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Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by tptacek on Friday August 25, 2023 @06:13PM (#37267656)
No, it's not at all a weak justification, and it is the primary reason you shouldn't get these scans done.

The problem here is our old friend the Bayesian Base Rate fallacy. The diseases you're looking to intercept and intervene against are, in the general population, pretty rare. That means that even if the indications you'd get from diagnostic imaging are extraordinarily accurate (they aren't), the overwhelming majority of the flags they raise are going to be false positives.

The cost of a false positive imaging flag is far worse than having to have an unpleasant chat with your doctor, or worrying for several weeks (do not discount the cost of worrying for several weeks, though; these scares can absolutely fuck up a month of your life). Rather: you'll pay the price in follow-up imaging, which won't be as benign as the MRI, or worse, in unnecessary intrusive diagnostics.

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by jstummbillig on Friday August 25, 2023 @06:25PM (#37267781)
Seems plausible. So what's up with the wealthy? They do not care? They do not know? They get talked into it by greedy physicians? Or is the story more likely just not true?
Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by DragonStrength on Friday August 25, 2023 @06:31PM (#37267829)
Well, it's not as if wealthy people are any different from the average Joe. They may go on HN instead of FB for their medical advice (and I've seen these sorts of scans advocated in comments here, to be clear), but that doesn't mean they have any more knowledge of outcomes for these screenings. What they do have is a knowledge of their own (and parents') mortality and means to do anything they can to prevent it. Buy a bunker in NZ, try to build a base on the moon, or spend a couple grand on a frivolous scan? Rich people gonna rich people.

Yes, the medical system in the US is for-profit and fee-based. Medical providers make money by building small businesses which do a lot of procedures. Here is another very expensive, uncovered procedure for them to bill.

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by robwwilliams on Friday August 25, 2023 @06:56PM (#37268065)
In general, physician do not understand false discovery rates, and when profit motives are involved they do not even want to hear about FDRs.
Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by bcrosby95 on Friday August 25, 2023 @07:08PM (#37268156)
I've noticed that many educated people expect other, otherwise educated people to not exhibit certain dumb behaviors. In reality, people are people. They will do dumb shit regardless of how rich or educated they are.
Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by prepend on Friday August 25, 2023 @07:37PM (#37268398)
They can afford it. And they are able to pay for anything medical their doc recommends.

I am curious but not willing to spend $5-20k in scans and tests. Especially since they can be done annually. Why not? There’s no medical guidelines for what period has higher positive impact.

My doctor has mentioned tests that cost thousands and have a low probability of useful information. I say no. If I was rich, I’d probably do any test if the only downside was cost.

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by refurb on Saturday August 26, 2023 @05:45AM (#37271157)
Yes, they actually do.

The question about "VIP healthcare" pops up all the time on certain subreddits and the physicians who comment usually say "it's not worth it at all".

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by DragonStrength on Friday August 25, 2023 @06:27PM (#37267793)
Yes, orthopedics has gone down this road. Intervention based only on imaging does not have the best outcomes. Not every abnormality is cause for alarm. Using genetic profiling and family history to decide who to check for conditions is not merely for the benefit of the at-risk; it is also to protect those who might show false positives from unnecessary interventions.
Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by robwwilliams on Friday August 25, 2023 @06:50PM (#37268008)
Absolutely right! The WSJ article could have done a much better job on this topic but instead ends with a rare true positive cancer detection success by a for-profit scanning company. That one rare success needs to be weighed against NN false positives. And a fraction of the true positives might well resolve on their own.

What next—trolling assisted living communities?

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by zajio1am on Friday August 25, 2023 @06:56PM (#37268055)
Point is that if you know that overwhelming majority of the result are false positives so that it is not worth to follow-up them with additional diagnostics, then reasonable step is to not follow-up in that case.

It is a fallacy to account the cost of follow-up procedure to the initial scan, when the follow-up procedures are not necessary regardless of the result from the scan.

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by prepend on Friday August 25, 2023 @07:33PM (#37268356)
> then reasonable step is to not follow-up in that case.

Then a more reasonable step is not to get the scan. Why do the scan if you don’t follow up.

