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Re:Omicron variant more resistant to vaccine but causes less... by ljm on Tuesday December 14, 2021 @10:40AM (#29552747)
> COVID clearly isn't going away at this point, so by all means try to replace it with something weaker!

Probably naive to think we could totally eradicate it within a couple of years, particularly as far as vaccine fearmongering is concerned. Would be nice to see it join Smallpox and Polio though.

That said, we've accepted an annual winter uptick in flu infections and we just tell people most vulnerable to get their yearly flu jab; less vulnerable folks can stay at home for a bit and manage the symptoms. If that's what we have to do for covid every winter then so be it.

I would still call that a victory overall.

Re:Omicron variant more resistant to vaccine but causes less... by azekai on Tuesday December 14, 2021 @11:06AM (#29553101)
>Probably naive to think we could totally eradicate it within a couple of years, particularly as far as vaccine fearmongering is concerned. Would be nice to see it join Smallpox and Polio though.

We would have to completely redesign our current method of vaccination, then. We do not have a sterilizing vaccine for COVID (like we did for smallpox and polio). The current vaccines all use spike proteins to prepare a body's antibodies against the main infection tool of the COVID virus. This method indirectly prevents the virus from efficiently infecting cells in vaccinated hosts, but it does not and cannot eradicate the virus.

Re:Omicron variant more resistant to vaccine but causes less... by sjg007 on Tuesday December 14, 2021 @11:53AM (#29553885)
Huh? I would suggest you read: https://www.theatlantic.com/science/archive/2021/09/steriliz...

We don't actually have sterilizing vaccines for smallpox or polio either.

Re:Omicron variant more resistant to vaccine but causes less... by azekai on Tuesday December 14, 2021 @05:23PM (#29558930)
That article strikes me as largely playing a semantic game. From the article:

>The classic tale of sterilizing immunity unfolds something like this: A pathogen attempts to infiltrate a body; antibodies, lurking in the vicinity thanks to vaccination or a previous infection, instantly zap it out of existence, so speedily that the microbe can’t even reproduce. No symptoms manifest, and most of the body’s immune cells never get involved, a bit like an intruder smacking up against an electric fence around a building, leaving the security guards inside none the wiser.

and

>This is a very neat story. And it is “almost impossible to prove,” Mark Slifka, an immunologist and vaccine expert at Oregon Health & Science University, told me. To show sterilizing immunity, researchers have to demonstrate that an infection never occurred—a big ask, considering that microbiologists can’t even agree on what an infection actually is.

If that is the definition used, yes, you are right. It is also basically useless as a term, as it is 'almost impossible to prove.' If you wish to use another term, we can do that. Instead of sterilizing, I could simply say 'highly effective.' Suffice to say, the mechanisms used by the COVID vaccine and the polio vaccine are very different. At most, the polio vaccine only included 3 strains (or variants)- the Salk vaccine, the first, only targeted type 1, but two more were added later over the course of years.

All of this is to say- the highly effective polio vaccine works because there are very few polio variants and people are immunized against them directly.

The COVID vaccine does not make one immune to the virus, or immune to the spike protein. The presence of the spike protein in the vaccine provokes an autoimmune response in the form of antibodies that will target that spike protein. This is somewhat effective, and a clever 'hack' that allows us a measure of protection. However, different spike proteins can be used by different variant viruses.

I am not antivaccine, and while autoimmune systems can be fairly complex, it is certainly worth discussing. Frankly I find the obfuscation and sloppy, ideological reporting to be frustrating. On all sides I see a lack of rigor and emotional attempts at control.

Re:Omicron variant more resistant to vaccine but causes less... by tbihl on Tuesday December 14, 2021 @06:21PM (#29559541)
Sometimes I feel like I repeat myself.

Would someone who is flagging this comment please, instead, respond to it? If it is so trivially dismissed, please show the rest of us.

Re:Omicron variant more resistant to vaccine but causes less... by sjg007 on Tuesday December 14, 2021 @10:02PM (#29561557)
The argument that this is a semantic game is not a very good one. The whole point of the article is to demonstrate that there really is no such thing as a sterilizing vaccine; As our scientific knowledge and technology has improved over the years we see that.
Re:Omicron variant more resistant to vaccine but causes less... by tbihl on Tuesday December 14, 2021 @11:21AM (#29553317)
Would someone who is flagging this comment please, instead, respond to it? If it is so trivially dismissed, please show the rest of us.
Re:Omicron variant more resistant to vaccine but causes less... by CorrectHorseBat on Tuesday December 14, 2021 @11:49AM (#29553791)
What other target would be better for a sterilizing vaccine?
Re:Omicron variant more resistant to vaccine but causes less... by lostlogin on Tuesday December 14, 2021 @12:34PM (#29554454)
Malaria.
Re:Omicron variant more resistant to vaccine but causes less... by bagels on Tuesday December 14, 2021 @11:31AM (#29553468)
Is it possible for one to be developed?
Re:Omicron variant more resistant to vaccine but causes less... by kiba on Tuesday December 14, 2021 @10:46AM (#29552842)
That said, we've accepted an annual winter uptick in flu infections and we just tell people most vulnerable to get their yearly flu jab; less vulnerable folks can stay at home for a bit and manage the symptoms. If that's what we have to do for covid every winter then so be it.

