News for hackers. Stuff that matters.
Re:Amodei Re. Regulation by eloisant on Monday August 17, 2026 @07:10AM (#49329103)
Besides cancer isn't really "a disease" but rather "a family of diseases" that can vary a lot. Even breast cancer can be one of many different cancers.

It's like saying "we'll cure infectious diseases"

Re:Amodei Re. Regulation by traceroute66 on Monday August 17, 2026 @07:17AM (#49329167)
> It's like saying "we'll cure infectious diseases"

Don't worry, I'm sure that's his next blog post. Right after Claude has finished solving famine and poverty. ;)

Re:Amodei Re. Regulation by Applejinx on Monday August 17, 2026 @09:29AM (#49330517)
Technically, killing everybody is one way of solving famine and poverty.

How weird that all those humans seem not to trust the logic of their betters ;P

Re:Amodei Re. Regulation by subygan on Monday August 17, 2026 @09:47AM (#49330797)
you're right. it coincidentally solves cancer and infectious diseases as well.

the ultimate utopia

Re:Amodei Re. Regulation by lesuorac on Monday August 17, 2026 @10:45AM (#49331913)
Look, it's really simple we'll have 3 laws that the robots follow and nothing will go wrong.
Re:Amodei Re. Regulation by kennywinker on Monday August 17, 2026 @12:33PM (#49333755)
Except instead of bots that follow asimov’s three laws we’re getting bots that follow the ferengi rules of acquisition.
Re:Amodei Re. Regulation by no-name-here on Tuesday August 18, 2026 @06:27AM (#49343651)
Ah the 3 laws have edge cases? Actually our industry will just release bots with none of the 3 laws, including bots for military use where their whole purpose is the opposite of the 3 laws.
Re:Amodei Re. Regulation by kennywinker on Monday August 17, 2026 @12:31PM (#49333730)
The solution to famine and poverty is not exactly a mystery.

We have more than enough food on the planet for everyone, and we have the ability to deliver bombs or soldiers or amazon packages to anywhere in the world in days or hours. Combine excess food with amazon or army level logistics, and famine is gone.

What people mean when they say “solve famine” is can we make people not starve without actually doing or changing anything - which is of course impossible.

Re:Amodei Re. Regulation by delis-thumbs-7e on Monday August 17, 2026 @02:35PM (#49335620)
> Combine excess food with amazon or army level logistics, and famine is gone.

We do this. Have you ever heard of UN World Food Programme? $14B funding in 2022 (since then dropped drastically, guess why).

Has it solved famine? No. Would it solve famine if it got the funding it needs? Unlikely.

Because you cannot just spend billions of dollars to send amazin food parcels across the world and expect that to fix climate change, draught, poverty, colonialism, racism, illiteracy, lack of education, and propably 100 other issues all contributing to the fact that we still have not end hunger. And no, AI won’t solve it either.

Re:Amodei Re. Regulation by kennywinker on Monday August 17, 2026 @03:26PM (#49336333)
The UN estimates it would cost $93 billion a year to end world hunger (https://news.un.org/en/story/2025/11/1166397)

So one would expect $14b/year would solve about 14/93 = 15% of world hunger.

> The World Food Programme supports over 152 million people annually and delivers life-saving food assistance where needed most. (https://en.wikipedia.org/wiki/World_Food_Programme)

An estimated 757 million people are food insecure (https://www.who.int/news/item/24-07-2024-hunger-numbers-stub...)

152/757 = the world food program helps ~20% of people who are food insecure. That's well in the ballpark of the estimated 15% spend.

If we spend that extra $93b, we'd be well within the range to actually stop world hunger.

Yes, "climate change, draught, poverty, colonialism, racism, illiteracy, lack of education" are still issues. No, you don't have to solve those problems to feed people. Don't let perfect be the enemy of good.

Re:Amodei Re. Regulation by nickff on Monday August 17, 2026 @05:31PM (#49337945)
> "If we spend that extra $93b, we'd be well within the range to actually stop world hunger."

Almost all recent famines have been caused (either deliberately or incidentally) by government policies, not lack of money. The UN spending 93 BB may (somewhat) improve the situation, but is unlikely to end food insecurity.