This is why not all screenings are recommended. People think that insurance won’t pay for scans because insurance is a jerk. They don’t pay because the scans aren’t medically effective at protecting populations.

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by coryrc on Friday August 25, 2023 @08:19PM (#37268653)
Because you can check it on the next scan and see if things are growing.
Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by drcode on Friday August 25, 2023 @09:12PM (#37268992)
Follow up procedures should be adjusted based on whether the original test was preventative or not, titrating the amount of risk and cost appropriately

The fact that we treat diagnostic results the same regardless of priors just means our medical system is still stuck in the stone age

Saying the screenings aren't recommended is just saying "we're too dumb to use the results of this screening the correct way, so you shouldn't get the screening"

We can only hope that the new developments in AI will mean that modern statistical procedures will finally be applied to medicine as a side effect (though I wouldn't hold my breath)

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by tptacek on Friday August 25, 2023 @11:01PM (#37269573)
The premise of the article is that all of these tests were "preventative".
Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by prepend on Saturday August 26, 2023 @09:19AM (#37272633)
> we're too dumb to use the results of this screening the correct way, so you shouldn't get the screening

I agree with this. One day we might be smart enough. But they say is not today. It’s ok to be dumb.

It’s also dumb to spend thousands of dollars on these diagnostic scans that we’re too dumb to use.

We can plan around our stupidity. We can also research new ways to use these data and, hopefully, one day be less dumb.

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by robbiep on Friday August 25, 2023 @07:46PM (#37268459)
You are misunderstanding how ‘incidentalomas’ are reviewed and managed. You don’t know it’s a false positive until you’ve done the invasive diagnostic tests subsequently (with non-zero risk), at which point you can classify it as a false positive
Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by Gibbon1 on Saturday August 26, 2023 @04:45AM (#37270874)
An issue that gets brushed over is you have various possible results to an invasive diagnostic test.

1. Bad 2. Indeterminate 3. Benign 4. Nondiagnostic

One and two are simple enough. Three and four are really problematic. And they are more common that people assume. Worse people confuse the two.

Indeterminate says they have a sample that is sufficient but can't be assigned to Bad or Benign. What do you do then? If you treat some large percentage will be treated for nothing. If you don't some percentage will see progression.

Nondiagnostic says there are issues with the sample that make a determination impossible at all. What do you do then? Repeat the biopsy? What if you get another Nondiagnostic? Forget about it?

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by vikramkr on Friday August 25, 2023 @08:07PM (#37268584)
The point is that if you know the test has so many false positives that you're going to ignore the results, just don't run the test. What's the point of running a test if you're never going to follow up?
Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by orionsbelt on Friday August 25, 2023 @08:47PM (#37268837)
You can follow-up when it's warranted. See the below anecdote. I'm guessing as to the details, but perhaps the thyroid was cancerous early, but it was too indeterminate, so they did nothing. But then when it started growing, they could change the approach. It's a piece of date, to weigh amongst the overall mix. The problem is most people will demand too much action.

"Bob Nelsen says that he has a family history of cancer, so began getting annual Prenuvo scans around 10 years ago.

    - The early scans showed a nodule in his thyroid, but doctors didn't believe it was problematic. Then a scan in 2018 showed that the nodule had changed, which isn't supposed to happen in healthy people.

    - "When I went into Stanford for surgery, I asked how many patients they'd had with five years of longitudinal data on their thyroid, and they said I was the first," Nelsen tells Axios. "The medical profession is trained to be reactive, not proactive."

    - He adds that the scans also discovered a small scar on his brain, which he assumes came from falling off his bike and getting knocked out when he was 11 years-old."
Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by vikramkr on Friday August 25, 2023 @09:37PM (#37269126)
You know whether or not it's warranted before you run the test. That's the whole point of the discussion around when preventative testing is appropriate. The key is that the test is just one additional data point. Before running the test - you want to make sure that the data from the test will be useful for whatever purpose you want the test for (false positives could be ok if the point is to minimize false negatives). That way when you run the test, it's always "warranted" to follow up if needed. We do mammograms for healthy seeming people all the time - it's totally feasible that we'll determine that these new approaches are informative enough to become recommended for the general public, but we're still on that scientific journey
Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by civilitty on Friday August 25, 2023 @07:04PM (#37268126)
It's really easy to demonstrate with some basic math too. All of the numbers below are pulled from memory from a textbook example:

Imagine you have a test with a 1% false positive rate when screening for a disease that has a prevalence of 1 in 1,000 and the invasive operation to confirm the diagnosis has a 10% chance of serious (potentially life altering) complications like internal infection or an embolism.

