News for hackers. Stuff that matters.
Re:Lesson of ivermectin: meta-analyses based on summary data... by rory on Wednesday September 22, 2021 @10:55AM (#28617011)
Ivermectin probably doesn't do anything to fight Covid-19, but the American media has really shown their corruption in the way they've treated it.

It's clearly a safe drug to take in human-designed doses, and it's cheap to produce. Laughing at people for poisoning themselves with "horse dewormer" instead of pointing out that they are turning to the vet store because their access to medicine has been marginalized is sick.

And maybe it does help, I don't know. Unproven != disproven.

Re:Lesson of ivermectin: meta-analyses based on summary data... by tptacek on Wednesday September 22, 2021 @10:56AM (#28617027)
It matters a lot if ivermectin doesn't do anything to stop C19, even if it is otherwise safe (it surely is, dosed professionally). People take ivermectin instead of vaccinating or complying with NPIs. If ivermectin doesn't work, that is a very, very big deal.
Re:Lesson of ivermectin: meta-analyses based on summary data... by rory on Wednesday September 22, 2021 @11:15AM (#28617278)
> People take ivermectin instead of vaccinating or complying with NPIs

Doing one thing but not another doesn't imply you're doing one thing instead of another.

Do you truly believe the people ODing on ivermectin would be lining up for vaccinations if it didn't exist?

Re:Lesson of ivermectin: meta-analyses based on summary data... by myrmidon on Wednesday September 22, 2021 @11:31AM (#28617494)
Lining up? Not necessarily.

But it seems almost certain to me that at least some people feel safe thanks to taking ivermectin (while distrusting mainstream vaccines), and those people would turn eventually to the vaccines if those were the only perceived path towards C19 safety.

Re:Lesson of ivermectin: meta-analyses based on summary data... by rory on Wednesday September 22, 2021 @11:39AM (#28617610)
Perhaps on the margin some would, but I suspect most would fall into the "natural immunity" camp.

So in my mind, we need to weigh the damage done by blocking safe ivermectin use for some number of people to the damage done by a much-smaller number of people remaining unvaccinated when they otherwise would get the jab.

Seems like it could go either way depending on your specific assumptions.

Re:Lesson of ivermectin: meta-analyses based on summary data... by threecheese on Wednesday September 22, 2021 @11:48AM (#28617748)
One doesn't imply the other, but it is certainly happening. People are using (being led to use) ivermectin as a prophylactic against covid, an alternative to the vaccine.
Re:Lesson of ivermectin: meta-analyses based on summary data... by tptacek on Wednesday September 22, 2021 @12:33PM (#28618398)
I don't know what this is supposed to mean, but a close family member took ivermectin instead of being vaccinated, and caught a serious case.
Re:Lesson of ivermectin: meta-analyses based on summary data... by rory on Wednesday September 22, 2021 @01:01PM (#28618774)
It's pretty simple: had ivermectin not existed, would that person have gotten vaccinated?
Re:Lesson of ivermectin: meta-analyses based on summary data... by tootie on Wednesday September 22, 2021 @03:42PM (#28620861)
On The Media did a really good segment with a journalist from Mother Jones of all places. She broke down the rise of Ivermectin and the whiplash response to demonize it even when, as you say, it is safe for human consumption and had at least some positive in vitro test results. As much as it is not worthy of being recommended as a treatment, it's unlikely to be harmful and has/had at least a slim chance of working.

https://www.wnycstudios.org/podcasts/otm/segments/how-iverme...

Re:Lesson of ivermectin: meta-analyses based on summary data... by rualca on Wednesday September 22, 2021 @04:11PM (#28621146)
> As much as it is not worthy of being recommended as a treatment, it's unlikely to be harmful and has/had at least a slim chance of working.

Keep in mind that Ivermectin is being pushed within antivaxers circles as a prophylactic and the true COVID-19 cure, in contrast with all COVID-19 vaccines and even mask mandates.

Thus it's false to claim that this push towards Ivermectin is harmless as, at best, it's pushed as a placebo that empowers vulnerable people to catch and spread the disease, which ultimately means they are harming themselves and everyone around them.

Re:Lesson of ivermectin: meta-analyses based on summary data... by tootie on Wednesday September 22, 2021 @04:22PM (#28621263)
That's not the argument though. Listen to the segment. Giving people false hope and baseless medical advice is one thing, but the anti-ivermectin crowd was going overboard including amplifying specious stories about rampant ivermectin poisoning. Ivermectin is absolutely prescribed to humans for some conditions and is being actively studied as an anti-viral agent against other illnesses (notably dengue and yellow fever). Doctors can prescribe it to patients unable to be vaccinated within their discretion. The debate here is that you can't counter one form of misinformation with your own or else nobody is credible.
Re:Lesson of ivermectin: meta-analyses based on summary data... by rualca on Wednesday September 22, 2021 @04:26PM (#28621313)
> That's not the argument though.

It's not the argument? It is a statement of fact. There is no way around it. Consuming a placebo to subsequently validate and provide incentives to put yourself and others at risk is the whole reason why Ivermectin poses a major problem. No one complains that people take paracetamol even though it is not effective at reducing Covid19 spread. Why is that?

Re:Lesson of ivermectin: meta-analyses based on summary data... by tootie on Wednesday September 22, 2021 @08:07PM (#28623690)
Just listen to it. It is absolutely not about advocating in favor of ivermectin. It is about very wrong information spread against ivermectin as a response to the misinformation spread in favor of it.
Re:Lesson of ivermectin: meta-analyses based on summary data... by trainsplanes on Wednesday September 22, 2021 @10:43PM (#28624701)
One problem is that people are self-treating with it. Eyeballing measurements of medicine bought at a farm supply store and sticking it in your child's mouth isn't good.

Furthermore, enabling random unproven treatments is on the same level as saying we should stand by and support homeopathic treatments as a valid alternative to vaccines during a pandemic. We don't let people choose between a tetanus shot or a cup of green tea and olive oil when they step on a rusty nail. It doesn't make sense to let them choose between worm meds and a vaccine when it comes to covid.

Re:Lesson of ivermectin: meta-analyses based on summary data... by VikingCoder on Wednesday September 22, 2021 @04:56PM (#28621687)
> Unproven != disproven.

How many people have been convinced by the supposed effectiveness of Ivermectin and Hydroxychloroquine that they then decided to not get vaccinated?

It's really not as simple as "unproven != disproven".

Re:Lesson of ivermectin: meta-analyses based on summary data... by SnowProblem on Wednesday September 22, 2021 @05:26PM (#28622056)
In my estimation, probably fewer than authorities think.

US Census collect data on reasons for vaccine hesitancy [1]. #1 and #3 are distrust - of vaccines and of government - which anecdotally matches my network. If that's the case, then we should expect that mischaracterizing treatments to promote vaccines [2] would not be very effective, and most Western countries now are leveling off fairly low in their vaccination rates [3]. But rather than more honesty, we're getting more mandates.

I think Dr. John's Cambell's position, of honest assessment, would have been better as the official position [4]. It's hard to imagine how trust could be regained now though without some sort of reckoning.

1. https://www.census.gov/library/visualizations/interactive/ho...

2. https://www.youtube.com/watch?v=_gndsUjgPYo

3. https://youtu.be/hVtX7tY1B0U?t=210

4. https://www.youtube.com/watch?v=eO9cjy3Rydc&t=600

Re:Lesson of ivermectin: meta-analyses based on summary data... by rajin444 on Wednesday September 22, 2021 @05:08PM (#28621839)
How many people were convinced of the "95+%" effectiveness of the vaccine only to learn that it fades? Why weren't they told it would fade up front?
Re:Lesson of ivermectin: meta-analyses based on summary data... by robbiep on Wednesday September 22, 2021 @05:30PM (#28622113)
Firstly, it wasn’t at all clear how quickly antibody levels would fall, because the data wasn’t available. But it was clear to everybody with scientific literacy that antibody levels would fall over time, because that’s how immune responses work.

