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Re:Brain imaging before and after Covid-19 in UK Biobank by JohnJamesRambo on Sunday June 20, 2021 @10:22AM (#27570284)
I wish I could get people that are avoiding the COVID vaccine “because we don’t know what the long term effects are” to realize that we have real data showing that there are long term effects from getting full blown COVID. You don’t want a tiny piece of mRNA but you want the whole organism reproducing in your body? The whole genome and all the proteins made?
Re:Brain imaging before and after Covid-19 in UK Biobank by causality0 on Sunday June 20, 2021 @11:04AM (#27570721)
Yeah. I had complete loss of smell and taste, which came back about 90% over the next six weeks. It was fine for a month and then it went wonky. Probably 30% of my "scent spectrum" has now been replaced with the same burnt meat smell/taste. Everything from chocolate to feces to hamburgers now has the same core odor.

It really, really sucks.

Re:Brain imaging before and after Covid-19 in UK Biobank by kace91 on Sunday June 20, 2021 @11:55AM (#27571286)
Don't lose hope. I got in October, similar effects, and I've been recovering a lot of my smell and taste, veery slowly and in "bursts".

Nowadays I'm almost fully ok, the only smells I haven't recovered are body odor (which I can smell, it's just really different) and feces and trash, which for some reason smell in a very particular sweet way, kinda like rotten meat.

That last one, for some reason, seems to be really common, since several friends that also lost smell have had the same exact change.

Re:Brain imaging before and after Covid-19 in UK Biobank by causality0 on Sunday June 20, 2021 @12:04PM (#27571357)
Yeah, the first time I recovered my smell feces took the longest to come back. Since I already recovered and didn't catch covid again, I can't help but think my current problem arises from some kind of incorrect healing. Like a nerve pathway is connecting to the wrong thing somehow.
Re:Brain imaging before and after Covid-19 in UK Biobank by drclau on Sunday June 20, 2021 @12:11PM (#27571426)
This is probably the first time I read about these side effects. Are you certain it's your perception that has changed (ie. neurological changes), as opposed to the actual smell? I would not be surprised at all if Covid has an impact on the gut flora.
Re:Brain imaging before and after Covid-19 in UK Biobank by colordrops on Sunday June 20, 2021 @12:14PM (#27571459)
According to a Harvard article I read, it's caused by damage to the sensors in the nose, rather than brain damage. I have the problem myself and it's definitely not changes to the smells themselves.
Re:Brain imaging before and after Covid-19 in UK Biobank by 411111111111111 on Sunday June 20, 2021 @02:22PM (#27572582)
The effect isn't unique to covid-19 either. I heard from several people when that 2017 flu went around that they had the same issue. One of them was complaining for over a year until smell/taste finally got better/normal again.

(Not trying to downplay covid-19. Just pointing out that it's not an unknown side effect from this type of disease)

Re:Brain imaging before and after Covid-19 in UK Biobank by thoughtpeddler on Monday June 21, 2021 @04:00PM (#27583619)
Wow, very similar experience here, except the sweetness I smell isn't likable to rotten meet, but rather sort of like aging strawberries/fruit. I smell this semi-sweet fruit-like smell particularly strongly with anything alcoholic, including hand sanitizer. I had covid anosmia for about 6 weeks during December-January '20, but this sweet smelling parosmia has only been around the last 2 months or so. Such a mystery to me.
Re:Brain imaging before and after Covid-19 in UK Biobank by kace91 on Monday June 21, 2021 @06:42PM (#27585487)
Yup, now that you mention it, aging strawberries is a nice description. Funny that it's universal.

I wonder if we have special "wiring" for enhancing human-produced smells? Kinda like how the brain is capable of distinguishing human faces by small details that we don't see that well for other species.

I do miss those odors, to be honest...

Re:Brain imaging before and after Covid-19 in UK Biobank by thoughtpeddler on Tuesday June 22, 2021 @08:34AM (#27590863)
Interesting! Yes, I believe there's a genetic component here to how covid impacts sense of smell/taste long-term.

What I'm just surprised by is how my smell totally recovered after 6 weeks, but then months later this semi-sweet aging strawberries smell kicked in (with many things, but mainly ethanol-containing products). My covid experience itself thankfully was fairly benign too.

If my olfactory neurons repaired themselves, then what triggered disrepair months later?

To be clear, I've been on the keto diet since January, and that definitely can produce fruity alcohol breath as a natural byproduct, so when I ran this concern with my GP, they said it's very likely not covid, and more likely my diet. But that didn't quite sit well with me, and now that you and others on here mention your experience, I'm more convinced this is some kind of odd post-covid long-term effect. TBD!

Re:Brain imaging before and after Covid-19 in UK Biobank by dboreham on Sunday June 20, 2021 @11:40AM (#27571103)
My cousin (20s) lost his sense of taste and hasn't recovered it months later. Son (teen) lost his for a week then recovered it. Reports however that he has pernanently lost his sense of thurst. Ymmv.
Re:Brain imaging before and after Covid-19 in UK Biobank by SkyMarshal on Sunday June 20, 2021 @12:05PM (#27571370)
> Reports however that he has pernanently lost his sense of thurst.

Wow that is weird, hadn’t heard of that one yet, and seems kind of dangerous. Is he taking extra precautions to stay hydrated?

Re:Brain imaging before and after Covid-19 in UK Biobank by morsch on Sunday June 20, 2021 @01:45PM (#27572270)
I heard on a cooking podcast (probably this episode of cooking issues[1]) that smell training has helped some people with anosmia. I have no idea if it helps with loss of smell related to covid. Have any of you tried it?

Here's an example (no affiliation, just the ones with the best SEO, I am not a doctor): https://abscent.org/learn-us/smell-training

[1] https://heritageradionetwork.org/episode/live-datta-lab-feat...

Re:Brain imaging before and after Covid-19 in UK Biobank by muststopmyths on Sunday June 20, 2021 @11:13AM (#27570799)
Did getting vaccinated change anything ? I've heard that vaccinations helped people with long COVID.

Hope you recover fully.

Edit: since someone asked for citations, here is a CNN link

https://us.cnn.com/2021/04/03/health/long-haulers-vaccine-we...

I follow the "This week in virology" podcast and they have discussed this extensively as well. Dr Daniel Griffin, cited in the CNN article is a weekly contributor on this podcast, and has mentioned the effect in question multiple times.

Re:Brain imaging before and after Covid-19 in UK Biobank by causality0 on Sunday June 20, 2021 @11:35AM (#27571034)
Unfortunately not. The change in smell happened a few days before my first shot. That's lucky though, as there's no telling what I'd believe if I'd been fine and then thought the shot ruined my taste.
Re:Brain imaging before and after Covid-19 in UK Biobank by incrudible on Sunday June 20, 2021 @05:15PM (#27573978)
Fatigue and rapid heartbeat being cured by a vaccine sounds like psychosomatic long COVID. This is a hot button topic that few professionals will bother examining in a critical fashion.

Loss of sense of smell is not psychosomatic. Unfortunately, viral infections can cause sometimes permanent loss.

Re:Brain imaging before and after Covid-19 in UK Biobank by takeda on Sunday June 20, 2021 @12:41PM (#27571682)
Unfortunately the vaccine helps only in about 20% of the cases.
Re:Brain imaging before and after Covid-19 in UK Biobank by seaman1921 on Sunday June 20, 2021 @11:37AM (#27571063)
please stop with comments starting with 'i've heard that' - there is enough misinformation already.

Please. add. citations.

Re:Brain imaging before and after Covid-19 in UK Biobank by ysavir on Sunday June 20, 2021 @11:39AM (#27571094)
They're literally asking for someone to weigh in with first-hand experience on something they heard but are not sure about. It's a valid question that I would also like to hear about.

Citations are more relevant for when people are making a claim than for when they are investigating a claim.

