+ classrooms.

Further, actually paying attention to the emotional state of a child and nurturing it carefully at the times it needs that would be hard to pull off in a group of _five_ kids.

But at all costs, we need every mom and dad in the country working all the time to maximize the size of our economy (and help the rich keep getting richer). We need conforming, beaten down worker bees who've been trained to drag out of bed and go where dictated all day long to fill all the jobs that keep the economy humming.

So any changes in the favor of nurturing kids reasonably (not even optimally, just reasonably) just aren't in the cards. But we can make some nice posters about it.

Re:The Cause of Depression Is Probably Not What You Think by RobotToaster on Thursday January 26, 2023 @04:24PM (#34539045)
I've read early life adversity can cause epigenetic changes.
Re:The Cause of Depression Is Probably Not What You Think by citilife on Thursday January 26, 2023 @05:43PM (#34539951)
Probably wont be taken well, but IMO depression is an illness in the spiritual sense. Depression is described as being sad, alone and without hope. That's quite literally what spirituality is for.

I think it's probably impossible to treat with drugs because what people really need are friends, hope and a good outlook on life (which often comes from hope). I'm sure drugs can improve people with imbalances and I'm also sure it's not just one thing that causes depression. That said, it seems like it can often be solved with more traditional means -- finding community and purpose.

Re:The Cause of Depression Is Probably Not What You Think by curioussavage on Thursday January 26, 2023 @09:08PM (#34541603)
I think it’s impossible for many to be treated without drugs. I think it’s irresponsible to tell people with a disease that saps their energy and motivation that the solution is to pick themselves up, willpower their way through it and go be social and active etc. medicine itself is a very traditional means of helping people, probably as old as civilization.

No need for an “imbalance” as justification to get help through medication. This attitude is a form of ableism that can ultimately be deadly for the people it’s targeted at if they buy into it.

Coming from a spiritual and community oriented background people aren’t doing well. “medicine bad” and constant implicit and explicit messages they get - that they must not be doing it right, doesn’t help at all.

Re:The Cause of Depression Is Probably Not What You Think by zadler on Thursday January 26, 2023 @06:07PM (#34540155)
ADHD is the same thing for many people. It’s an infant driven to distraction because of “problems in the environment”. Well maybe there are congenital cases, but there are others that aren’t, and there’s no money in the root cause analysis.
Re:The Cause of Depression Is Probably Not What You Think by curioussavage on Thursday January 26, 2023 @09:45PM (#34541840)
It’s a brain development disorder. That means the brain doesn’t develop the same. Not just a baby “driven to distraction”. Genes and environment. For example it’s more common in premature babies. Plenty of past and ongoing research
Re:The Cause of Depression Is Probably Not What You Think by softfalcon on Thursday January 26, 2023 @06:08PM (#34540172)
This is similar to my formative years. At 5 1/2, moved to a new city. Was bullied as the outsider foreigner kid until around 12 when we moved to another city. Was bullied again as the outsider foreigner kid.

I turned into a depressed, "emo", grumpy kid around 8-12 and that became an angry, misunderstood kid after the second move. It has been decades since that time, but I am doing better now.

Being depressed, moody, overly serious, is my default now. I've learned to work past it like you've described, change my outlook. It still sucks having a default downer attitude in my head though. Still more work to go.

My parents and siblings were always perplexed by this. To this day, they still think nothing is wrong with how it all went down. I was just a "problem kid". That worked for them, problem kid was a convenient scape-goat for all the other familial difficulties we had going on.

If I ever have kids, I'll do my best to not disrupt their lives the way mine was. Hopefully, I'll be a lot more attuned to make sure they're dealing with social pressures better than I did. No one needs to live the way I lived, it's not mentally healthy.