What’s been fascinating about the data arising from Pfizer, moderne and astra Zeneca dosing intervals is that it seems quite likely that the spacing is quite to highly responsible for this rather than something inherent to the formulation which is adding to our body of evidence and understanding

Re:Lesson of ivermectin: meta-analyses based on summary data... by unreal37 on Thursday September 23, 2021 @12:23AM (#28625198)
I certainly knew last year, as we were watching the stage-1 stage-2 trial results come out, that "how long it lasts" was not known. The news was even saying, it may need to be renewed every few years.

And I'm not really a big follower of science. I just assumed it was like "the flu shot" which you need to get every year.

Re:Lesson of ivermectin: meta-analyses based on summary data... by davidw on Wednesday September 22, 2021 @03:26PM (#28620647)
The actual vaccine is free, though.

Edit: we can talk plenty about how bad the US health care system is, but in this case, the actual vaccine, that does a fantastic job of protecting people from COVID, is free in that you don't have to spend a dime out of pocket.

Re:Lesson of ivermectin: meta-analyses based on summary data... by hellotomyrars on Wednesday September 22, 2021 @10:06PM (#28624489)
If vaccines weren’t so political across the same divide as free/socialized healthcare people might actually realize that it isn’t the end of the world or the American way of life to have access to healthcare. Oh well.
Re:Lesson of ivermectin: meta-analyses based on summary data... by ufo on Thursday September 23, 2021 @12:44AM (#28625282)
The human-designated dose of ivermectin is usually a one-time dose. One of the problems is that not only have some people use non-human doses, but there are also many who are on a continuous regimen of ivermectin. That can also be dangerous, because it is not how the drug was designed to be used!
Re:Lesson of ivermectin: meta-analyses based on summary data... by shadowgovt on Wednesday September 22, 2021 @11:02AM (#28617099)
How many users have been taking it in human-designed doses, given that it's not generally prescribed for COVID-19 (and therefore those who are taking it for that purpose are mostly self-medicating)?
Re:Lesson of ivermectin: meta-analyses based on summary data... by xtracto on Wednesday September 22, 2021 @11:43AM (#28617664)
Outside of the US is prescribed quite often. It is in the Mexican Health System Protocol ([1] page 6) and has been widely researched [2] in there. Also, in Mexico Ivermectin was widely available (without prescription) before Covid19. It is commonly used in children against lice, and also in the general population as a dewormer once a year (in Mexico, people are used to take these type of medications once a year).

I understand the hesitation Americans have against it, given its lack of availability (I would never consume a medicine made for animals) but from my outside perspective, the issue has been politicized so much that both "left" and "right" Americans get blinded by their views and are not open to even talk about it (it's either, you eat dewormer antivaxxer! or muh freedom!).

I got my two vaccines as soon as I could (I had covid in march 2020 and had a terrible time, and I am totally pro vaccines, shit in Mexico we get a heck of a lot of vaccines haha) but given the safety profile of Ivermectin, I am 100% in favour of people taking it if they get COVID19.

[1] http://educacionensalud.imss.gob.mx/es/system/files/Algoritm...

[2] https://covid19.cdmx.gob.mx/storage/app/media/Articulos/revi...

Re:Lesson of ivermectin: meta-analyses based on summary data... by h2odragon on Wednesday September 22, 2021 @11:55AM (#28617867)
> (I would never consume a medicine made for animals)

Why not?

I either pay $150+ all up for a doctor visit, prescription, etc for antibiotics, or $20 for a bottle of "fish antibiotics" at the feed store. Either way I get amoxicillin; but from the feed store I get 3x the amount and in smaller capsules which makes adjusting dose easier.

We stock the "horse paste" ivermectin for our half dozen hounds, I've been known to have a lick of it myself when ive been out barefoot in the mud, just in case. we have whipworm out here and they're not likely to take in humans but when they do its nasty.

Re:Lesson of ivermectin: meta-analyses based on summary data... by shapefrog on Wednesday September 22, 2021 @05:09PM (#28621849)
I take it you have no problem eating dog food for your 3 square meals a day plus a few of those chew biscuits for a snack?
Re:Lesson of ivermectin: meta-analyses based on summary data... by OrvalWintermute on Thursday September 23, 2021 @01:43AM (#28625537)
It is kind of crunchy.

Imagine the wet type would go rather well on Carr's Table Water crackers. Could jazz it up with a name like Pate di Cane, perhaps add a dollop of creme fraiche for appearance

Re:Lesson of ivermectin: meta-analyses based on summary data... by shapefrog on Thursday September 23, 2021 @01:22PM (#28632230)
I am thinking a more authentic experience than that.

Up end the can into a metal bowl, chuck it on the floor and whistle that dinner is ready. Then if you have been a really good boy, hang around under the dinner table and hope some people food scraps will find their way into your lap.

Re:Lesson of ivermectin: meta-analyses based on summary data... by shadowgovt on Wednesday September 22, 2021 @12:08PM (#28618046)
Fish antibiotics might be fine, but since they aren't regulated for human consumption it's more of a gamble. Plenty of chemicals that don't hurt fish that the manufacturer therefore won't be testing for that can be harmful to a human. But more importantly in the case of antibiotics: how do you know amoxicillin is the right one for what ails you? There are multiple antibiotics for multiple bacteria, and applying the wrong one can throw your microbiome out of whack with no treatment to the disease itself.

Health care in the US is broken for several reasons, but "Doctors see a patient before prescribing the right medicine" isn't one of them. DIY medicine has dangers, and the FDA regulations are paid for in blood.

https://www.smithsonianmag.com/science-nature/here-are-reaso...

Re:Lesson of ivermectin: meta-analyses based on summary data... by h2odragon on Wednesday September 22, 2021 @12:20PM (#28618235)
> how do you know amoxicillin is the right one for what ails you?

In our case, that's what the doctor prescribes for my wife's chronic sinus infections whenever she asks one about them, and I've been stocking it as a goto first antibiotic for veterinary use since i started caring for my animals 30yr ago.

In anyone else's case, there's no great barrier to educating yourself about what you put in your body and why, and taking responsibility for your own health. Doctors are consultants, not priests.

Re:Lesson of ivermectin: meta-analyses based on summary data... by xtracto on Wednesday September 22, 2021 @01:04PM (#28618831)
> Doctors are consultants, not priests.

Oh man you couldn't be more spot on. There's no magic in what doctors do and how doctors prescribe a medication. There are two advantages that a doctor can have over an educated layman: 1) Experience: the number of cases they have seen and thus can make an educated inference to what is going on. 2) Their knowledge of anatomy (all they studied during their 4-6 years education).

Having been living with a chronic condition for more than 20 years, having gone to more than 10 specialists in 3 different countries and countless of studies I've seen the limitation of Medical Doctors (they are human beens at the end). There comes a time when you get to see that you understand your body better than any doctor could.

Re:Lesson of ivermectin: meta-analyses based on summary data... by shadowgovt on Wednesday September 22, 2021 @01:21PM (#28619073)
Your circumstance is one of the flaws in the US system. Having been given a solid diagnosis once for that initial $150 charge, instead of relatively-inexpensive maintenance of health that could be done without doctor intervention, we require doctors to re-see and re-prescribe when a patient has a chronic condition.

There is some wisdom in that (while "when you hear hoofbeats, think horses, not zebra" is a good maxim, sometimes it's horses and zebra), but IMHO once you're diagnosed with something chronic and treatable, minimize the red-tape to keep it treated.

Re:Lesson of ivermectin: meta-analyses based on summary data... by Clubber on Wednesday September 22, 2021 @03:55PM (#28621019)
>Having been given a solid diagnosis once for that initial $150 charge, instead of relatively-inexpensive maintenance of health that could be done without doctor intervention, we require doctors to re-see and re-prescribe when a patient has a chronic condition.

>There is some wisdom in that

It's pretty convenient for the doctors as well. $150 to write some shit on a pad and sign it. Good work if you can get it.

Re:Lesson of ivermectin: meta-analyses based on summary data... by shadowgovt on Wednesday September 22, 2021 @06:07PM (#28622612)
Humans are very complicated, and writing the wrong stuff on a pad can get someone killed.

