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Re:Malaria 'Completely Stopped' by Microbe by GoToRO on Monday May 04, 2020 @09:15AM (#23067631)
I would really like to know if covid19 is worse than malaria, globally. Up until now it seems that it is worse only because it affects us. I was shocked to find out there is no treatment for malaria when I traveled in affected areas. I felt the same way as I am today, except I was the only one feeling like that.
Re:Malaria 'Completely Stopped' by Microbe by jml7c5 on Monday May 04, 2020 @09:59AM (#23068135)
Around 500,000 people died of malaria in 2018. COVID-19 deaths are currently at 250,000 (according to worldometers.info), but deaths are only just starting to slow down, and it's unclear how many deaths are going unreported. (There has been suggestion that in some places, actual deaths may be twice as high; apparently even after one adds reported COVID-19 deaths to an area's expected "regular" deaths, there is a shortfall vs actual deaths.)

It's worth noting that in terms of person-years lost, an average malaria death is significantly worse as it predominantly kills children under the age of 5.

Re:Malaria 'Completely Stopped' by Microbe by koheripbal on Monday May 04, 2020 @11:00AM (#23068837)
The 2018 number is 405K according to the WHO - and it's dropping every year, significantly, despite exploding populations.

source: https://www.who.int/news-room/feature-stories/detail/world-m...

Tremendous progress is being made against Malaria. Of course, it's not enough until will destroy this scourge.

Re:Malaria 'Completely Stopped' by Microbe by jml7c5 on Monday May 04, 2020 @12:02PM (#23069628)
I'm not sure how I ended up with "around 500,000" instead of the (readily available) actual number. Thank you for the correction.
Re:Malaria 'Completely Stopped' by Microbe by roywiggins on Monday May 04, 2020 @10:44AM (#23068658)
Someone has actually crunched the numbers on this! The person-years lost for COVID is currently about 10 years on average.

https://www.wsj.com/articles/coronavirus-kills-people-an-ave...

Re:Malaria 'Completely Stopped' by Microbe by kurthr on Monday May 04, 2020 @11:53AM (#23069483)
Alternately, the person years of those children haven’t started, and can easily be replaced... Maybe we shouldn’t just be ranking people by age, if we want to come to moral outcomes?
Re:Malaria 'Completely Stopped' by Microbe by gajomi on Monday May 04, 2020 @01:29PM (#23070852)
> we shouldn’t just be ranking people by age, if we want to come to moral outcomes?

Agreed. But I think quantifications can still be useful.

Person-years probably aren't the right sort of quantification though, in that they blend together too many kinds of human experience. But I imagine most people would agree that statements like "X% of grandparents, lost 10 years earlier than expected" or "Y% of children under 10" allow for comparing the relative impact on families.

Quantifying losses doesn't mean that we consider the quantified as fungible.

Re:Malaria 'Completely Stopped' by Microbe by wizzwizz4 on Tuesday May 05, 2020 @08:04AM (#23079089)
> Quantifying losses doesn't mean that we consider the quantified as fungible.

Unless you're a hospital director on a budget, or something. (I don't know how such people cope; there's no winning decision there.)

Re:Malaria 'Completely Stopped' by Microbe by lotsofpulp on Monday May 04, 2020 @07:31PM (#23074624)
I don’t understand what you mean when you write person years of those children haven’t started yet? They were born, so how have their person years not started?

And in context of opportunity cost, in a situation where limited medical resources need to be allocated, it’s not a controversial opinion that a 90 year old can be let go in favor of saving a 10 year old.

Re:Malaria 'Completely Stopped' by Microbe by SamReidHughes on Monday May 04, 2020 @11:32PM (#23076196)
The notion of valuing a life at age 15 higher than at age 5 is pretty reasonable. If the value starts at zero at conception, ends at zero at death, then -- if it's a continuous function -- there has to be a rising curve followed by a falling curve. And this seems to fit with some choices I'd make in contrived trolley problem scenarios. Though it's not the only variable, when you get to particularities.
Re:Malaria 'Completely Stopped' by Microbe by SamBam on Monday May 04, 2020 @10:21AM (#23068365)
> in terms of person-years lost

"Potential" person years lost, I guess. If you used "person years" the same way you use "Our firm has a combined 125 years of experience" then it's the other way round.