Accepted? I would call that normalizing as well. According to an estimate, about 290,000 to 650,000 globally died of the flu each year.[1]

Normalization means it's a problem out of mind out of sight. We stop demanding these problems to be solved.

1. https://www.who.int/news/item/13-12-2017-up-to-650-000-peopl...

Re:Omicron variant more resistant to vaccine but causes less... by rkk3 on Tuesday December 14, 2021 @12:01PM (#29554022)
At a certain point we accept the tradeoffs and get on with it. A few hundred thousand people die of the flu every year. So what? It's tragic, but that is life.
Re:Omicron variant more resistant to vaccine but causes less... by kiba on Tuesday December 14, 2021 @12:35PM (#29554471)
Normalization is not about accepting tradeoff. It's accepting defeat.

At some point, drastic measures start being worse than the disease. It doesn't mean we should ignore the few hundred thousand death.

Re:Omicron variant more resistant to vaccine but causes less... by rkk3 on Tuesday December 14, 2021 @02:20PM (#29556085)
56 Million people die a year. There are vaccine's and treatments available for the Flu. The deaths aren't 0 but don't think it's something to moralize about and call a defeat.
Re:Omicron variant more resistant to vaccine but causes less... by systemvoltage on Tuesday December 14, 2021 @11:07AM (#29553116)
If it means more lockdowns and more restrictions, more government powers; absolutely normalize COVID. We have given up enough.
Re:Omicron variant more resistant to vaccine but causes less... by kiba on Tuesday December 14, 2021 @11:18AM (#29553267)
Just because our economy cannot withstand further lockdowns and restrictions doesn't mean that the normalization of COVID is any more excusable. It just means we failed.
Re:Omicron variant more resistant to vaccine but causes less... by selectodude on Tuesday December 14, 2021 @11:47AM (#29553753)
It has nothing to do with the economy. Humans are social creatures. You can pay me $100,000/mo to sit in my house indefinitely and I can almost guarantee you it'll end in depression and suicide.
Re:Omicron variant more resistant to vaccine but causes less... by systemvoltage on Tuesday December 14, 2021 @12:15PM (#29554205)
To take this to extreme: We’ve failed to solve deaths. We should have solutions to aging and indefinite life.

Since we have 100% death ratio, show us your health history along with your verifiable ID. We are the ministry of Truth and Safety.

In all seriousness: We need to push back on robbing of civil liberties. No one cared to check for flu vaccine. It should be the same for COVID now that it’s getting weaker and it won’t end forever.

Re:Omicron variant more resistant to vaccine but causes less... by capdeck on Tuesday December 14, 2021 @10:49AM (#29552871)
> I would still call that a victory overall.

Humanity declared victory over every single pathogen to date (eradicated, contained or seasonal) because we are still here and thriving. We should go on with our lives.

Re:Omicron variant more resistant to vaccine but causes less... by notreallyserio on Tuesday December 14, 2021 @11:08AM (#29553137)
In the mean time we should do whatever we can to avoid filling hospitals to capacity.
Re:Omicron variant more resistant to vaccine but causes less... by spookthesunset on Tuesday December 14, 2021 @01:33PM (#29555349)
Maybe build more hospitals? I mean, in march of 2020 we expressly locked down to build up healthcare capacity. Where is it?
Re:Omicron variant more resistant to vaccine but causes less... by jaywalk on Tuesday December 14, 2021 @03:13PM (#29556891)
It's almost completely a staffing issue at this point. Good thing we fired a bunch of healthcare workers because they didn't want to get vaccinated!
Re:Omicron variant more resistant to vaccine but causes less... by spookthesunset on Tuesday December 14, 2021 @03:32PM (#29557183)
> It's almost completely a staffing issue at this point

So these politicians should treat this like an emergency and drive dumptrucks of money up to healthcare staff not working and get them back. Get nursing students. Do whatever it takes. Think outside of the box. This is supposed to be an emergency, is it not?

I mean, if it was an emergency and healthcare was truly an issue, why aren't those hospital tents and hospital ships docked in the harbor of every major city? "Lack of staff" is just an excuse in an emergency. You work around it. Make it happen. It's an emergency, right?

And if it isn't an emergency, why are we mandating anything at all? Shouldn't we all be going about our lives like we did prior to march 2020? If it isn't an emergency why are governments still using emergency powers to push mandates onto citizens instead of actually dealing with hospital shortages?

