Curious.

Could you please share your physical activity level around the time of supplementation?

One of the most interesting studies I found in my research of vitamin D was a study in an elder care center where the patients were given massive doses of vitamin D.

The result of the massive doses were that patience had less hip fractures, but more falls compared to the control.

Now take this next part with a grain of salt because it’s me extrapolating from this result, but due to the known effects of vitamin D on muscle strength and also on bone density, I imagine that these patients were more active, but because vitamin D doesn’t give you coordination as well as strength they were falling more, their bones were more dense so they had less fractures per fall.

The point I’m trying to make and the reason I am curious about your own activity level, is that perhaps that there is a sensation or feeling of your muscles being more primed for action which can be agitating. Perhaps regular activity can link one’s sense of proprioception with increased muscular ability.

Apologies in advance if this is too personal of a pry.

I run 3-5 times a week but otherwise pretty sedentary.

Thank you for replying!

When does a professional come into play? You assumed you're deficient, you asked chatgpt, and now you're asking for anecdotes from HN. Go get some blood work done and talk to a professional who actually knows about these things.

> talk to a professional who actually knows about these things

And gives a damn, and is up to date. Difficult to find professionals like that around here, even with money.

It's shocking to me when people openly claim to have used chatgpt for advice on something as important as this.

I don't think there's an easy answer as we all have differently tuned bodies with different known/unknown beningn/malevolent conditions. It's probably good to do some short term experimenting, try eating more magnesium and calcium rich foods and see how you feel. If you really want to be objective, get your blood contents measured. (Although blood levels don't show everything, like calcium stores in the bones.)

Yeah, experimentation makes sense.

I've had it happen twice, with two different dosages. First time was at a higher dosage than 1000 and I think it happened sooner.

I'm just calling it out here, because sometimes you get lucky and someone else had the same issue and has the answer and will resolve the mystery.

I'm not saying Vit D is bad, I'm just curious if others have had difficulties with it.

My doctors opinion on it is everyone is low on Vit D, so just take some.

Never had/heard of your problem with Vitamin D.

A web search brings up - https://www.reddit.com/r/Biohackers/comments/1ia6yyb/update_...

tl;dr - some Vit D supplements are based on lanolin. if you're sensitive to it, you may switch to a supplement that doesn't use lanolin. also one response talks about taking a multi-Vitamin B supplement for anger issues with Vit.D

This is helpful. I will try this!

Always take magnesium with vit D. Ask an LLM why.

I do take magnesium, but I could try to up it when I take D. Thanks

I don’t know why you’re being downloaded.

I took 5000 IU of vitamin D for one month and I just happen to have a blood test that was coming up. My calcium levels were elevated. I was told to take this dose by my doctor, because my vitamin D levels, not deficient she felt they were very low.

During this time, my mood also worsened.

Some of us may be more sensitive to calcium transport when taking vitamin D than others, and this is clearly due to genetics. Interestingly enough, there is something in fish which controls this, I can’t think of it off the top of my head right now, but I will look it up and post it later.

So now I only get my vitamin D from natural occurring vitamin D in seafood, and the sun.

Not sure why you're being downvoted, so I created an account specifically to respond.

I've had the same issue. Even when I take low doses of 400iu, vitamin D causes extreme anxiety and mood issues that only go away a couple of days after I stop taking it. I've had to completely cut it out and can't take supplements that contain it. I've also taken various brands so I would assume the additives would be different but who knows. If you search this symptom online, you'll find a lot of people with the same reaction but never any explanation.

Definitely interested to see if anyone has had this same issue and was able to fix it.

Anyway, just a word of caution to anyone reading. Because even 400iu makes me feel very uncomfortable. I don't want to know what would happen at 4,000iu.

Out of curiosity, the various brands, were any of them in liquid form?

The reason I ask is because it's possible to be intolerant or allergic to one of the filler ingredients in a tablet.

No, they weren't, and that's a good suggestion that I need to try.

Get a well-rated softgel form without iffy ingredients like caramel coloring.

I think at this point, they should just go straight to liquid with an eyedropper, no gelatin capsule or anything in order to try and rule out as much as possible.

The problem with an exposed liquid is that will definitely lose its potency a lot quicker. A softgel keeps the active ingredient somewhat protected from oxidation. It also depends on the level of antioxidant present in the liquid. This matters in the tail end of the bottle.

Exactly the same issue!

I have been trying to increase my Vitamin D levels for 15 years now but I just can't tolerate this supplement.

  Lower dosage: ~500-1000 IE -> side effects come after around 3-4 days of daily intake.
  Higher dosage: ~5000 IE -> side effects after a few hours.

I tried following most advice over here in the past but it did not work: https://vitamindwiki.com/Vitamin+D+Cofactors+in+a+nutshell

I'll just live with my low blood Vitamin D levels.

1000 ui per day? Thats a small dose, I am myself taking 800 per day but when I skip I just compound it for next dose since D works this way and accumulates, not like vitamin C. I had bad case of deficiency recently (when finally some blood work was done) and initial treatment to jumpstart was IIRC 100k ui.

Maybe you have some sort of sensitivity to medium in which its dissolved?

I've experienced something similar and I believe D3 is not to blame.

I took 5k iu oil softgels and got a unique and indescribable BAD feeling. It crept up very gradually over the course of a month and a half and I had a hard time realizing what was happening. It took me over a month to recover after I stopped.

Another time I've taken 2k iu dry D3 and had zero side-effects.

A couple of years after that D3 mishap, I tried some omega-3 and after a two weeks I realized that that unique bad feeling was making a comeback.

Again, another time I tried a different brand of omega-3 I had no side-effects.

I have a bunch of food sensitivities. So I believe that was a reaction to some contaminants in the oil.

Read these articles, maybe it gives some insight. The idea that you need high doses of vitamin D might not be as scientifically sound as you’d think

https://www.devaboone.com/post/vitamin-d-part-1-back-to-basi...

https://www.devaboone.com/post/vitamin-d-part-2-shannon-s-st...

https://www.devaboone.com/post/vitamin-d-part-3-the-evidence