High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset

Re:High‑dose Vitamin D reduces disease activity in early mul... by vitanxiety on Tuesday March 25, 2025 @10:02AM (#43471450)

Not sure why you're being downvoted, so I created an account specifically to respond.

I've had the same issue. Even when I take low doses of 400iu, vitamin D causes extreme anxiety and mood issues that only go away a couple of days after I stop taking it. I've had to completely cut it out and can't take supplements that contain it. I've also taken various brands so I would assume the additives would be different but who knows. If you search this symptom online, you'll find a lot of people with the same reaction but never any explanation.

Definitely interested to see if anyone has had this same issue and was able to fix it.

Anyway, just a word of caution to anyone reading. Because even 400iu makes me feel very uncomfortable. I don't want to know what would happen at 4,000iu.

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Re:High‑dose Vitamin D reduces disease activity in early mul... by Sunspark on Tuesday March 25, 2025 @10:22AM (#43471722)

Out of curiosity, the various brands, were any of them in liquid form?

The reason I ask is because it's possible to be intolerant or allergic to one of the filler ingredients in a tablet.

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Re:High‑dose Vitamin D reduces disease activity in early mul... by vitanxiety on Tuesday March 25, 2025 @11:55AM (#43472807)

No, they weren't, and that's a good suggestion that I need to try.

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Re:High‑dose Vitamin D reduces disease activity in early mul... by OutOfHere on Tuesday March 25, 2025 @11:19PM (#43478550)

Get a well-rated softgel form without iffy ingredients like caramel coloring.

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Re:High‑dose Vitamin D reduces disease activity in early mul... by Sunspark on Wednesday March 26, 2025 @01:58PM (#43484901)

I think at this point, they should just go straight to liquid with an eyedropper, no gelatin capsule or anything in order to try and rule out as much as possible.

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Re:High‑dose Vitamin D reduces disease activity in early mul... by OutOfHere on Wednesday March 26, 2025 @05:18PM (#43487412)

The problem with an exposed liquid is that will definitely lose its potency a lot quicker. A softgel keeps the active ingredient somewhat protected from oxidation. It also depends on the level of antioxidant present in the liquid. This matters in the tail end of the bottle.

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Re:High‑dose Vitamin D reduces disease activity in early mul... by 7839284023 on Wednesday March 26, 2025 @12:14PM (#43483790)

Exactly the same issue!

I have been trying to increase my Vitamin D levels for 15 years now but I just can't tolerate this supplement.

  Lower dosage: ~500-1000 IE -> side effects come after around 3-4 days of daily intake.
  Higher dosage: ~5000 IE -> side effects after a few hours.

I tried following most advice over here in the past but it did not work: https://vitamindwiki.com/Vitamin+D+Cofactors+in+a+nutshell

I'll just live with my low blood Vitamin D levels.

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