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Re:Why soap works so well on most viruses by twic on Thursday March 12, 2020 @01:51PM (#22559620)
As a biochemist, i think it's absolutely clear that viruses are not alive, because they don't do anything. No metabolism, no signalling, no changes in structure, no use of energy or materials. They just float about! It's only when they encounter a cell that anything happens, and then it's mostly the cell's machinery doing it.

If i was a molecular biologist, i would probably think it was absolutely clear that viruses are alive, because they contain a genome, and proteins encoded by the genome, and they use the proteins to make more copies of the genome. What else is life?

Re:Why soap works so well on most viruses by whalabi on Thursday March 12, 2020 @04:07PM (#22561184)
I'm of the opinion that whether something is alive or not is arbitrary, and depends on your definition. Humans just came up with the word to describe a class of things.

You could define biological life in a way that includes or excludes viruses, I would suggest, and be right either way.

(Also if a biological virus is alive, is a computer virus alive? It's self-replicating and has DNA in the form of code.)

Re:Why soap works so well on most viruses by Gibbon1 on Thursday March 12, 2020 @04:15PM (#22561265)
I have three tests for what's alive and what's not. Those are from most fundamental to least.

Fundamentally life is a thermodynamic machine. Takes energy and converts a portion of it to 'work'.

Under homeostatic control. There are feedback systems that maintain the integrity of the organism.

In theory has a way of reproducing. This more applies to the species as a whole. Since individuals incapable of reproducing are none the less alive.

Viruses only meet the last and weaker criteria in my book.

Re:Why soap works so well on most viruses by undersuit on Thursday March 12, 2020 @02:49PM (#22560310)
The virus isn't the lifeform. The virus is just one component needed for the lifeform to exist and reproduce. The lifeform is the infection.
Re:Why soap works so well on most viruses by pas on Thursday March 12, 2020 @03:03PM (#22560500)
So the lifeform is the disease? I think assigning "lifeform" status to an illness is not really helpful.

Viruses are just replicators. Grey/Green/Brown/Bio goo. They are just dumb machines made by brute-forcing (fuzzing) more complex machines' immune systems.

Viruses might be a different branch on the RNA-replicator tree. Probably when the first replicators started some found - again via brute-forced mutations - that there are some replicators that they can take advantage of to replicate themselves.

And it just seems that closing this security hole is neigh impossible as long as we don't start to seriously tinker with that low level of "life" (eg. cellular machinery, transport, nucleus, messenger and transcription security).

Re:Why soap works so well on most viruses by akiselev on Thursday March 12, 2020 @09:50PM (#22564009)
> Viruses might be a different branch on the RNA-replicator tree. Probably when the first replicators started some found - again via brute-forced mutations - that there are some replicators that they can take advantage of to replicate themselves.

One of the dominant theories for how eukaryotic organisms evolved (and by extension multicellular life) is by incorporating viruses and other prokaryotes internally and there's evidence a variety of viruses permanently entered the gene pool of several animals that were theoretically naturally selected for. It's less a branch and more a mobius rat's nest.

Re:Why soap works so well on most viruses by undersuit on Thursday March 12, 2020 @04:15PM (#22561263)
> They are just dumb machines made by brute-forcing (fuzzing)

But that's no different how the rest of biology works. A parasite like Giardia is relatively just a dumb machine brute forcing itself through my immune system.

Re:Why soap works so well on most viruses by pas on Friday March 13, 2020 @09:41AM (#22567162)
No, no, of course not. You're right. The same exploitation of complexity-difference can be observed all the way up the hierarchy. But that doesn't make it "living". (Or if you define liveness on a spectrum, like we sort of do with sentience/consciousness, then viruses are alive like rust is conscious.)

It's very likely an invariant of complexity. Trade offs (and friendly turtles) all the way. And of course evolution doesn't optimize for QALY at all. So it's not surprising that it hasn't really spent much resources on closing the gap. And now we try to do it because we do find it a better goal than "just" thriving in every imaginable niche on whatever complexity it's possible. (We want to maintain our complexity plus occupy more niches.)