None of this makes any sense at all when you really start thinking about it. Absolutely none of it... Never did, never will...

Re:Omicron variant more resistant to vaccine but causes less... by capdeck on Tuesday December 14, 2021 @01:22PM (#29555194)
... or maybe we should stop closing hospitals during the pandemic?

[US Closing Hospitals At Record Pace During Pandemic - YouTube](https://www.youtube.com/watch?v=Zz46ZQSRdRE)

Re:Omicron variant more resistant to vaccine but causes less... by rajup on Tuesday December 14, 2021 @12:06PM (#29554086)
Sounds good. 2 years on with enough vaccines and antiviral pills on the way if you still believe hospitals are "filled to capacity", I'd like what you're smoking.
Re:Omicron variant more resistant to vaccine but causes less... by isoskeles on Tuesday December 14, 2021 @12:39PM (#29554540)
I’m smoking a wadded-up copy of that Rolling Stone article about gunshot victims waiting for the ER.
Re:Omicron variant more resistant to vaccine but causes less... by sjwalter on Tuesday December 14, 2021 @11:21AM (#29553309)
Sure, but hospitals are run at a level to hit peak capacity at the point when vitamin D deficiency peaks.

Here's LA County using overflow tents in 2018 because the flu season was particularly bad: https://www.latimes.com/local/lanow/la-me-ln-flu-demand-2018...

So it's not like this is some new threat. "2 weeks to flatten the curve" came along with some understanding that hospitals would increase their resources. Instead, in many states, they've spent more time working out which unvaccinated staff to fire and how than they have increasing staffing levels.

Re:Omicron variant more resistant to vaccine but causes less... by jatone on Tuesday December 14, 2021 @10:43AM (#29552790)
I havent seen any evidence covid is seasonal. it may become seasonal. but nothing in the past 2 years as indicated it is.
Re:Omicron variant more resistant to vaccine but causes less... by tbihl on Tuesday December 14, 2021 @11:19AM (#29553288)
Just so other commenters can understand: are you saying that you haven't seen the charts with enormous spikes on them every time a place enters a cold season? Or that you find them to be uncompelling for some (as yet undisclosed) reason?
Re:Omicron variant more resistant to vaccine but causes less... by unmole on Tuesday December 14, 2021 @11:52AM (#29553873)
The second wave hit India at the height of summer. That outlier is big enough for me to be sceptical.
Re:Omicron variant more resistant to vaccine but causes less... by coolspot on Tuesday December 14, 2021 @12:00PM (#29553994)
Have you seen infection/death charts? It peaks in winter and at its minimum in summer.
Re:Omicron variant more resistant to vaccine but causes less... by unmole on Tuesday December 14, 2021 @12:39PM (#29554533)
Have you seen the charts for India?
Re:Omicron variant more resistant to vaccine but causes less... by selectodude on Tuesday December 14, 2021 @02:02PM (#29555843)
Have you seen the charts for literally the rest of the world?

You're picking an outlier as proof that its not seasonal. Others may say it's the exception that proves the rule.

Re:Omicron variant more resistant to vaccine but causes less... by unmole on Tuesday December 14, 2021 @02:17PM (#29556032)
> Have you seen the charts for literally the rest of the world?

I just did. There are no discernable spikes coinciding with cold weather for India, Brazil, the UK or Russia.

Re:Omicron variant more resistant to vaccine but causes less... by selectodude on Tuesday December 14, 2021 @02:34PM (#29556298)
I decided to check Brazil really quickly and there's a very steep drop off once summer hit. I don't even need to bother with the UK.
Re:Omicron variant more resistant to vaccine but causes less... by unmole on Tuesday December 14, 2021 @02:47PM (#29556498)
The steep drop off starts of in July which in Brazil is winter.
Re:Omicron variant more resistant to vaccine but causes less... by Izkata on Tuesday December 14, 2021 @06:18PM (#29559515)
Most of Brazil is pretty temperate year-round, so they don't really have a very sharp flu season, but what they do have typically peaks around June, which fits with when the covid drop started.

https://en.wikipedia.org/wiki/Flu_season#Timing -> https://academic.oup.com/aje/article/165/12/1434/125289

> In the Fourier analysis, the seasonality of influenza in Brazil was characterized by a semiannual pattern, peaking in the winter month of June (amplitude = 27 percent), with a second, smaller peak during the summer (January; amplitude = 13 percent; figure 2).

Re:Omicron variant more resistant to vaccine but causes less... by roywiggins on Tuesday December 14, 2021 @11:31AM (#29553460)
It won't join smallpox because it has lots of animal reservoirs.

https://www.cnn.com/2021/11/17/health/covid-deer-animals/ind...