Eliminating corrupt leaders (i.e. Kim Jong Un, Vladimir Putin, etc.), and poor regulation (e.g. Bombay Fodder and Grain Control Act, 1939) would be much more effective.

https://en.wikipedia.org/wiki/Famine#20th_century

Re:Amodei Re. Regulation by kennywinker on Monday August 17, 2026 @07:19PM (#49339021)
> Almost all recent famines have been caused (either deliberately or incidentally) by government policies, not lack of money.

Actually, they were caused by lack of food.

> Eliminating corrupt leaders (i.e. Kim Jong Un, Vladimir Putin, etc.)

Yes, which of the 757 million food insecure people is Putin responsible for their food insecurity?

North Korea has about 26mil residents, so if they were all starving that'd be 3.4% of the food insecure people. Gaza has about 2mil, so we can pin a further 0.03% on shitty governments.

Obviously it'd be great if putin, un and netanyahu were gone. They suck for a variety of reasons. But it doesn't change the fact that we could spend money and feed most of the people who are going hungry

Re:Amodei Re. Regulation by nickff on Monday August 17, 2026 @07:30PM (#49339117)
>"Actually, they were caused by lack of food."

This is a tautology; a lack of food can't be caused by a lack of food, as it is a lack of food.

>"Yes, which of the 757 million food insecure people is Putin responsible for their food insecurity?"

In Putin's case, he has caused the price of food to increase through his war on Ukraine, as the cost of fertilizer makes many agricultural products uneconomical to grow for customers in less-developed nations.

>"But it doesn't change the fact that we could spend money and feed most of the people who are going hungry"

There was food literally rotting away (elsewhere in India) during the 2013 drought in Maharashtra, but it wasn't possible/worth transporting it to the affected region (due to government interference).[1] In places like Bangladesh, recent governments have used famine as a tool for obtaining foreign aid while also exterminating or weakening opposition.[2] During the 1990s North Korean famine, plenty of food was offered to the regime, but it was mostly rejected, and that which was accepted was not widely distributed. [3]

[1] https://en.wikipedia.org/wiki/2013_drought_in_Maharashtra

[2] https://asianews.network/over-a-quarter-of-bangladeshis-suff...

[3] https://en.wikipedia.org/wiki/1990s_North_Korean_famine#Fail...

Re:Amodei Re. Regulation by kennywinker on Tuesday August 18, 2026 @02:07AM (#49341895)
I'm not arguing that governments don't cause famine directly or indirectly, I'm arguing that there are very few examples of govs that won't let food aid in. Or, enough food aid. For those specific cases, yes the only solution is to engage with the government - either pressuring them diplomatically, or by use of force. But for everywhere else, where people are going hungry because of poverty and neglect, the thing they need is literally just food, and someone willing to spend the money to get that food to them.
Re:Amodei Re. Regulation by delis-thumbs-7e on Tuesday August 18, 2026 @05:16AM (#49343249)
Basically you are asking $93b yearly at point when the biggest donor US has already slashed the funding and cannot even stop poverty insode it’s own nation. Maybe you are just trolling or arguing for sports, but you are completely missing the point why hunger and famines happen and why they cannot be solved with throwing money at them. Look at it this way, would Trump end hunger in Mississippi (about 600k people) if, say, Luxemburg would donate USA anout $400m required to end it[1]?

Mind you, UN’s Food -programme (together with education, progress of farming technologies etc) has been a huge success and hunger has dropped historically low. I couldn’t find data on how Trump’s cuts have affected the levels, but I doubt it has been a positive change by any regard.

Going back to the original allegory, just like cancer, hunger is a vastly complex problem with strong political ties (why have still have we not illegalised cigarettes for instance?) and no gee-wiz tech gadget, even as expensive as LLM model, will solve neither of them.

[1] https://www.feedingamerica.org/hunger-in-america/mississippi

Re:Amodei Re. Regulation by kennywinker on Tuesday August 18, 2026 @10:15AM (#49345948)
As my first link points out - $93b is less than 1% of annual military spending.