(Grim discussion, I guess, but I'm just not certain I agree with the unspoken assumption that seems to be in that statement, that the younger the death, the more tragic/more effect on society.)

Re:Malaria 'Completely Stopped' by Microbe by jml7c5 on Monday May 04, 2020 @12:14PM (#23069812)
Yes, "potential person years" or a similar phrasing would have been clearer.

>(Grim discussion, I guess, but I'm just not certain I agree with the unspoken assumption that seems to be in that statement, that the younger the death, the more tragic/more effect on society.)

It is a matter of morality and personal ethics. I chose to mention it only because the discrepancy in this case is so large, and it felt almost misleading to not relate the information. That said, I regret framing it in such a coldly utilitarian way.

Re:Malaria 'Completely Stopped' by Microbe by vikramkr on Monday May 04, 2020 @02:22PM (#23071469)
These cold terms are how these discussions are had in industry. It's the core behind value based pricing - quality adjusted life years or QALYs are what many health systems use to determine what they will or wont pay for. As long as money is scarce, these are how conversations are had. A drug that saves a child's life is worth more, and people are willing to pay more, than a drug that saves an older person's life. There are cutoffs and thresholds. In the UK, with a few exceptions, a drug cant cost much more than 30 thousand pounds for each extra quality adjusted year of life (e.g. an extra year bedridden might only count as 30% of a year, while an extra year closer to functional might count as 95%) for NICE to approve paying for it. In the developing world, the value of a human life is set at about 2x GDP per capita per QALY. In the US, for a drug to be cost effective, it should be less than 150,000 dollars per QALY (but many drugs aren't).
Re:Malaria 'Completely Stopped' by Microbe by thaumasiotes on Monday May 04, 2020 @03:18PM (#23072129)
The usual metric is QALY, "quality-adjusted life years". (The idea of quality adjustment being that three years of being 82-84 isn't as good as three years of being 22-24.)
Re:Malaria 'Completely Stopped' by Microbe by xiphias2 on Monday May 04, 2020 @11:11AM (#23068973)
It's a horrible assumption. I know that my parents probably have only 5-15 years of their life left, so I make sure to have contact with them as much as possible, and keep up longevity research, though I know that they don't like to experiment as much as I would in their place.
Re:Malaria 'Completely Stopped' by Microbe by SamBam on Monday May 04, 2020 @01:54PM (#23071142)
> I know that they don't like to experiment as much as I would in their place.

Hard to know. Do you think there's zero chance that, when you're their age, you might be the one telling your adult kid that you've had a happy, long life, and don't feel the need to experiment with longevity?

Re:Malaria 'Completely Stopped' by Microbe by HarryHirsch on Monday May 04, 2020 @11:10AM (#23068968)
average malaria death is significantly worse as it predominantly kills children under the age of 5

It's not only deaths, it's also lost opportunity, as malaria is a chronic disease. Children miss out on schooling, adults miss out on work, and malarious areas miss out on investment.

Re:Malaria 'Completely Stopped' by Microbe by jimmaswell on Monday May 04, 2020 @11:38AM (#23069295)
> unclear how many deaths are going unreported

I'd been hearing the numbers might be inflated from diagnoses on dead people without tests. Hard to know what's really going on with anything with all the conflicting information.

Re:Malaria 'Completely Stopped' by Microbe by SamBam on Monday May 04, 2020 @02:00PM (#23071211)
Almost certainly the other way around. The most useful measure is "excess deaths" -- those are simply the statistical "excess" of deaths we are currently experiencing compared with the average at this time in years past, and are uninfluenced by diagnoses, coroners, politicians, etc.

Here are some good state-by state graphs [1], and here's a country-wide graph [2]

By any measure, our "excess deaths" since February have spiked enormously, and significantly more than the current official Covid death count.

Some may be due to hospitals overflowing preventing other care. But it's pretty clearly all Corona-related.

