Psilocybin repairs 'brains cells damaged by depression' in mice: study

Re:Psilocybin repairs 'brains cells damaged by depression' i... by miltondts on Wednesday July 07, 2021 @04:42AM (#27758816)

A quick google search seems to confirm that fasting can indeed help with depression:

https://link.springer.com/article/10.1007/s12603-013-0344-9

https://www.sciencedirect.com/science/article/pii/S027858462...

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Re:Psilocybin repairs 'brains cells damaged by depression' i... by me_me_me on Wednesday July 07, 2021 @05:33AM (#27759164)

Did multiple quite few 5 days fast, the max i got to was 10 days.

I experienced none of the effects. People claim to be sharper and more energised during fast, but all I experienced was noticeable sluggishness (no glucose, only fat as energy source) and bit more pissy about small things (though I recognise it and never act on it).

P.S. Worth mentioning, any water fast above 4 days can be potentially dangerous if you don't take supplements that regulate your bodily functions, like salt, potassium, magnesium etc. I have read accounts of people doing only water fast no supplements for 10-15 days and report serious symptoms of their body shutting down (maily cells dying due to lack of salt).

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Re:Psilocybin repairs 'brains cells damaged by depression' i... by nszceta on Wednesday July 07, 2021 @10:03AM (#27761233)

In my experience it is dangerous to go more than a day without electrolyte and multivitamin supplementation.

Care must be taken to avoid potassium overdose if supplementing with potassium. Sodium chloride is well tolerated on the order of no more than 20 grams per day spread out over the whole day.

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Re:Psilocybin repairs 'brains cells damaged by depression' i... by nradov on Wednesday July 07, 2021 @03:45PM (#27765027)

If you can't go without multivitamin supplementation for a day then there's something medically wrong with your body.

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Re:Psilocybin repairs 'brains cells damaged by depression' i... by dQw4w9WgXcQ on Wednesday July 07, 2021 @12:07AM (#27757244)

Another potential positive benefit of fasting is it deprives the body of the energy/nutrients it needs to physiologically repress unexpressed emotions. Certainly if you have any past major traumas buried deep it may be beneficial to have someone well-fed along for the ride who can guide your thinking, but there's nothing quite like an extended fast to force you to jettison old cargo and take that ride on the emotional rollercoaster you've been avoidng for years.

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Re:Psilocybin repairs 'brains cells damaged by depression' i... by goodpoint on Wednesday July 07, 2021 @05:50AM (#27759270)

> deprives the body of the energy/nutrients it needs to physiologically repress unexpressed emotions

Citation desperately needed.

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Re:Psilocybin repairs 'brains cells damaged by depression' i... by ww2buff on Wednesday July 07, 2021 @12:12AM (#27757275)

What is the physiological mechanism through which we repress unexpressed emotions, and which nutrients does it consume?

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Re:Psilocybin repairs 'brains cells damaged by depression' i... by nefitty on Wednesday July 07, 2021 @12:27AM (#27757366)

As I began reading that comment I assumed it was a satirical response but it seems the user actually believes humans can “purge” emotions.

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Re:Psilocybin repairs 'brains cells damaged by depression' i... by NiceWayToDoIT on Wednesday July 07, 2021 @02:12AM (#27757942)

Not "purge" but rather "starve" or "transform" or even better "disrupt" standard chemical pathways. As many emotions depend on dopamine, serotonin, oxytocin and endorphins, starving/fasting kicks in the primary mode of operation and reduces disbalance caused by excess amount of nutrients... For instance there is a link between diabetes and depression https://archive.ph/f50wd

...

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Re:Psilocybin repairs 'brains cells damaged by depression' i... by dQw4w9WgXcQ on Wednesday July 07, 2021 @12:42AM (#27757446)

And as I read this comment, I'm amazed that this user doesn't believe calorie intake is a core component of emotional regulation and stress management. Has the user ever heard of terms like "stress eating" or that "hangry" has made it into the dictionary? Or has the user ever realized that despite all the stressors of Navy BUD/S and Army Ranger bootcamps, the one thing they do not restrict is calorie intake (and why)? Alas, poor skeptical user.

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Re:Psilocybin repairs 'brains cells damaged by depression' i... by iratewizard on Wednesday July 07, 2021 @12:48AM (#27757485)

I believe they're criticizing the somewhat unfounded idea of a stress-induced uncovering of past traumas in order to purge emotions about said traumas.

