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Re:First person receives Pfizer Covid-19 vaccine in UK by ck2 on Tuesday December 08, 2020 @06:21AM (#25343945)
Good luck to the average person getting it in the USA before March.

Even with half the population refusing it because the anti-vax people might be even more crazy than the anti-maskers.

Which makes you wonder which country will have covid longest.

Re:First person receives Pfizer Covid-19 vaccine in UK by briefcomment on Tuesday December 08, 2020 @07:55AM (#25344487)
Can someone explain why it’s not enough to just vaccinate people who want to get vaccinated? Doesn’t that cover everyone who wants to avoid covid19?
Re:First person receives Pfizer Covid-19 vaccine in UK by CivBase on Tuesday December 08, 2020 @09:37AM (#25345646)
Theoretically if we return to "life as normal" once the vaccine has been distributed to everyone who wants it, but a significant portion of high risk individuals do not get vaccinated, it could overwhelm our hospitals.

That said, I think the fears about many people refusing the vaccine are completely overblown. All of the folks who I've talked to who are concerned about the vaccine have expressed willingness to get it after it has been out for a few months without major side effects. They wont qualify to be first in line anyways, so they'll have to wait regardless.

Re:First person receives Pfizer Covid-19 vaccine in UK by einarfd on Tuesday December 08, 2020 @08:21AM (#25344668)
No vaccine is ever 100%, you will see that some vaccinated people do get sick. In addition you have people that can't be vaccinated, these are still at risk. But if you vaccinated enough people, the successful vaccinated will act as a kind of firewall and hinder the sickness from effectively spreading.
Re:First person receives Pfizer Covid-19 vaccine in UK by briefcomment on Tuesday December 08, 2020 @09:03AM (#25345168)
But comments above state that the vaccine doesn't effect spread. If that's true, then vaccinating everyone would not address any of those points.
Re:First person receives Pfizer Covid-19 vaccine in UK by ghaff on Tuesday December 08, 2020 @09:17AM (#25345382)
It hasn't been proven to affect spread (because that wasn't tested for). But it's generally assumed it does to at least a degree.
Re:First person receives Pfizer Covid-19 vaccine in UK by tgb on Tuesday December 08, 2020 @10:53AM (#25346864)
It's also much harder to test spread. You'd have to do repeated follow-up of all participants with frequent testing. When you have 40,000 participants, that's a significant concern. Trials like these are called "large, simple trials" since at that scale it's impractical to have a complicated study design at that scale. In addition to the pure expense, it's difficult to comply consistently with the protocol if it's complicated and you need to implement it at dozens or hundreds of sites. And recruiting people becomes harder and harder as you need additional follow-up, and attrition is higher (and likely biased: you're more likely to take your test if you think you might be sick).

So it's entirely reasonable to just study symptomatic cases in these trials.

Re:First person receives Pfizer Covid-19 vaccine in UK by sollewitt on Tuesday December 08, 2020 @11:09AM (#25347095)
IIUC, you want to vaccinate everyone to get actual herd immunity as quickly as possible so the virus can't spread before it has mutated into different strains.

The more of the population unvaccinated, the larger population available for new strains to generate in, the higher probability of multiple strains.

It's not guaranteed the current vaccines inoculate against new strains, so you could be right back at square one next winter, with a new virulent strain.

Re:First person receives Pfizer Covid-19 vaccine in UK by tim333 on Wednesday December 09, 2020 @01:18AM (#25355875)
There's probably a good chunk of people who want neither covid nor the vaccine. Life's messy like that.
Re:First person receives Pfizer Covid-19 vaccine in UK by minikites on Tuesday December 08, 2020 @11:40AM (#25347633)
For the same reason everyone who buys a motor vehicle has to buy one with a catalytic converter. The actions of every individual affect society as a whole.
Re:First person receives Pfizer Covid-19 vaccine in UK by harambae on Tuesday December 08, 2020 @03:31PM (#25350937)
Because we can't be bothered to go after cruise ships? https://news.ycombinator.com/item?id=19016428
Re:First person receives Pfizer Covid-19 vaccine in UK by minikites on Tuesday December 08, 2020 @05:23PM (#25352254)
Why is your reply framed as an exclusive "or" choice?
Re:First person receives Pfizer Covid-19 vaccine in UK by akmarinov on Tuesday December 08, 2020 @06:36AM (#25344031)
The US vaccination plan has vaccinating non-essential (read average) people starting at around May-June, so no way it happens in March.

