I used to supplement with a huge oversupply of lysine, enough that I could smell it on my skin, and taste it in my saliva. I could never detect any effect, whether shortening an outbreak, reducing severity, or preventing an outbreak. I have had to conclude that nerve cells that host the virus manage to keep excess lysine outside the cell.

A peanut or nut binge would definitely worsen an outbreak, though.

Oral acyclovir also has no effect on the strain(s) I have. I have had an outbreak start while taking acyclovir prophylactically, and proceed through the whole cycle.

Valacyclovir 1000mg still works. Initially, one tablet. Now, 2 or 3.