News for hackers. Stuff that matters.
Re:Wuhan seafood market may not be source of novel virus spr... by yurlungur on Friday January 31, 2020 @05:18PM (#22206489)
The market resides in the heart of the city so it could be that there was some other route of transmission through carriers without symptoms, animals etc.

To claim that this came from a lab certain requires more evidence than its mere existence. The whole RNA sequence is available online and so far no expert to my knowledge has claimed it looks synthetic.

Re:Wuhan seafood market may not be source of novel virus spr... by perennate on Friday January 31, 2020 @05:56PM (#22206806)
I didn't read anything in the posted article that indicates that the China-based researchers think it came from a lab or looks synthetic. So I didn't understand why you are responding to a claim that they aren't making.
Re:Wuhan seafood market may not be source of novel virus spr... by graeme on Friday January 31, 2020 @06:03PM (#22206869)
Lots of posts in this thread were making the claim about the lab. They’re less upvoted now.
Re:Wuhan seafood market may not be source of novel virus spr... by perennate on Friday January 31, 2020 @06:04PM (#22206885)
Ah that makes more sense, it was confusing because it was posted as a top-level comment instead of a reply.
Re:Wuhan seafood market may not be source of novel virus spr... by chadmeister on Friday January 31, 2020 @08:46PM (#22207945)
Thank you for clarifying this! I will rescind my downvotes
Re:Wuhan seafood market may not be source of novel virus spr... by ajross on Friday January 31, 2020 @07:36PM (#22207523)
The virology lab thing is a very popular conspiracy theory. Really the only evidence is that the virus started in the general viscinity of the lab, and that the lab was (somewhat vaguely, but not completely implausibly) suspected of doing bioweapons research.

It's worth rebutting. The nonsense is a little out of control.

Re:Wuhan seafood market may not be source of novel virus spr... by LargoLasskhyfv on Friday January 31, 2020 @08:58PM (#22208017)
You know? I thought about your 'nonsense' and recalled something rather old in 'internet time'.

Anyways, i just searched for russian bio lab accident and this came up first: https://arstechnica.com/science/2016/11/decades-after-deadly...

I'm sure there is more to find about that, but for the purpose of rebutting your nonsense i deem it sufficient.

What do i mean by that? The theories aren't unfounded when looking back, because they happened! It doesn't really matter where, when, by whom, and what exactly. Just that it did happen multiple times.

Cheers.

edit: Well, it even has a wikipedia article if you prefer that https://en.wikipedia.org/wiki/Sverdlovsk_anthrax_leak

Re:Wuhan seafood market may not be source of novel virus spr... by betterbeehome on Saturday February 01, 2020 @12:00AM (#22208794)
I don't get it. Why are people knee-jerk adverse to this idea? We're not arguing with flat earthers or moon landing skeptics. It's entirely plausible. With people putting their reputation on it, too. Dany Shoham (Israeli biological warfare expert) put his name on the line point this out before a lot of people.

It's not out of the realm of possibility and shouldn't be disregarded out of hand like it has been. Could be from there or maybe not. We really need more information from China to settle some of these discussions.

Re:Wuhan seafood market may not be source of novel virus spr... by beowulfey on Saturday February 01, 2020 @05:25AM (#22209782)
The tricky part is that we have zero evidence. It’s not that it’s not a reasonable hypothesis, it’s that it’s nothing more than speculation. This is fine in general, but many people do not generally understand the difference between a hypothesis and pure speculation, and may attribute more weight to a guess than it deserves.

It is important to remember that there is zero evidence of this theory, and yet despite that it is spreading through the Internet populace faster than the virus itself.

Re:Wuhan seafood market may not be source of novel virus spr... by Aperocky on Saturday February 01, 2020 @01:00AM (#22209001)
> Dany Shoham

So the same guy that claimed ISIS have biological weapon? Other than public information, so what does he know that others don’t? this guy has no credibility to begin with.

Re:Wuhan seafood market may not be source of novel virus spr... by roenxi on Saturday February 01, 2020 @03:04AM (#22209355)
The odds are fairly slim. Wuhan is a large Chinese city that has a greater population than most countries.

There is going to be an (X) in Wuhan for any value of (X) anyone cares to name. The fog of uncertainty is still thick; nobody has much of an idea what is going on. Anyone claiming that they have a theory on where the virus came from is fantasising. The knee-jerk people probably don't want them drowning out a weak signal with useless noise.