1. https://www.nytimes.com/interactive/2020/04/28/us/coronaviru...

2. https://www.washingtonpost.com/investigations/2020/05/02/exc...

Re:Malaria 'Completely Stopped' by Microbe by ballenf on Monday May 04, 2020 @03:15PM (#23072101)
I agree, but the real number would be comparing to lockdown death rates w/o covid.

Over the past few years, the evidence linking human health and overall mortality to isolation and human contact has been increasing. Don't get me wrong I'm staying locked down for the foreseeable future, but I have family and close friends whose mental health I'm seriously worried about. Not to mention physical health from stress, isolation, reduced activity, and can't afford to eat as healthy / stress-eating.

No idea if those are trends that will even come close to direct covid deaths, but we can't make informed decisions considering them.

> But it's pretty clearly all Corona-related.

If you count the above as "Corona-related", then I don't think the number has much meaning in terms of informing public policy.

Re:Malaria 'Completely Stopped' by Microbe by xoa on Monday May 04, 2020 @04:43PM (#23073021)
It actually has been studied and it looks like, in terms of absolute bulk numbers, that at least in developed countries like the US lockdown decreases deaths overall. Here's an Ars article from last week with a summary and some links for some further reading if you're interested [1]. Basically though while suicides go up, a lot of other causes of death plummet. Auto accidents for example a big source of yearly mortality that drop a ton if, well, people aren't getting in their vehicles so much. Air pollution has plummeted [2] as well, another significant source of deaths. People are bored at home and thus work out more, tend to eat better, etc.

Of course as that article and any other responsible ones should point out, the benefits and harms fall quite unevenly, and there is a lot of real misery too. And at some point the economic harm from ongoing lock down would certainly affect more and more people regardless of previous income. But even so as far as society overall goes it at worst looks like a wash right now, and seems more likely to lean towards fewer deaths. So excess vs previous years does look like a valid number to use as some level of gut check given the ongoing poor state of testing.

----

1: https://arstechnica.com/science/2020/04/recessions-dont-lead...

2: https://www.wsj.com/articles/coronavirus-offers-a-clear-view...

Re:Malaria 'Completely Stopped' by Microbe by joshuahedlund on Monday May 04, 2020 @11:54AM (#23069509)
> Hard to know what's really going on with anything with all the conflicting information.

Yes, but you don't have to give up. If you use critical thinking and assess the competing claims and the strength of the evidence for them, it becomes clear that the evidence for inflated counts is extremely weak, bordering on hearsay, and inconsistent with the overall data, while the evidence for extra uncounted deaths is much broader and stronger and consistent with the overall data, so while there is uncertainty about the true numbers, on net it's reasonable to assume more deaths are being missed than overcounted.

Re:Malaria 'Completely Stopped' by Microbe by amenod on Monday May 04, 2020 @03:40PM (#23072390)
Does that really seem reasonable to you?

Should we assume that social isolation, lack of physical activity, change of habits, being laid off a job and worse health care (preventive for example) have no impact on the number of deaths? That's quite a big assumption.

Re:Malaria 'Completely Stopped' by Microbe by jml7c5 on Monday May 04, 2020 @12:30PM (#23070023)
Take a look at: https://fullfact.org/health/covid-deaths/

There are certainly some deaths being incorrectly attributed to COVID-19, but I think the data conclusively rejects the hypothesis that there is rampant COVID-19 over-reporting.

Re:Malaria 'Completely Stopped' by Microbe by danenania on Monday May 04, 2020 @01:31PM (#23070886)
The main difference is that malaria, as bad as it is, is not contagious between people. So while the numbers are bad, there’s effectively a lid on them—they aren’t suddenly going to start growing exponentially.

With covid, the worst case scenario with no mitigation is quite literally that everyone in the world gets it in fairly short order, which could cause tens of millions of deaths even with low IFR estimates, plus all the social and economic destabilization that implies.

Re:Malaria 'Completely Stopped' by Microbe by darkerside on Monday May 04, 2020 @09:19AM (#23067672)
I thought hydroxychloroquine was a much vaunted treatment for malaria?