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Re:Psilocybin repairs 'brains cells damaged by depression' i... by ostenning on Wednesday July 07, 2021 @01:05AM (#27757585)

It’s not about the content, it’s about the delivery. People need to be more respectful of others anecdotal experiences. Evidence based Science cannot read between the lines all the time

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Re:Psilocybin repairs 'brains cells damaged by depression' i... by dQw4w9WgXcQ on Wednesday July 07, 2021 @12:52AM (#27757512)

And they are all welcome to point at the chair and claim it won't hold any weight. But until they try sitting the fuck down their critique is irrelevant.

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Re:Psilocybin repairs 'brains cells damaged by depression' i... by eloisius on Wednesday July 07, 2021 @01:05AM (#27757584)

I posit that drinking a daily capful of bleach will purge you of past trauma and negative emotions. Your critique is irrelevant unless you try it.

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Re:Psilocybin repairs 'brains cells damaged by depression' i... by dQw4w9WgXcQ on Wednesday July 07, 2021 @01:27AM (#27757729)

Except I've already tried the thing I'm "positing", so it would only be right that you try your capful of bleach regimen first, report back to me with your positive results, and then I will gladly follow.

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Re:Psilocybin repairs 'brains cells damaged by depression' i... by vasco on Wednesday July 07, 2021 @02:48AM (#27758132)

For anyone confused enough, bleach WILL kill you.

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Re:Psilocybin repairs 'brains cells damaged by depression' i... by eloisius on Wednesday July 07, 2021 @03:38AM (#27758429)

Yeah, I guess I should state the obvious punchline in case anyone is dumb enough to follow the fringe diet advice they read on HN: Drinking bleach will kill you and thus purge you of all past trauma and negative emotions.

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Re:Psilocybin repairs 'brains cells damaged by depression' i... by devwastaken on Wednesday July 07, 2021 @01:16AM (#27757656)

People don't have to "believe" in it. If what you're saying is true so easily, then it should be very easy to form a trial that proves it.

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Re:Psilocybin repairs 'brains cells damaged by depression' i... by nradov on Wednesday July 07, 2021 @03:53PM (#27765102)

Army Ranger School does restrict calorie intake.

https://mwi.usma.edu/challenge-ranger-school-can/

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Re:Psilocybin repairs 'brains cells damaged by depression' i... by dQw4w9WgXcQ on Wednesday July 07, 2021 @12:22AM (#27757341)

Try a 72-hr fast sometime and you'll have your answers and more!

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Re:Psilocybin repairs 'brains cells damaged by depression' i... by 14u2c on Wednesday July 07, 2021 @12:31AM (#27757384)

Ah yes, hunger induced delirium.

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Re:Psilocybin repairs 'brains cells damaged by depression' i... by NiceWayToDoIT on Wednesday July 07, 2021 @02:01AM (#27757899)

Nothing as special will happen after 72hrs of food fasting... humans can go on surprisingly long without food 8-42days and without food + water around 7 days.

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Re:Psilocybin repairs 'brains cells damaged by depression' i... by 14u2c on Wednesday July 07, 2021 @02:24AM (#27758004)

Sure, you'll survive without lasting damage, but thinking such a fast itself won't impact your brain chemistry seems a bit much.

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Re:Psilocybin repairs 'brains cells damaged by depression' i... by NiceWayToDoIT on Wednesday July 07, 2021 @03:01AM (#27758209)

It will impact there is no doubt about it, but not in such dramatic way as 'hunger induced delirium' you need much longer fast than 72hrs (talking about food fasting, not sure about dry fast). 24hrs to 72hrs food fast is quite common as part of preparations for medical procedures as colonoscopy...

https://news.ycombinator.com/item?id=27757942

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Re:Psilocybin repairs 'brains cells damaged by depression' i... by daddylongstroke on Thursday July 08, 2021 @09:35AM (#27771761)

...and you know, also something humans routinely did for hundreds of thousands of years without ill effect (called winter time).

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Re:Psilocybin repairs 'brains cells damaged by depression' i... by tomrod on Tuesday July 06, 2021 @11:54PM (#27757161)

Citation(s)?

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Re:Psilocybin repairs 'brains cells damaged by depression' i... by TimSchumann on Wednesday July 07, 2021 @12:01AM (#27757213)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3106288/

With the obligatory 'In Mice' addendum.