Amoxicillin isn't available without a prescription because using the wrong antibiotic on a disease can make the patient worse.

Re:Lesson of ivermectin: meta-analyses based on summary data... by Clubber on Wednesday September 22, 2021 @06:45PM (#28623004)
The example I was replying to was when the patient was already diagnosed with a chronic illness and still had to go back to the doctor every month or so to renew the script, because reasons.
Re:Lesson of ivermectin: meta-analyses based on summary data... by shadowgovt on Wednesday September 22, 2021 @07:19PM (#28623296)
Me too.

When the disease is something that requires frequent reapplication of antibiotics, it's important to confirm periodically that they're working (and that the problem isn't a different bacteria that's amoxicillin-resistant).

Re:Lesson of ivermectin: meta-analyses based on summary data... by Clubber on Friday September 24, 2021 @03:07PM (#28646569)
That's a convenient method when the patient can also make a phone call / appointment to inform the doctor they don't seem to be working rather than extorting (and I'm not using that word lightly) $150+ a month. Also consider the multitudes of other medications where there is no real argument to require a monthly extortion fee.

It seems to be this is more for the benefit of the healthcare system financially rather than the patient or the health of the population as a whole.

Re:Lesson of ivermectin: meta-analyses based on summary data... by shadowgovt on Saturday September 25, 2021 @10:27AM (#28653459)
> Also consider the multitudes of other medications where there is no real argument to require a monthly extortion fee.

I think that's really where one needs to look to square the circle. The drugs available prescription-free have lower risk of injury or disruption when abused. Antibiotics are not in that category, which is why they require doctor oversight and a prescription. Take too much, and you can damage your digestive tract. Take too little, or the wrong kind, and you can worsen the infection by killing the bacteria that the immune system can control, leaving their food supply for the ones the immune system is struggling against.

They could require less doctor oversight perhaps, but probably not zero.

Re:Lesson of ivermectin: meta-analyses based on summary data... by shadowgovt on Wednesday September 22, 2021 @11:54AM (#28617859)
My mistake; my comment was extremely US-centric.

In the US, there isn't a taboo against taking it because it's generally animal-prescribed; it's used as a human anti-parasitic here too. The issue is that people are self-medicating with veterinary-supply doses because it isn't prescribed for COVID-19 (as it's not indicated for treating it).

Re:Lesson of ivermectin: meta-analyses based on summary data... by buescher on Wednesday September 22, 2021 @11:17AM (#28617305)
Fortunately for me, I know next to nothing about ivermectin, except that the American left is very, very concerned people might be taking it, and I don't know of anyone actually taking it that doesn't have a radio show or podcast. So in my ignorance I would guess very few people are actually taking it and a lot of people are talking about it.
Re:Lesson of ivermectin: meta-analyses based on summary data... by jdsfighter on Wednesday September 22, 2021 @01:16PM (#28619005)
Alternate data point, I live in one of the major cities in Oklahoma. I work for a mostly blue collar shop. The overwhelming majority of our workers are unvaccinated, and I'd say a large fraction of them are very vocal about their use of ivermectin.
Re:Lesson of ivermectin: meta-analyses based on summary data... by davidw on Wednesday September 22, 2021 @03:27PM (#28620661)
People are turning up in hospitals because they've OD'd on it.
Re:Lesson of ivermectin: meta-analyses based on summary data... by swader999 on Wednesday September 22, 2021 @03:38PM (#28620792)
No they aren't. All of those reports have been retracted.
Re:Lesson of ivermectin: meta-analyses based on summary data... by davidw on Wednesday September 22, 2021 @03:41PM (#28620838)
https://news.ohsu.edu/2021/09/17/five-oregonians-hospitalize... doesn't look retracted to me.

Only stands to reason that if people are taking it kind of randomly, a few are going to screw up and take too much.

Re:Lesson of ivermectin: meta-analyses based on summary data... by swader999 on Wednesday September 22, 2021 @03:48PM (#28620907)
Probably ingested the pour on treatment or one of the brands that mix other active ingredients that you don't want.
Re:Lesson of ivermectin: meta-analyses based on summary data... by tawmec on Wednesday September 22, 2021 @08:42PM (#28623933)
Not once in that article is an overdose mentioned.
Re:Lesson of ivermectin: meta-analyses based on summary data... by davidw on Thursday September 23, 2021 @12:39AM (#28625263)
So you're suggesting that taking even a regular dose might send people to the ICU?
Re:Lesson of ivermectin: meta-analyses based on summary data... by tawmec on Thursday September 23, 2021 @04:05PM (#28634544)
The article linked simply says there have been people who misused ivermectin who presented at the hospital. For what reason they went we have no idea because it does not say.

For all we know the two individuals who landed in the ICU were admitted because they were attempting to unsuccessfully self-treat COVID and ended up there, not because of the ivermectin misuse but because of COVID itself.

Re:Lesson of ivermectin: meta-analyses based on summary data... by input_sh on Wednesday September 22, 2021 @11:23AM (#28617398)
There's a right-wing group prescribing it: https://en.m.wikipedia.org/wiki/America%27s_Frontline_Doctor...

They're also the ones that pushed Hydroxychloroquine, have connections to the Tea Party, that "demon semen" lady Trump endorsed is associated with them, and they had their leader and their chief of communication arrested due to their participation in Jan 6th.

They're also the reason you'll see Joe Rogan now spreading ivermectin bullshit.

Re:Lesson of ivermectin: meta-analyses based on summary data... by tzs on Wednesday September 22, 2021 @12:19PM (#28618216)
They've also been selling telemedicine consultations to prescribe ivermectin, taking the money, and then not delivering the consultation [1]. They are a straight up scam posing as a charity.

[1] https://time.com/6092368/americas-frontline-doctors-covid-19...

Re:Lesson of ivermectin: meta-analyses based on summary data... by unanswered on Wednesday September 22, 2021 @07:19PM (#28623300)
> given that it's not generally prescribed for COVID-19

This is disinformation, it turns out. Plenty of doctors are prescribing it. Anyone in the US can go online to one of a dozen telemedicine services and get a prescription for an appropriate dose of ivermectin within hours. This can then be filled at any pharmacy in most states which prohibit pharmacists from refusing to fill prescriptions because they heard on CNN it was for horses. But the media will never report this.

Re:Lesson of ivermectin: meta-analyses based on summary data... by shadowgovt on Wednesday September 22, 2021 @08:49PM (#28623985)
What percentage does "plenty" represent?
Re:Lesson of ivermectin: meta-analyses based on summary data... by soperj on Wednesday September 22, 2021 @11:13AM (#28617253)
Their access to the vaccine hasn't been marginalized.
Re:Lesson of ivermectin: meta-analyses based on summary data... by ashtonkem on Wednesday September 22, 2021 @10:57AM (#28617032)
People are literally taking horse formulations of ivermectin because doctors are rightfully refusing to prescribe ivermectin for an off label and ineffective use.

Oh, and the access to this medicine is “marginalized” BECAUSE IT DOESNT WORK TO TREAT COVID. We generally do not expect doctors to prescribe medicine that will not work or is not appropriate for the patients condition. Complaining about their access being marginalized is like complaining that my doctor is marginalizing my access to Ketamine because I don’t need it.

It’s not “corruption” to point that out.

Re:Lesson of ivermectin: meta-analyses based on summary data... by buu700 on Wednesday September 22, 2021 @11:40AM (#28617628)
In fairness, I see no reason why anyone should be blocked from buying any drug they want, whether it be ivermectin or heroin. The consequence of this restriction is that a subset of the prospective customers will settle for a potentially (more) dangerous alternative source, whether that be horse formulations or black market heroin cut with fentanyl.

It's also a valid point that unproven and disproven aren't equivalent. While I don't think anyone should take medical advice from political sources or for political reasons (therefore, as far as I'm aware, the well studied vaccines should be preferred to ivermectin by the vast majority of people at this time), I do think that it should be anyone's right to have full bodily autonomy and make whatever choices they want. Mainstream consensus is wrong often enough, e.g. the disastrous food pyramid that contributed to today's obesity epidemic.