COVID certainly has a lower mortality right now, but it's only because of the extreme precautions we've all taken. In a world where we didn't bother, I presume that would completely change.

Re:Malaria 'Completely Stopped' by Microbe by vidarh on Monday May 04, 2020 @09:27AM (#23067766)
Malaria has kept getting resistant against more and more medication. This map [1] is pretty terrifying - very few areas that have malaria does not have some extent of (hydro-)chloroquine resistant malaria.

[1] https://en.wikipedia.org/wiki/Malaria#/media/File:Paludisme....

Re:Malaria 'Completely Stopped' by Microbe by burnishing on Monday May 04, 2020 @11:42AM (#23069340)
What precautions would reduce the mortality? Social distancing, masks, etc. can decrease the chances of spreading the disease but I don't see how they reduce mortality once you catch it.
Re:Malaria 'Completely Stopped' by Microbe by elliekelly on Monday May 04, 2020 @09:32AM (#23067812)
I think it depends on the strain (species?) of malaria and even the geography of where a person has been infected. Some infections are more resistant to treatment than others.
Re:Malaria 'Completely Stopped' by Microbe by screye on Monday May 04, 2020 @09:47AM (#23067999)
> COVID certainly has a lower mortality right now

Yep. A vast majority of those who've contracted COVID are asymptomatic. The mortality rate might be significantly lower than previously reported.

Re:Malaria 'Completely Stopped' by Microbe by athenot on Monday May 04, 2020 @10:07AM (#23068214)
One way to find out is to look at the overall death rates (of all causes) in an area and see how it evolved. NY started doing that and found there's a discrepancy. One explanation among others is that some people who've caught it and died from it never got a positive test (either no test, or false negative).

That seems to point to the opposite happening: a higher mortality that is still not fully understood for lack of accurate data.

Re:Malaria 'Completely Stopped' by Microbe by kmonsen on Monday May 04, 2020 @11:03AM (#23068874)
I do overall agree with you, but Norway has lower than usual number of deaths this year, so not sure what to do with that. I guess if you just compare the deaths to average you are still under reporting because of the stay at home orders it is sort of expected that less people die.
Re:Malaria 'Completely Stopped' by Microbe by fakedang on Monday May 04, 2020 @01:50PM (#23071100)
Not just Norway, India too.
Re:Malaria 'Completely Stopped' by Microbe by TsiCClawOfLight on Monday May 04, 2020 @10:43AM (#23068653)
Don't forget the secondary effects of shutting down entire countries: depression, supply chain failures, sudden poverty, degradation of infrastructure, and increasingly lack of exercise and unhealthy eating as this drags on.

I suspect that will account for most of the differential, and possibly even be the more important number. (because many countries diagnose deaths with covid as deaths by covid)

Re:Malaria 'Completely Stopped' by Microbe by cma on Monday May 04, 2020 @12:03PM (#23069644)
Later on it may be a major factor, but right now it is probably outweighed in the counts by less car accident deaths, lower transmission of other communicable respiratory diseases, and less work and leisure accidents.
Re:Malaria 'Completely Stopped' by Microbe by stOneskull on Monday May 04, 2020 @11:15AM (#23069012)
The secondary effects are much worse. The virus is being used as an excuse to get more control of the people and planet by the psychopaths. They don't really care about us.
Re:Malaria 'Completely Stopped' by Microbe by seppin on Monday May 04, 2020 @02:40PM (#23071669)
I don't know why something so easily disproved is being repeated so often. The worst-case of an economic shutdown is not worse than 2 million dead people.

Added bonus: the economic outcome of 2 million dead people is bad too, perhaps worse than a shutdown of (largely) healthy people. It's not an either/or, economic hardship right now is unavoidable. The choice is between getting a handle on the virus or not, and thousands dead instead of millions.

Re:Malaria 'Completely Stopped' by Microbe by cycomanic on Monday May 04, 2020 @11:39AM (#23069309)
The antibody tests in New York showed 12. 3% for the state and 19% infection rate for the city

https://www.axios.com/coronavirus-new-york-antibody-test-f4f...