If you test 10,000 people, you'll identify 10 true cases (assuming 0% false negative rate) and 100 false cases. Meanwhile testing those 110 people will result in 11 patients suffering serious complications. Once you include the complicated math of quality-adjusted life years, it's almost never worth it.

In reality the numbers are a lot worse - there is a long tail of diseases with 2-10% false positive rate tests and 1 in 10,000 incidence or worse, with 20% of patients experience QALY effecting complications from false positives. On top of that there are a lot of interventions that require invasive procedures with low rates of success.

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by cyberax on Friday August 25, 2023 @10:16PM (#37269342)
> Once you include the complicated math of quality-adjusted life years, it's almost never worth it.

This is an actuarial argument, that applies is you want to have the most efficient overall healthcare system. In other words, if you have to ration the access to MRIs and to followup tests.

Now suppose that you are not limited by scarcity. It would absolutely make sense to use the minimally invasive procedures, but perhaps weigh the results a bit less heavily for followup tests.

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by moralestapia on Friday August 25, 2023 @07:07PM (#37268151)
Hmm ... idk. I disagree with that (sort of) argument in so many ways.

>The disease [...] are, in the general population, pretty rare.

Cancer is not rare, particularly from a certain age. Early detection heavily skews the odds on one's side. This is such common knowledge that it feels weird having to justify it here.

I know I'm not a "survey performed under the most strict standards of quality" but among my close groups of friends and family there have been a few cases where they got lucky enough to detect this disease very early on, and their treatment and outcome was significantly better (and cheaper, while we are at it, bc you mention cost as well) than if they've just waited even a couple more months.

OTOH, I have yet to hear a story from someone who had some sort of scan done, found something worth to take a look at, that then turned out to be nothing and, for some strange reason, had its life significantly affected by that.

Doctors are not stupid, they know (or intuitively correct for) this Bayesian Base Rate you mention, plus they have other things like years of experience in their particular field. It's not like someone's going to cut your arm the moment you find a weird looking lump growing inside.

>these scares can absolutely fuck up a month of your life

That sounds quite immature, tbh. It's definitely a small price to pay compared to all the trouble you save by potentially detecting issues early on. "Oh, but needles hurt :'(", sure, but their benefit far outweigh such small nuisance. This is also an argument I would've thought anyone would just get naturally, and yet I have to explicitly bring it up here, weird.

Also, if it came to be the case that everyone got scanned regularly, that massive trove of new data would definitely help improve the accuracy of said tests. It definitely won't make matters worse, but better.

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by Johnny555 on Friday August 25, 2023 @07:20PM (#37268246)
>OTOH, I have yet to hear a story from someone who had some sort of scan done, found something worth to take a look at that turned out to be nothing and that, for some strange reason, was significantly affected by that

The go-to for a lot of the "take a look at that" procedures is a biopsy, and a biopsy is not a risk free procedure. I'm surprised that you know more than one person that's had a full-body scan, but don't know anyone that's had a biopsy complication, I know one person who spent several days in the hospital on IV antibiotics after an infection after a Prostate biopsy (which was negative)

>>these scares can absolutely fuck up a month of your life

>That sounds quite immature, tbh. It's definitely a small price to pay compared to all the trouble you save by potentially detecting issues early on.

Have you ever had a cancer or other serious disease diagnosis? It can be surprisingly stressful and detrimental to your health even if it is something that can be effectively treated.

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by moralestapia on Friday August 25, 2023 @07:34PM (#37268371)
>The go-to for a lot of the "take a look at that"

It's not, sounds like you're not familiar at all with all of this.

There's some road to cover from imaging -> biopsy. Blood tests, more detailed imaging, keeping an eye on it for some time, etc...