I agree with the thrust of your point that the idea that there's some kind of widespread anti-Republican medical discrimination or corruption going on is silly. Just pointing out that how things currently are is not how they ought to be, and that this situation is arguably just a subset of the widely reviled War on Drugs.

Re:Lesson of ivermectin: meta-analyses based on summary data... by rory on Wednesday September 22, 2021 @12:52PM (#28618655)
(As the GP) I really appreciate and generally agree with your perspective, but:

> the idea that there's some kind of widespread anti-Republican medical discrimination or corruption going on

is a total mischaracterization of what I was saying. In fact, it's essentially pulled from thin air.

The corruption of the news media is in their choice to mock and literally laugh at people sick from veterinary iver because kicking the out-group is popular with their audience (read $$). They do this instead of explaining (in a meaningful way) how we got here, and what steps we can take to make the situation better.

Re:Lesson of ivermectin: meta-analyses based on summary data... by buu700 on Wednesday September 22, 2021 @01:35PM (#28619253)
is a total mischaracterization of what I was saying. In fact, it's essentially pulled from thin air.

You did refer to "marginalization" of (Republicans') access to medicine. It was unclear whether you were only referring to the effect of well established federal drug policy and standards of the medical industry or a more specific/deliberate marginalization effort.

The corruption of the news media is in their choice to mock and literally laugh [...]

Ah, well I'm not aware of that, but that may be because I typically rely more on text-based media than video.

Re:Lesson of ivermectin: meta-analyses based on summary data... by ashtonkem on Wednesday September 22, 2021 @02:51PM (#28620202)
> The corruption of the news media is in their choice to mock and literally laugh at people sick from veterinary iver because kicking the out-group is popular with their audience (read $$). They do this instead of explaining (in a meaningful way) how we got here, and what steps we can take to make the situation better.

The idea that this is somehow the media’s fault for not being sufficiently patient and understanding with the ivermectin crowd is actually quite pathetic. Stop infantilizing these people; they are adults with their own agency. Their bad decisions are not the fault of the media[0].

0 - Especially since this crowd was shouting “fake news” for years. How exactly is the media going to convince a bunch of people who are convinced that they’re liars?

Re:Lesson of ivermectin: meta-analyses based on summary data... by titzer on Wednesday September 22, 2021 @03:52PM (#28620968)
It's just more blame game. Who you blame is who you hate. Racists blame black people for being poor, anti-abortion activists blame women for being "promiscuous", coastals blame red staters for being stupid backwoods yokels, red staters blame ivy tower socialists or immigrants, liberals blame rich people, socialists blame corporations, conservatives blame government, Islamic terrorists blame the great Satan, on and on.

Hate = blame

Love = forgiveness

Listen and see whom people blame and that's who they hate. See who they apologize for and that's who they love.

Been that way since forever.

Re:Lesson of ivermectin: meta-analyses based on summary data... by dhimes on Wednesday September 22, 2021 @04:16PM (#28621189)
...And: What you hate tends to be what you don't understand. Also since forever.
Re:Lesson of ivermectin: meta-analyses based on summary data... by abxnlk on Wednesday September 22, 2021 @11:58AM (#28617911)
First of all, trying out random substances or applying existing medicines to different illnesses is exactly how doctors and the pharma industry operate.

It's not like doctors actually always understand what is going on; for example, I think even the precise mechanism of anesthetics isn't well understood yet.

So people volunteer to test a human approved drug for a different application. I don't believe in Ivermectin specifically, but there's nothing fundamentally wrong with that. It's what medicine does, and most researchers at universities don't have a clue either (as we now see in the entire Covid19 comedy).

Re:Lesson of ivermectin: meta-analyses based on summary data... by PaulDavisThe1st on Wednesday September 22, 2021 @01:03PM (#28618823)
> First of all, trying out random substances or applying existing medicines to different illnesses is exactly how doctors and the pharma industry operate.

Sure, but with methodology and metrics to allow the separation of actual effects from placebo, and in some cases even just enough methodology to be able to measure anything at all.

Re:Lesson of ivermectin: meta-analyses based on summary data... by brandonmenc on Wednesday September 22, 2021 @11:13AM (#28617257)
> People are literally taking horse formulations of ivermectin

People are taking the horse formulation because most pharmacists won't even fill an off-label prescription for the drug, which - even if it has no effect on COVID - is safe and taken by a quarter billion people every year.

Let people take it. It's not harmful.

Or, make a big huge deal about people taking it and, well, then it becomes a big huge deal.

Re:Lesson of ivermectin: meta-analyses based on summary data... by heavyset_go on Wednesday September 22, 2021 @05:41PM (#28622241)
It's not a placebo pill, it's an active medication that has effects on the body and undergoes metabolism. Ivermectin inhibits cytochrome P450, which the majority of prescription and OTC drugs are metabolized by.

Administration of a P450 inhibitor will cause the levels of other medications in a person's blood to rise, and will cause some prodrugs to be ineffective due to reduced metabolism.

I can't even walk into a doctors' office and get prescribed Singulair, an allergy medication, without giving them a reason to believe that I need it. And if I was a doctor, I'd err on the side of caution, as well, when it comes to prescribing things I don't think my hypothetical patients need. Not only is it a question of ethics, it's also a question of legal liability and keeping a license to practice.

Re:Lesson of ivermectin: meta-analyses based on summary data... by brandonmenc on Wednesday September 22, 2021 @09:13PM (#28624134)
I agree that a doctor should not prescribe a drug that is going to interact dangerously with a patient's other medication. I also agree that a pharmacist should not fill a prescription if they know it will interact dangerously with the patient's other medication.

But I also don't know the dosage schedule doctors who are prescribing Ivermectin are using. They're probably using one from a research paper that they believe justifies its use to treat or prevent COVID. Those dosage schedules are afaict similar to how it's used to treat on-label conditions - take one dose every three months, or whatever.

It's pure speculation that doctors are out there writing prescriptions for dangerous dosages of Ivermectin.

However one thing for sure is that in lieu of a prescription, people are more likely to self-medicate with a dangerous formulation and dosage, ex: horse paste.

Re:Lesson of ivermectin: meta-analyses based on summary data... by cma on Wednesday September 22, 2021 @11:53AM (#28617835)
> is safe and taken by a quarter billion people every year.

Usually yearly or bi-yearly. Not bi-weekly. There is much less safety data on doses that frequent.

Re:Lesson of ivermectin: meta-analyses based on summary data... by brandonmenc on Wednesday September 22, 2021 @12:23PM (#28618267)
> There is much less safety data on doses that frequent.

You can say the same thing about COVID boosters.

Re:Lesson of ivermectin: meta-analyses based on summary data... by manwe150 on Thursday September 23, 2021 @12:16AM (#28625168)
Yes, but we also have efficacy data on vaccine boosters from small trials that seems reproducible. We don’t have that for ivermectin (the original article here). And the FDA is still arguing about who benefits sufficiently from a booster, but has not yet made it widely available either.
Re:Lesson of ivermectin: meta-analyses based on summary data... by snovv_crash on Wednesday September 22, 2021 @03:52PM (#28620965)
And yet there is a wealth of data on both the safety and the efficacy of covid vaccines, and there is also a wealth of data on the effects of getting covid.

So why are people going for something without any data?

Re:Lesson of ivermectin: meta-analyses based on summary data... by brandonmenc on Wednesday September 22, 2021 @09:29PM (#28624245)
I specifically said boosters.

However, there is no data on the long-term effects of the COVID vaccines, mRNA or otherwise. That's an indisputable scientific fact. They just haven't existed long enough for that data to be available. Hopefully a decade from now we'll discover that they were safe.

We do have data on the long-term effects of Ivermectin.

Someone who is not concerned about COVID will take neither a vaccine nor Ivermectin. Someone who is concerned about COVID but who is also concerned about the long-term effects of the vaccine may opt to take Ivermectin. It's their choice. It could also end up being the wrong choice.