Re:Brain imaging before and after Covid-19 in UK Biobank by xenospn on Sunday June 20, 2021 @05:07PM (#27573916)
My social media manager had the exact same reaction. She says it’s getting better very slowly - she can still only stomach eating rice and bread, though. Everything else makes her throw up immediately.
Re:Brain imaging before and after Covid-19 in UK Biobank by londons_explore on Sunday June 20, 2021 @05:46PM (#27574195)
Who are you that you can't operate social media yourself?
Re:Brain imaging before and after Covid-19 in UK Biobank by ganzuul on Sunday June 20, 2021 @11:07AM (#27570749)
How old are you? Were you completely healthy before?
Re:Brain imaging before and after Covid-19 in UK Biobank by Jill_the_Pill on Sunday June 20, 2021 @01:06PM (#27571904)
My 21-yo daughter was previously completely healthy and fit, and she has now experienced a year of long covid. Already skinny, she lost 16 pounds because food didn't register as food (messed up smell and taste) and she couldn't choke it down. She had a couple of weeks where she could tolerate almost no foods but almonds and miso soup. So much fatigue last summer that she couldn't even sit up for very long. New and persistent depression, sensitivity to noise. Please don't try to minimize this illness by blaming it on people's existing health conditions.
Re:Brain imaging before and after Covid-19 in UK Biobank by ganzuul on Sunday June 20, 2021 @04:12PM (#27573480)
I'm not blaming. I'm trying to gather data because I'm having a serious problem with trust.
Re:Brain imaging before and after Covid-19 in UK Biobank by causality0 on Sunday June 20, 2021 @11:37AM (#27571067)
30. Overweight but no actual medical problems. Not prescribed any medications. Not a drug, cigarette, or alcohol user.
Re:Brain imaging before and after Covid-19 in UK Biobank by brigandish on Sunday June 20, 2021 @12:08PM (#27571407)
I don't mean be invidious, but being overweight is an actual medical problem, one that's been strongly linked[1][2][3] with susceptibility and severity of the disease.

I can't recommend reading the World Obesity Atlas pdf enough as it provides possible explanations for the disparities in cases and deaths we've seen in different societies.

[1] https://www.worldobesity.org/resources/resource-library/covi...

[2] https://www.gov.uk/government/publications/excess-weight-and...

[3] https://pubmed.ncbi.nlm.nih.gov/32788355/

Re:Brain imaging before and after Covid-19 in UK Biobank by 0x737368 on Sunday June 20, 2021 @02:00PM (#27572401)
Lol at parent comment being downvoted - being overweight is absolutely a medical problem, people need to stop normalising it.
Re:Brain imaging before and after Covid-19 in UK Biobank by throwkeep on Sunday June 20, 2021 @12:22PM (#27571525)
There are valid concerns and a difficult risk benefit analysis for some cohorts, I think. What are your thoughts on this? Put yourself in her shoes:

"I held off on a COVID vaccine because I wanted to wait for data with positive signals for both pregnancy in the short term and long-run fertility. I’m trying to get pregnant, and those are the two things I care about most.

Vaccine data is so politicized that it’s actually somewhat difficult to find full studies, results discussions or data sets as a layman, because every search term redirects you to “yes, get vaccinated right now, your concerns are merely ignorance”

The other study that concerns me shows that the vaccine’s lipid nanoparticles— which carry the RNA instructions for the spike protein — move beyond the deltoid muscle they’re injected into and accumulate in other tissues, and seem to accumulate in ovarian tissue preferentially.

That study looked at a very small sample, but given what we think we know about the spike protein — it likely causes some degree of tissue damage on its own, independent of the virus — it’s something that definitely demands further study

Anyway, I feel like I need to come clean at this point. For a long time I was avoiding the vaccine because I wanted to hold out for more data. Now I’m actively choosing not to get it because what I’ve seen is providing the opposite of a positive safety signal for my purposes.

It’s really important that I clarify I’m not at a high risk of exposure. I generally don’t work or even socialize outside my home. Lockdown life frankly doesn’t look that different from my preferred lifestyle. If I were a high exposure risk I would think about this differently

I’m in the process of getting a prescription for prophylactic ivermectin, which has also become extremely politicized — to the point of becoming a censored topic on some platforms. I’m not giving advice, here. I’m not making broader efficacy claims. I’m just trying to be honest

COVID is no joke. You do not want to get COVID. “Long COVID” symptoms should concern you even if you don’t think an infection would kill you. But the vaccines are very new and skipped a great deal of otherwise required safety testing, and some of this data is really worrisome."

https://mobile.twitter.com/webdevMason/status/14056498962128...

Re:Brain imaging before and after Covid-19 in UK Biobank by peter422 on Sunday June 20, 2021 @12:43PM (#27571709)
The vaccines did not skip any safety tests, they just compressed the schedule because millions of people were dying of a preventable disease.

At this point hundreds of millions of people have taken the various vaccines. There clearly are no major short or medium term effects (other than the reported, rare side effects).

Also you can literally read all the documents provided to the FDA concerning the efficacy and safety of the vaccines. There isn't a giant conspiracy, all the original studies and data are in the open.

Re:Brain imaging before and after Covid-19 in UK Biobank by mikem170 on Sunday June 20, 2021 @01:17PM (#27572019)
The parent never mentioned a conspiracy. They did mention running into a lot of glibly dismissive dead ends researching their concerns.

I don't think their decision is unreasonable. I'm personally not looking at the same factors, and think of covid vaccination differently. I'm guessing you do, also. I personally don't see a problem with that. Who am I to tell force someone else to my way of thinking?

Re:Brain imaging before and after Covid-19 in UK Biobank by peter422 on Sunday June 20, 2021 @02:14PM (#27572511)
The OP said it was hard to find the data and documents. I searched for “fda vaccine pfizer documents” and the 2nd link is the FDA page with every document and study that was reviewed for approval.

The information is not hard to find. Yes, there are a lot of pro-vaccine resources and anti-vaccine resources as well, but it’s obviously not hard to find the source materials.

Re:Brain imaging before and after Covid-19 in UK Biobank by jdhendrickson on Sunday June 20, 2021 @01:46PM (#27572273)
That philosophy is fine when the resulting issues only harm the person taking that attitude, herd immunity, viral mutation due to more hosts, and a plethora of other reasons don't allow us to take the live and let live attitude about vaccinations this time around.
Re:Brain imaging before and after Covid-19 in UK Biobank by mikem170 on Sunday June 20, 2021 @02:03PM (#27572430)
But it's still a heavy thing to force other people into something. We live in quasi-democracies and a significant percentage of people feel differently than you do. There's also a significant percentage of people, me included, who are willing to respect that people have different understandings of the risks.

Lots of things harm us as a group, and we accept them. We don't, and can't, aim for zero risk.

Re:Brain imaging before and after Covid-19 in UK Biobank by lagadu on Sunday June 20, 2021 @02:15PM (#27572517)
I'll be getting downvoted but it doesn't matter: it's you. You and people like you are the reason I'm not getting vaccinated. I'm from a time when having and exercising autonomy over what one does or does not with their own body was something celebrated, however now society has normalized insulting and bullying people for making their own choices.

I will not tolerate a society that does this, fortunately I'm in a position to hurt it by simply not getting vaccinated. I have no doubts that it's perfectly safe and I'd be fine, with the bonus of being more protected.

So yes. You are the reason I'm doing my part to ensure we'll never achieve herd immunity. Good job.

Re:Brain imaging before and after Covid-19 in UK Biobank by kybernetikos on Sunday June 20, 2021 @06:37PM (#27574492)
> I will not tolerate a society that does this, fortunately I'm in a position to hurt it by simply not getting vaccinated.

Don't think of it as hurting a society that upsets you, think of it as hurting the individual people who get a serious disease through no fault of their own and suffer and die from it. It's very unlikely you'll hurt any of the people who have upset you - they are probably all well vaccinated.

There are all sorts of actions you could take to promote bodily autonomy, and I'd support them, but if you're really choosing to do this one out of spite because some small section of society has offended you, then I would encourage you to find a different way to express your distress.

> So yes. You are the reason I'm doing my part to ensure we'll never achieve herd immunity. Good job.

Along with your old fashioned view on bodily autonomy, I'd suggest you take a old fashioned view on personal responsibility too and try to avoid blaming others for a choice that you are making.

Re:Brain imaging before and after Covid-19 in UK Biobank by lagadu on Monday June 21, 2021 @07:00AM (#27578019)
No offense but those are pretty weak arguments. I'm not looking to hurt specific individuals, but rather society as a whole; large social phenomena aren't the fault of any individual (although granted some specific individuals may carry a lot of fault, given their positions, Trump and other far-right high-profile individuals such as Orban or Bolsonaro being a prime example of that but that's not what we're discussing here).

Two outcomes: either my not taking the vaccine has no impact on society as a whole so it doesn't matter, or it helps having a negative impact in society as a whole and therefore it also directly or indirectly hurts the groups who upset me (be it via further restrictions, health or economic downturns), in which case I feel vindicated. Most importantly: in both cases my actions spite those who would pressure me into doing it which by itself is a good enough outcome for me.

That last argument goes both ways: people who feel it's acceptable to bully me out of my autonomy should take personal responsibility for the choice they are making, so dismissing that argument is effortless on my part.

edit: I should point out that for very personal reasons I won't be getting in to, autonomy over the self is something that I hold very close to my heart.