Doctors, the elderly and other more at risk groups will get it before that.

Re:First person receives Pfizer Covid-19 vaccine in UK by bluGill on Tuesday December 08, 2020 @09:39AM (#25345683)
The plans are expect to change as/if other vaccines become available. If the other vaccines in the pipeline get approved on the expected best case schedule we will be vaccinating anyone who wants it starting march. If there are unexpected issues things could take longer (the UK could still discover something and withdraw Pfizers' approval as a worst case)
Re:First person receives Pfizer Covid-19 vaccine in UK by rconti on Tuesday December 08, 2020 @11:18AM (#25347257)
I thought we were constrained by supply chain issues? Even if a vaccine was approved that didn't require ultra-low temperature storage, we need glass vials, etc.
Re:First person receives Pfizer Covid-19 vaccine in UK by bluGill on Tuesday December 08, 2020 @01:38PM (#25349540)
Most of the supplies are very common. We make enough glass vials to contain all covid vaccines many times over - they are used for many other medical processes. There are supply chain issues with some of the chemicals needed for mRNA vaccines. I'm sure other vaccines have a different set of chemicals in short supply. Over all, the supplies that apply to all vaccines are well supplied.
Re:First person receives Pfizer Covid-19 vaccine in UK by learc83 on Tuesday December 08, 2020 @08:08AM (#25344570)
The US vaccination plan is state by state. In many states people working in food service and grocery stores, people under 60 who are overweight, have high blood pressure, asthma etc... will be offered the vaccine in phase 2. It’s not just doctors and the elderly, it’s a huge chunk of the population.

And depending on how many people actually want the vaccine and how many are approved it’s possible that healthy, under 65, non essential workers could start being offered the vaccine.

Re:First person receives Pfizer Covid-19 vaccine in UK by ghaff on Tuesday December 08, 2020 @09:16AM (#25345362)
It varies by state but I expect most will at least roughly follow CDC guidelines. There will probably be variance in who is considered essential and who gets it after essential works, at risk, and 65+. At least some places are looking to start vaccinate younger people who are more likely to spread and only then do other older age groups.
Re:First person receives Pfizer Covid-19 vaccine in UK by learc83 on Tuesday December 08, 2020 @09:25AM (#25345494)
Pretty much every state has a publicly available vaccine plan that you can read. The variance is pretty big even though it mostly follows the same progression. My stepdad can get the vaccine in phase 1b in his state, but not my mom. The state over from her my mom could get it in phase 1b, but not my stepdad.

My fiancée's parent's can't get it until phase 3 in their state, but they could both get it in phase 1b in my parent's state.

Re:First person receives Pfizer Covid-19 vaccine in UK by ghaff on Tuesday December 08, 2020 @09:47AM (#25345804)
Relatively small differences in the rules can certainly affect one's position in line quite a bit. For example, an otherwise not at particular risk 60 year old is actually going to be pretty close to the end of the line in a lot of places (even though they may count as "elderly" elsewhere).
Re:First person receives Pfizer Covid-19 vaccine in UK by learc83 on Tuesday December 08, 2020 @09:54AM (#25345909)
That's true. States seems to be split on 60 vs 65 as the age cutoff for healthy adults.
Re:First person receives Pfizer Covid-19 vaccine in UK by standardUser on Tuesday December 08, 2020 @10:26AM (#25346407)
Average people will be getting vaccines long before May. That just sounds like naysaying for the sake of naysaying. Or maybe you have inside info about which additional vaccines will be granted approval and when?
Re:First person receives Pfizer Covid-19 vaccine in UK by umanwizard on Tuesday December 08, 2020 @10:32AM (#25346502)
> The US vaccination plan