I am arguing nothing except that it’s possible if we are willing to spend the money. No AGI is required to come up with a magic solution. It literally just requires spending a lot of money.

> Look at it this way, would Trump end hunger in Mississippi (about 600k people) if, say, Luxemburg would donate USA anout $400m required to end it[1]?

Probably not. But would trump step in and prevent luxemburg from stocking mississippi’s food banks? Could luxemburg send containers of non-perishable food to community centers in every city in the state?

Re:Amodei Re. Regulation by calvinmorrison on Monday August 17, 2026 @03:01PM (#49335970)
> (since then dropped drastically, guess why).

> Has it solved famine? No.

Hoist by your own petard

Re:Amodei Re. Regulation by kennywinker on Monday August 17, 2026 @03:16PM (#49336183)
Assuming everything they said is true, how on earth is that a self-own?

You know that saving millions of lives every year is better than NOT saving millions of lives, right? Just because something doesn't solve the problem 100% doesn't mean it's not VERY VERY good.

Re:Amodei Re. Regulation by fnord123 on Monday August 17, 2026 @07:23AM (#49329217)
We will cure virus.
Re:Amodei Re. Regulation by FeteCommuniste on Monday August 17, 2026 @07:35AM (#49329278)
We will cure carpet. We will cure desk. We will cure lamp.
Re:Amodei Re. Regulation by kridsdale1 on Monday August 17, 2026 @03:30PM (#49336385)
That really got out of hand. You may want to lay low.
Re:Amodei Re. Regulation by andrekandre on Monday August 17, 2026 @04:15PM (#49336957)
wait till they get the 'war on carpet' on, no one will be spared...
Re:Amodei Re. Regulation by kanzure on Monday August 17, 2026 @08:22AM (#49329717)
> We will cure virus.

It is possible to prevent most viruses by recoding the human genome (requires embryo engineering or pre-embryo engineering) to use alternate codons that existing natty viruses don't use. This wouldn't prevent synthetic viruses from being developed that use the alternate codons, of course. See (1) https://diyhpl.us/wiki/transcripts/hgp-write/2016-05-10/ultr... and (2) https://diyhpl.us/wiki/transcripts/hgp-write/2017-05-09/ultr... and (3) https://x.com/RokoMijic/status/1720875112541364535 for some background.

As for "curing cancer", I suspect that Anthropic or OpenAI will use their high status/reputation to launder the existing solutions (germline, p53, enhanced DNA damage repair pathways, higher tumor-suppressor-to-oncogene copy number, more robust tumor-suppressor networks, more self-anti-cancer apoptosis, CD47 suppression, etc) that society has refused to accept. They might have enough reputation to get people to look at these ideas. It won't cure people with stage 5 turbo-cancer a.k.a the walking dead, but hopefully we won't be moving the goal posts _that_ much on them.

Re:Amodei Re. Regulation by colingauvin on Monday August 17, 2026 @09:17AM (#49330356)
Ignoring the impracticality of trying to deploy this, codon bias exists for a reason, it's a translation-regulation mechanism and you'd wind up having to do a massive amount of protein engineering to not mess up everything.
Re:Amodei Re. Regulation by RandomLensman on Monday August 17, 2026 @08:36AM (#49329852)
How would you address the non-interchangeable nature of synonymous codons? Do we know the right replacements?
Re:Amodei Re. Regulation by kanzure on Monday August 17, 2026 @08:41AM (#49329906)
Well, first, I would have to check and see if the synoynmous codons are important for virus reproduction. Second, this technique requires (AFAIK) lots of cell line viability testing and lots of tweaking. I don't think it's as simple as code swapping all the codons and then all the biology magically works the right way, biology is rarely that simple. Requires effort.
Re:Amodei Re. Regulation by RandomLensman on Monday August 17, 2026 @08:52AM (#49330043)
This sounds highly speculative then, i.e., the biology could never work out, no?
Re:Amodei Re. Regulation by kanzure on Monday August 17, 2026 @08:59AM (#49330128)
It depends on what you consider to be speculative. It's certainly not a product available to the mass consumer market, if that's what you mean. But that's also kind of an uninteresting fact, right?