Have you heard of Pap tests? A lot of them come out find signs which could be indicative of a developing cervical cancer. Do all these women get their cervix removed the next week? No, not at all. Most of the time the symptoms go away in a few weeks. Still, pap tests are done for a reason.

Pap tests are the single thing that completely obliterates the "screening everyone is bad" argument.

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by godsfshrmn on Friday August 25, 2023 @11:18PM (#37269658)
Except it is.

"Tissue is the issue"

I have yet to see any of my radiologists differentiate a lung nodule that was actually a metastasis from the colon (which can easily miss on PET ) from primary adenocarcinoma/small cell/etc. Neither a pancreatic neuroendocrine tumor from an adenocarcinoma based on a CT or PET.

I have (and often) see my patients incidentally discover masses on imaging. Perfect example- a pancreatic mass on imaging. Next stop is an anxiety filled few weeks while they wait for their biopsy to be scheduled. You then have an additional radiation exposure as these are CT guided. You hope the radiologist doesn't poke a hole in a nearby vessel, induce pancreatitis just by doing the biopsy itself, nor develop a subsequent infection related to the procedure. They then wait an additional week for pathology to result, often only to see normal pancreatic cells indicating this is a cyst.

All of this is often the result of looking for a seemingly innocent diagnosis. Eg an ultrasound to reassure your patient that their abdominal pain is not their gallbladder.

I had a similar event earlier today with a cervical lymph node seen on an ultrasound. Thyroid nodules, renal masses, lung nodules. How long do you have?

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by cyberax on Saturday August 26, 2023 @01:59AM (#37270262)
Now imagine that you started getting MRI screening every year. You'll be able to afford to wait to make sure a strange mass doesn't get larger.
Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by kevinmchugh on Saturday August 26, 2023 @01:51AM (#37270248)
I got bloodwork done for the first time in a long time. My liver enzymes were high. I don't have hep C. I cut out drinking for a while, liver enzymes were still high. They did some imaging and maybe saw some fat on my liver. They did some more imaging later and didn't see the fat. Enzymes are still high. My next option is a biopsy, the hepatologists tell me.

If I do the biopsy and they don't find cancer or something, they'll just tell me to drink less and eat better. Seems like mostly downside to doing the biopsy.

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by BeetleB on Friday August 25, 2023 @07:16PM (#37268220)
> Cancer is not rare. Early detection heavily skews the odds on one's side.

Depends on the cancer and even the doctors are torn. Most breast tumors and prostate tumors will not kill you or affect your life much. Treating them likely will (especially for prostate). Depending on the model, the overall health of the population is actually reduced by early detection because in most of these tumors treatment is worse than the disease.

One of my doctors is a strong believer in periodic prostate exams after 40. The other recommends only if there are other symptoms. You can guess which is the older one and which is the younger one.

Years ago there was the whole Gardasil controversy. What was often excluded in the noise was that if it were mandated for all girls as some states were recommending, it would be so expensive that funding for other health programs would need to be reduced. The studies were showing that this kind of preventative approach would again reduce the health of the state's population.

Preventive medicine is good - to an extent. Beyond that it is bad.

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by moralestapia on Friday August 25, 2023 @07:37PM (#37268396)
>it would be so expensive that funding for other health programs would need to be reduced

But that's a different thing. I'm sorry, I will not talk about that.

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by BeetleB on Friday August 25, 2023 @07:45PM (#37268444)
> But that's a different thing. I'm sorry, I will not talk about that.

For people setting policies (and that includes doctors) cost is absolutely not a different thing.

If you can afford to pay for everything without involving insurance, by all means do whatever tests you want. If you're a doctor you don't want to maybe help Betty while definitely hiring Veronica.

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by moralestapia on Friday August 25, 2023 @07:47PM (#37268463)
>I'm sorry, I will not talk about that.
Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by BeetleB on Friday August 25, 2023 @07:51PM (#37268491)
You are also not the only participant in the conversation.
Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by paulmd on Friday August 25, 2023 @09:53PM (#37269220)
I think you’ve missed that he’s not a participant in your conversation at all.
Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by gusgus01 on Friday August 25, 2023 @07:36PM (#37268389)
I'm interested in those studies. Do you have them handy or will I need to resort to some Google fu?
Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by BeetleB on Friday August 25, 2023 @07:53PM (#37268501)
Here's a related one : https://www.npr.org/sections/health-shots/2014/09/02/3452005...