No such thing, AFAIK

Re:First person receives Pfizer Covid-19 vaccine in UK by jacquesm on Tuesday December 08, 2020 @06:45AM (#25344088)
Good chance that there is significant overlap between anti-maskers and anti-vaxxers.
Re:First person receives Pfizer Covid-19 vaccine in UK by vixen99 on Tuesday December 08, 2020 @08:12AM (#25344608)
Generalized category labelling is not helpful though it may be enjoyable. We can ignore stalwarts of either extreme camp while taking note of, for instance, the measured tone of the Danish study on mask wearing.
Re:First person receives Pfizer Covid-19 vaccine in UK by ketamine__ on Tuesday December 08, 2020 @08:17AM (#25344638)
...
Re:First person receives Pfizer Covid-19 vaccine in UK by bluGill on Tuesday December 08, 2020 @09:42AM (#25345729)
Most people working without air conditioning are in a job where they should have a mask that is a lot more uncomfortable than a simple N95! There are a lot of chemicals that a N95 won't filter and those are typically used by the types of people who don't have air conditioning.
Re:First person receives Pfizer Covid-19 vaccine in UK by lagadu on Tuesday December 08, 2020 @06:32AM (#25343999)
All countries will have covid forever[0]: it's an endemic disease to nearly all continents now, much like the flu or aids.

[0]for values of "forever" that don't go into the far future where viruses may have a cure or an effective form of erradication.

Re:First person receives Pfizer Covid-19 vaccine in UK by zebrafish on Tuesday December 08, 2020 @09:06AM (#25345212)
You should provide sources for claims like this or at least claims stated in this way. The actual real truth is, like most things with this virus that showed up a few months ago, nobody knows for sure.
Re:First person receives Pfizer Covid-19 vaccine in UK by idnefju on Tuesday December 08, 2020 @06:46AM (#25344090)
Australia doesn’t have it. Wasn’t impossible, just had to stop air travel and lockdown for a period. Now the only people with COVID are returned Australian travellers from overseas who have to go on hotel quarantine
Re:First person receives Pfizer Covid-19 vaccine in UK by wrinkl3 on Tuesday December 08, 2020 @07:04AM (#25344168)
Yeah but for how long? Unless Australia is willing to keep screening all arrivals and containing outbreaks indefinitely, Covid is gonna start circulating there at some point.
Re:First person receives Pfizer Covid-19 vaccine in UK by iso1631 on Tuesday December 08, 2020 @07:17AM (#25344240)
Require proof of vaccine to come to Austraila. Native population mostly vaccinated. Even if someone did manage to get in with covid, it might not spread particularly easily.

Sure covid will probably continue to exist, just like H1N1 exists

Re:First person receives Pfizer Covid-19 vaccine in UK by dragontamer on Tuesday December 08, 2020 @10:52AM (#25346858)
> Sure covid will probably continue to exist, just like H1N1 exists

Flu immunity only lasts 6 months.

COVID immunity seems to already be longer than Flu / H1N1 immunity.

Now if COVID immunity is only 1-year or 2-years, then yes, it will flare up over time. But if COVID immunity is like 5 years or 10 years, then we can pretty much forget-about-it after the vaccine.

No one knows how long the immunity is, aside from lasting longer than any test so far.

Re:First person receives Pfizer Covid-19 vaccine in UK by iso1631 on Tuesday December 08, 2020 @11:04AM (#25347025)
We still haven't eradicated measles despite a vaccine giving lifelong immunity so I suspect covid won't be eradicated any time soon. It won't be a problem for the vast majority of people either though
Re:First person receives Pfizer Covid-19 vaccine in UK by bun_at_work on Tuesday December 08, 2020 @11:30AM (#25347470)
What do you mean flu immunity only lasts 6mo? As I understand it, flu vaccines are done yearly due to mutations rendering the vaccine impotent for the next strain. However, it seems like you're implying that the vaccine "wears off" or something.

What do you mean?

Re:First person receives Pfizer Covid-19 vaccine in UK by dragontamer on Tuesday December 08, 2020 @11:35AM (#25347535)
https://www.cdc.gov/flu/prevent/keyfacts.htm

> However, getting vaccinated early (for example, in July or August) is likely to be associated with reduced protection against flu infection later in the flu season, particularly among older adults

August / July is too early, people's flu immunity wears off before the end of the season. This is well known.