Re:Wuhan seafood market may not be source of novel virus spr... by crubier on Saturday February 01, 2020 @03:40AM (#22209485)
There is only one Biosafety level 4 laboratory in China, and it opened... last year in... Wuhan. I am not saying there is a link, but I would not dismiss it too fast.
Re:Wuhan seafood market may not be source of novel virus spr... by biolurker1 on Saturday February 01, 2020 @07:08AM (#22210085)
What is the probability that in Wuhan exists the only X in the vast country and Y happens only once in a decade or so
Re:Wuhan seafood market may not be source of novel virus spr... by roenxi on Saturday February 01, 2020 @08:11AM (#22210316)
There'd be a bunch of BSL-3 facilities all over the place. It isn't like the Black Death or the Spanish Flu needed a BSL-4 facility to incubate in.

It is possible; but a lot of things are possible. It is a mighty leap from a starting point of basically no primary evidence and all the people who have on-the-ground access to evidence are very busy managing a rapidly growing crisis.

Re:Wuhan seafood market may not be source of novel virus spr... by trenning on Saturday February 01, 2020 @01:08PM (#22212049)
There's also that time the USG tested the effects of bioweapon spreading on San Francisco and other US cities. It's not like countries don't have a history of this.

https://www.businessinsider.com/military-government-secret-e...

Re:Wuhan seafood market may not be source of novel virus spr... by yibg on Saturday February 01, 2020 @01:10AM (#22209025)
They have happened at some place at some point in the past seems pretty weak to go on. A lot of things have happened in the past, doesn't mean they're all potential causes this time around. Seems to me we need a bit more than we've had bio lab incidents before.

I mean by this measure any time someone crashes a car it could be an assassination attempt. It's happened before.

Re:Wuhan seafood market may not be source of novel virus spr... by LargoLasskhyfv on Saturday February 01, 2020 @01:56AM (#22209156)
I didn't mean to say that something like this IS the cause, just that it could be. Right now we don't have enough data and facts to confirm or dismiss either.

What rubs me the wrong way are the people instantly dismissing something like this as unlikely, or even impossible ignoring history.

Re:Wuhan seafood market may not be source of novel virus spr... by stef25 on Saturday February 01, 2020 @01:25AM (#22209062)
Because it happened before means it's happened again?

The amount of novel virus to have emerged from labs so far is probably very close to, if not zero.

Re:Wuhan seafood market may not be source of novel virus spr... by LargoLasskhyfv on Saturday February 01, 2020 @01:57AM (#22209162)
Do you want to believe that, or do you know?
Re:Wuhan seafood market may not be source of novel virus spr... by IIAOPSW on Friday January 31, 2020 @09:40PM (#22208237)
A conspiracy theory is a symptom of what people already suspect and believe about those in positions of authority. In this case the suspicion is that the epidemic is a result of a preventable accident and the incompetence and corner-cutting of the lab is being covered up to save face. People believe it because safety endangering corruption, saving face, and covering up industrial accidents are all very prevalent in Chinese society. In recent memory there's been high profile cases like the tainted milk powder, the HSR accident (that was literally buried), the explosion in tian jin etc.
Re:Wuhan seafood market may not be source of novel virus spr... by CriticalCathed on Friday January 31, 2020 @06:57PM (#22207263)
Well, there's one pre-print paper that goes as far as saying that because some segments of the RNA resemble, closely, parts of HIV, that those may have been inserted by human efforts. Of course, there's been a lot of pushback to this assertion; detractor say that this "inserted segment" actually shows up in all kinds of things and it also being in HIV is not significant here.

For the article and the pushback, see this link and its comments:

https://www.biorxiv.org/content/10.1101/2020.01.30.927871v1

Re:Wuhan seafood market may not be source of novel virus spr... by RossBencina on Saturday February 01, 2020 @03:31AM (#22209451)
Re:Wuhan seafood market may not be source of novel virus spr... by RivieraKid on Friday January 31, 2020 @06:30PM (#22207080)
The lab theory seems unlikely but out of curiosity, how would a lab approach creating a dangerous virus? Presumably they would iteratively try modifying an existing RNA, synthesize it, then breed the virus and test it on mice?
Re:Wuhan seafood market may not be source of novel virus spr... by Aperocky on Friday January 31, 2020 @05:38PM (#22206652)
To add to this, there are 20+ genomes available now.

It’s being closely tracked and any claims should not be made without genome.

Re:Wuhan seafood market may not be source of novel virus spr... by stevenwoo on Saturday February 01, 2020 @10:12AM (#22210875)
Some sort of stock market manipulation ploy? https://www.theverge.com/2020/1/31/21117663/twitter-zero-hed...
Re:Wuhan seafood market may not be source of novel virus spr... by mc32 on Friday January 31, 2020 @05:40PM (#22206667)
Modified, not synthetic.
Re:Wuhan seafood market may not be source of novel virus spr... by svara on Friday January 31, 2020 @06:36PM (#22207117)
A couple of days ago I posted a link to the BLASTN sequence alignment between the 2003 SARS virus and the Wuhan virus in a comment on one of the other discussions here.