Re:Lesson of ivermectin: meta-analyses based on summary data... by snovv_crash on Thursday September 23, 2021 @01:46AM (#28625548)
Can you show any other vaccine which has long term, but not short term negative side effects, which this concern might be based on?

Because this seems like whataboutism, and of course it's impossible to prove a negative, and people are dying while waiting.

> We do have data on the long-term effects of Ivermectin

At bi-annual dosage rates, yes. Not daily or even weekly.

Re:Lesson of ivermectin: meta-analyses based on summary data... by brandonmenc on Thursday September 23, 2021 @11:11AM (#28630312)
> Can you show any other vaccine which has long term, but not short term negative side effects, which this concern might be based on?

I don't know. But we still may be in the "short-term side effect" phase for the COVID vaccines. It hasn't even been a year.

> Because this seems like whataboutism, and of course it's impossible to prove a negative, and people are dying while waiting.

Not sure how it's whataboutism to point out that some people have lower risks of contracting serious COVID, and that their decision to take a very new vaccine may be different than someone who is more at risk for contracting serious COVID.

If they miscalculate and die, well, that's their decision.

> At bi-annual dosage rates, yes. Not daily or even weekly.

Are the COVID/Ivermectin studies doctors are referencing for prescription dosages recommending daily Ivermectin use?

Re:Lesson of ivermectin: meta-analyses based on summary data... by snovv_crash on Friday September 24, 2021 @06:43PM (#28648594)
It's been over a year for the initial trials, no long term issues yet. How long seems reasonable to you? What are you basing this timeframe on?

If covid is a low risk, then the vaccine, which is essentially just the immune response to covid without any of the actual viral damage, should be much more benign, yes? I'm failing to see the risk here.

The treatment regimens in current Ivermectin studies are usually daily dosage, for which there are no long term studies for humans. Prophylactic usage of Ivermectin is all over the place, but seems to mostly be within 72h of exposure, so several doses per week, which also doesn't have long term studies. Staying on antibiotics for long periods is generally a bad idea due to disturbing the gut microbiota.

Re:Lesson of ivermectin: meta-analyses based on summary data... by manwe150 on Thursday September 23, 2021 @12:18AM (#28625177)
The long term effect of ivermectin seems to be long-COVID (according to the article), which is rare, but just as bad as being unvaccinated, if not worse.
Re:Lesson of ivermectin: meta-analyses based on summary data... by 8note on Wednesday September 22, 2021 @05:41PM (#28622242)
There is some data though, such as it causeing your intestinal lining to strip off and look like worms in your poo
Re:Lesson of ivermectin: meta-analyses based on summary data... by sgt101 on Wednesday September 22, 2021 @11:51AM (#28617807)
I get where you are coming from, but I think that there is a nuance that you have missed. Like many, many drugs - and vaccines - ivemectin has some unpleasant and dangerous side effects in some people rarely. You can see these if you look the drug up :https://www.medicalnewstoday.com/articles/ivermectin-oral-ta... for example.

The point is that if this drug did help people make it through covid (like the vaccines do) then it would be worth the risk of these horrible things happening - if they were rare (they are). But unfortunately it looks like this is not true, so people are taking a risk of having a horrid side effect with no chance of the pill working.

On the other hand if you take the pill to avoid river blindness then the risk of the side effect seems well worth taking to me. But not for covid - 0 benefit for 0.001 risk is not good trade.

Re:Lesson of ivermectin: meta-analyses based on summary data... by brandonmenc on Wednesday September 22, 2021 @12:03PM (#28617971)
All of this is for the patient and their doctor to decide.

Not the pharmacist. Not the FDA.

Re:Lesson of ivermectin: meta-analyses based on summary data... by PaulDavisThe1st on Wednesday September 22, 2021 @01:02PM (#28618787)
They're [often] using the horse formulation because their doctor said no.
Re:Lesson of ivermectin: meta-analyses based on summary data... by angelzen on Wednesday September 22, 2021 @04:12PM (#28621153)
This is such a hypothetical. How many people got ivermectin against their doctor prescription, and how many got adverse effects from that? 1 in 100M?
Re:Lesson of ivermectin: meta-analyses based on summary data... by PaulDavisThe1st on Wednesday September 22, 2021 @04:35PM (#28621429)
Who said anything about adverse effects?
Re:Lesson of ivermectin: meta-analyses based on summary data... by angelzen on Wednesday September 22, 2021 @05:40PM (#28622226)
GGP: ivemectin has some unpleasant and dangerous side effects in some people rarely. [...] people are taking a risk of having a horrid side effect with no chance of the pill working.

GP: All of this is for the patient and their doctor to decide.

P: They're [often] using the horse formulation because their doctor said no.

X: How many got the horse formulation and how many got adverse effects from [horse formulation]?

C: Who said anything about adverse effects?

It this human brain on Twitter? We can't possibly read 4 short stanzas in a row and keep the context?

Re:Lesson of ivermectin: meta-analyses based on summary data... by ABeeSea on Wednesday September 22, 2021 @04:51PM (#28621622)
Farm supply stores are out of stock from idiots buying livestock formation. Some are now requiring proof of horse ownership to buy it.

https://www.google.com/amp/s/news.yahoo.com/amphtml/vegas-st...

Re:Lesson of ivermectin: meta-analyses based on summary data... by sgt101 on Wednesday September 22, 2021 @12:28PM (#28618340)
I agree about the pharmacist - but the drug regulator really does have to have a role. There is a serious information imbalance between patients and doctors and both big pharma and lunatic talkshow host millionaries. Regulation is important to help prevent junk getting pushed into kids arms to make bastards money. It's not perfect and they get a lot wrong, but without it you and I are at the mercy of some very mercy short people.
Re:Lesson of ivermectin: meta-analyses based on summary data... by threeseed on Wednesday September 22, 2021 @04:58PM (#28621714)
Pharmacists are not there to blindly dispense drugs.

They have a legal and moral obligation to understand how those drugs are going to be used and whether the patient is at risk for taking them.

Re:Lesson of ivermectin: meta-analyses based on summary data... by brandonmenc on Wednesday September 22, 2021 @09:01PM (#28624057)
My understanding is that - depending on the jurisdiction - a pharmacist is allowed to refuse filling a prescription if:

- They are morally opposed to the medication, ex: "abortion pills"

- They know that the patient is taking another drug that would result in a deadly interaction

- The patient is drug-seeking a scheduled drug, ex: they've brought multiple valid prescriptions for opiates, but from different doctors

The pharmacist doesn't know why you've been prescribed Ivermectin. They can ask, but you're under no obligation to tell them. Maybe you need it for river blindness. Unlikely, but it's none of their business.

I guess a pharmacist could claim moral opposition to filling an Ivermectin prescription if they believe that sans Ivermectin the patient would instead get a COVID vaccine. That makes sense to me. But it's a slippery slope I'm uncomfortable with.

Re:Lesson of ivermectin: meta-analyses based on summary data... by rualca on Wednesday September 22, 2021 @04:21PM (#28621257)
> All of this is for the patient and their doctor to decide.

> Not the pharmacist. Not the FDA.

In case you don't know,the FDA is the US regulatory body whose mission is to " [protect] the public health by ensuring the safety, efficacy, and security of human and veterinary drugs, biological products, and medical devices;"

In the US, doctors only prescribe drugs that have been verified by the FDA, and pharmacists only distribute drugs approved by the FDA.

If not the FDA, who do you think is responsible in the US to ensure a drug works and is safe?

The FDA is pretty much the US instition devoted to anti-quackery and anti-fraud. Why is this a problem?

Re:Lesson of ivermectin: meta-analyses based on summary data... by brandonmenc on Wednesday September 22, 2021 @08:44PM (#28623946)
I know what the FDA is, what they do, and I agree it is necessary.

The FDA has approved the use of Ivermectin in humans. We're not talking about like, heroin, or some toxic chemical that isn't even a drug.

1 in 5 prescriptions are off-label.