It mentions Angelina Jolie as a good example of how fear can lead to drastic actions.

Probably better to find an article talking about the general problem to find more references.

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by BeetleB on Friday August 25, 2023 @08:01PM (#37268543)
Wikipedia has this:

The Cochrane collaboration (2013) states that the best quality evidence neither demonstrates a reduction in cancer specific, nor a reduction in all cause mortality from screening mammography. When less rigorous trials are added to the analysis there is a reduction in mortality due to breast cancer of 0.05% (a decrease of 1 in 2000 deaths from breast cancer over 10 years or a relative decrease of 15% from breast cancer). Screening over 10 years results in a 30% increase in rates of over-diagnosis and over-treatment (3 to 14 per 1000) and more than half will have at least one falsely positive test. This has resulted in the view that it is not clear whether mammography screening does more good or harm. Cochrane states that, due to recent improvements in breast cancer treatment, and the risks of false positives from breast cancer screening leading to unnecessary treatment, "it therefore no longer seems beneficial to attend for breast cancer screening" at any age. Whether MRI as a screening method has greater harms or benefits when compared to standard mammography is not known.

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by moralestapia on Friday August 25, 2023 @08:20PM (#37268663)
>it is not clear whether mammography screening does more good or harm
Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by BeetleB on Friday August 25, 2023 @08:56PM (#37268896)
> the best quality evidence neither demonstrates a reduction in cancer specific, nor a reduction in all cause mortality from screening mammography.
Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by moralestapia on Friday August 25, 2023 @08:59PM (#37268915)
But you are arguing that regular screening is bad.

You forgot your lines, man!

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by BeetleB on Friday August 25, 2023 @09:43PM (#37269156)
> Depending on the model...
Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by loloquwowndueo on Friday August 25, 2023 @08:01PM (#37268540)
I can’t guess. Which is the older one?
Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by BeetleB on Friday August 25, 2023 @08:03PM (#37268553)
The one recommending it for everyone over 40.

They pushback against too much screening is relatively recent, and thus younger doctors are more likely to adopt it.

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by randallsquared on Friday August 25, 2023 @09:08PM (#37268965)
I also couldn't guess. There are equally plausible stories the other way: "obviously the older one is the one who doesn't recommend, since they're more experienced and have seen over thousands of patients how often it doesn't help...".
Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by Retric on Friday August 25, 2023 @08:04PM (#37268559)
Untreated detectable cancers still kill relatively quickly, the only time they’re not a major concern is when people have other major medical issues.

For perspective even with all the advances in modern medicine in 2020 and thus a pandemic, cancer was still the #2 killer in the US after heart disease. It killed over 600,000 Americans in 2020 and that’s a 27% improvement over what it was doing as recently as 2001.

That said, there’s currently believed to be a long undetectable period where the body fights off most pre cancers. We’re approaching the ability to detect cancers below 0.5mm which we don’t have much clinical data on.

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by fortran77 on Friday August 25, 2023 @08:39PM (#37268788)
Untrue wrt prostate cancer. Since the average date it’s detected is 70 and 2/3rds of the population is obese, then of course most people will die of something else. If you are non-obese and in good shape, then get aggressive treatment.
Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by BeetleB on Friday August 25, 2023 @08:55PM (#37268893)
That aggressive treatment may leave you incontinent before you turn 50, and likely would not have killed you if untreated.
Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by fortran77 on Friday August 25, 2023 @09:16PM (#37269010)
“Likely” to not have killed you only if you’re part of the obese and overweight majority. For right-sized people, it’s likely to kill you.
Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by BeetleB on Friday August 25, 2023 @09:43PM (#37269159)
Citation?
Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by cyberax on Friday August 25, 2023 @09:52PM (#37269214)
> Most breast tumors and prostate tumors will not kill you or affect your life much.

This is yet another fallacy.

A prostate cancer takes about 10 years to kill you. If you're 80, then it's probably not worth pursuing aggressive treatment. You're likely to die of something else.

However, if you're 40 then it's another story entirely.