You can see they are closely related, at about 88% sequence identity. There are point mutations spread more or less evenly over the entire genome. This is how evolution works on genomes, and basically rules out genetic engineering, since researchers would perform specific localized changes to specific proteins, or contiguous insertions of genetic material from evolutionarily distant sources.

Source: Go over to NCBI and do the alignment yourself, also am PhD biologist.

PS: The amount of pseudoscience being peddled for attention or thrills in these threads is getting really worrying to me, I had expected something totally different from this community. :/

Re:Wuhan seafood market may not be source of novel virus spr... by SECProto on Friday January 31, 2020 @08:31PM (#22207872)
> The amount of pseudoscience being peddled for attention or thrills in these threads is getting really worrying to me, I had expected something totally different from this community. :/

I believe this is generally the case with most topics outside the standard focus of this site (which I would posit is computers generally). There tends to be a mixture of intelligent, accurate commentary, and intelligent but misled commentary (and my observers bias would further distort the separation between those two categories). It tends to get better as discussion continues, but not always.

That said, this topic is more likely to be sensationalized than most.

Re:Wuhan seafood market may not be source of novel virus spr... by OJFord on Friday January 31, 2020 @10:38PM (#22208479)
When you know enough about something, there's horrible misinformation on it everywhere, even on HN.

But one of my favourite things about HN is the rebuttals, deep-dives, and 'well, actually's of informed commenters discussing niches I know little about.

Re:Wuhan seafood market may not be source of novel virus spr... by SECProto on Friday January 31, 2020 @11:30PM (#22208668)
For sure. The best way to get the right answer on [hackernews] isn't to ask a question, it's to give the wrong answer.
Re:Wuhan seafood market may not be source of novel virus spr... by mirimir on Saturday February 01, 2020 @01:46AM (#22209128)
Actually, both have worked for me.

But yeah, wrong answers are more informative.

Re:Wuhan seafood market may not be source of novel virus spr... by wtmt on Friday January 31, 2020 @10:52PM (#22208529)
If you’re an expert in this area, it would help everyone else if you compose and put up a top level comment explaining things. It could get upvoted to be among the first few comments, steering the conversation accordingly. Replies to specific comments with limited information won’t help as much since they won’t bubble up.
Re:Wuhan seafood market may not be source of novel virus spr... by nostrademons on Friday January 31, 2020 @11:31PM (#22208675)
(They actually bubble up their parent comment thread, if they're upvoted highly enough. I've seen comment threads where the #1 post has negative point values, but is on top because the response is from someone with firsthand knowledge of the issue which gets upvoted to 100s of points.)
Re:Wuhan seafood market may not be source of novel virus spr... by clarry on Saturday February 01, 2020 @07:34AM (#22210187)
> Source: Go over to NCBI and do the alignment yourself, also am PhD biologist.

> PS: The amount of pseudoscience being peddled for attention or thrills in these threads is getting really worrying to me, I had expected something totally different from this community. :/

On the flip side, I've seen lots of "experts" chime in and say things that prove to be wrong. For example, during the early stages of the 2011 Fukushima disaster, I recall reading comments by lots of "experts" explaining how there's little to worry about and they referred to things like core catchers and all the other mechanisms that are supposed to protect a (modern) nuclear power plant in emergency. As is evident, much of their expertise did not apply and things that weren't supposed to go wrong went wrong.

I don't remember specific cases but I'm pretty sure I've witnessed a similar pattern over and over again here, and just seeing news of coronavirus outbreak immediately brought back memory of -- and prediction of -- experts chiming in telling people why it's nothing to be concerned about and why all the pop news scare is overblown. I'm getting kind of a dejavu feeling here.

Re:Wuhan seafood market may not be source of novel virus spr... by aguyfromnb on Saturday February 01, 2020 @08:39AM (#22210437)
>On the flip side, I've seen lots of "experts" chime in and say things that prove to be wrong.

If you go back and read about any newsworthy event there are experts getting it wrong.

Re:Wuhan seafood market may not be source of novel virus spr... by throwaway41968 on Saturday February 01, 2020 @11:39AM (#22211427)
>The amount of pseudoscience being peddled for attention or thrills in these threads is getting really worrying to me, I had expected something totally different from this community. :/

HN is good when it comes to technology, and that's what I browse it for. When it comes to genetics or biology...not so much. Engineer's disease runs definitely stronger than coronaviruses here.