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Re:Psilocybin repairs 'brains cells damaged by depression' i... by dna_polymerase on Wednesday July 07, 2021 @05:08AM (#27759005)

Also worth checking out in the context: https://peterattiamd.com/the-mouse-trap-lost-in-translation/

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Re:Psilocybin repairs 'brains cells damaged by depression' i... by tomrod on Wednesday July 07, 2021 @12:40AM (#27757434)

Thanks.

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Re:Psilocybin repairs 'brains cells damaged by depression' i... by el_dev_hell on Tuesday July 06, 2021 @11:55PM (#27757171)

That sounds really interesting. Do you have any book recommendations that explain this process (ideally targeted at a non-medical audience)?

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Re:Psilocybin repairs 'brains cells damaged by depression' i... by dna_polymerase on Wednesday July 07, 2021 @05:05AM (#27758979)

Dr Peter Attia is obsessed with the topic :)

https://peterattiamd.com/tag/autophagy/

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Re:Psilocybin repairs 'brains cells damaged by depression' i... by lugged on Tuesday July 06, 2021 @11:59PM (#27757198)

Not a book but this does a good job exlaining it, https://youtu.be/FGoLcJxApCA

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Re:Psilocybin repairs 'brains cells damaged by depression' i... by totetsu on Wednesday July 07, 2021 @12:21AM (#27757337)

"the strong eat the weak", "autophagosomes are like soldiers", said my body builder standing in front of a "home farmstead" festooned set. .. this video is doing a lot more than explaining autophagy..

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Re:Psilocybin repairs 'brains cells damaged by depression' i... by lugged on Wednesday July 07, 2021 @07:52AM (#27760006)

What it does for you is between you and your YouTube overlords.

For me, I try not to judge people for their body shape and listen to what they have to say regardless.

The "festooned set" is a common thing across YouTube influencers and affiliate marketers, this guy particularly likes to push bone broth and other keto related stuff. Doesn't mean he isn't damn well versed in the subject matter though.

If you like I can track down some old 3 hour long talks on autophagy and fasting if you'd prefer, those doc's are pretty funny too sometimes.

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Re:Psilocybin repairs 'brains cells damaged by depression' i... by totetsu on Wednesday July 07, 2021 @11:00AM (#27761899)

Sorry if my comment seemed negative about the guy. Sometimes videos that have very marked signs like this one tickle my semiotics senses. It's a highly appealing video and I just wanted to pause and think why, and what other things it was transmitting.

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Re:Psilocybin repairs 'brains cells damaged by depression' i... by lugged on Wednesday July 07, 2021 @11:53AM (#27762504)

Not too negative, just wanted to make sure he was taken seriously, the amount of research and peer reviewed articles he covers in his videos is quite intensive, he doesn't half ass it at all.

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Re:Psilocybin repairs 'brains cells damaged by depression' i... by TimSchumann on Tuesday July 06, 2021 @11:59PM (#27757199)

I think 'The Cancer Code' by Dr. Jason Fung does a decent job of laying the groundwork.

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Re:Psilocybin repairs 'brains cells damaged by depression' i... by eyeball on Wednesday July 07, 2021 @12:09AM (#27757262)

That guy is a quack.

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Re:Psilocybin repairs 'brains cells damaged by depression' i... by TimSchumann on Wednesday July 07, 2021 @12:31AM (#27757385)

I mean, he's a licensed practicing physician in Toronto, Ontario and nothing he advocates seems too far out of the mainstream medical science to me.

Also, I just pulled out a copy of the book I mentioned, and in the appendix he's got 467 citations. I'd say ballpark over half of those are peer reviewed medical journals.

Doesn't seem very duck-like, but I'm interested to hear your take on why he's a quack.

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Re:Psilocybin repairs 'brains cells damaged by depression' i... by jk888 on Wednesday July 07, 2021 @12:51AM (#27757501)

Any able bodied individual with a decent understanding of microbiology can grow some mushrooms too.

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Re:Psilocybin repairs 'brains cells damaged by depression' i... by 55555 on Tuesday July 06, 2021 @11:57PM (#27757188)

In other words, Jilly Juice.

IME, there is always some nugget of truth behind bizarre public crazes.

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Re:Psilocybin repairs 'brains cells damaged by depression' i... by TimSchumann on Tuesday July 06, 2021 @11:57PM (#27757190)

You actually don't need the multivitamin. Salt is essential though. Magnesium and Potassium are also really good supplements to add.

But agree, fasting is great for cleaning up the biological cruft.

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