lawrenceyan

Not sure if you'll see this comment since it's been a week, but how did you find this out? Is 3.5 Pro officially cancelled internally? Are they only working on 4 Pro now?

True

I'd argue the reason we’ve spun our wheels on Alzheimer's for decades isn't just about a flawed amyloid model. It’s a symptom of a much larger, dying paradigm in biotech.

For decades, the industry standard was to hunt for targeted small molecules to solve singular biological issues. And to be fair, I don't think this was because of a lack of vision as it was simply the strict limit of our technological capabilities at the time. But attempting to treat a cascading, systemic disease like Alzheimer's with a single targeted molecule is like hoping replacing one pipe will solve the problem when the issue is that the entire plumbing system is corroding.

This fundamental mismatch is exactly why clinical progress has stalled, and I believe the future of treating Alzheimer's will instead closely mirror how our approach to oncology has evolved.

We spent years searching for a universal molecule to cure cancer before we accepted reality. We now know that effective treatment often requires sequencing a tumor's mutanome to develop a highly personalized intervention for the individual. As neurodegenerative systems fail with age, we face that exact same biological complexity. A traditional small molecule is not going to rescue a globally failing network.

My personal take is that we won't see a true breakthrough in Alzheimer's until capital fully rotates out of these legacy, single-target pipelines and into programmable biological systems.

What Andreessen is hinting at, albeit still largely surface level, is 无心 or no mind.

Popular in martial arts and Buddhist philosophy, I think practically what you should take away is that body and mind are fundamentally intertwined.

Introspection is a practice of the mind, specifically cognition centered around portions of the brain like the prefrontal cortex. There’s a lot more to who you are and areas you can hone / cultivate.

The HN crowd is probably overweighted on cognition, and could do with spending more time in other areas: https://www.cheltenhamzen.co.uk/writings/gut-instinct

Hetzner bare metal ran much of crypto for many years before they cracked down on it.

There's something deeply poetic about using modern engineering knowledge to breathe new life into the warm, fuzzy glow of an analog CRT.

This is really cool, thanks for surfacing.

Going to be so awesome when we have native crypto rails live in game for mmorpgs.

Biggest update I see is that he thinks AI 2027 is actually going to happen.

Build out distribution first and generate network effects.

This piece totally misreads the temperament of actual builders imo. The author confuses a malicious will to power with a genuine, if sometimes naive, optimism that code/crypto can solve human coordination problems.

Found this short story on Openclaw to be relevant:

https://x.com/gf_256/status/2018844976486945112

Part of the reason why I come to HN is that conversations like these still happen.