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Re:Novel drug could protect brains from damage after repeat ... by cat_plus_plus on Wednesday February 07, 2024 @11:22PM (#39298092)
If you end up taking a drug because someone bangs you on your head everyday, it's good that it's there, but you might also want to put a stop to that.
Re:Novel drug could protect brains from damage after repeat ... by gnicholas on Thursday February 08, 2024 @12:14AM (#39298499)
Could be useful for soldiers, who may be subject to concussions on an unfortunately regular basis.
Re:Novel drug could protect brains from damage after repeat ... by refurb on Thursday February 08, 2024 @05:21AM (#39300323)
Much of the TBI research is funded by the DOD.
Re:Novel drug could protect brains from damage after repeat ... by whaleofatw2022 on Thursday February 08, 2024 @07:31AM (#39301162)
Breachers.

In fact a former colleague's husband fell into that bucket. He was a breacher for the local PD, and too much of that (the compression wave bounces your brain around inside the skull) caused him to have all sorts of issues that took years to stabilize.

Re:Novel drug could protect brains from damage after repeat ... by bdcravens on Wednesday February 07, 2024 @11:37PM (#39298210)
Perhaps, but many sports (such as football and American football) are far too popular to end anytime soon.

Additionally, it may be given as a precaution after a first concussion (car wreck, for example), even if that person is unlikely to be "banged on the head everyday"

Re:Novel drug could protect brains from damage after repeat ... by toomuchtodo on Thursday February 08, 2024 @12:09AM (#39298458)
Re:Novel drug could protect brains from damage after repeat ... by jbluepolarbear on Thursday February 08, 2024 @03:04AM (#39299500)
Sorry, no one is gonna prefer to watch flag football over full contact tackling. This is an absurd article. And the fact that the Olympics are holding a flag football event is a joke.
Re:Novel drug could protect brains from damage after repeat ... by stavros on Thursday February 08, 2024 @03:34AM (#39299674)
That's what the Romans said when they tried to go from fighting to the death to fighting until someone yielded.
Re:Novel drug could protect brains from damage after repeat ... by mrguyorama on Thursday February 08, 2024 @01:32PM (#39305659)
Roman gladiatorial combat rarely went to the death. Fighters were valuable media personalities, much like pro athletes today, supposedly including product endorsements and billboard advertising! Battles and fighters were focused on spectacle. It was basically just the WWE
Re:Novel drug could protect brains from damage after repeat ... by importantbrian on Thursday February 08, 2024 @02:15PM (#39306222)
Really, no one? Flag participation is already higher for 6 to 12-year-olds than tackle. Lots of girls participate in flag. I suspect they'll be interested in watching the sport they grew up playing. It might never be more popular than tackle, but to say no one will prefer watching it is silly.
Re:Novel drug could protect brains from damage after repeat ... by anonzzzies on Thursday February 08, 2024 @02:39AM (#39299365)
Any stats on this? Sports (that cause these injuries) are a choice/entertainment and people should pay for playing (like you should pay if you are obese, smoke or drink), but how much of this are actual accidents (cars, normal bike riding, work, army)?
Re:Novel drug could protect brains from damage after repeat ... by krisoft on Thursday February 08, 2024 @04:05AM (#39299869)
> people should pay for playing

I’m sorry, what? There are two ways I can interpret what you wrote. “Should pay” as in the people who play sports should buy their own concussion medicine. Which is okay I guess? But nobody talked about financing.

Which makes me think you mean “should pay” as in people who choose to partake in sports should suffer harm (as in pay the metaphorical “price”). Is that how you mean it? Because that sounds extremely cruel and twisted morality. There is nothing “should” about that. That makes it sound as if these people deserve the harm even if we could prevent it.

Re:Novel drug could protect brains from damage after repeat ... by anonzzzies on Thursday February 08, 2024 @05:10AM (#39300262)
No that's not how I mean it, sorry. I mean if you put yourself in danger, society shouldn't necessarily pay. Sports is healthy if it's not a sport that endangers your body and that should be rewarded; sports that are proven to give you multiple injuries (concussions etc) are not very different from bad addictions. It's your choice/responsibility, not 'ours'.

But no I definitely didn't mean the tail end. Sorry if you read that into it; I would never say that.

Re:Novel drug could protect brains from damage after repeat ... by krisoft on Thursday February 08, 2024 @07:01AM (#39300956)
Thank you for the clarification, and I'm sorry for misunderstanding it.

In that case I agree with you.

Re:Novel drug could protect brains from damage after repeat ... by lupusreal on Thursday February 08, 2024 @06:03AM (#39300578)
You don't have to end the sport, just opt not to play it yourself. The GP's suggestion is valid; if you're getting hit in the head a lit you should stop doing that.
Re:Novel drug could protect brains from damage after repeat ... by importantbrian on Thursday February 08, 2024 @02:06PM (#39306104)
While American Football won't end anytime soon -- depending on your definition of soon. It's worth noting that youth participation rates are falling dramatically, and there are big regional differences. It will take a while, but football will eventually end up as a niche regional sport. Unless a drug like this or some revolutionary piece of safety equipment came along. Then I could see the sport staying on top long term.
Re:Novel drug could protect brains from damage after repeat ... by rain_iwakura on Wednesday February 07, 2024 @11:46PM (#39298292)
i'm not sure if know this but a concussion increases a risk of another concussion. your brain loses ability to balance the body movements and it's a death spiral that a lot of people can't get out of. unless you mean someone who plays sports known for the risk.
Re:Novel drug could protect brains from damage after repeat ... by caseyohara on Thursday February 08, 2024 @12:33AM (#39298630)
Studies seem to confirm that concussion increases the risk of subsequent concussion, and I guess it might be true that the brain loses the ability to balance the body leading to more concussions. But the brain itself seems more susceptible to concussion after having one; I don't think it's exclusively a matter of balance or body movements. Especially when you consider athletes (esp. American football) where their concussions are not usually the result of a slip-and-fall type incident like an elderly person.