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by cyberax on Friday August 25, 2023 @10:20PM (#37269355)
> What was often excluded in the noise was that if it were mandated for all girls as some states were recommending, it would be so expensive that funding for other health programs would need to be reduced.

This is an argument from scarcity. If you have a severely limited amount of a resource, it makes sense to sacrifice some people, so that more people can receive life-saving care.

If the resource is not scarce, then this simply doesn't apply. These days HPV vaccine (in Europe) is around $30, so it makes sense to just vaccinate everybody.

> Preventive medicine is good - to an extent. Beyond that it is bad.

Nope. It's always good, but sometimes it's too expensive.

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by BeetleB on Saturday August 26, 2023 @01:25AM (#37270161)
> These days HPV vaccine (in Europe) is around $30, so it makes sense to just vaccinate everybody.

These days it's likely a very different from 2007 when it was being debated.

There argument wasn't that no one should get Gardasil. Just that it would hurt the health of the society if it was mandated for all. Obviously if you had the money it's good to get it

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by cyberax on Saturday August 26, 2023 @01:55AM (#37270254)
Yes, and this argument indeed holds in the case of extra MRI screenings. We simply don't have enough MRI units to screen everybody every year.

On the other hand, the quantity of MRI units is not fixed. We can always build more, they are just inherently very expensive. And if you can afford an MRI scan from your personal disposable income, then what's the problem?

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by AlbertCory on Friday August 25, 2023 @07:21PM (#37268260)
> I have yet to hear a story from someone who had some sort of scan done, found something worth to take a look at that turned out to be nothing and that, for some strange reason, was significantly affected by that.

Silly comment. They tell you there's a 16% false positive rate. Maybe you don't know any of these people, but I'd certainly be willing to bet money that some of them got worried sick about it.

In addition, an older case is prostate cancer. At least in the older days, they would do painful procedures that left the patient with significantly lower quality of life, when in fact, many men with prostate cancer die of something else. Nowadays they're a little smarter about it.

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by moralestapia on Friday August 25, 2023 @07:39PM (#37268406)
>At least in the older days, they would do painful procedures [...]

>Nowadays they're a little smarter about it.

??? So, what's your point? I'm confused. I live in 2023.

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by AlbertCory on Friday August 25, 2023 @08:20PM (#37268669)
That's one well-known example. Others probably exist as well but haven't been dealt with yet.
Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by sokoloff on Friday August 25, 2023 @07:43PM (#37268434)
Most men diagnosed with prostate cancer will die with it rather than from it.
Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by whiddershins on Friday August 25, 2023 @07:56PM (#37268519)
You may not agree, but for context please understand this is a well discussed and researched statistical effect.

It’s hard to dial it in just right, but study after study have borne out that more diagnostics can often lead to worse outcomes.

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by gochi on Friday August 25, 2023 @08:50PM (#37268850)
I have a very hard time believing that your friends and family are getting PET/MRI scans routinely, as opposed to what most people actually do which is "hey I found this lump/I feel bad here, please can you check if this is bad and scan for anything else?"

This is an important distinction, because you can delude yourself and your medical team into believing you are healthy because you had a clean scan x months ago, as part of your annual deep checkup or whatever you want to call it. Leading into that part of if your friends had waited a couple more months it would have been a very different outcome!

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by moralestapia on Friday August 25, 2023 @08:57PM (#37268903)
Never said such thing.

You're arguing against something your mind made up.

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by bsder on Friday August 25, 2023 @10:56PM (#37269555)
> OTOH, I have yet to hear a story from someone who had some sort of scan done, found something worth to take a look at, that then turned out to be nothing and, for some strange reason, had its life significantly affected by that.

My friend's wife had a scan done when she was 55 and they found "something they wanted to look at" in her breasts and needed to do a biopsy.

She has anxiety. Her blood pressure spiked to a dangerous zone. It stayed elevated even as they tried to control it with medication. It didn't go back to normal until the biopsy came back negative.

During that time, she was at significant risk of having a stroke or heart attack. All for eventually nothing.

Things like women who have a small cancer that is treated with suregry and quick radiation but insist on getting a mastectomy are not rare, either.