Confirmed and probable deaths are 16700 for a population of 8.4 million we come to about 1% IFR. However the excess deaths (for example how we count deaths during flu seasons) are 21000, so we are likely undercounting covid 19 deaths. Based on that number the IFR is 1.2% both these numbers are significantly higher than the flu. The other thing is that the numbers there are taken at similar times. However there is an incubation time of about 4 days (IIRC) and a time to death from first symptoms of about 10 days. So we really should compare the infection rate now with the death toll in 2 weeks. Which likely will increase IFR

https://www.nationalreview.com/corner/coronavirus-crisis-210...

Re:Malaria 'Completely Stopped' by Microbe by cc81 on Monday May 04, 2020 @04:42PM (#23073013)
19.9% for the city.

You are still in the end of the flu season though so some of those excess death numbers might be that.

Re:Malaria 'Completely Stopped' by Microbe by krzyk on Monday May 04, 2020 @10:05AM (#23068200)
> A vast majority of those who've contracted COVID are asymptomatic.

Any sources on that?

From the https://www.eurosurveillance.org/content/10.2807/1560-7917.E... it looks like at most 17% could be asymptomatic, but I'm not sure if it wouldn't be lower if they waited longer.

Re:Malaria 'Completely Stopped' by Microbe by klmadfejno on Monday May 04, 2020 @10:21AM (#23068377)
Age affects everything. The diamond princess cohort is much older than the population average. Older people are more likely to die from the disease, suffer symptoms from the disease, and catch the disease, all things being held equal.

The concept of death rates, symptomatic rates, and even transmission rates as a generic term is meaningless because it depends entirely on the age demographics of the population (and behavior, and other things, etc.).

The idea the most people who catch it are asymptomatic is true if our antibody tests aren't throwing out massive false positive rates. For something closer to the general population, the USS Theodore Roosevelt is probably a better guess.

https://en.wikipedia.org/wiki/COVID-19_pandemic_on_USS_Theod...

Looks like 90% of them had the disease on April 11. By April 20, 60% were asymptomatic. The last update seems to have been on April 22, with about 50% asymptomatic. That's probably a good bet for an actual figure in my opinion.

Re:Malaria 'Completely Stopped' by Microbe by danilocesar on Monday May 04, 2020 @10:50AM (#23068724)
> Looks like 90% of them had the disease on April 11. By April 20, 60% were asymptomatic.

That's not what the wikipedia says... 94% of the crew has been tested for Covid, with 678 positives. Infection rate ~15%.

From those infected, ~60% didn't show symptoms.

Re:Malaria 'Completely Stopped' by Microbe by klmadfejno on Monday May 04, 2020 @04:53PM (#23073122)
That's correct, my mistake on the infection rate of 90%. The 60% on the wiki figure is coming from an article written April 16. I did a bit of digging and found a navy statement from the 22nd which said 50%.

However given my error on the 90%, it seems much more likely that a large proportion of the people asymptomatic on the 22nd had caught it more recently than I was assuming, so the asymptomatic rate is probably a bit worse.

Re:Malaria 'Completely Stopped' by Microbe by yojo on Monday May 04, 2020 @10:37AM (#23068574)
I would assume the crew of a military ship are substantially younger and healthier than the general population. Since both health and age seem to play a key role, 50% is almost certainly an upper bound, with the true number lying between 17% and 50%
Re:Malaria 'Completely Stopped' by Microbe by klmadfejno on Monday May 04, 2020 @05:03PM (#23073220)
Most will be in the range of 20-40. Some will be older, but none will be kids. So take it as you will. The true number doesn't have any intuitive meaning anyway, since the likelihood of being infected is correlated with the likelihood of being symptomatic.

E.g. if hypothetically people under 20 never exhibit symptoms but also never get the disease, they won't bring the asymptomatic rate down because they won't be infected in the first place.

Averages suck in this context.