Re:Brain imaging before and after Covid-19 in UK Biobank by kybernetikos on Monday June 21, 2021 @08:38AM (#27578549)
> I'm not looking to hurt specific individuals, but rather society as a whole

I phrased it that way because I worry that in seeking to spite society as a whole you're missing the fact that you'll likely hurt specific individuals. Most of whom have nothing to do with the reasons you want to spite society.

> in both cases my actions spite those who would pressure me

They really don't. The people your actions (and public support of them) will most likely contribute towards hurting (and possibly killing) are those who are sick in other ways, or those who hold similar views to yourself.

If you live in a democracy, there are much better, well tested ways for you to promote bodily autonomy without deliberately taking actions most likely to harm people you agree with or the sick and weak. I'd love to see the cause of bodily autonomy promoted in ways I could respect, but this action won't help with that.

> people who feel it's acceptable to bully me out of my autonomy should take personal responsibility for the choice they are making, so dismissing that argument is effortless on my part.

Well, I think it's a poor dismissal. If people are bullying you, then they need to be responsible for their bullying, not for what you do in reaction to it. If you're really insisting on people being responsible for other peoples reactions, then don't you worry what you'll be responsible for when people react to your behavior?

It's my opinion that allowing yourself to be so affected by other people's views (whether it's towards spite or compliance) is fundamentally a less good way to live than deciding what you think is right and living according to that.

I do understand the extreme self-hurting aversive reaction to behavior you don't like (and there are places for it), but the internet has made that kind of attitude dangerous - you'll find bullies on every side of every topic, and to let which bullies your filter bubble rubbed you against dictate your behavior in serious ways is to cede way too much of your precious autonomy.

Re:Brain imaging before and after Covid-19 in UK Biobank by bananabiscuit on Sunday June 20, 2021 @01:59PM (#27572389)
Steps were not skipped, but they are left incomplete. None of the vaccines have left Phase 3 yet, have they? Also it’s really hard to be confident in the data collected about vaccine safety as there is a social stigma associated with claiming that you have a negative effect from the vaccine.
Re:Brain imaging before and after Covid-19 in UK Biobank by peter422 on Sunday June 20, 2021 @02:10PM (#27572478)
Is there? Everybody I've met talked about how the 2nd shot knocked them out for a few days at least.

From my POV there is a heavy stigma associated with anti-vaccine activists downplaying and disbelieving the very real stats about covid sicknesses and deaths.

Re:Brain imaging before and after Covid-19 in UK Biobank by faeriechangling on Sunday June 20, 2021 @02:35PM (#27572723)
It's semantics at the end of the day. Less tests were done overall in accordance with a prepared in advance plan to rapidly deploy a vaccine in the case of a global pandemic. More risk was taken for more reward. It's questionable if more risk was even taken at all given the unknowns of COVID itself.

At this point the COVID vaccines are among the most "tested" medicines in history just on merit of their huge scale deployment, with them only truly lacking much insight into what happens after 2 years, which is something we hardly know about COVID itself.

Re:Brain imaging before and after Covid-19 in UK Biobank by xwolfi on Sunday June 20, 2021 @12:37PM (#27571648)
You're right in a way but I think these people are still a tad wrong. It's not that everyone deny there can be side effects, on pregnancy or otherwise. It's that if nobody does the sacrifice, and everybody has his little thing he wants to protect (you want to get pregnant, I want to keep on working, my wife wants to be there for our kid, our parents have diabetes, etc etc) then nobody gets the vaccine.

Get it, whatever it cost you, because it's your duty.

Re:Brain imaging before and after Covid-19 in UK Biobank by takeda on Sunday June 20, 2021 @12:50PM (#27571772)
I was also on the fence about vaccine, but what made me take is realization that there isn't only side effects of vaccine, but also side effects of catching covid. Media made us obsessed about deaths, but majority of people survive and among of them small portion get side effects. From what I remember it was about 1 every 10 people that had some kind of issue that lasted after recovering.

Even the blood clots that were found with AZ and J&J are happening with the virus itself at higher rate.

So it's just a simply choosing lesser risk.

Re:Brain imaging before and after Covid-19 in UK Biobank by incrudible on Sunday June 20, 2021 @05:33PM (#27574127)
If the risk of (serious) DVT is lower with the vaccine, why did Norway come to the opposite conclusion and ban AZ?
Re:Brain imaging before and after Covid-19 in UK Biobank by takeda on Monday June 21, 2021 @12:20AM (#27576286)
Because the whole pandemic became politicized, and majority decisions are actually driven by politics. The countries are going against the narrative that they are purposefully trying to kill people with vaccines as a method of population control.

There was also heavy disinformation campaign against AZ because AZ was the only non-profit vaccine made and its presence was standing in the way of Sputnik V being introduced into EU[1]. J&J has similar issues and it wasn't affected as much. Pfizer[2][3] was also targeted similarly, but the problem was that not much could be found on mRNA vaccines. I guess the worst one was some inflammation of hart in young people that resolves on its own.

[1] https://www.biospace.com/article/russia-sees-opportunity-in-...

[2] https://www.rferl.org/a/russia-pfizer-covid-disinformation-s...

[3] https://www.euronews.com/2021/04/29/eu-slams-russia-and-chin...

Re:Brain imaging before and after Covid-19 in UK Biobank by incrudible on Monday June 21, 2021 @04:34AM (#27577348)
I don't think so, because the Norwegian government made that decision based on a risk/reward analysis by their own public health institute. COVID deaths in the female under 40 group are group are exceedingly rare, likely more so than (lethal) DVT in the vaccinated. It wasn't necessarily a popular decision.

The "Russian disinformation" argument doesn't really work either, because Russia targeted mRNA vaccines specifically. The Sputnik vaccine (in theory) has the same problem as the AZ and J&J vaccines, also being based on viral vectors.

Re:Brain imaging before and after Covid-19 in UK Biobank by faeriechangling on Sunday June 20, 2021 @02:29PM (#27572659)
I haven't found it exceedingly hard to find data supportive or critical of vaccination despite the fact that the pro-vaxxers feel morally entitled and even obligated to censor the planet. Where there isn't censorship there is forced editorialization or often both. Such things aren't unusual though and I predicted it before it happened based on the known correlation between disease outbreaks and authoritarianism. Mind that you have to know how to FIND uncensored communities of anti-vax cranks who will gladly shove the most plausible theories they can devise in your face.

The fact that the lab leak hypothesis stopped being a heterodoxy despite long being censored by big social media networks by non-medical professionals pretending that by citing politifact they were proxy medical professionals was shrugged off and censorship didn't even pause. Negative feedback has no effect on the strategy even when it reveals a stunning lack of expertise on the part of the censors. We even saw papers like WaPo just quietly retroactively correcting headlines and continuing to dish out Pinocchio ratings.

I don't find the data to convince me of the anti-vax argument at all, save for potential arguments that there might be an angle to freeride at least short term off other people mitigating covid through vaccination and non-vaccination measures.

Re:Brain imaging before and after Covid-19 in UK Biobank by bruce343434 on Sunday June 20, 2021 @12:32PM (#27571604)
> data is worrisome

I'd love to learn more about this but run into the walls your described about everyone dismissing your worries. Where is this data?

Re:Brain imaging before and after Covid-19 in UK Biobank by majgr on Sunday June 20, 2021 @04:33PM (#27573651)
> The other study that concerns me shows that the vaccine’s lipid nanoparticles— which carry the RNA instructions for the spike protein — move beyond the deltoid muscle they’re injected into and accumulate in other tissues, and seem to accumulate in ovarian tissue preferentially.

This is really nasty, I'm inhaling litres of it per year while vaping.

Re:Brain imaging before and after Covid-19 in UK Biobank by faeriechangling on Sunday June 20, 2021 @02:23PM (#27572595)
Yeah this one has perticularly irked me we have data on the vaccines dating back almost as far as data on COVID. There is less overall cases and less overall time so there are more unknowns but there isn't also the same phenomenon we see of "COVID long haulers" amongst vaccine recipients. So far we have MORE evidence of spooky but speculative long term effects for COVID itself.

The only argument that has made sense to me is the Freerider argument, or "both COVID and the vaccine have unknown effects so I will try to avoid both" because COVID cases are currently so low particularly when bolstered with "I'm open to taking the vaccine especially if cases go up but want to delay for more data for now". I'm sceptical it's going to be possible for anybody but a marginal minority to be a Freerider who doesn't vaccinate/distance/wear PPE long term because R0=5.7 in Wuhan during the initial outbreak so it seems like it takes mass scale efforts to reduce transmission no matter how one goes about it.