Meaning, to treat conditions that the FDA has not approved the drugs for. This idea that doctors are only allowed to prescribe drugs for FDA-approved use is just like, incorrect.

Re:Lesson of ivermectin: meta-analyses based on summary data... by vernie on Wednesday September 22, 2021 @11:33AM (#28617519)
Is that really the reason or is it that they can't get a doctor to write them an off-label prescription?
Re:Lesson of ivermectin: meta-analyses based on summary data... by cableshaft on Wednesday September 22, 2021 @11:56AM (#28617889)
A friend of mine found a doctor to prescribe it but his pharmacy won't fill it. He is so pissed.

He was only planning to take small doses here or there as he's a teacher and around sick kids all the time, as if it were like Zinc to hopefully help reduce the severity of Covid-19 if he does get it, but despite going through the effort and succeeding in finding a doctor willing to prescribe it (and my friend even signed a document saying he understands it's an experimental treatment and will assume any risks), his local CVS is refusing to fill it.

My opinion is if you can get a proper doctor to prescribe it (by proper doctor I mean none of this "I got a medical exemption for wearing a mask from my Chiropractor" bullshit like is going on in Florida), a pharmacy shouldn't be allowed to decide not to fill it, as if they know better than your doctor.

Re:Lesson of ivermectin: meta-analyses based on summary data... by ashtonkem on Wednesday September 22, 2021 @04:52PM (#28621642)
> pharmacy shouldn't be allowed to decide not to fill it, as if they know better than your doctor.

It sounds like you have a pretty misguided idea of how pharmacies and pharmacists worked before Covid. You’re describing a situation where pharmacists act at the behest of doctors who know best, when in reality pharmacists have always had some level of independent authority over what drugs get dispensed to whom thanks to their expertise. It’s part of the pharmacists job to watch out for bad prescriptions, both in terms of abuse (e.g. opioids) improper dosages, and unintended side effects and interactions between drugs. In some states pharmacists have their own ability to prescribe medicine on their own.

I’m not sure exactly how much control a pharmacist should have over whether a valid prescription is filled, but the idea that they’re only expected to blindly fulfill the order of your doctor is not correct, and never was. In fact, they probably know more about the drugs you’re prescribed than your doctor does, as that’s their entire speciality. (Especially given the long and sordid history of doctors pushing drugs on the basis of pharmaceutical sales reps, doctors often actually know very little about what they prescribe).

Re:Lesson of ivermectin: meta-analyses based on summary data... by nobody9999 on Wednesday September 22, 2021 @05:23PM (#28622021)
>t sounds like you have a pretty misguided idea of how pharmacies and pharmacists worked before Covid. You’re describing a situation where pharmacists act at the behest of doctors who know best, when in reality pharmacists have always had some level of independent authority over what drugs get dispensed to whom thanks to their expertise. It’s part of the pharmacists job to watch out for bad prescriptions, both in terms of abuse (e.g. opioids) improper dosages, and unintended side effects and interactions between drugs. In some states pharmacists have their own ability to prescribe medicine on their own.

Absolutely. I had to fire my doctor after he prescribed a sulfa drug to me, even though I'd made it clear that I have an allergy to sulfa drugs.

In fact, I would never have known (well, until I became sick/dead) that the drug prescribed was a sulfa drug if the pharmacist hadn't known the drug involved and checked it against known allergies. He contacted both me and my doctor and a different drug was prescribed.

In fact, it's entirely possible that I'm alive today thanks to the expertise and knowledge of the pharmacist.

Re:Lesson of ivermectin: meta-analyses based on summary data... by cableshaft on Wednesday September 22, 2021 @09:21PM (#28624193)
Not really disagreeing that a pharmacist might know more about the drugs than a doctor. I wasn't warned about the potential side effects of Ciprofloxacin once, just told it was an "antibiotic" by the specialist I saw, and the pharmacist did clue me in about some side effects, which I promptly had some of the worst ones after a single pill. I might not have made the connection it was a bad reaction to the pills without their warning, at least not so quickly. I continued to have side effects off and on for years afterwards.

I learned my lesson and now do my own research before just taking any medicine a doctor wants to prescribe now.

But I still don't think pharmacists should be able to just override the decision of a doctor. Make sure the person is fully informed of potential dangers, side effects and correct usage, sure, but not override the doctor. The doctor has had an opportunity to examine and talk to the patient at length, multiple times over multiple visits, and know their history and specific needs, the pharmacist doesn't know any of that background and are most likely just making assumptions.

I mean if it's literal rat poison or a dose guaranteed to kill the person is being prescribed, maybe they can hold off on fulfilling it and alert authorities, but otherwise?

Opioids are a major problem, as there are addicts that cycle doctors to get multiple prescriptions so some doctors might not realize it's being overprescribed, but that's a matter of addiction and abuse and I don't know how a pharmacist is expected to know when it's being abused or not, unless they're getting them all filled at the same pharmacy. Again, they're not spending enough time with these people to know what their situation is. The most interaction I have with my pharmacist is "Picking up a prescription." "Verify your address please?" "My address." "Okay this has these side effects and you should only have it after a meal." "Okay thanks." Yeah that's totally enough for them to make a medical decision on my behalf. /s

If anything, I think them deciding when to withhold medicine could make them MORE liable, not less, because they're inserting themself into the decision process. What if their withholding fulfillment of a prescription results in that person dying? If the doctor said yes and they said no, that seems to open up room for litigation to me.

Re:Lesson of ivermectin: meta-analyses based on summary data... by ashtonkem on Wednesday September 22, 2021 @09:26PM (#28624226)
> But I still don't think pharmacists should be able to just override the decision of a doctor.

You’re free to believe that, but understand that this is well in the “wishes and hopes” territory more than a factual understanding of how doctors, patients, and pharmacists actually interact. Personally I believe the idea that we’d spend a huge amount of time and effort as a society training a whole class of specialists and then declare that they must abide by the decisions made by a generalist to be quite odd. Your personal doctor isn’t able to override your oncologist, so why should they be able to override the experts on prescribed medicine?

> If anything, I think them deciding when to withhold medicine could make them MORE liable, not less, because they're inserting themself into the decision process.

I’m sorry, but that’s clearly motivated reasoning and completely unrelated to the actual law. Pharmacists are subject to medical malpractice laws just like every other type of doctor, there’s no magical “I didn’t insert myself into the process therefore I’m not liable” clause.

Re:Lesson of ivermectin: meta-analyses based on summary data... by cableshaft on Wednesday September 22, 2021 @09:34PM (#28624274)
> “My experience is enough to determine for everyone else” is a really bad look.

Let's put it this way, I haven't seen any evidence based on what I've seen that this isn't the normal interaction with a pharmacist after decades of seeing pharmacists myself, or sitting waiting for my parents to get medicine filled, or watching other users interact with pharmacists while I've been waiting in line, etc., across multiple pharmacies in multiple cities.

If there's a more personal and intimate pharmacist reaction that you see as common (or even uncommon), please share those details for me. I would love to have an example otherwise.

Re:Lesson of ivermectin: meta-analyses based on summary data... by cableshaft on Wednesday September 22, 2021 @10:26PM (#28624604)
> You’re free to believe that, but understand that this is well in the “wishes and hopes” territory more than a factual understanding of how doctors, patients, and pharmacists actually interact.

I made a good faith effort in researching this, and here are some examples of interaction you might be alluding to:

1. The doctor made an obvious mistake in dosage or a might not be aware of safer alternatives and the pharmacist contacts the doctor to verify that there wasn't a mistake on the prescription or mention those alternatives and see if they can persuade the doctor to change the prescription. Great, no issues with me. Everyone makes human mistakes. I do it in software also.

2. Something obvious they can see about the patient gives them some information that contradicts the prescription (i.e. an obviously pregnant women being given a drug that's dangerous to pregnant people). Again, they contact the doctor to inform and verify. Again, no issues from me.