"Synthetic genomes unveil the effects of synonymous recoding" https://www.biorxiv.org/content/10.1101/2024.06.16.599206v1

"Probing the limits of genetic recoding using multi-omics-guided evolution" https://www.nature.com/articles/s41467-026-74300-9

"Escherichia coli with a 57-codon genetic code" https://www.science.org/doi/abs/10.1126/science.ady4368

Re:Amodei Re. Regulation by RandomLensman on Monday August 17, 2026 @09:07AM (#49330218)
Speculative whether it could be done with humans without severe side effects that would make it useless/pointless.

Is it a product available to humans at all?

Re:Amodei Re. Regulation by jacquesm on Monday August 17, 2026 @08:24AM (#49329730)
What could possibly go wrong...
Re:Amodei Re. Regulation by datakan on Monday August 17, 2026 @08:45AM (#49329958)
I've seen this episode before
Re:Amodei Re. Regulation by kennywinker on Monday August 17, 2026 @12:34PM (#49333779)
Oo is this the one where barclay becomes a spider?!
Re:Amodei Re. Regulation by andrekandre on Monday August 17, 2026 @04:17PM (#49336986)
could be, or the one where dr pulaski becomes an old lady...
Re:Amodei Re. Regulation by semiquaver on Monday August 17, 2026 @09:27PM (#49340002)
Or the one where Tom Paris and Janeway turn into lizards and have babies.
Re:Amodei Re. Regulation by andrekandre on Tuesday August 18, 2026 @11:21AM (#49347011)
i forgot about that one, that also reminds me, what janeway did to poor tuvix...
Re:Amodei Re. Regulation by fwip on Monday August 17, 2026 @06:13PM (#49338392)
Honestly, the most likely thing is lots and lots of dead fetuses due to developmental abnormalities. I'd be surprised if it ever got to the point of resulting in a dead infant.
Re:Amodei Re. Regulation by kanzure on Wednesday August 19, 2026 @09:58AM (#49361726)
Quality control and testing is absolutely essential, yeah. It's hard work and the plan shouldn't be misconstrued as "rewrite the whole genome of an embryo today and go for the first birth immediately" because that would be stupid when we know there is other work to be done. It shouldn't surprise ANYONE that making significant progress against cancer, aging, or other issues, would take lots of work and not doing the immediate obvious broken thing.
Re:Amodei Re. Regulation by alphazard on Monday August 17, 2026 @07:46AM (#49329353)
"Cancer isn't a single disease" is often shouted from the Dunning-Kruger peak of cancer research. I think it was popularized by an explainer video on Youtube, and now it's being memed. The people who think this way want to legitimize funding a particular research niche that they benefit from.

A more sophisticated view is that cancer (one idea) is an problem of rates (like most things in biology) and there is a tumor burden per unit time from whatever causes vs. the immune system's capacity to detect and destroy them per unit time. As humans age, the balance tips in one direction. If the balance is too far off for too long, tumors accumulate, doctors take notice, and assign whatever labels to the condition.

Looking into particular causes of tumors (and calling each cause its own cancer) can create a vast research program that employs a lot of people, since there are so many mutations that lead to tumors. But interrupting the development of a particular mutation is not going to have the same society-changing effect that solving the fundamental issue of rates would.

Re:Amodei Re. Regulation by root-parent on Monday August 17, 2026 @08:08AM (#49329565)
>> "Cancer isn't a single disease" is often shouted from the Dunning-Kruger peak of cancer research.

Literally first phrase on Cancer Wikipedia entry.... [1]

"Cancer is a group of diseases involving uncontrolled cell growth typically resulting in tumors with the potential to invade or spread to other parts of the body...."

[1] - https://en.wikipedia.org/wiki/Cancer

Re:Amodei Re. Regulation by inciampati on Monday August 17, 2026 @07:59AM (#49329480)
And this business of rates is also why getting the immune system—such as via personalized vaccine—to recognize a tumor is functionally "curing cancer". The problem is it isn't one disease in the sense that different tissues, cell types, and systems are affected leading to different parameters in the design and delivery of said vaccines.
Re:Amodei Re. Regulation by datsci_est_2015 on Monday August 17, 2026 @09:54AM (#49330923)
Is there something like a meta-Dunning-Kruger, where someone invokes Dunning-Kruger in a way that itself is a potential Dunning-Kruger phenomenon?