Re:Why soap works so well on most viruses by filleduchaos on Thursday March 12, 2020 @09:05PM (#22563772)
I think you are narrowing on one phrase and ignoring all of the context around it, which is generally not very conducive to understanding a speaker's point.
Re:Why soap works so well on most viruses by Paul-ish on Thursday March 12, 2020 @03:08PM (#22560553)
Physically, what constitutes the infection?
Re:Why soap works so well on most viruses by undersuit on Thursday March 12, 2020 @04:19PM (#22561298)
The viral RNA, whatever the viral RNA is producing, and whatever components of the cell are directly working on the new viruses. There are intracellular parasites, a viral infection is just an intracellular parasite... that doesn't have a definite boundary like a cell membrane.
Re:Why soap works so well on most viruses by mratsim on Thursday March 12, 2020 @03:08PM (#22560552)
interesting point of view
Re:Why soap works so well on most viruses by undersuit on Thursday March 12, 2020 @06:55PM (#22562862)
I think I came around to that way of thinking after reading about multi-part viruses: https://www.the-scientist.com/the-nutshell/newly-discovered-...
Re:Why soap works so well on most viruses by twic on Friday March 13, 2020 @05:31AM (#22565895)
See also adeno-associated viruses, which can only replicate in a cell which has been infected by another virus:

https://en.wikipedia.org/wiki/Adeno-associated_virus#Infecti...

Re:Why soap works so well on most viruses by achillesheels on Thursday March 12, 2020 @02:58PM (#22560422)
This is the key point I think: viruses have no metabolism. There is no stable energy transfer with their environment. Their genomic feedback does not promote metabolic growth (ie greater energy transmission rates).
Re:Why soap works so well on most viruses by chmike on Thursday March 12, 2020 @02:11PM (#22559839)
A virus is not able to reproduce itself on its own. Because of that I don't consider virus as a life form. I'm biologist, in case it matters.
Re:Why soap works so well on most viruses by SigmundA on Thursday March 12, 2020 @02:24PM (#22559985)
I cannot reproduce on my own, I need a mate and food and water and air to properly reproduce, that is most life is dependent on its environment to survive including other organisms depending on their needs.

A virus needs a host like any parasite, without the host many parasites would not be able to reproduce.

Re:Why soap works so well on most viruses by akiselev on Thursday March 12, 2020 @09:58PM (#22564049)
On a technical level, whether something can reproduce by itself or not is defined by whether they use their own chemical machinery to produce the offspring, such as when a cell divides itself or organisms produce their own gametes.

To be pedantic, all you need is at most two (or three, maybe?) of the right gender to reproduce in a vacuum (metaphorically) to make it a living organism. A virus can't reproduce with another virus that way because it can't do anything on its own other than float around waiting for a host, no matter how many strains you mix it with. The host does the actual reproducing for the virus.

Re:Why soap works so well on most viruses by kazinator on Friday March 13, 2020 @11:16AM (#22567918)
Indeed; the virus being reproduced is just a side effect of the cell making reproducing actions.

Cells can repeatedly produce certain proteins. For instance, a silkworm can spin out a thread of silk. That doesn't meant that molecules of silk are alive because they are reproducing.

Re:Why soap works so well on most viruses by SigmundA on Friday March 13, 2020 @01:07PM (#22568959)
Silk doesn't go on and reproduce through another silk worm once made its complete.

Any parasite that requires its host for reproduction could be said to be a byproduct of the host continuing its biological functions usually at the expense of the host.

Nature draws no clear lines, humans apply taxonomy, any line we draw about what is alive and what isn't will be arbitrary.

My opinion is a virus is alive as it core process is based on how all life on earth operates through DNA/RNA. That is my arbitrary line, a distinct self contained genetic code that continues to replicate and evolve is alive. If that code can no longer continue replicating successfully it is dead.

Re:Why soap works so well on most viruses by kazinator on Thursday March 12, 2020 @09:15PM (#22563828)
A virus by itself does not perform any biological functions whatsoever; it just alters the course of events in a host cell.

Potassium cyanide can alter what happens in a cell; that doesn't mean potassium cyanide is alive.

Re:Why soap works so well on most viruses by uoaei on Thursday March 12, 2020 @02:36PM (#22560145)
Humans aren't either. We need food and water and a hospitable environment to get to a point where we can do that.
Re:Why soap works so well on most viruses by undersuit on Thursday March 12, 2020 @02:46PM (#22560278)
I think that's a pretty good analogy. Viruses are just as incapable of being considered life as our chromosomes are, until you give them a support network.
Re:Why soap works so well on most viruses by filleduchaos on Thursday March 12, 2020 @09:06PM (#22563776)
This is a confusion of _can_ and _will_.
Re:Why soap works so well on most viruses by twic on Thursday March 12, 2020 @02:32PM (#22560089)
Are lichen fungi life forms?
Re:Why soap works so well on most viruses by stjohnswarts on Thursday March 12, 2020 @11:42PM (#22564524)
Not unlike prions? which have some qualities of "life" but really can't be considered as such?