3. Patients sometimes see other specialists and get prescriptions from them without informing their PCP (sometimes on accident), whereas a pharmacy probably sees all of these prescriptions, and can catch when two prescriptions could have dangerous interactions that a PCP or specialist might not realize they were causing because they weren't aware of the other prescription. Again they contact the physician and verify. Again, no issues from me.

4. The pharmacist has a religious reason not to want to fulfill a prescription. Some states that's allowed, some they aren't. In those where it's allowed, most pharmacies have a policy that they must allow another pharmacist at the facility to fulfill the prescription or help transfer the prescription to another doctor. Fine with me.

Note that for the first three, they generally contact the doctor and verify/try to persuade, not outright override and refuse. They help catch problems, not generally cause them. It looks like there are several states where pharmacists are actually required to provide medication[1], although that link mentions specifically personal beliefs, so I don't know if it applies for the other three issues as well.

If that's all you mean, then I don't think we disagree actually. But it doesn't look like it's as clear-cut legally as you were suggesting before, and I'm far from alone in thinking that pharmacists can't just decide never to fulfill a prescription without a damn good reason (i.e. it's definitely going to kill the patient).

[1]: https://www.nbcnews.com/news/us-news/can-pharmacist-legally-...

Re:Lesson of ivermectin: meta-analyses based on summary data... by ashtonkem on Wednesday September 22, 2021 @10:34PM (#28624647)
Pharmacists can refuse to fill prescriptions they believe will harm the patient. The law does not restrict it to the narrow circumstances you have listed. “You are giving a deworming medicine for Covid as an off label use. No, I believe that this will harm the patient” is 100% within their legal right. My state explicitly states that every pharmacist should consider whether an act is “consistent with the licensee or registrant’s education, training or practice experience” even if it is not expressly forbidden by the bylaws. This is much more expansive than you’re implying.

Legally in my state they must refuse to fill prescriptions they believe were not created by a proper doctor patient relationship, which includes a lot of these Ivermectin phone doctors. But that’s a slightly different issue.

Re:Lesson of ivermectin: meta-analyses based on summary data... by cableshaft on Wednesday September 22, 2021 @11:07PM (#28624846)
I'm not going to go down the Ivermectin research hole as I've mostly been avoiding it myself.

But Ivermectin is not just a "dewormer" as the media has been running with to sensationalize things and try to throw shade at Joe Rogan for taking, and is known to have antiviral and anti-inflammatory properties, and is known to be safe in proper doses because it's been prescribed to humans for quite some time.

Dr. John Campbell is a highly respected doctor that, since the beginning of this pandemic, has been going over medical studies and data and making them understandable to the general public (I do watch a good handful of his videos, but I've been skipping the Ivermectin ones up until tonight).

The very first video[1] of him going over Ivermectin has a peer-reviewed meta-study that gives moderate-certainty level evidence that when clinicians have given Ivermectin to patients it's resulted in a 62% reduced risk of death compared to not taking it. And honestly that surprised me, up until I watched that tonight I was certain he was going to say it may have had a very mild positive effect and that's all.

[1]: https://www.youtube.com/watch?v=3j7am9kjMrk

I also know my friend highly respects this guy and watches his videos a lot as well. Probably why he was seeking the prescription in the first place, was after seeing the information from these studies, instead of just "well the FDA hasn't approved it therefore it's poison".

Again I'm not going to dig deeper than that right now, I've already spent most of my limited free time this evening doing this instead of other productive things. But yeah, sure looks like a pharmacist could potentially be doing harm by preventing these prescriptions from fulfilling.

I don't even care about this drug specifically (I've been actively avoiding reading up on it and just threw it in with Hydroxychloroquine as a non-drug up until now). It just bothered me to learn that pharmacists were refusing to fill a prescribed drug.

And after listening to my friend provide his reasoning for wanting to take it in small doses, I figured he had researched this a lot more than I had up to this point and was willing to give him the benefit of the doubt.

Re:Lesson of ivermectin: meta-analyses based on summary data... by ashtonkem on Thursday September 23, 2021 @10:30AM (#28629663)
Sigh

There are severe issues with the Ivermectin studies that have shown a positive effect. One of them is believed to be an outright piece of fraud. This was literally discussed in the article this thread is about.

If you're just going to ignore the article posted and "do your own research", then stop wasting our time here.

Re:Lesson of ivermectin: meta-analyses based on summary data... by cableshaft on Thursday September 23, 2021 @11:53AM (#28630953)
I mentioned the previous comment I am not well researched in this. I didn't even make the connection that the video is referring to the same study that this thread was talking about.

It doesn't matter, I don't care about Ivermectin or what you or anyone think about it, good or bad. I'm not planning to take it and never was.

My point was if something (ANYTHING) gets prescribed by a doctor, pharmacists should generally fill it barring those other reasons I mentioned above. I made my point, you made yours. Have a good day.

Re:Lesson of ivermectin: meta-analyses based on summary data... by snovv_crash on Wednesday September 22, 2021 @03:54PM (#28620999)
The pharmacy probably doesn't want any liability so it's easier to just blanket-ban 'fad' medicine.

And we make fun of the Chinese using rhino horn for erectile disfunction...

Re:Lesson of ivermectin: meta-analyses based on summary data... by threeseed on Wednesday September 22, 2021 @05:03PM (#28621785)
> pharmacy shouldn't be allowed to decide not to fill it, as if they know better than your doctor

They are legally required to make decisions about whether or not to fill it.

They are not just some supermarket cashier.

Re:Lesson of ivermectin: meta-analyses based on summary data... by unreal37 on Thursday September 23, 2021 @12:34AM (#28625243)
Pharmacists go to school 4-6 years to learn about drugs. But hey - they don't get to use any of that knowledge in their job... "Just give me the little white box in cabinet #2 please."

Why do Pharmacists even study and train for up to 6 years if you don't want their opinion on how this drug will affect you?

Re:Lesson of ivermectin: meta-analyses based on summary data... by julianz on Wednesday September 22, 2021 @05:35PM (#28622172)
This "friend of yours" should probably get vaccinated then, because we know that works pretty well.
Re:Lesson of ivermectin: meta-analyses based on summary data... by cableshaft on Wednesday September 22, 2021 @08:55PM (#28624025)
He is vaccinated. He's been vaccinated since April. Breakthrough infections are a thing. He's also concerned about recent data from Israel about waning efficacy. He'd get a booster shot today if he could get it.

Also thank you for what I presume is you insuinuating by putting "friend of yours" in quotes that you think I'm talking about myself. I've been vaccinated since April and I have been a lot more careful about this virus than at least probably 90% of the people out there, at least in the US. I still wear masks outside the house and avoid going indoors very often (I didn't do it at all until I was vaccinated).

Hell, I wore masks on hiking trails outdoors while holding my breath when walking past others on the trail back in 2020, which was probably overkill in retrospect. I also only had food delivered, never even going through the drive thru, and didn't order anything that couldn't be heated in the microwave for 3 minutes to try to kill the virus since it was unclear whether it transmitted via surfaces back then (so no sushi, sandwiches, salads, ice cream, iced coffee, etc).

Personally I wouldn't try to hunt down some of these alternative drugs, which I'm pretty skeptical of, but there seems to have been some mixed data on this one and I can at least understand why someone might want to give it a shot in reasonable and proven to be safe doses, especially if they have no choice but to be surrounded by it all day long (I work from home, my risk at work is nonexistent).

