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Re:Vaccine hopes rise as Oxford jab prompts immune response ... by henearkr on Monday October 26, 2020 @07:50AM (#24895101)
This IS good news.

Now (soon, hopefully) people can acquire immunity through a vaccine, instead of through a virus that leaves long-lasting damage to the body (in particular, but not limited to, the brain).

Re:Vaccine hopes rise as Oxford jab prompts immune response ... by cheph on Monday October 26, 2020 @08:12AM (#24895252)
> leaves long-lasting damage to the body (in particular, but not limited to, the brain).

In what percentage of people who get COVID-19 is there long-lasting damage to the body? What other conditions did the people who get long-lasting damage to the body have? How does these numbers compare with other diseases?

Would appreciate citations.

Re:Vaccine hopes rise as Oxford jab prompts immune response ... by henearkr on Monday October 26, 2020 @08:29AM (#24895398)
Most people with COVID even with few symptoms have a loss of smell. If you like numbers, I read that around 80% of people with COVID report loss of smell.

And this is one kind of neurological effect. This is a more global view of how the virus could affect the brain:

https://www.scientificamerican.com/article/what-we-know-so-f...

And I'm not even touching the subjects of damage to the heart, clotting problems, etc.

Re:Vaccine hopes rise as Oxford jab prompts immune response ... by jlokier on Monday October 26, 2020 @08:40AM (#24895483)
The loss of smell is thought to be sensory, not due to affecting the brain.

However, those covid-induced strokes definitely affect the brain.

Re:Vaccine hopes rise as Oxford jab prompts immune response ... by henearkr on Monday October 26, 2020 @08:43AM (#24895514)
Yes you're right indeed, the Scientific American article even mentions what you say.
Re:Vaccine hopes rise as Oxford jab prompts immune response ... by OJFord on Monday October 26, 2020 @08:58AM (#24895656)
Nobody had it long enough ago to answer that. SARS-CoV-1 (1) patients have suffered years afterwards, see e.g. this article from 2010:

https://www.thestar.com/life/health_wellness/2010/09/02/sars...

Re:Vaccine hopes rise as Oxford jab prompts immune response ... by anoncake on Monday October 26, 2020 @10:03AM (#24896251)
SARS was 20 times as deadly as Covid.
Re:Vaccine hopes rise as Oxford jab prompts immune response ... by umanwizard on Monday October 26, 2020 @07:57AM (#24895148)
Do you have a source on how common severe long-term effects from Covid are? All I’ve seen are anecdotes.
Re:Vaccine hopes rise as Oxford jab prompts immune response ... by mcintyre1994 on Monday October 26, 2020 @08:11AM (#24895244)
There are some stats here for the UK, based on a symptom tracking app that's been active since about March. https://news.sky.com/story/coronavirus-long-covid-warning-as...

> One in 20 people with coronavirus are likely to have symptoms for eight weeks or more, according to a new study by King's College London.

> The research, which uses data from the COVID Symptom Study App, suggested so-called "long COVID" affects around 10% of 18 to 49-year-olds who become unwell with coronavirus.

Whole study is here: https://www.kcl.ac.uk/news/study-identifies-those-most-risk-...

Re:Vaccine hopes rise as Oxford jab prompts immune response ... by umanwizard on Monday October 26, 2020 @08:21AM (#24895316)
From your first link: 10% had any symptoms lasting longer than four weeks. That’s not “severe long-term effects”.

The actual study seems to say 1 in 20 have symptoms for eight weeks, which might be closer to what you could fairly describe as “long-term”, but says nothing about the severity (though I haven’t waded through the whole article).

Anyway, the drop-off from 10% having symptoms at 4 weeks to 5% at 8 weeks is encouraging - it intuitively suggests that the negative symptoms aren’t permanent, even if they take a long time to go away.

Re:Vaccine hopes rise as Oxford jab prompts immune response ... by breakfastduck on Monday October 26, 2020 @08:31AM (#24895409)
8 weeks certainly shouldn't be classified as 'long term'.

Long term health effect claims are being made all over the show - if this is the measure that is outrageous reporting.

Most people would worry about 'long term health effects' as they'd usually assume that it's going to go on for years.

Re:Vaccine hopes rise as Oxford jab prompts immune response ... by LandR on Monday October 26, 2020 @08:42AM (#24895497)
Yeah, last time I was sick I had the flu. I had lingering effects for around 8-10 weeks after. Eventually I had to go to hospital to get checked.

I feel a lot of Covid effects are being massively overblown because people aren't aware that other more common viruses that we don't worry about can have these "long term" effects as well.

Re:Vaccine hopes rise as Oxford jab prompts immune response ... by jlokier on Monday October 26, 2020 @08:53AM (#24895607)
People aren't worried about 8-10 weeks of lingering effects.

Those 4 week and 8 week statistics are part of an attempt to understand what's going on. It doesn't mean 8 weeks is considered long covid.

They are worried about effects where people got it months ago and are still disabled from it. Things like still struggling to walk upstairs 6 months after getting covid.

And that young, fit people are reporting it, not just "old".

The worry is that it doesn't appear to be getting better for them yet. The greatest worry is that people who get it might never recover, or might take years to recover. We can't know yet.