Re:First person receives Pfizer Covid-19 vaccine in UK by bun_at_work on Tuesday December 08, 2020 @11:39AM (#25347618)
Thanks for the share. From the link:

> Why do I need a flu vaccine every year? A flu vaccine is needed every season for two reasons. First, a person’s immune protection from vaccination declines over time, so an annual vaccine is needed for optimal protection. Second, because flu viruses are constantly changing, flu vaccines may be updated from one season to the next to protect against the viruses that research suggests may be most common during the upcoming flu season. For the best protection, everyone 6 months and older should get vaccinated annually.

Re:First person receives Pfizer Covid-19 vaccine in UK by dragontamer on Tuesday December 08, 2020 @12:01PM (#25347976)
Yeah, you're not wrong, but neither am I. Both effects happen. The flu has unusually short immunity in humans: most diseases have an immunity that lasts longer than that.

A big worry about COVID19 was the length of immunity. As a novel disease, no one knew how long human immunity would last. Fortunately, it seems to be for a long time (more than 8 months, which is the length of time these studies have been going). As such, we know COVID19 immunity is "longer than the flu", already.

Re:First person receives Pfizer Covid-19 vaccine in UK by howlgarnish on Tuesday December 08, 2020 @09:07AM (#25345233)
Qantas (the Australian airline) has already announced that they intend to require COVID vaccination as a condition for boarding international flights: https://www.channelnewsasia.com/news/world/qantas-covid-19-v...

Australia is also not even letting citizens leave the country without special permission. I don't see them loosening up until there's actual herd immunity via vaccination in the country.

Re:First person receives Pfizer Covid-19 vaccine in UK by Scoundreller on Tuesday December 08, 2020 @12:06PM (#25348057)
I think Australia lets you leave. It’s just really hard to get back.
Re:First person receives Pfizer Covid-19 vaccine in UK by taejo on Tuesday December 08, 2020 @07:08AM (#25344195)
They could make proof of vaccination an entry requirement. Combine that with widespread domestic vaccination and you've got a very good chance of containing any infections that make it into the country.
Re:First person receives Pfizer Covid-19 vaccine in UK by thinkingemote on Tuesday December 08, 2020 @07:14AM (#25344232)
vaccination doesn't mean you cannot get the virus and spread it around. it protects you from the effects of Covid-19, the disease, caused by your body's reaction to the virus.

Those vaccinated, because they have less symptoms, less coughing basically, might not spread it around as much, but we don't know that yet. Remember asymptomatic spreading is a big concern for this virus.

Re:First person receives Pfizer Covid-19 vaccine in UK by taejo on Tuesday December 08, 2020 @07:57AM (#25344493)
You're right that the recent efficacy studies of the COVID vaccines only demonstrated protection from the disease. That doesn't mean that they do not prevent spreading the disease, only that we don't know whether they do. Presumably the reason for this choice of endpoint is that we can detect sickness, but we can't reliably detect transmission.

If I may pick another nit, it's not asymptomatic but presymptomatic that seem to be the major concern, from what I've heard: that is, people who spread the disease will eventually show symptoms (usually within a day or two). The balance of evidence seems to suggest that people with viral loads that never get high enough to cause illness are probably not enough to cause a significant number of transmissions, but we will have to wait for widespread vaccination to confirm it.

Re:First person receives Pfizer Covid-19 vaccine in UK by nl on Tuesday December 08, 2020 @07:47AM (#25344429)
This is getting downvotes, but it is at least somewhat correct.

> it protects you from the effects of Covid-19, the disease, caused by your body's reaction to the virus.

There isn't really evidence either way for this. To quote Nature[1]:

"Tests on more than 43,000 people have shown that the Pfizer vaccine is 95% effective at preventing disease"

> vaccination doesn't mean you cannot get the virus and spread it around.