Re:Lesson of ivermectin: meta-analyses based on summary data... by ashtonkem on Wednesday September 22, 2021 @07:26PM (#28623352)
Rumor has it that it’s even free!
Re:Lesson of ivermectin: meta-analyses based on summary data... by mint2 on Wednesday September 22, 2021 @04:29PM (#28621351)
Is your friend vaccinated?
Re:Lesson of ivermectin: meta-analyses based on summary data... by cableshaft on Wednesday September 22, 2021 @08:56PM (#28624027)
Yes, he's been vaccinated since April, around the same time I got it.
Re:Lesson of ivermectin: meta-analyses based on summary data... by brandonmenc on Wednesday September 22, 2021 @11:34AM (#28617547)
It's probably both, but why would a doctor risk losing their license over this? Yet another unintended consequence. Doctors are supposed to be able to write prescriptions for off-label use.
Re:Lesson of ivermectin: meta-analyses based on summary data... by sgt101 on Wednesday September 22, 2021 @11:52AM (#28617818)
If they have reason to believe that it's beneficial. If they don't then they are being reckless.
[dead]
Re:Lesson of ivermectin: meta-analyses based on summary data... by dhimes on Wednesday September 22, 2021 @04:03PM (#28621112)
Did you self-medicate, or were you under the direction of a medical doctor?
Re:Lesson of ivermectin: meta-analyses based on summary data... by swader999 on Wednesday September 22, 2021 @05:11PM (#28621869)
My doctor told me to wait it out, anywhere up to twelve more months. Yes, I self medicated. Suicide would have been my other choice had I not had Ivermectin - felt like I was slowly dying to begin with. It was very debilitating and impossible to work.
Re:Lesson of ivermectin: meta-analyses based on summary data... by threeseed on Wednesday September 22, 2021 @05:06PM (#28621818)
HN should delete this post and probably your account.

You are actively encouraging people to get on a path that ends up in overdose and death.

Re:Lesson of ivermectin: meta-analyses based on summary data... by swader999 on Wednesday September 22, 2021 @05:12PM (#28621883)
It has a safer profile than Tylenol, Advil and Asprin.
Re:Lesson of ivermectin: meta-analyses based on summary data... by symlinkk on Wednesday September 22, 2021 @05:25PM (#28622047)
“Apple is evil for adding CSAM checks, imagine if a totalitarian government used that to silence people”

“You should be permanently silenced for suggesting a medical drug”

Are you feeling any cognitive dissonance?

Re:Lesson of ivermectin: meta-analyses based on summary data... by threeseed on Wednesday September 22, 2021 @04:56PM (#28621693)
> is safe and taken by a quarter billion people every year

When taken in dosages that have been determined based on extensive studies and research.

This doesn't apply to COVID so it is completely responsible for them not to supply it.

Re:Lesson of ivermectin: meta-analyses based on summary data... by rory on Wednesday September 22, 2021 @11:09AM (#28617185)
Although it has more dangers than ivermectin, why shouldn't you have access to ketamine if you feel it helps you? A lot of people believe it has off-label benefits for their mental health, and maybe it does.

Perhaps we just have different general perspectives on the individual and society.

Re:Lesson of ivermectin: meta-analyses based on summary data... by dionian on Wednesday September 22, 2021 @11:26AM (#28617439)
I suspect most people would disagree, and I think I might too, but it's curious to examine the arguments and justifications for disagreeing
Re:Lesson of ivermectin: meta-analyses based on summary data... by shapefrog on Wednesday September 22, 2021 @05:06PM (#28621819)
Why not all drugs of all types. Why call it an opiod crisis and not just here is what happens when you give everyone whatever drugs they hear on the internet make you feel good?

First you deny someone ivermectin, next minute you are saying only 1 oxycotin with your beer.

Re:Lesson of ivermectin: meta-analyses based on summary data... by rory on Wednesday September 22, 2021 @05:22PM (#28621995)
The important difference between these drugs is that opiates are incredibly addictive, while ketamine is less addictive than tobacco or alcohol. Ivermectin isn't addictive at all.

Ironically, the opioid crisis is caused far more by people's trust in mainstream medicine than by any internet fad.

Re:Lesson of ivermectin: meta-analyses based on summary data... by cmrdporcupine on Wednesday September 22, 2021 @10:58PM (#28624801)
Repeated recreational use of ketamine over years can lead to permanent urinary tract damage, potentially leading to incontinence, etc. "Ketamine bladder syndrome"

https://www.nursingtimes.net/clinical-archive/medicine-manag...

Re:Lesson of ivermectin: meta-analyses based on summary data... by rory on Thursday September 23, 2021 @10:08AM (#28629365)
Correct, as I mentioned up-thread ketamine use has dangers.
Re:Lesson of ivermectin: meta-analyses based on summary data... by shapefrog on Wednesday September 22, 2021 @05:32PM (#28622126)
> people's trust in mainstream medicine

Mainstream medicine says it is incredibly addictive with an incredibly low lethal dose.

People like to get high, a lot. Probably second only to triggering the libs / whatever the lib version is.

Re:Lesson of ivermectin: meta-analyses based on summary data... by rory on Wednesday September 22, 2021 @05:53PM (#28622402)
> In the late 1990s, pharmaceutical companies reassured the medical community that patients would not become addicted to opioid pain relievers and healthcare providers began to prescribe them at greater rates.

> Increased prescription of opioid medications led to widespread misuse of both prescription and non-prescription opioids before it became clear that these medications could indeed be highly addictive.

I assumed this was well-known.

https://www.hhs.gov/opioids/about-the-epidemic/index.html

Re:Lesson of ivermectin: meta-analyses based on summary data... by shapefrog on Wednesday September 22, 2021 @06:31PM (#28622862)
> The Opium Wars were two wars waged between the Qing dynasty and Western powers in the mid-19th century.

I assumed this was well-known.

Re:Lesson of ivermectin: meta-analyses based on summary data... by xdennis on Wednesday September 22, 2021 @12:02PM (#28617966)
In some countries they give free needles to heroin addicts. Why do they care about harm there but for ivermectin they "force" the misinformed people to take the horse paste form?
Re:Lesson of ivermectin: meta-analyses based on summary data... by JohnWhigham on Wednesday September 22, 2021 @01:16PM (#28619004)
Because half the country and the mainstream media would rather revel in laughter at those people than help them. They rationalize it as them being too dumb to take the vaccine instead of probing why exactly people are so distrustful of massive conglomerates that can't be held responsible in any way for any side effects their products may cause.

The culture wars have fucked this country hard.

Re:Lesson of ivermectin: meta-analyses based on summary data... by shrubble on Wednesday September 22, 2021 @11:18AM (#28617344)
Incidentally, approximately 11 to 14% of the USA population has pinworms, which can be easily stopped by ivermectin. Given the very high level of safety of ivermectin, it might make sense to make it easier to get on this basis alone.
Re:Lesson of ivermectin: meta-analyses based on summary data... by buescher on Wednesday September 22, 2021 @12:01PM (#28617945)
I can't sell you ivermectin, but I CAN sell you pinworms, and then you can go to your doctor...
Re:Lesson of ivermectin: meta-analyses based on summary data... by KarlKemp on Thursday September 23, 2021 @12:52AM (#28625313)
I looked it up at some point, and it wasn’t among the recommended treatments of pinworm.
Re:Lesson of ivermectin: meta-analyses based on summary data... by x86_64Ubuntu on Wednesday September 22, 2021 @03:49PM (#28620925)
The vaccine is free, so I'm confused about where you get that this is an access issue.
Re:Lesson of ivermectin: meta-analyses based on summary data... by NaturalPhallacy on Thursday September 23, 2021 @12:18AM (#28625174)
It's not free. It's a massive wealth transfer from the working class to the same pharma companies that charge $600 for insulin. We paid for it.
Re:Lesson of ivermectin: meta-analyses based on summary data... by p1necone on Wednesday September 22, 2021 @05:55PM (#28622442)
There's thousands of safe medications that probably do nothing to stop covid. Just because one of them has been latched on to by right wing nutjobs doesn't mean it makes any sense for people to take that over the stuff that's actually been shown to help.
Re:Lesson of ivermectin: meta-analyses based on summary data... by gdulli on Wednesday September 22, 2021 @11:08AM (#28617183)
The "horse dewormer" aspect is definitely a red herring, while the underlying problem is the choice to self-medicate based on culture war status of vaccines vs. talk-show-host-endorsed drugs. And the inevitable overdoses resulting from that. The media is not wrong to discourage this type of self-medication.

But access to the vaccines here is free and widespread now, so while we could talk all day about problems with access to health care in this country, it doesn't apply here. People may be choosing to distrust the vaccines and thus triggering a shortage of beds and treatment that they themselves will later need.