> Also, it is now known that, after a concussion, there is greater susceptibility to sustaining another concussion and that subsequent concussions occur with less force and take longer to resolve.

Source: Concussions and their consequences: current diagnosis, management and prevention https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735746/

That paper cites this paper (https://jamanetwork.com/journals/jama/article-abstract/19766...) which seems to suggest it has more to do with post-injury neuronal vulnerability.

> Our study suggests that players with a history of previous concussions are more likely to have future concussive injuries than those with no history; 1 in 15 players with a concussion may have additional concussions in the same playing season; and previous concussions may be associated with slower recovery of neurological function.

> Additionally, our study suggests that a history of concussion is associated with prolonged recovery following subsequent concussions. The increased risk of future injury, as well as slower recovery, may be indicative of increased neuronal vulnerability following recurrent concussive injuries.

Re:Novel drug could protect brains from damage after repeat ... by yieldcrv on Thursday February 08, 2024 @02:04AM (#39299147)
Personally I’m looking forward to Peter Thiel’s new sports league
Re:Novel drug could protect brains from damage after repeat ... by xlii on Thursday February 08, 2024 @02:44AM (#39299391)
As far as I know there aren’t any sports which are completely safe and without side effects. Sport can ruin your joints (eg. running), spine (eg. weightlifting) and cause plethora of other health issues (anecdotally I know many people who got serious injuries from while leisurely playing team games).

Usually there’s net gain from those activities, and what sport one practices vastly depends on preference and I’d rather encourage people to get hit in the head in controlled environment versus growing roots in the chair.

As a fan of practicing fighting sports I find such drug a great addition to all the other protection amateur can have.

Re:Novel drug could protect brains from damage after repeat ... by stavros on Thursday February 08, 2024 @03:41AM (#39299719)
Swimming?
Re:Novel drug could protect brains from damage after repeat ... by ntlve on Thursday February 08, 2024 @04:12AM (#39299912)
Re:Novel drug could protect brains from damage after repeat ... by lupusreal on Thursday February 08, 2024 @06:07AM (#39300602)
> The traditional view that swimmers naturally gravitate toward swimming because of preexisting respiratory disorders has been challenged

Lolwut. Anybody who could believe that has never been a swimmer. Of course aspirating drops of pool water, and the chlorinated air lingering above pools, is going to be a lung problem. Why in the world would anybody with preexisting respiratory issues gravitate towards swimming? That's ludicrous.

> The traditional explanation for this higher prevalence rate is one of selection bias. The suggestion that swimming is a more suitable activity compared to both cycling and running in asthmatics5 is not surprising. For example, the hydrostatic compression effect of water can reduce the effort required to generate expiratory flow,

Dumbest thing I've ever read.

Re:Novel drug could protect brains from damage after repeat ... by rob74 on Thursday February 08, 2024 @04:59AM (#39300201)
Cycling is better for the joints than running. Unfortunately, bicycles are so damned effective that you have to cycle for a lot longer to burn the same amount of calories as when running...
Re:Novel drug could protect brains from damage after repeat ... by doubled112 on Thursday February 08, 2024 @08:36AM (#39301728)
All my effort is transformed into forward motion. This is awful!
Re:Novel drug could protect brains from damage after repeat ... by Taylor_OD on Thursday February 08, 2024 @11:55AM (#39304300)
Isnt it fairly common for cyclist to get seriously injured in other ways though? Most serious cyclists I know have had at least 1 seemingly major accident with a car. And I live in a city that has a pretty significant bike lanes/routes distribution.
Re:Novel drug could protect brains from damage after repeat ... by PeterStuer on Thursday February 08, 2024 @06:02AM (#39300576)
It might also be we'll greenlight sports that have more head impact. There is definetly an audience for it, and now it will be just as (un)safe as before.
Re:Novel drug could protect brains from damage after repeat ... by lotsofpulp on Thursday February 08, 2024 @06:49AM (#39300860)
I prefer joint damage from running or back pain rather than expose those around me to the effects of brain damage.

Also, there are ways to run and weight lift (mostly just doing overdo it) that result in zero or near zero damage, whereas there are no ways to have your brain impact your skull with zero damage.

Re:Novel drug could protect brains from damage after repeat ... by neogodless on Thursday February 08, 2024 @08:08AM (#39301501)
Presumably you only mean sports. I'm tall. My first big concussion was so stupid. I had a box of stuff in the floor near the wall under a heavy wall-mounted shelf. Stood up after picking something out of the box and smashed my head.

Since then I've had several minor ones, but as stated elsewhere, you become more easily susceptible to the effects of a concussion from even relatively small impacts after a big one. The others include helping someone move something in their garage and hitting my head on a ceiling mounted HVAC unit, stepping out of the shower (I've got terrible eyesight) and hitting the top of the door frame, those sorts of things.

You could have those happen and be fine but it seems because they happened after the bigger concussion, I'll have symptoms again, especially sensitivity to low refresh rate screens or PWM.

I try to avoid it, but I'm not going to avoid living my life. And I'm not going to stop being tall.

So if medicine can help protect my brain, I'm interested in it.

Re:Novel drug could protect brains from damage after repeat ... by instagib on Thursday February 08, 2024 @01:36PM (#39305702)
Same, I’m regrettably at an average of one concussion per year. Some described as mild or moderate TBI.

I would be very cautious after a concussion. I had one in one month (odd to pass out and not fall down) then another the following month (slip and fall) then became disabled for about a year.

I’ve read that supplementing with high dose creatine and exercise can help post concussion or with migraines which I regularly get now.