Re:Brain imaging before and after Covid-19 in UK Biobank by mrfusion on Sunday June 20, 2021 @12:13PM (#27571449)
If you find yourself saying or thinking "It's so simple why don't people understand" with regard to a political or social issue, there's a good chance you don't fully understand the issue.
Re:Brain imaging before and after Covid-19 in UK Biobank by plank_time on Sunday June 20, 2021 @10:42AM (#27570497)
What is the percentage of people who suffered any long term brain effects?

And did they do the same study against people who got the flu and other diseases?

Re:Brain imaging before and after Covid-19 in UK Biobank by dangom on Sunday June 20, 2021 @11:57AM (#27571298)
They looked at longitudinal data from people before and after COVID. Most of these people had the flu before, none had COVID because it didn't exist in humans then. There is no way to run the exact same study (UK biobank) on people who got the flu.
Re:Brain imaging before and after Covid-19 in UK Biobank by lima on Sunday June 20, 2021 @11:00AM (#27570682)
> And did they do the same study against people who got the flu and other diseases?

Does this matter?

Re:Brain imaging before and after Covid-19 in UK Biobank by LikelyClueless on Sunday June 20, 2021 @11:19AM (#27570852)
I would try to avoid the flu more if I had an idea of how much brain damage it could cause. I understand the comparison to the flu is a touchy subject, but the question can still be asked from a standpoint of curiosity. Is this disease showing completely new symptoms for a viral infection, or have we been over analyzing any little details that are not so uncommon? Does it matter? I certainly would like to know the answer.
Re:Brain imaging before and after Covid-19 in UK Biobank by carlmr on Sunday June 20, 2021 @01:41PM (#27572233)
There does seem to be some indication of brain effects in the flu. https://www.newsweek.com/does-flu-affect-your-mind-bad-memor...
Re:Brain imaging before and after Covid-19 in UK Biobank by plank_time on Sunday June 20, 2021 @12:16PM (#27571481)
The flu causes myocarditis in a similar way that COVID has been reported to cause in children. Having a comparison of rates of issues would be useful so as to figure out if it’s important or not.

The same goes for this reported brain issue. If it is a real issue, comparing against other known issues will tell us how dangerous it is.

Re:Brain imaging before and after Covid-19 in UK Biobank by ekianjo on Sunday June 20, 2021 @11:15AM (#27570823)
> Does this matter?

Who knows? Maybe there's a ton of viral infections out there that cause some form of brain damage and get no attention at all. Attention bias at play.

Re:Brain imaging before and after Covid-19 in UK Biobank by Frost1x on Sunday June 20, 2021 @11:13AM (#27570800)
Would be interesting to know. If you're alarmist about COVID affecting brain tissue long term and we have protections against other diseases that also have long term effects on brain tissues, it reasons to me that you should also be as adamant if not more for protecting against those diseases.

There's a lot of funding studying COVID, for good reasons. Why not use those findings to further other areas as well? We now have some interesting comparisons to look at. Might be even more good reasons to promote getting your annual flu shot.

Re:Brain imaging before and after Covid-19 in UK Biobank by ganzuul on Sunday June 20, 2021 @11:12AM (#27570791)
Hard to tell in advance, without the information. Was this a flippant dismissal or a genuine question?
Re:Brain imaging before and after Covid-19 in UK Biobank by lima on Sunday June 20, 2021 @11:41AM (#27571125)
Genuine question.
Re:Brain imaging before and after Covid-19 in UK Biobank by mkhpalm on Sunday June 20, 2021 @02:35PM (#27572716)
> Does this matter?

If we believe in science, probably.

Re:Brain imaging before and after Covid-19 in UK Biobank by curmudgeon22 on Sunday June 20, 2021 @02:43PM (#27572783)
I think it's reasonable to do a personal assessment of the risk. Yes, COVID can have very negative short and long term effects. BUT, what are an individuals chance of getting COVID? Quite a bit less than 100%. That's not the same math as the vaccine.
Re:Brain imaging before and after Covid-19 in UK Biobank by Obsnold on Sunday June 20, 2021 @08:40PM (#27575141)
I think this depends a lot on the time scales you are looking at. COVID isn’t going to go anywhere once the pandemic is declared over. The chance of you getting it at some point is very high.
Re:Brain imaging before and after Covid-19 in UK Biobank by papito on Sunday June 20, 2021 @05:18PM (#27574008)
This WP article mentions cases where the "COVID long haulers" have the aftereffects go away after the vaccine, which we don't know why yet, exactly.

https://www.washingtonpost.com/health/long-haul-covid-vaccin...

Re:Brain imaging before and after Covid-19 in UK Biobank by splithalf on Sunday June 20, 2021 @06:15PM (#27574363)
But the virus is “all natural”!

You can trust Mother Nature more than a bunch of creepy pharma-scientists. Didn’t you see Godzilla?

Re:Brain imaging before and after Covid-19 in UK Biobank by Claudus on Sunday June 20, 2021 @11:03AM (#27570712)
Maybe they are waiting for a study on “Brain imaging before and after Covid-19 Vaccination...”
[dead]
Re:Brain imaging before and after Covid-19 in UK Biobank by goodoldneon on Sunday June 20, 2021 @10:41AM (#27570487)
It’s hard to trust people who make a bold claim, only to back it up with “do the research”. Why don’t you link to some of these reputable Ivermectin studies?
Re:Brain imaging before and after Covid-19 in UK Biobank by megous on Sunday June 20, 2021 @11:22AM (#27570884)
Re:Brain imaging before and after Covid-19 in UK Biobank by leot on Sunday June 20, 2021 @11:10AM (#27570772)
Re:Brain imaging before and after Covid-19 in UK Biobank by plank_time on Sunday June 20, 2021 @10:43AM (#27570511)
I thought Ecuador heavily used ivermectin with no discernible benefit.
Re:Brain imaging before and after Covid-19 in UK Biobank by nradov on Sunday June 20, 2021 @06:41PM (#27574514)
Re:Brain imaging before and after Covid-19 in UK Biobank by namelessone on Sunday June 20, 2021 @10:40AM (#27570474)
>and I won't bother linking to resources related to Ivermectin

I'm not informed enough to comment on the content of your post, but this is a horrible way to start a productive discussion.

Re:Brain imaging before and after Covid-19 in UK Biobank by bavent on Sunday June 20, 2021 @10:58AM (#27570654)
They aren’t trying to start a productive discussion. Anti-vaxxers don’t approach debates in good faith. They tend to drop long-winded comments that vaguely link together different conspiracies and anecdotal bits of “evidence” but then never cite sources and never back up their claims when pushed.
Re:Brain imaging before and after Covid-19 in UK Biobank by mpfundstein on Sunday June 20, 2021 @01:52PM (#27572329)
because all anti vaxxers are the same, right?
Re:Brain imaging before and after Covid-19 in UK Biobank by bavent on Sunday June 20, 2021 @03:17PM (#27573063)
No, they are all individual beautiful little snowflakes, except they converge on agreeing on one thing. Thinking vaccines cause $X and also are vaguely linked to other things that aren’t proven. I’m criticizing them for that one thing, that they all have in common, which does allow me to categorize them as a group, when it relates to that one thing.
Re:Brain imaging before and after Covid-19 in UK Biobank by AndrewUnmuted on Sunday June 20, 2021 @12:00PM (#27571326)
> Anti-vaxxers don’t approach debates in good faith.

Neither do people who make blanket pronouncements about an entire broad demographic of people, after labeling them with loaded & vindictive terminology.

Re:Brain imaging before and after Covid-19 in UK Biobank by bavent on Sunday June 20, 2021 @03:17PM (#27573069)
Neither do people who make blanket statements about people making blanket statements.
Re:Brain imaging before and after Covid-19 in UK Biobank by loceng on Sunday June 20, 2021 @01:20PM (#27572049)
I'm not an antivaxxer but lazy people like you won't differentiate and don't differentiate well which is why research studies published are poorly understood and bad conclusions are perpetuated and in part why we're in this mess.

But yes, terrible way to start productive conversation but even when linking and putting the effort in the HN intellectual mob has already ideologically and shallowly investigated and come to shallow/poor conclusions and downvote and don't bother engaging further: how is someone downvoting a good beginning to a productive conversation?

Re:Brain imaging before and after Covid-19 in UK Biobank by bavent on Sunday June 20, 2021 @03:14PM (#27573045)
Lazy people like me? I’ve tried engaging with anti-vaxxers. It’s completely unproductive. Every single time. When I’ve tried something a hundred times and get the same result, why bother continuing to try?