I'm inclined to believe that the thing - that everyone intelligent says is complicated - is actually complicated. I would be surprised if the thing - that everyone intelligent says is complicated - is actually simple.

This is almost like an application of the conspiracy theory gambit where you try to find out how many people would have to be "in on it" in order to disprove the theory's likelihood. Like flat earth.

Re:Amodei Re. Regulation by bigfishrunning on Monday August 17, 2026 @01:05PM (#49334256)
People are constantly Dunning-Krugering the Dunning-Kruger effect
Re:Amodei Re. Regulation by preg_match on Monday August 17, 2026 @10:44AM (#49331896)
No, cancer is actually many diseases. They hold some commonalities, but it’s not one thing. That’s why chemotherapy can straight cure some cancers and do nothing for others. That’s also why we have hundreds of chemotherapy drugs.

Also, not even all cancers have tumors. You have solid tumor oncologists and then oncologists who specialize in blood and lymphatic cancers, “liquid cancers”.

In addition, cancer does not arise from one mutation. It’s a set of mutations that allow cancer to occur. You need mutations for growth, mutations for preventing cellular death, mutations for stealing energy, mutations for hiding from the immune system. Your body, right now, has probably millions of cells that could be candidates for cancer. They either kill themselves or your immune system nukes them. You really need the stars to align on this stuff to get actual cancer.

And then, it’s not like the cancer stops mutating. Cancer becomes resistant to chemotherapy through mutations. Cancer is “smart”, it will even temporary slow its own growth (metabolism) to intake less chemotherapy through treatment.

Re:Amodei Re. Regulation by alphazard on Monday August 17, 2026 @11:33AM (#49332720)
I should have expected this level of discourse from 2026 HN.

Here's another way of framing things that might encourage better discussion: Suppose in a few years, it was announced that an LLM did discover a cure for a cancer. What approach would you expect it to have taken?

1. Developing an intervention for every possible mutation that leads to loss of cellular identity, and uncontrolled growth.

2. Preserving immune function later into life.

3. Preserving genetic and epigenetic accuracy later into life.

Maybe it will be 1. But I would bet on 2 or 3. Which both assume that by reducing the difference between rates, the phenomenon of cancer could be reduced or eliminated.

Re:Amodei Re. Regulation by overgard on Monday August 17, 2026 @03:06PM (#49336053)
Or maybe these companies are just bullshitting.

Also: https://pivot-to-ai.com/2026/07/30/google-kills-alphafold-so...

Re:Amodei Re. Regulation by dcre on Monday August 17, 2026 @12:18PM (#49333485)
I have seen people suggest we will figure out how to prevent all infectious disease.
Re:Amodei Re. Regulation by siva7 on Monday August 17, 2026 @12:32PM (#49333746)
Claude cured a deaf person. Just look up news. All this negativity on HN is depressing..
Re:Amodei Re. Regulation by GPerson on Monday August 17, 2026 @12:51PM (#49334043)
Do you believe Anthropic is going to cure almost all human diseases including cancer in 5-10 years?
Re:Amodei Re. Regulation by overgard on Monday August 17, 2026 @03:00PM (#49335948)
Not to mention, hasn't the pharmaceutical industry taught us that curing diseases is a bad capitalist strategy? After all, why cure something if you can simply treat it, expensively, indefinitely.
Re:Amodei Re. Regulation by nshshbr on Tuesday August 18, 2026 @07:31PM (#49354419)
I always think the most salient comparison would be to say, "We will solve all computer bugs and eliminate all computer viruses and security vulnerabilities." No one ever even thinks to promise this, I think because it is obvious that even a superintelligent computer will never be totally free of errors or invulnerable to attack.

Or, even better, they never even respond to surging memory costs by saying, "Don't worry, our brilliant AI will figure out how to produce cheaper memory." Because they know it won't.

I genuinely don't know how to interpret the bizarre clichés these people think in. Cure cancer. Make death optional! I can't tell if they're crazy, stupid, or liars.