This paper isn't even really about the Alzheimers-herpes link, it's more about demoing how you can use HSV-1 with their brain structure to get what looks like a good model of Alzheimers disease. What they gave the model might not even be "real" Alzheimers. Their goal was to develop a really good research tool[0], not necessarily to show an AD/HSV link, and the cells in their model, as induced neuronal stem cells redifferentiated into brain-like tissue on a scaffold, might not be truly reacting like cells in your brain.
[0] from the discussion in the paper, here's the first line emphasizing the takeaway:
"Generating in vitro human models of sporadic AD poses a considerable challenge because of the complex, undefined etiology and slow disease progression that naturally occurs in patients. Here, we describe a multidisciplinary approach to address this critical need by generating robust and physiologically relevant 3D human tissues for studying sporadic AD through the use of hiNSC technology and HSV-1 in combination with a bioengineered brain tissue model."
The herpes-AD link is somewhat supported by this since clearly adding HSV to this brain model caused these AD-like developments, but that could be a factor of how the cells used to make these models react and their physiology might be different as differentiated induced stem cells.
My vet said the same (chronic respiratory problems in cats are often caused by feline herpesvirus). The effect on the cat is at best slight.
Also, the more I hear about the HSV/Alzheimer's link, the more I freak out about my shitty memory :(
That's the viral shedding.
Supplement before if I know I will be increasing UV exposure. e.g. visiting high desert
Visiting know stressful environment. (choose your own adventure)
Or if I think I might be starting to feel one coming on.
Outbreaks in the decades after are way down from outbreaks from the decades before, but please do remember correlation is not causation and becoming a person who can consider mitigation may be more significant then the particular ritual.
Oh and prescription anti-virals work wonders.
A peanut or nut binge would definitely worsen an outbreak, though.
Oral acyclovir also has no effect on the strain(s) I have. I have had an outbreak start while taking acyclovir prophylactically, and proceed through the whole cycle.
Valacyclovir 1000mg still works. Initially, one tablet. Now, 2 or 3.
TLDR: "Longer duration controlled studies of daily lysine doses exceeding 1.2 g/d are required to definitively test its role in herpes simplex prophylaxis"
EDIT: After reading through the provided table, to me it seems that most studies show little to no evidence that Lysine doses help against the virus. It looks like it's mostly placebo. (Disclaimer, I am not a virologist, this is my take on the paper.)