I’m also not trying to have a productive conversation with you - you started this thread with a post that basically said “woe is me, I’m going to get downvoted” and then you got downvoted. You didn’t cite any sources and I don’t really care enough to dig through your comment history to find where else you did cite them, because I am not invested in this enough.

Re:Brain imaging before and after Covid-19 in UK Biobank by loceng on Tuesday June 22, 2021 @11:50AM (#27593214)
Someone who enters a conversation blindly calling a person an anti-vaxxer isn't worth engaging with - completely unproductive. You're aware mRNA vaccines are new technology for vaccines or no, and that vaccines usually take 7 years to go through approval process - and this one was fast tracked to 1 year? There are perfectly healthy teenagers dying after this vaccine; true statement that you may dismiss whether you believe it or not. Are you aware too that the inventor of the mRNA technology is trying to sound alarm bells for the problems with the spike protein with this vaccine?

And, digging through my comment history, it was 3 or so comments below the comment I made saying to reference it - but you assumed and instead put more effort writing this reply than to actually quickly look to see if your assumption was correct or not. But since you're relatively lazy - making assumptions - here, I've gone into my history and pasted the links for you:

Related links on Ivermectin:

https://covid19criticalcare.com

https://bird-group.org/

https://vimeo.com/562724784

https://vimeo.com/557811163

https://www.youtube.com/watch?v=BNyAovuUxro

Re:Brain imaging before and after Covid-19 in UK Biobank by drno123 on Sunday June 20, 2021 @12:51PM (#27571775)
The difference being, if you choose to get vaccinated, it’s 100% chance that you get mRNA. If you did not get Covid so far, the chances are going down you ever will.
Re:Brain imaging before and after Covid-19 in UK Biobank by berberous on Sunday June 20, 2021 @01:14PM (#27571990)
In many countries, the number of people getting the vaccine has plateaued, and at a fairly low level. Combine that with loosening policies, lower precautions, and more transmissible variants (like the Delta variant), and I think a lot of unvaccinated people may be at higher risk of catching it then they expect.
Re:Brain imaging before and after Covid-19 in UK Biobank by lagadu on Sunday June 20, 2021 @03:39PM (#27573233)
Once the pandemic phase is over, it'll be yet another endemic disease, meaning that as time goes anyone's chance of getting it tends towards 100%.
Re:Brain imaging before and after Covid-19 in UK Biobank by thu2111 on Tuesday June 22, 2021 @10:09AM (#27591802)
Flu is endemic. Many people have never had it. The idea that 100% of people will get not only COVID but the exact strain that exists today does not seem well supported, especially as governments are already making noises about variants and booster shots.
Re:Brain imaging before and after Covid-19 in UK Biobank by ekianjo on Sunday June 20, 2021 @11:14AM (#27570810)
> we have real data showing that there are long term effects from getting full blown COVID.

As in, 90% (probably more because asymptomatic people are never tested) of people actually have no symptoms at all and seem to go along fine with it? Or are you talking about something else?

Re:Brain imaging before and after Covid-19 in UK Biobank by dboreham on Sunday June 20, 2021 @11:41AM (#27571122)
Study suggests the "90% who are fine" may not all be fine.
Re:Brain imaging before and after Covid-19 in UK Biobank by ekianjo on Sunday June 20, 2021 @12:16PM (#27571484)
> Our general approach in this study was therefore as follows: (i) utilise brain imaging data from 782 participants who have visited the UKB imaging centres for two scanning sessions, on average 3 years apart, with 394 of these having contracted COVID-19 in between their two scans;

Have they established with certainty that in the control group there were no-one with COVID19 infection in the first place?

Re:Brain imaging before and after Covid-19 in UK Biobank by olaulaja on Sunday June 20, 2021 @03:25PM (#27573118)
Having a few false negatives in the control group shouldn't really matter since that would only make the groups more similar and hide any differences that exist rather than hallucinating ones that don't.
Re:Brain imaging before and after Covid-19 in UK Biobank by hallway_monitor on Sunday June 20, 2021 @10:31AM (#27570389)
Agree completely. That said, ideally I don't want either. Since a lot of people wanted to get vaccinated immediately, I can avoid that and the virus with very high probability. If needed, I'll take v3 or so of the mRNA vaccine.
Re:Brain imaging before and after Covid-19 in UK Biobank by egeozcan on Sunday June 20, 2021 @10:36AM (#27570428)
If many people do what you are doing, some percentage can get the virus and allow it to mutate further, reducing the vaccine efficiency, putting others to risk.

Prisoner's dilemma at play.

meta edit: I don't like your post becoming completely gray and therefore up-voted you. It's a view that many people hold and it needs to be answered not by screaming "down-vote the selfish!" but rather with good arguments.

Re:Brain imaging before and after Covid-19 in UK Biobank by makomk on Sunday June 20, 2021 @12:49PM (#27571764)
Realistically, there's basically no chance of vaccinating enough people fast enough on a global scale to stop the virus mutating further and reducing the vaccine efficacy, probably not even of reducing the odds of it that much, and it's not even clear that the countries with the best vaccine rollouts will manage to stop it spreading at this point. And that's despite vaccination on an unprecedented speed and scale for a disease this new, using technology that didn't even exist a few years ago.
Re:Brain imaging before and after Covid-19 in UK Biobank by hallway_monitor on Sunday June 20, 2021 @10:49AM (#27570564)
Oh 100%. It's a selfish play I admit. But if there's greater than zero risk of any long-term unknown effects from a vaccine, the number of people already vaccinated means the expected value is probably negative for anyone who hasn't been vaccinated yet.
Re:Brain imaging before and after Covid-19 in UK Biobank by tux3 on Sunday June 20, 2021 @11:03AM (#27570710)
Ignoring the blatant disregard for the safety of others, your calculations are off the mark.

The Delta variant is the only one you should be concerned about from here on. And a single dose of vaccine only provides minimal protection against it.

For your scheme to be safe, you would need about 80% of people around you to have 2+ doses of a high-efficacy vaccine, and ideally all with Pfizer over Astra, given their relative efficacy.

There's a greater than zero risk you're going about this wrong and will end up catching a new variant. Vaccination works, if you ACTUALLY GET THE SHOTS.

Cheers

Re:Brain imaging before and after Covid-19 in UK Biobank by devit on Sunday June 20, 2021 @11:10AM (#27570779)
There seems to be a sizeable number of people who don't want to vaccinate, plus children under 12 won't be, and also the pandemic will survive in developing countries and travelers coming from them for a while.

So I think the risk of getting infected in fall may well be significant enough to make taking the vaccine a good decision.

Plus of course by vaccinating you no longer need to worry about minimizing infection risk, you don't need to get fake certificates to access things that are restricted to vaccinated people, you are free to travel to developing countries without risk.

Also if you don't vaccinate now and the pandemic somehow has a resurgence you will have to rush to vaccinate then and stay at least month in full isolation while others who are vaccinated are freely going to events instead of doing the isolation now that events haven't fully resumed yet.

Re:Brain imaging before and after Covid-19 in UK Biobank by megous on Sunday June 20, 2021 @11:32AM (#27571003)
Vaccination has its risks too. Long-term pain in the vaccinated shoulder, that will eventually spread to the other arm (due to sudden overuse), will not make you enjoy your life either.

Having to test regularly may be less of a bother in life, if you lose this stupid vaccination lottery..., if you want to play on the convenience note.

Re:Brain imaging before and after Covid-19 in UK Biobank by lrem on Sunday June 20, 2021 @11:00AM (#27570680)
Your very high probability rides on the virus dying down. Which will happen after enough people get vaccinated to bring Reff < 1. Which with the original variant required 50% of the population and probably only adults counted. With the newest variant, that threshold grows to about 80% and probably needs to involve children. The longer we wait, the higher the chance it will never die down.
Re:Brain imaging before and after Covid-19 in UK Biobank by drno123 on Sunday June 20, 2021 @02:15PM (#27572516)
People who have got Covid are also immune - there is a paper published in Nature which showed that even people who had mild cases of Covid have long-term (possibly) lifetime Covid immunity.

https://www.nature.com/articles/s41586-021-03647-4

Re:Brain imaging before and after Covid-19 in UK Biobank by vladTheInhaler on Sunday June 20, 2021 @06:47PM (#27574552)
Except that Covid isn't just one disease, and immunity is a moving target. If you got the original variant back in February 2020, that may or may not protect you from a new variant with new mechanisms for evading/suppressing immune response.
Re:Brain imaging before and after Covid-19 in UK Biobank by r3trohack3r on Sunday June 20, 2021 @11:23AM (#27570899)
I’m not sure which child to respond to, so responding here.