Re:Wuhan seafood market may not be source of novel virus spr... by diyseguy on Friday January 31, 2020 @08:49PM (#22207965)
Re:Wuhan seafood market may not be source of novel virus spr... by diyseguy on Saturday February 01, 2020 @01:29AM (#22209070)
Re:Wuhan seafood market may not be source of novel virus spr... by aguyfromnb on Saturday February 01, 2020 @08:35AM (#22210421)
>This is how evolution works on genomes, and basically rules out genetic engineering, since researchers would perform specific localized changes to specific proteins, or contiguous insertions of genetic material from evolutionarily distant sources.

Honest question: if this is common knowledge of people in the field, why wouldn't people genetically engineering a virus (and trying to hide it) do so in a fashion to make it look more like evolution in the genomes? Is that not possible to do?

Re:Wuhan seafood market may not be source of novel virus spr... by Accujack on Monday February 03, 2020 @03:45PM (#22228838)
Given that modifying an RNA virus to obtain specific results from an infection is very hard to begin with, also working with the limitation that your changes to the virus have to look "natural" makes it essentially impossible by being impractical.

On top of that, there's no reason to do it for a military weapon. For military use you don't infect a few people and hope it spreads, you infect a whole bunch and hope the whole thing spreads quickly enough that the virus can't be stopped, and it overwhelms an entire population by incapacitating or killing them.

Dispersing virus over a significant fraction of a population isn't easy or quiet, so whether it's a natural disease or GMO doesn't matter, because they'll know who did it.

The only scenario in which it makes sense to evolve a genetically engineered weapon in a way that hides its origins is for bioterrorism... and bioterrorism is very rare because it's a lot harder technically than terrorism that consists of shooting up a military base or running an exploding motorboat into a ship.

Re:Wuhan seafood market may not be source of novel virus spr... by throwaway41968 on Saturday February 01, 2020 @11:44AM (#22211453)
Doing a bunch of point mutations that "look" like a normal evolutionary process seems awfully expensive just to engineer a virus that's less threatening than, you know, the flu.
Re:Wuhan seafood market may not be source of novel virus spr... by aguyfromnb on Saturday February 01, 2020 @12:47PM (#22211869)
>a virus that's less threatening than, you know, the flu.

How can you say this as fact when we don't even know the morbidity rate of the coronavirus? The story isn't over yet, but it looks like it could be twice as deadly as influenza.

Re:Wuhan seafood market may not be source of novel virus spr... by throwaway41968 on Sunday February 02, 2020 @06:12PM (#22220120)
Bet you $500 it won't.
Re:Wuhan seafood market may not be source of novel virus spr... by gdm85 on Saturday February 01, 2020 @08:12AM (#22210320)
> The amount of pseudoscience being peddled for attention or thrills in these threads is getting really worrying to me

That's because a reality like Michael Crichton's novels is fun to imagine, albeit...fictional.

Re:Wuhan seafood market may not be source of novel virus spr... by MichaelMoser123 on Saturday February 01, 2020 @12:55AM (#22208980)
i looked up the discussion you mentioned, and a comment right next to yours came to an opposite conclusion, also based on some BLAST result (all of them now expired). I am just a confused laymen.
[dead]
Re:Wuhan seafood market may not be source of novel virus spr... by exdsq on Friday January 31, 2020 @07:46PM (#22207607)
Lobste.rs looks cool but I see you can only join if you're invited by an existing member. Would you mind sending one to me, or letting me know where I can go about getting one? :)