Humans are not rational.

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by andrekandre on Monday August 28, 2023 @05:29PM (#37300637)

  > Her blood pressure spiked to a dangerous zone.

  > Humans are not rational.
total anecdote but every time i go in for a yearly health exam my blood pressure and heart rate goes up, especially right before sitting down to get my blood pressure taken!

if i take it myself, for some reason im not nervous, comes out ok...

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by quadrature on Friday August 25, 2023 @08:39PM (#37268781)
Why isn’t it sufficient to follow up with MRI scans to ensure the cancer (assuming a tumour) isn’t growing ?.
Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by foundart on Friday August 25, 2023 @08:40PM (#37268792)
The Bayesian Base Rate fallacy is the key here.

"Suppose that at your regular physical exam you test positive for Disease X. Although Disease X has only mild symptoms, you are concerned and ask your doctor about the accuracy of the test. It turns out that the test is 95% accurate. It would appear that the probability that you have Disease X is therefore 0.95. However, the situation is not that simple."

For the exciting conclusion to this story, please see https://stats.libretexts.org/Bookshelves/Introductory_Statis...

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by jfoutz on Friday August 25, 2023 @08:41PM (#37268799)
I read your comment and was all ready to write a, I guess, rant about joint probability distributions and costs associated with tests and on and on. You know, a good old rant. But I took a moment to actually read the article. Low and behold, the first line, or perhaps the actual headline,

"Wealthy People Are Getting Full-Body Scans. Early Detection or Unnecessary?"

"Wealthy" appears 3 times. Multiple allusions to income, "summer in the Hamptons" and such.

I'd need to reflect a bit, but I think I'm pretty comfortable with applying FDA requirements and prohibiting any health claims, but feel free to let the snake-oil salesmen fleece away.

As an aside, I wanted to say snake-oil alone, but I learned recently snake-oil itself got a bad rap - https://www.collectorsweekly.com/articles/how-snake-oil-got-...

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by drcode on Friday August 25, 2023 @09:03PM (#37268935)
It's has nothing to do with the Bayesian Base Rate fallacy.

In this case we ABSOLUTELY KNOW the base rate is lower, since it was a preventative scan. The fallacy only happens if you then subsequently fail to adjust for the differing base rate.

If doctors later in the diagnostic process fail to take the differing base rate into account, that is not the fault of the preventative test, that is an error in determining what the correct follow up care is.

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by Calavar on Friday August 25, 2023 @09:26PM (#37269072)
> If doctors later in the diagnostic process fail to take the differing base rate into account, that is not the fault of the preventative test, that is an error in determining what the correct follow up care is.

In today's medical malpractice climate, many physicians intentionally ignore the differing base rate.

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by drcode on Friday August 25, 2023 @09:33PM (#37269100)
100% correct

But now we're no longer having a conversation about medicine

we're having a conversation about our broken legal system and our broken regulatory frameworks

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by tptacek on Friday August 25, 2023 @11:00PM (#37269567)
Sounds like it does in fact have a bunch to do with the base rate fallacy.
Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by drcode on Friday August 25, 2023 @11:37PM (#37269745)
I suppose that's fair way to look at it, but people are being left with the impression that the problem is inherent in the tests, when the problem is entirely separate from the tests themselves.
Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by tptacek on Friday August 25, 2023 @11:54PM (#37269805)
I suppose it's a fair way to look at it, too! It's good when we can reach a shared understanding of what's happening; so often, the dynamics of message boards work against that.
Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by lozenge on Friday August 25, 2023 @11:50PM (#37269790)
Most people aren't going to be happy with "the scan shows something unusual that would normally be concerning, but you say you feel fine so I'll trust you instead of the scan".
Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by n8henrie on Saturday August 26, 2023 @12:39AM (#37269990)
What is the base rate of a not-very-suspicious-but-maybe-a-little-bit finding on imaging of an asymptomatic person in the general not-sick population?

I think pretending that medicine is equipped to deal with this in a healthy way is stretching the limits of well established medical science, and beyond what I would expect even a well intentioned and astute physician to know how to approach (or at least have been trained to do so expertly).

Not that you're wrong, you're not, strictly speaking.