Re:Malaria 'Completely Stopped' by Microbe by toomanybeersies on Monday May 04, 2020 @10:48AM (#23068702)
There are indications that severity of infection is proportional to the initial viral load. I'd imagine that being locked in close quarters on a warship would subject the sailors to a higher viral load than you'd expect in the general population, and subsequently they'd have on average more severe infections, so it could be lower than 50%.
Re:Malaria 'Completely Stopped' by Microbe by wolco on Monday May 04, 2020 @10:56AM (#23068773)
More likely much higher when you start parsing how China determines COVID cases/deaths. Or those people not allowed in hospitals. There deaths do not count.. so there is a big difference but going the other way.
Re:Malaria 'Completely Stopped' by Microbe by IAmEveryone on Monday May 04, 2020 @09:43AM (#23067939)
Total confirmed Covid deaths currently stand at 230,000. But total mortality data, where available, points at excess mortality of around 50% to 100% more than that. That puts current mortality somewhere between 300,000 and 500,000. Malaria deaths are also around 400,000 says Wikipedia. But, crucially, that's annual death. Even in the optimistic case of Covid deaths currently being at their peak and going down as fast as they grew on the way up, total deaths are double Malaria's. And looking at the graphs, it doesn't seem like it's receding symmetrical to its growth.

As to regional differences, see here for some recent excess-mortality data that includes Ecuador and Brazil, two countries that don't have Malaria but share some characteristics with countries that do, such as climate and relative poverty: https://www.ft.com/__origami/service/image/v2/images/raw/htt...

This isn't going to spare the countries affected by Malaria, except that some of them have a demographic advantage.

The only redeeming factor in Covid's favour is that mortality isn't the only, and possibly not even the most important, harm of Malaria: Just like Covid, it kills only a minority of those infected. But survivors sometimes suffer chronic relapses, enduring symptoms such as fatigue, and, in children, cognitive deficits.

Re:Malaria 'Completely Stopped' by Microbe by azernik on Monday May 04, 2020 @10:56AM (#23068774)
There's some evidence that COVID-19 infections are going to cause long-lasting damage:

https://www.healthline.com/health-news/what-we-know-about-th...

Re:Malaria 'Completely Stopped' by Microbe by thaumasiotes on Monday May 04, 2020 @03:16PM (#23072108)
> I was shocked to find out there is no treatment for malaria when I traveled in affected areas.

I'd be shocked too; there IS a treatment for malaria.

Re:Malaria 'Completely Stopped' by Microbe by 7952 on Monday May 04, 2020 @12:38PM (#23070145)
The response to covid is due to its newness. That means that our response can have much greater effect and is more urgent.
Re:Malaria 'Completely Stopped' by Microbe by aaron695 on Monday May 04, 2020 @10:35AM (#23068546)
The flu kills around 600,000 each year -

https://www.who.int/news-room/detail/14-12-2017-up-to-650-00...

Covid-19 should kill 30 million.

.5% * 80% * 7.8 billion.

That will be over many years however. Maybe 2-3 years.

Some estimates put Covid-19 at 10 years lost per person average.

If you can get it multiple times, which is likely after a few years, it'll keep killing forever but it'll slow down, and we might even slow it even more in the richer countries, like we sort of bother with the Flu for, if a vaccine is ever possible.

Currently China has an unsustainable model going (School is not back properly) for 1.4 billion. If however they can move to a sustainable model, maybe they might not get it..... Good luck everyone else.

Re:Malaria 'Completely Stopped' by Microbe by cc81 on Monday May 04, 2020 @04:46PM (#23073049)
I think 80% for heard immunity is a pretty high count.

IFR is a guess and yours could be right. It is lower than NYC but the developing world is much younger than the west so they might have a much lower IFR unless their lack of available health care hurts them too much.

Hopefully IFR will drop as well as we learn to protect the elderly better.

Re:Malaria 'Completely Stopped' by Microbe by ngold on Monday May 04, 2020 @12:24PM (#23069963)
The aversion to testing by the American government is how we know that we live in dark times. I look forward to see what Silicon Valley finds in their testing of people that died in november.
Re:Malaria 'Completely Stopped' by Microbe by gmanley on Monday May 04, 2020 @01:35PM (#23070927)
What makes you think it's an aversion to testing? It seems to me more just general incompetence and slow response that caused the testing crisis in the US.