I’m pretty well aligned with this and I’m not sure why it’s getting the downvotes.

COVID has never been communicated to me as something serious for my age group. Maybe I’m misinformed, but I’ve never feared getting COVID. I was _terrified_ of needing hospital care _during a hockey stick_.

COVID was communicated to me as a hospital killer. I was terrified I’d have a bad time and not get the care I needed or, worse, steal care from someone else in a zero-sum game. And it wasn’t just COVID during that window. If we “hockey sticked” and exceeded hospital capacity, any care I needed (heart problems, broken bones, different virus, etc.) would all be wrapped up in the same zero-sum game.

I quarantined for months, then socially distanced, and now I’m pretty much back to life as normal. What changed for me: my perceived risk of my local hospitals getting knocked over by COVID is now close to zero. In my eyes we’ve weathered the storm.

Am I missing something?

Re:Brain imaging before and after Covid-19 in UK Biobank by nicoburns on Sunday June 20, 2021 @11:36AM (#27571048)
Long covid. I'm 28, fit and healthy, and I had covid that wasn't bad enough to require hospital treatment, but left with me with fatigue, shortness of breath and heart arrythmias that are only just improving 12 months later and are still not back to full fitness.
Re:Brain imaging before and after Covid-19 in UK Biobank by inglor_cz on Sunday June 20, 2021 @02:18PM (#27572539)
I am 42, fairly fit and healthy too, and I still suffer from minor heart arrhythmia and an occasional fatigue 6 months after contracting a mild case of covid.
Re:Brain imaging before and after Covid-19 in UK Biobank by r3trohack3r on Sunday June 20, 2021 @04:24PM (#27573582)
Several folks at my gym have said similar. They’re still at 80% capacity after 6+ months of contracting COVID, and are in their 20s and 30s. Sorry this is happening to you…
Re:Brain imaging before and after Covid-19 in UK Biobank by inglor_cz on Monday June 21, 2021 @02:49PM (#27582540)
Thanks for your kindness. I am slowly coming back. Let us hope that none of those aftereffects are permanent.
Re:Brain imaging before and after Covid-19 in UK Biobank by loteck on Sunday June 20, 2021 @12:15PM (#27571468)
Being a part of a chain of transmission that kills someone, when you could have instead been the person who broke the chain and saved a life?
Re:Brain imaging before and after Covid-19 in UK Biobank by r3trohack3r on Sunday June 20, 2021 @12:48PM (#27571757)
Are you advocating for full population vaccination of all contagious diseases with mortality rates (that have vaccines) or is there something special about COVID?
Re:Brain imaging before and after Covid-19 in UK Biobank by loteck on Sunday June 20, 2021 @12:53PM (#27571790)
I'm introducing into your narrative a notion of morality in addition to your narrative (and the siblings narrative) of whether covid vaccination is in your self-interest.
Re:Brain imaging before and after Covid-19 in UK Biobank by r3trohack3r on Sunday June 20, 2021 @04:22PM (#27573559)
It’s not purely self interest. If you note, my comment says my “or worse” outcome is that I steal hospital care from _someone else_ in a zero-sum game. I’m asking what is special about _this_ virus beyond being a “hospital killer.”

I don’t believe COVID has a monopoly on your narrative (chain of transmission leading to death). I’m asking if I should be special casing COVID, or treating it like any other virus.

Re:Brain imaging before and after Covid-19 in UK Biobank by loteck on Sunday June 20, 2021 @06:32PM (#27574458)
On a per-vaccine basis, you could consider the advice of doctors and health professionals, plus the moral implications you're comfortable with, and balance those against self-interest.

You've asked "what am I missing?" and from your narrative I'm asking if you're missing the morality.

Re:Brain imaging before and after Covid-19 in UK Biobank by r3trohack3r on Sunday June 20, 2021 @08:07PM (#27574950)
This is where I’m at too. I think we are on the same page, but saying it out loud to give you a chance to correct me.

I live in a community that hasn’t taken COVID seriously. Any chain of transmission I carry on would likely be “fungible” in my mind - If it wasn’t me, it would be someone else.

Strong anti-quarantine, anti-mask, anti-short-time-to-market-vaccine.

But mixed in are a lot of _strong_ pro-vaccine folks who collectively have offset the need for masks to keep the hospitals from falling over. They’ve carried the torch of public good in my mind. They’ve offset the primary risk of this pandemic.

I’m on the fence and it feels like my decision isn’t consequential beyond personal risk and daily interactions (friends/family). If I transmit, I feel like it would be in a hurd where transmission was likely anyways and I was a randomly selected path vs an amplifier.

I wore a mask to offset risk of transmission to keep hospitals online. But injecting myself with a novel vaccine… I feel like I’m better off rolling the dice on contracting COVID and re-rolling to get side effects, vs rolling the dice once for the vaccine.

My choice has been reduced to a personal choice. It’s the same choice I make when I travel for the holidays. Example: I get the flu vaccine when I go see elderly or young family members. But right now I don’t feel it’s a moral imperative for COVID where, if I pass on a vaccine, I’m a horrible person who doesn’t care about my fellow man.

Does that make sense or am I off base?

Re:Brain imaging before and after Covid-19 in UK Biobank by anthomtb on Sunday June 20, 2021 @10:45AM (#27570532)
Most of the arguments against accepting an mRNA shot read as “too new, do not want” to me. What are the specific long-term side effects that one should be aware of when accepting an mRNA shot?
Re:Brain imaging before and after Covid-19 in UK Biobank by megous on Sunday June 20, 2021 @11:51AM (#27571236)
This + side-effects not going away as advertised. Finding some longer term side effect studies is not that easy in general search engine, due to slew of regurgitated basic information about side effects.

Would be nice to have some data, instead of a ton of articles that say the same old "most symptoms go away within a few days". How does one decide whether to vaccinate or not based on such information? What is most? What is few days?

Some side effects are extremely common, like shoulder pain. Acceptable if it goes away in a week, let's say. But if there's a risk I'll have it for 3 months or forever, I'd like to know how common is that to make a calculated risk assessment. < 1% probably acceptable. >2-3% probably not.

And this will only be more apparent with time and more studies. The study I managed to find tracked people only for 8 days, had a nice graph of symptoms fading away with time. Mind calming exponential decay. :) Good, but 5% still had some symptoms at day 8. How many do have them at day 60?

I don't understand why such information has to be so hard to find for normal people, who don't spend days searching around on google scholar.

Re:Brain imaging before and after Covid-19 in UK Biobank by captainredbeard on Sunday June 20, 2021 @10:58AM (#27570655)
It’s more the effects of free circulating spike protein in the bloodstream than mRNA triggering ribosomes.
Re:Brain imaging before and after Covid-19 in UK Biobank by Majromax on Sunday June 20, 2021 @11:58AM (#27571310)
> It’s more the effects of free circulating spike protein in the bloodstream than mRNA triggering ribosomes.

The mRNA vaccines are designed to express the spike protein in a membrane-bound form; very little is found floating free. See https://www.deplatformdisease.com/blog/spike-protein-circula....

Additionally, the mRNA vaccines express a modified spike protein that is stabilized in its "prefusion" state (as seen on the virus itself before it binds with a cell), and the resulting complex seems to have somewhat fewer effects even when it does interact with a cell.

Re:Brain imaging before and after Covid-19 in UK Biobank by lima on Sunday June 20, 2021 @11:15AM (#27570819)
And cytotoxicity - with the second shot, the body will have cytotoxic T cells which could target some of the transfected cells.

But, why not to be worried:

- It's a normal process and most cells will be replaced.

- The effects would be tiny, especially compared to an infection with the real thing. If this was causing widespread issues, we would know by now.

- All studies done so far indicate that only a very small amount will enter systemic circulation.

It's a classic risk tradeoff, and the risks of taking the vaccine are much smaller than the risk of getting the real infection (billions of viruses replicating vs. one-time dose, real spike protein vs. stabilized spike protein).

Re:Brain imaging before and after Covid-19 in UK Biobank by ganzuul on Sunday June 20, 2021 @11:10AM (#27570774)
I don't understand what you are saying.

What is the significance of either of those?