This might be true:

"But none has demonstrated that it prevents infection altogether, or reduces the spread of the virus in a population. This leaves open the chance that those who are vaccinated could remain susceptible to asymptomatic infection — and could transmit that infection to others who remain vulnerable. “In the worst-case scenario, you have people walking around feeling fine, but shedding virus everywhere"

[1] https://www.nature.com/articles/d41586-020-03441-8

Re:First person receives Pfizer Covid-19 vaccine in UK by weddpros on Tuesday December 08, 2020 @08:05AM (#25344553)
How can the vaccine prevent entry of the virus in cells, yet the virus can still replicate? I can’t understand why they state we don’t know, because of how I image viruses and vaccination works. Can someone help me understand this paradox?
Re:First person receives Pfizer Covid-19 vaccine in UK by bun_at_work on Tuesday December 08, 2020 @11:36AM (#25347566)
https://www.youtube.com/watch?v=zQGOcOUBi6s

Here's a nice video on the immune system that might help you out. Their other videos on the immune system, the complement system, and viruses might also be helpful. Not the most technical deep dives, but good, abstracted explanations.

In short, I don't think the vaccine prevents entry of the virus into the cells. That still happens, as it's a mechanical protein interaction (as far as I know). However, the vaccine (mRNA ones at least) work by producing the protein on the outside of the virus and putting that in your system, so your immune system learns how to respond. At least that's my mile-high interpretation.

Re:First person receives Pfizer Covid-19 vaccine in UK by fakedang on Tuesday December 08, 2020 @12:26PM (#25348400)
I presume it's because of the inadvertent time delay in response by the immune system, during which time it would be possible to spread the virus.
Re:First person receives Pfizer Covid-19 vaccine in UK by dTal on Tuesday December 08, 2020 @07:26AM (#25344296)
>Unless Australia is willing to keep screening all arrivals and containing outbreaks indefinitely

It's possible. There is no rabies in the UK, for exactly this reason.

Re:First person receives Pfizer Covid-19 vaccine in UK by mns on Tuesday December 08, 2020 @07:37AM (#25344374)
You don't get rabies by someone sneezing behind you in a poorly ventilated area.
Re:First person receives Pfizer Covid-19 vaccine in UK by ChrisRR on Tuesday December 08, 2020 @08:07AM (#25344559)
And are you going to keep your borders closed forever?

And i guarantee some people still have it. There's no way it's been eradicated completely. All it takes is for one infected person to visit 2 people, and those 2 people to visit 2 others.

Re:First person receives Pfizer Covid-19 vaccine in UK by prawn on Tuesday December 08, 2020 @10:13AM (#25346204)
And presumably that's been happening for months, yet there are limited outbreaks and they are swiftly contained through contact tracing and quarantine.

Victoria was swamped yet has not had a case for 30 days now. Cross-border travel varies depending on the status of each state, but is tracked and quarantine enforced at various levels if it's available.

Testing is freely available and fairly fast.

Nationwide, there is currently one locally acquired case over the last 7 days, and 74 from overseas in the same period.

Presumably we'll bubble with NZ at some point and carefully go from there, plus see how the availability of vaccines starts to change the equation beyond that. In my circles, people are keen to travel again, but everyone is pretty matter of fact about the situation and curious about timings rather than desperate to open up.

Re:First person receives Pfizer Covid-19 vaccine in UK by walkingolof on Tuesday December 08, 2020 @07:00AM (#25344155)
Helps to have no land borders, not saying Australia didn’t do a great job curbing it ..
Re:First person receives Pfizer Covid-19 vaccine in UK by peterkelly on Tuesday December 08, 2020 @08:17AM (#25344643)
Thailand has done an even better job, with just under 4,200 infections total since January. It has land borders with four other countries, the most porous of which is Myanmar. Very recently there have been some cases of infected people crossing over illegally from the latter; health authorities have been doing very thorough contact tracing so it remains to be seen if this will escalate. But last week was the first time in months there was more than a handful of cases nationwide, excluding foreign travelers in quarantine.

Why has it worked so well here? I don't know the full answer, but by and large people have been very responsible. The last time I was at an airport, back in early February, every single person was wearing a mask, and in lots of public places the majority of people continue to do so. Mask wearing has not been politicised here. Also every shopping mall and most restaurants/public places scan you for temperature on entry and have a book where you can (optionally) write down your name or register with an app to be notified if it is later discovered an infected person has been there the same day you were.