Re:The Cause of Depression Is Probably Not What You Think by lawrenceyan on Thursday January 26, 2023 @06:24PM (#34540300)
If you want to dive further and resolve things: http://sodapi.leighb.com/
Re:The Cause of Depression Is Probably Not What You Think by TaupeRanger on Thursday January 26, 2023 @06:53PM (#34540565)
For every one of these anecdotes, there's another where the kid has a great childhood and school experience but still ends up depressed. Or one that is severely bullied but ended up enlightened and happy. Psychiatrists can come up with whatever post hoc explanations they want, but as you said, it's multifactorial, and therefore does not admit simple explanations.
Re:The Cause of Depression Is Probably Not What You Think by jakeinspace on Thursday January 26, 2023 @07:59PM (#34541147)
Yeah, I'd fit in that camp. I don't think I've got any repressed childhood trauma hiding under 20 layers, ready for a psychiatrist to uncover, I'm just sad. There are good days and bad.
Re:The Cause of Depression Is Probably Not What You Think by likeabbas on Thursday January 26, 2023 @08:03PM (#34541176)
Anyone can succumb to depression. I was giving my experience as an example to show that it’s important for people to understand why they are depressed, and that psychiatry may help you find the reason.
Re:The Cause of Depression Is Probably Not What You Think by TaupeRanger on Thursday January 26, 2023 @11:13PM (#34542384)
My point is that you don't know if psychiatry actually gave you the reason. It may actually have nothing to do with that.
Re:The Cause of Depression Is Probably Not What You Think by heavyset_go on Thursday January 26, 2023 @08:11PM (#34541221)
The link between childhood abuse and neglect and mental illness like depression is well documented.
Re:The Cause of Depression Is Probably Not What You Think by cvccvroomvroom on Thursday January 26, 2023 @11:43PM (#34542565)
Depression seems like dementia/Alzheimer's: not a single disease but a process with holistic factors.

Interestingly, I'm convinced depressive state accumulates during a sleep cycle. Missing a single dose of mirtazapine and then sleeping feels exactly like an alcohol hangover. I'm also convinced alcohol is a CNS depressant and abuse of it induces depression.

Edit: Similar experience. Chaotic home life with fighting parents with high anxiety levels. Emotional problems, speech issues, out-of-norm appearance and intellect, bullying, and intense untreated depression and ADHD-PI for many years. Too many factors to control for. I suspect genes and epigenetics.

Re:The Cause of Depression Is Probably Not What You Think by goldenchrome on Thursday January 26, 2023 @11:55PM (#34542635)
I’ve had a similar experience so I’m sympathetic. However, I don’t totally believe what your psychiatrist told you. People don’t just get randomly bullied, just like people don’t get randomly popular. I believe that there’s a common set of personality types across our species and you (and I) are just less socially adaptive. So we’re weirder, more prone to being an outsider, and less likely to make friends.

I wouldn’t put this all on your experiences from a two year period from decades ago. It’s probably just who you are.

I think it’s important to frame it this way in order to empower yourself. If it’s just who you are, then you can accept it, adjust the way you live, and even alter your perspective enough where you don’t feel weighed down anymore.

But if it’s an injustice that happened to you far in the past then you’re a victim and you just have to deal with it because you didn’t get lucky.

Many people don’t want to take my perspective because it sort of sounds like I’m saying that some people deserve to be bullied. I do think it’s true in a way, but then I’m not one who thinks life should be fair.

Re:The Cause of Depression Is Probably Not What You Think by nequo on Friday January 27, 2023 @12:01AM (#34542674)
I think that's a good point.

Maybe there is truth to both, and the brain is plastic, so we can also change who we are.

Re:The Cause of Depression Is Probably Not What You Think by fithisux on Friday January 27, 2023 @12:36AM (#34542886)
In a big degree it reflects me.
Re:The Cause of Depression Is Probably Not What You Think by pilif on Friday January 27, 2023 @12:53AM (#34543022)
Let me add a counter anecdote: from kindergarten through primary school and high school my life was hell thanks to bullying (being slightly neurodivergent in the 80ies and 90ies is a recipe for disaster) to the point of me nearly killing myself.

Once I left school behind me and met people who respected me, I managed to let all of that past behind me and become a very happy person with (so far) zero depressive tendencies. There is still some trauma left when I see my kid being teased or teasing somebody (to a much smaller scale than what I went through), but aside of that I'm very glad my brain managed to escape hell unscathed.