Re:Brain imaging before and after Covid-19 in UK Biobank by dukeofdoom on Sunday June 20, 2021 @11:34AM (#27571021)
As someone not getting the vaccine. I'll explain my reasoning. At this point, the odds of getting COVID are small. And much better treatments are around the corner. Thus a 1% mortality rate for the elderly, with multiple co-morbidities, will be even lower for someone my age should I get it at some point. Vaccines introduce a foreign substance 100% of the time into your body, sometimes have side effects. I won't even date girls that got the vaccine, until more is known about long term effects. I'm worried about possibility of birth defects should a pregnancy occur.
Re:Brain imaging before and after Covid-19 in UK Biobank by ch4s3 on Sunday June 20, 2021 @11:42AM (#27571135)
> until more is known about long term effects

I'm curious about this line of reasoning. We've been testing mRNA treatments for other diseases for about 25 years now. The approach was abandoned for gene therapy because the effects weren't long lasting. We have follow up data on people who participated in those studies, and to my knowledge there aren't any documented negative long term effects. We know what the vaccine encodes, a spike protein, which is produced for a few weeks and the the mRNA wears out and is cleaned up by the cells. The proteins also don't persist in the body for very long. The other ingredients in the vaccine aren't anything special.

History also demonstrated that negative vaccine reactions typically happen quickly, and not years down the line.

With all of that in mind, why would one be concerned with long term effects? Is there something I'm missing? Is the position one of maximalist caution? If so, are you applying that to other areas of your life?

Re:Brain imaging before and after Covid-19 in UK Biobank by krona on Sunday June 20, 2021 @12:08PM (#27571405)
The other ingredients in the vaccine aren't anything special.

Polyethylene glycol, for one, has never been used before in an approved vaccine. It is thought to be the cause of some rare anaphylactic reactions.

There are dozens of other compounds in the Pfizer vaccine; the reason for them being there and their effects are, for the most part, a trade secret.

Re:Brain imaging before and after Covid-19 in UK Biobank by ch4s3 on Sunday June 20, 2021 @12:42PM (#27571701)
It seems like the amount of PEG in the vaccine is two orders of magnitude than the levels in existing drugs[1].

[1] https://www.sciencemag.org/news/2020/12/suspicions-grow-nano...

Re:Brain imaging before and after Covid-19 in UK Biobank by dukeofdoom on Sunday June 20, 2021 @11:59AM (#27571320)
Not caution. Willingness to accept death should it come. I'm part of the natural world, and viruses are a natural way that keep population in balance. All these vaccines are keeping more kindling for a bigger fire down humanity's timeline. I would probably reconsider if the odds where much worse than 1%.
Re:Brain imaging before and after Covid-19 in UK Biobank by ch4s3 on Sunday June 20, 2021 @12:40PM (#27571675)
This doesn't make a lot of logical sense to me.

> natural way that keep population in balance

This is essentially a faith based belief, and not something rooted in personal risk as you previously mentioned.

> All these vaccines are keeping more kindling for a bigger fire down humanity's timeline.

Viral infections don't just kill you or you'll be fine. There are expensive (to society) effects of lots of people having diminished physical and cognitive capacity after infection. More over, by not being vaccinated you are imposing extra risk on anyone you contact who is unlucky enough to be in the narrow slice of people who are vaccinated but still susceptible to infection.

I don't see how you can argue from a perspective of unknown vaccine risk and some sort of concept of needing a virus to kill "excess population." That just seems perverse to me.

Re:Brain imaging before and after Covid-19 in UK Biobank by dukeofdoom on Sunday June 20, 2021 @01:27PM (#27572117)
I don't need the virus to kill anyone. Its part of the natural world. Viruses are literarily part of our genetic code, and may have helped to evolve the placenta. We have evolved along side of them. They're not there to only harm us, they also benefit us. It doesn't matter what I think anyway.

There's a limit to how much armour you can wear. There's always a cost.

And lets say each vaccine harms you just a tiny bit, which they clearly do. How much is the accumulated damage from all the vaccines we currently take or will need to take into humanity's future vs a naturally evolved immunity.

Re:Brain imaging before and after Covid-19 in UK Biobank by ch4s3 on Sunday June 20, 2021 @03:39PM (#27573230)
> And lets say each vaccine harms you just a tiny bit, which they clearly do

I don’t think this is supported by evidence at all.

Re:Brain imaging before and after Covid-19 in UK Biobank by dukeofdoom on Sunday June 20, 2021 @05:26PM (#27574065)
I have scarring from a TB vaccine on my arm the size of a dime. It's certainly not without effect to have an strong immune response to a foreign substance in your body. I'm not even going to mention the preservatives and other substances they put in them.

The strongest hunch that something is off with an animal population, is a low fertility rate. You have negative, declining reproductive rate hovering around 1.6

Re:Brain imaging before and after Covid-19 in UK Biobank by ch4s3 on Sunday June 20, 2021 @08:17PM (#27575020)
> I have scarring from a TB vaccine on my arm the size of a dime.

That isn't some systemic malady, it's a scar. I've got one from cutting myself shaving, but shaving isn't really a problem.

> You have negative, declining reproductive rate hovering around 1.6

This is clearly because people are choosing to have fewer children as they get richer. And is a bizarre point as you earlier argued that the virus killing people was good for "natural balance."

It's really hard to believe you're acting in good faith here and not just trolling.

Re:Brain imaging before and after Covid-19 in UK Biobank by dukeofdoom on Sunday June 20, 2021 @09:02PM (#27575272)
1. To be comparable, it would be more like you cut yourself shaving, and had a severe infection resulting in a permanent scar on your face the size of a dime.

Evidence is provided of adverse effects here for the US. https://vaers.hhs.gov/data.html

"During this time, VAERS received 5,343 reports of death (0.0017%) among people who received a COVID-19 vaccine.: https://www.cdc.gov/coronavirus/2019-ncov/vaccines/safety/ad...

For Canada:

There have been a total of 7,408 reports (26.3 reports per 100,000 doses administered) up to and including June 11, 2021.

https://health-infobase.canada.ca/covid-19/vaccine-safety/

2. That's just one plausible explanation you are given without questioning. It might be true to some extent, but its not the only reason for the decline.

Western Women are not able to have children in large numbers, some are struggling to even have one and are spending thousands of dollars on IVF fertility treatments now into their 40s trying.

"About 10 percent of women (6.1 million) in the United States ages 15-44 have difficulty getting pregnant or staying pregnant, according to the Centers for Disease Control and Prevention (CDC)."

https://www.womenshealth.gov/a-z-topics/infertility#:~:text=....

Re:Brain imaging before and after Covid-19 in UK Biobank by ch4s3 on Monday June 21, 2021 @10:57AM (#27579789)
This is clearly in bad faith. You've jumped for stating you own fears, to some malthusian nonsense, and now proposing that vaccines lower fertility. You're spewing conspiracy and not acting within the standards of the community. Please take this elsewhere.
Re:Brain imaging before and after Covid-19 in UK Biobank by dukeofdoom on Monday June 21, 2021 @06:40PM (#27585469)
You stated that there's no evidence that vaccine harm you even a tiny bit. I provided evidence from the governments own database.
Re:Brain imaging before and after Covid-19 in UK Biobank by mekkkkkk on Sunday June 20, 2021 @12:34PM (#27571627)
But the thing is that getting vaccinated isn't just a matter of individual safety. It's a way to minimize the spread throughout the whole of society. Even if the death rate would be only 1%, it's a whole lot of unnecessary death when dealing with a large population. Not to mention all the non-lethal yet life altering conditions that may follow full blown COVID.

Regarding your naturalistic argument, I doubt that you have the same outlook when it comes to other aspects of life. There is no shortage of natural causes of death that we try to avoid in our everyday lives. Unless you are proposing that we use COVID as an opportunity to literally and explicitly cull the human population, I don't think that reasoning holds water.

Re:Brain imaging before and after Covid-19 in UK Biobank by dukeofdoom on Sunday June 20, 2021 @01:50PM (#27572311)
Here's an article of odds of dying from various things.

https://robertroybritt.medium.com/odds-of-dying-what-you-sho...

Car Accidents are around 1/103. I've been to India car Pollution probably kills more.

Will you give up driving to make the roads safer for others? How about just give up google, because apparently they paid for some of the GOF research labs.

Re:Brain imaging before and after Covid-19 in UK Biobank by justapassenger on Sunday June 20, 2021 @12:13PM (#27571450)
If you truly believe that viruses are here to keep our population in balance and we should be part of natural world, why would higher chances of dying affect your decision? Following your logic it just means that nature have much stronger reasons to decimate humanity. Shouldn’t you accept it?
Re:Brain imaging before and after Covid-19 in UK Biobank by the-rc on Sunday June 20, 2021 @12:23PM (#27571541)
There's even greater herd immunity for measles and co., yet there are outbreaks among unvaccinated people all the time. Perhaps those odds are not that small. COVID-19 is probably never going to go away.