Re:First person receives Pfizer Covid-19 vaccine in UK by PurpleFoxy on Tuesday December 08, 2020 @07:04AM (#25344169)
Does it really? Has it been found that a significant source of infections was illegal immigration? Or that without it there would not have already been internal spreading?
Re:First person receives Pfizer Covid-19 vaccine in UK by iso1631 on Tuesday December 08, 2020 @07:24AM (#25344289)
Doesn't matter. If you don't have covid, and nobody comes in, you won't get covid.

But that's not feasible in most countries.

Austrailia and NZ don't rely on a just-in-time cross border economy like the US and Europe. Goods arrive after being on boats which have been off shore for days or weeks.

Compare with the US-Canada "border closure", where thousands of trucks, and their drivers, have crossed each way every day all year.

Re:First person receives Pfizer Covid-19 vaccine in UK by Scoundreller on Tuesday December 08, 2020 @12:08PM (#25348097)
Canada-US could do what they already do with trains: crew change at the border.

Or even trailer drop-off and pick-up for no-chance-of-personal-contact changes.

They just choose not to.

Re:First person receives Pfizer Covid-19 vaccine in UK by iso1631 on Tuesday December 08, 2020 @12:19PM (#25348285)
That's still orders of magnitude more goods crossing a border without a quarentine period than you get from air freight to Aus/NZ
Re:First person receives Pfizer Covid-19 vaccine in UK by Scoundreller on Tuesday December 08, 2020 @12:23PM (#25348335)
I don’t think the issue is quarantining/isolation of goods, but the people transporting it.

Canadian cross-border truckers arriving back from ??? USA are largely exempt from quarantine requirements upon return.

Re:First person receives Pfizer Covid-19 vaccine in UK by geomark on Tuesday December 08, 2020 @08:34AM (#25344777)
That's what is happening at this moment in Thailand. There were no local transmissions for many months. Borders are closed and anyone coming into the country has to go directly to 14 day quarantine and test clean before they get out. But then some Thais went to Myanmar and snuck back into Chiang Mai in northern Thailand illegally. They were infected and have now spread the infection locally in Thailand to at least a few people. Some cases took flights to Bangkok. There is a frantic effort to track and trace everyone who might have been exposed.
Re:First person receives Pfizer Covid-19 vaccine in UK by paublyrne on Tuesday December 08, 2020 @06:52AM (#25344123)
It's likely this will change next year when Australia lifts quarantining. It will be considered an acceptable risk given that most people will not be vulnerable to it.
Re:First person receives Pfizer Covid-19 vaccine in UK by csjr on Tuesday December 08, 2020 @07:20AM (#25344256)
This! I was thinking about this recently. How the politicians have failed to implement such simple policies?
Re:First person receives Pfizer Covid-19 vaccine in UK by barry-cotter on Tuesday December 08, 2020 @07:28AM (#25344317)
Blame the World Health Organization.

> Countries may gain time in the short-term as they limit travel to fight the new coronavirus pandemic, but the World Health Organization thinks overall that “it doesn't help to restrict movement," a top adviser to the U.N. health agency's chief said Thursday.

https://www.euronews.com/2020/03/13/world-health-organizatio...

Re:First person receives Pfizer Covid-19 vaccine in UK by amanaplanacanal on Tuesday December 08, 2020 @11:18AM (#25347244)
It probably depends on when you do it too. If it’s already widespread in your population, closing borders isn’t going to help much.
Re:First person receives Pfizer Covid-19 vaccine in UK by fakedang on Tuesday December 08, 2020 @12:31PM (#25348489)
That was in March. The messaging from Jan was pretty much the same, if not even more lax. The WHO is to be blamed significantly for not communicating properly.
Re:First person receives Pfizer Covid-19 vaccine in UK by peteretep on Tuesday December 08, 2020 @06:39AM (#25344051)
The reason we have AIDS is because vaccination against HIV is very difficult and expensive. I don’t see how this generalises to all viruses? Several viruses have been eradicated, and several more have been effectively eradicated in countries with functioning healthcare