edward [dot] haigh [at] iohk [dot] io

Re:Wuhan seafood market may not be source of novel virus spr... by exdsq on Saturday February 01, 2020 @04:41AM (#22209651)
Not sure how this comment was downvoted!
Re:Wuhan seafood market may not be source of novel virus spr... by DrAwdeOccarim on Friday January 31, 2020 @08:32PM (#22207876)
Do you need biotech people?
Re:Wuhan seafood market may not be source of novel virus spr... by ggffryuuj on Saturday February 01, 2020 @07:56AM (#22210250)
We need smart people. The topics are only ever software development but none the less I’ve reviewed your comment history and you can have an invite if you want.
Re:Wuhan seafood market may not be source of novel virus spr... by DrAwdeOccarim on Saturday February 01, 2020 @09:18AM (#22210600)
Re:Wuhan seafood market may not be source of novel virus spr... by ggffryuuj on Friday January 31, 2020 @08:13PM (#22207784)
I’ve reviewed your comment history and was pleased with the technical stuff and lack of flaming. Expect an invite in the next 24 hours
Re:Wuhan seafood market may not be source of novel virus spr... by wtmt on Friday January 31, 2020 @10:56PM (#22208547)
This kind of “Gmail Beta” thingy that makes the service a premium and doesn’t allow people to join in good faith is why I didn’t join said site. I once waited there for an invite on chat, was polite and everything, but didn’t get invited. I also didn’t see many comments on most posts there. So the exclusivity, as I saw it then, was a drawback to the quantity and quality of the site and discussions. I’m no longer interested in begging around for something that wouldn’t be as valuable as HN.
Re:Wuhan seafood market may not be source of novel virus spr... by salemh on Friday January 31, 2020 @05:44PM (#22206707)
Any source you have found credible? Their is a lot of information going around in both directions.
Re:Wuhan seafood market may not be source of novel virus spr... by corporateslave5 on Friday January 31, 2020 @06:03PM (#22206870)
I personally think any academics thinking parts are synthetic aren’t speaking about it
Re:Wuhan seafood market may not be source of novel virus spr... by ashildr on Friday January 31, 2020 @06:45PM (#22207179)
You have a very lax definition of “Information”. There is absolutely nothing suggesting that Wuhan is man made. I expected a little more scientific perspective from this forum.
Re:Wuhan seafood market may not be source of novel virus spr... by dang on Saturday February 01, 2020 @02:24AM (#22209228)
This forum has millions of readers. Human nature inevitably shows up at scale. Double that for human nature on the internet.
Re:Wuhan seafood market may not be source of novel virus spr... by droithomme on Friday January 31, 2020 @09:39PM (#22208232)
> so far no expert to my knowledge has claimed it looks synthetic

True, it's no single expert. It's experts. The HIV-1 insertions, made at functional points, are reasonably suspicious and worthy of further analysis.

Re:Wuhan seafood market may not be source of novel virus spr... by corporate_shi11 on Friday January 31, 2020 @09:00PM (#22208030)
>"The whole RNA sequence is available online and so far no expert to my knowledge has claimed it looks synthetic."

This is no longer true. See:

'Uncanny similarity of unique inserts in the 2019-nCoV spike protein to HIV-1 gp120 and Gag'

https://www.biorxiv.org/content/10.1101/2020.01.30.927871v1

These are findings from IIT researchers who have found "uncanny" similarities between nCov and HIV which could increase virality.

Re:Wuhan seafood market may not be source of novel virus spr... by longtom on Friday January 31, 2020 @09:22PM (#22208140)
This finding has been debunked in the meanwhile though. The suspicious inserts are fairly short and NOT unique to HIV.

See these threads:

https://twitter.com/trvrb/status/1223337991168380928

https://twitter.com/bblarsen1/status/1223343688400527360

Seems the entire publish and peer-review cycle occurs on the scale of hours or days now, lol.

Re:Wuhan seafood market may not be source of novel virus spr... by erokar on Friday January 31, 2020 @06:58PM (#22207268)
Parts of the HIV virus have been identified in it: https://www.biorxiv.org/content/10.1101/2020.01.30.927871v1....

"Our analysis of the spike glycoprotein of 2019-nCoV revealed several interesting findings: First, we identified 4 unique inserts in the 2019-nCoV spike glycoprotein that are not present in any other coronavirus reported till date. To our surprise, all the 4 inserts in the 2019-nCoV mapped to It is made available under a CC-BY-NC-ND 4.0 International license. preprint (which was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. bioRxiv preprint first posted online Jan. 31, 2020; doi: http://dx.doi.org/10.1101/2020.01.30.927871. The copyright holder for this short segments of amino acids in the HIV-1 gp120 and Gag among all annotated virus proteins in the NCBI database. This uncanny similarity of novel inserts in the 2019- nCoV spike protein to HIV-1 gp120 and Gag is unlikely to be fortuitous."

https://mobile.twitter.com/DrEricDing/status/122330594672370...

Re:Wuhan seafood market may not be source of novel virus spr... by drcode on Friday January 31, 2020 @07:02PM (#22207301)
Other people have written about the HIV-lookalike segment mentioned in that paper and believe it is likely due to chance https://twitter.com/HelenBranswell/status/122336155449582387...
Re:Wuhan seafood market may not be source of novel virus spr... by Aperocky on Friday January 31, 2020 @07:17PM (#22207402)
Can it be the jumped from bat to human happened in an immunocompromised individual with HIV?
Re:Wuhan seafood market may not be source of novel virus spr... by justinzollars on Friday January 31, 2020 @07:44PM (#22207595)
This paper is not yet peer reviewed. I'm sure this claim will be studied exhaustively in the coming days/weeks.