And you worry about the long term side effects for the vaccine's one protein, but only focus on the treatment (and not the side effects) for the virus that has 29 of them and tries its best to multiply itself. Do you see how this line of reasoning doesn't seem to compute?

Re:Brain imaging before and after Covid-19 in UK Biobank by MAGZine on Sunday June 20, 2021 @11:47AM (#27571192)
There ultimate treatment has arrived in the form of prevention. The urgency to develop covid specific therapeutics has dissipated for the same reason "your chance of getting it is lower."

Though even that is highly dependent on where you live, who you interact with, if you travel, etc. Lots of vaccine skeptics tend to share views and group, which makes conditions ripe for mini-outbreaks.

"Other people got the vaccine so I don't have to" is logic that looks sound on the surface but I think recent skepticism has shown that enough people all playing this card has the potential for disaster/devestation that is easily avoided.

Anyhow, you should talk your physician about this stuff, who is an authority who can give you information and help diffuse worried in a meaningful way.

Re:Brain imaging before and after Covid-19 in UK Biobank by dukeofdoom on Sunday June 20, 2021 @12:03PM (#27571350)
With more information coming out, and now a significant probability that the Virus was created in the lab. I am not culpable for saving humanity from the actions of rouge governments. Blame them, not me.
Re:Brain imaging before and after Covid-19 in UK Biobank by b0sk on Sunday June 20, 2021 @11:43AM (#27571152)
> At this point, the odds of getting COVID are small.

That's because the herd around you has been vaccinated. So you are OK with others getting vaccinated for your benefit but wouldn't do your part to benefit the herd. Awesome!

Maybe your post is parody. Can't really tell.

Re:Brain imaging before and after Covid-19 in UK Biobank by brigandish on Sunday June 20, 2021 @12:13PM (#27571451)
> So you are OK with others getting vaccinated for your benefit but wouldn't do your part to benefit the herd.

Shouldn't they be okay with getting vaccinated? They did it for their own reasons, and that's a good thing, but they're not martyrs or saints.

Re:Brain imaging before and after Covid-19 in UK Biobank by dukeofdoom on Sunday June 20, 2021 @11:47AM (#27571196)
I never asked the herd to do anything, thus I am not in any way obliged to them morally. They did it for their own protection. I was willing to accept the 1% of dying, even if no one was vaccinated.
Re:Brain imaging before and after Covid-19 in UK Biobank by dntrkv on Sunday June 20, 2021 @11:38AM (#27571076)
> Vaccines introduce a foreign substance 100% of the time into your body

So does the virus. And all of our data shows the virus is much, much worse.

Re:Brain imaging before and after Covid-19 in UK Biobank by dukeofdoom on Sunday June 20, 2021 @11:40AM (#27571113)
yes, but by taking the vaccine 100% chance of doing that. Virus, only if I get it.
Re:Brain imaging before and after Covid-19 in UK Biobank by MAGZine on Sunday June 20, 2021 @11:51AM (#27571239)
You're weighing a real possibility against an unfounded one.

P(Complications|Covid) has a calculatable probability.

P(Complications|Vaccine) is not, because we don't even know if they exist. And further, we strongly suspect they don't.

In other words, I think you're trading one hand for (at best) one in the bush.

Re:Brain imaging before and after Covid-19 in UK Biobank by krona on Sunday June 20, 2021 @12:23PM (#27571535)
P(Complications|ChAdOx1) is definitely not zero, especially for people < 40 years of age.
Re:Brain imaging before and after Covid-19 in UK Biobank by sethammons on Sunday June 20, 2021 @12:27PM (#27571567)
Two of my brothers-in-law were hospitalized after receiving the vaccine.
Re:Brain imaging before and after Covid-19 in UK Biobank by ohlookabird on Sunday June 20, 2021 @12:44PM (#27571716)
For what?
Re:Brain imaging before and after Covid-19 in UK Biobank by rubidium on Sunday June 20, 2021 @11:40AM (#27571108)
Appreciate the candor. Agree odds are low now of getting it.

When you’re healthy you get the vaccine for others, not yourself.

Studies so far show no difference in baby outcomes.

Re:Brain imaging before and after Covid-19 in UK Biobank by ekianjo on Sunday June 20, 2021 @11:19AM (#27570853)
> You don’t want a tiny piece of mRNA but you want the whole organism reproducing in your body?

Rather than injecting yourself with mRNA which will create long-term antibodies in your organism which will be reactivated any time something like COVID19 appears again in the nature, it's probably safer to rely on COVID19 treatments are are short lived (as in, metabolized) and reduce the viral load swiftly.

Re:Brain imaging before and after Covid-19 in UK Biobank by electrondood on Sunday June 20, 2021 @11:31AM (#27570990)
mRNA is short-lived, metabolized, etc. That's exactly how Pfizer and Moderna vaccines work.

> Once the instructions (mRNA) are inside the immune cells, the cells use them to make the protein piece. After the protein piece is made, the cell breaks down the instructions and gets rid of them. [0]

You seem to be arguing against the principle of vaccination in general.

[0] https://www.cdc.gov/coronavirus/2019-ncov/vaccines/different...

Re:Brain imaging before and after Covid-19 in UK Biobank by ekianjo on Sunday June 20, 2021 @12:25PM (#27571551)
mRNA are short-lived but the modified spike-specific T cells T-cells they create are not.
Re:Brain imaging before and after Covid-19 in UK Biobank by jlokier on Sunday June 20, 2021 @07:34PM (#27574773)
But that's just ordinary, natural human immunity. Your body naturally produces "thing-specific T-cells" for a large number of "not self" things it has encountered throughout your life, to defend you from them.

It's part of how your body's automatic anti-virus system works. It has a very clever system, where some cells learn to recognise foreign proteins.

There is no spike protein actually in these T cells. They are just trained to recognise spike protein, waiting to mobilise quickly to pretect you from it if it's detected in future.

Why would you not want that?

Do you have some evidence that your spike-specific T cells themselves cause harm, in a way that your other thing-specific T cells do not? (It's not impossible, but seems unlikely.)

Re:Brain imaging before and after Covid-19 in UK Biobank by Majromax on Sunday June 20, 2021 @11:48AM (#27571205)
> Rather than injecting yourself with mRNA which will create long-term antibodies in your organism which will be reactivated any time something like COVID19 appears again in the nature,

That's... supposed to be bad?

Re:Brain imaging before and after Covid-19 in UK Biobank by vajrabum on Sunday June 20, 2021 @11:35AM (#27571041)
What other viral diseases are easily treatable by medication as opposed to vaccination? Are there any?
Re:Brain imaging before and after Covid-19 in UK Biobank by codezero on Sunday June 20, 2021 @11:56AM (#27571295)
I’m sure most people would prefer vaccines, but herpes is a commonly medicated virus lacking in vaccination availability.
Re:Brain imaging before and after Covid-19 in UK Biobank by nradov on Sunday June 20, 2021 @06:43PM (#27574519)
Hepatitis C can be cured in most patients with a course of sofosbuvir (Sovaldi).
Re:Brain imaging before and after Covid-19 in UK Biobank by ekianjo on Sunday June 20, 2021 @12:13PM (#27571453)
HIV is effectively treated by tri-therapies.
Re:Brain imaging before and after Covid-19 in UK Biobank by sterlind on Sunday June 20, 2021 @12:51PM (#27571782)
it took a long time for HAART to be developed though, and a lot of people died during the AZT-only era.

if I had the option of choosing an effective HIV vaccine (god if only!) and HAART, I'd definitely choose the vaccine. HAART is apparently really rough on people.. it ages you.

Re:Brain imaging before and after Covid-19 in UK Biobank by AndrewUnmuted on Sunday June 20, 2021 @11:57AM (#27571299)
We also have data showing that there are negative long-term effects from getting the full-blown COVID vaccine. [0] The range of negative outcomes for just about any medical procedure range from none to death, so this should not be surprising.

One really cannot, and should not, use this kind of reasoning for what should be a private, personal matter.

[0] https://www.reddit.com/r/CovidVaccinated/ (Note the "I am not anti-vaccination" qualifiers in most submissions.)

Re:Brain imaging before and after Covid-19 in UK Biobank by evgen on Sunday June 20, 2021 @02:54PM (#27572894)
"I am not anti-vax" is always the first lie we hear from every anti-vax idiot. Now that the general anti-vax position has been so thoroughly debunked everyone knows to avoid someone who is obviously displaying this particular mental illness, so they have learned to be much more circumspect about their claims and how to position their anti-vax arguments. It will usually start with a bit of sea lioning and concern trolling before they move into arguments that tend to end with 'just saying...'