Flu and other viruses affect some people that way, but it's a small number of unlucky people. The worry is that the number affected by long covid in this way are a much larger number of people.

Re:Vaccine hopes rise as Oxford jab prompts immune response ... by breakfastduck on Monday October 26, 2020 @11:12AM (#24897008)
I have a colleague who is essentially disabled from it & has not returned to work, after 8 months, so I have first hand experience of what you speak.

My fear is that this is super, super, super rare, but figures are including long term as low as 8 weeks, so we have absolutely no idea how small / large the number of people having this critical level of long term effect actually is.

Re:Vaccine hopes rise as Oxford jab prompts immune response ... by jlokier on Monday October 26, 2020 @08:44AM (#24895529)
> Most people would worry about 'long term health effects' as they'd usually assume that it's going to go on for years.

There are plenty of anecdotes to be found of people reporting debilitating long-covid symptoms for 6 months so far. That's "still sick since I had it back in March/April".

(It hasn't been around for a year so nothing can be said about that timescale yet.)

That's significant enough that public health officials are talking openly about it as a concern, so it's not just a few isolated anecdata.

There are some reports suggesting neurological impairment. Along with observed blood changes (thickening), which is concerning regarding long term damage for rational reasons. If that turns out to be true, that sort of damage tends to never completely recover. Rather you learn to adapt and live with it.

Re:Vaccine hopes rise as Oxford jab prompts immune response ... by breakfastduck on Monday October 26, 2020 @11:14AM (#24897028)
Yes, my colleague is one of them. He has still not recovered after 8 months and is unable to work.

However, they stating they're also counting 8-10 weeks as long term, so the stats are obviously way inflated. I'd really like to know the number of people having the extreme effects, without the media trying to inflate the figure.

Re:Vaccine hopes rise as Oxford jab prompts immune response ... by singemonkey on Monday October 26, 2020 @07:53AM (#24895122)
As well as acquiring immunity without being infectious.

However, the efficacy of this vaccine (and all the other candidates) still needs to be clarified - ie is it like a measles vaccination (~90% efficacy) or the flu vaccines (~ 25% - 50% I believe).

Re:Vaccine hopes rise as Oxford jab prompts immune response ... by lbeltrame on Monday October 26, 2020 @08:03AM (#24895181)
For the FDA to even consider an emergency use authorization, they have put the following requirements:

- Efficacy of at least 60%

- Lower bound of efficacy (confidence interval) >= 30%

- Minimum safety data for at least one or two months post vaccination (I don't remember if it's one or two)

- At least five severe cases in the control arm

- Requirements for the trials to go on even if efficacy is found for an additional year after the trial end (for most of the trials, this means two years in total)

Re:Vaccine hopes rise as Oxford jab prompts immune response ... by viraptor on Monday October 26, 2020 @08:01AM (#24895166)
Sounds right for the flu. I was curious about the details - here's a good starting point. https://www.cdc.gov/flu/vaccines-work/vaccineeffect.htm?CDC_...
Re:Vaccine hopes rise as Oxford jab prompts immune response ... by soulofmischief on Monday October 26, 2020 @08:05AM (#24895199)
> in particular, but not limited to, the brain

Judging from our response to Covid-19, if this had actually been the collectively-feared zombie virus, the pandemic would have been far worse than any fictional account has manage to capture so far.

Re:Vaccine hopes rise as Oxford jab prompts immune response ... by mcv on Monday October 26, 2020 @11:13AM (#24897024)
Future zombie apocalypse stories need to include people who deny it as a hoax, blame it on foreign countries, claim it's just a mild flu, just continue partying as if there's no risk at all, claim it's caused by 5G technology, claim it's a conspiracy by the elite to accomplish whatever, and political parties split on the topic.
Re:Vaccine hopes rise as Oxford jab prompts immune response ... by emiliobumachar on Monday October 26, 2020 @08:26AM (#24895364)
It can't get much worse than everybody dead except for a dozen people in a basement, can it?
Re:Vaccine hopes rise as Oxford jab prompts immune response ... by uxcolumbo on Monday October 26, 2020 @08:35AM (#24895442)
How so?

World War Z

Walking Dead

Shawn of the Dead *

28 Days Later

The Last of Us

What's worse than the above?

* (ok maybe not this one)

Re:Vaccine hopes rise as Oxford jab prompts immune response ... by TimPC on Monday October 26, 2020 @12:03PM (#24897609)
Also if there was a real zombie virus none of the movies so far have captured the sheer absolute terror of hard to defend transmission vectors like mosquitos, which would be likely to get the virus. Brings a whole new level of issues to not getting bit.
Re:Vaccine hopes rise as Oxford jab prompts immune response ... by soulofmischief on Monday October 26, 2020 @10:59AM (#24896837)
As science fiction is speculative, I do not fault any of those listed media however I feel none of them truly captured the sociopolitical insanity that would occur, the sheer level of ignorance and incompetence which causes anything that could go wrong, to go wrong.
Re:Vaccine hopes rise as Oxford jab prompts immune response ... by joe_momma on Tuesday October 27, 2020 @08:04AM (#24906589)
We are headed towards: Hunger Games, Children of Men, Demolition Man, Judge Dredd, Escape from NY/LA