Relevant piece: https://dynomight.net/diagnostics/

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by cyberax on Friday August 25, 2023 @09:44PM (#37269167)
> No, it's not at all a weak justification, and it is the primary reason you shouldn't get these scans done.

Yes, it is weak. The so-called downside is that you might need to do intrusive procedures as a followup.

But guess what? You don't HAVE to do that.

> The cost of a false positive imaging flag is far worse

Now think about the costs of not detecting a true reading. Most cancers start having visible symptoms only when they are far too advanced to be cured.

So the status quo is: you wait until you get an incurable disease, and then use MRI to solemnly confirm that. And then use it to give you estimates on how soon you'll die.

> Rather: you'll pay the price in follow-up imaging, which won't be as benign as the MRI, or worse, in unnecessary intrusive diagnostics.

Or you can just wait for a bit and do another MRI to check if there's any worsening. If you can afford an MRI, you likely can afford a second one.

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by tptacek on Friday August 25, 2023 @11:02PM (#37269582)
The point is that they're mathematically guaranteed to be, overwhelmingly, false readings.
Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by cyberax on Friday August 25, 2023 @11:15PM (#37269646)
And so what?

That's also exactly the case with most safety systems.

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by tptacek on Friday August 25, 2023 @11:22PM (#37269686)
Most safety systems pose very little risk of making random incisions into your peritoneum.
Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by cyberax on Saturday August 26, 2023 @01:50AM (#37270245)
Well, here's your problem. Don't make random incisions into your peritoneum.

If you have an abnormal result on the MRI, just wait for some time to check if it's really abnormal.

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by alkibiades on Saturday August 26, 2023 @02:27AM (#37270341)
yes but the expected value of having a true positive is infinite because it saves your life. so that seems to outweigh the cost of false positive even if that’s more likely
Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by inkyoto on Saturday August 26, 2023 @06:37AM (#37271507)
> The problem here is our old friend the Bayesian Base Rate fallacy. The diseases you're looking to intercept and intervene against are, in the general population, pretty rare.

This is pseudoscience at best and quakery at worst.

Body is not a Kubernetes cluster that can be restarted or reprovisioned from scratch when it has become too late to fix an aling pod or a service on the spot.

Physiological processes taking place in the body are more akin to stochastic processes whose behaviour can be accurately projected only to a certain extent (the extent varies depending on what the actual process is) based on levels of our current (but evolving) understanding of the biochemistry and phsysiology. Therefore, our bodies require a set of anomaly detection monitoring alarms, of which preventive health scans (whatever that means, not just CT/MRT/etc) are one example. If one such stochastic process goes awry, it can trigger an irreversible cascading failure in the body with the only outcome: premature death.

Take inflammation as an example. Inflammation is a root cause of multiple severe as well as degenerative health problems that impair the healthy aging of the body. Inflammation is notoriously difficult to detect via conventional testing means such as blood tests, unless somebody is looking for a specific inflammation biomarker. Routine blood tests do not do that (other than checking the monocyte and eosinophils counts), and when the inflammation reveals itself, it is already loud (pain or impaired wellbeing) and severe (a heart attack) or it is already too late (late stage cancers).

Inflammation starts out small and incospicous, and it takes a long time to progress and develop into something more unpleasant. Alzeheimer's, Parkinson, cancers, heart disease, IBS and many, many other health conditions have all been implicated to be caused by chronic inflammation processes that went undetected and were allowed to unfold, with plenty of sufficient (although not always fully conclusive yet) evidence. The vast majority of people of this planet are thought to have inflammatory processes going on of varying degrees of severity – from benign (that the body eventually suppresses) to malignant.

If a routine preventive health scan can unravel an inflammatory process early on, it is a win – for the patient (improves the long term prognosis and the quality of life) and for the health care system (early treatments are usually simpler and are more cost efficient, therefore less or no expenditure later).

Even if a preventive health scan is a false positive, it is still a net positive, is a net win as it indicates the lack of a health problem, and it is long term investment that time, effort and money for everyone.

Re:Wealthy People Are Getting Full-Body Scans. Early Detecti... by bookofjoe on Sunday August 27, 2023 @07:41AM (#37281655)