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Re:Anti-Aging Startup Raises $116M With Bezos Backing by a13n on Thursday October 27, 2016 @07:13PM (#12811286)
I'm not a billionaire and I'm not old, but I am so excited about anti-aging. I know Hacker News is super negative, but who doesn't want to live longer?! Of all the pain points humans experience, you'd think death lies pretty high on the list. Why are people fighting this?
Re:Anti-Aging Startup Raises $116M With Bezos Backing by pointytrees on Thursday October 27, 2016 @07:22PM (#12811353)
I sometimes talk about wanting to live forever and get weird stares. Are you joking me?? I want to hike every trail in the world. I want to climb every mountain. I want to play every video game. I want to beat the hardest raids in every expansion of WoW. I want to learn multiple langauges. I want to spend several years living in every biome. I want to learn all of the programming languages. I want to go back to school for more degrees. I want to build several businesses. I want to write computer games from scratch. I want to travel to the stars. I want to live on the moon. I want to live on Mars. I want to get a doctorate degree. Or two or three? Gah, not enough time.
Re:Anti-Aging Startup Raises $116M With Bezos Backing by matt_wulfeck on Thursday October 27, 2016 @07:48PM (#12811524)
Thankfully death comes along and sorts through the wants from the willing. It has a nice way of making space for a newer generation of thinkers. Old prejudices die, new thinkers arrive.

There's nothing wrong with your thinking. In my humble opinion it shows your personal desires without much concern for everyone else. I guess this is the rub I get from most people that extol the Silicon Valley dream of extending the lives*

*of those that will inevitably be able to pay for it.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by eli_gottlieb on Thursday October 27, 2016 @08:29PM (#12811774)
>There's nothing wrong with your thinking. In my humble opinion it shows your personal desires without much concern for everyone else.

Oh shush. You know, I've got a 93-year-old grandmother with a damned sharp wit who should not fucking need assisted living and should be able to remember what we were talking about five minutes ago. I've also got a 68-or-so uncle who came down with Parkinson's Disease almost instantly upon his retirement from a lifetime of practicing medicine.

That's not to mention the in-laws with fibromyalgia and the step-father with several "bad lifestyle" diseases.

If your argument in favor of aging and death is, "Indiscriminately inflicting extreme suffering to randomly-selected people for every moment of their lives really helps to freshen up the world", you should reconsider. The problems I mentioned are not unique and special things that happened like a car accident happens. They're just what happens to everyone from living long enough. The bit at the end where you go to sleep and never wake up is nothing; the problem is the decades of suffering followed by that.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by notgood on Thursday October 27, 2016 @09:17PM (#12812141)
People like to assume the natural course its somehow the best course, but its far from the true, the fact its that from a biological perspective its much easier to start from scratch than to remain alive for too long; and that's how evolution works, evolution does not care much about what happens after your reproductive years have gone by (so to speak), maybe only enough so you can take care of your offspring while is needed, but thats about it.

Dragon Flys only live for 4 weeks, but its enough time to reproduce and that's all "mother nature" cares about, and hardly anyone would suggest that living 4 weeks is long enough; so we need to understand our lifespans are just as arbitrary.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by pdonis on Friday October 28, 2016 @12:01AM (#12812966)
> evolution does not care much about what happens after your reproductive years have gone by

So what? We humans care.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by Taek on Friday October 28, 2016 @02:09AM (#12813504)
The tools that made us successful as a species capped our lifespans. Technology may have changed that equation such that it makes more sense to live longer (or forever), but if immortality had made evolutionary sense up to this point we'd see a few immortals walking around.

For whatever reason, hardcoded death was the more successful route for a species to take. (with some notable exceptions. I believe there are species of lobsters that won't die if you put them in the right environment, I believe a species of jellyfish as well, and then some microorganisms as well)

Re:Anti-Aging Startup Raises $116M With Bezos Backing by ehnto on Friday October 28, 2016 @03:35AM (#12813799)
Mother nature could never have awareness for the contexts in which we live now.

Purely biological success knows nothing of the societies we have built and the knowledge, ability to experience, and the complex contexts within which we all live our lives. Death really doesn't make sense for an individual, and no one is really itching for Humans V1.1 so the idea of letting evolution continue doesn't make much sense either.

If I could stop aging right now, I would be content with what I am capable of. Even if I die in 30 years from bus to head syndrome, I will have been fit and active for those years and that is a much better situation than slowly deteriorating to death.

That is the reality medicine has given us already, and anti-aging is only the focusing of a subset of general health issues that tend to cause problems as we age. It isn't the search for the imoral and exclusive elixr of life as some people seem to claim it is.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by Taek on Friday October 28, 2016 @04:05AM (#12813910)
> no one is really itching for humans v1.1

Then why are we spending so much energy trying to augment ourselves? Better exercise, better diets, better schools, less disease, etc.

I would say that almost everyone can name something about themselves that they wish evolution had optimized more. (And if not evolution, then direct intervention).

Re:Anti-Aging Startup Raises $116M With Bezos Backing by ehnto on Friday October 28, 2016 @04:32AM (#12814034)
I guess that was my point, no one is expecting to enjoy the benefits of evolution (because of course they will be dead). So the argument of halting evolution or that it goes against the so far proven way to become a better species makes no sense. Better that we focus on working with what we have.

Perhaps the version was number a bad way to express that though!

Re:Anti-Aging Startup Raises $116M With Bezos Backing by ThomPete on Thursday October 27, 2016 @09:33PM (#12812245)
This strikes me as an odd argument.

Basically you are saying that it's better we die so that a new generation can come and then die for others come around just to die to make way for others.

Whats the purpose of that for the individual? Why is that by any metrics desirable for humans to die for other humans to come along to just die for yet others?

But what is the purpose of that?

Re:Anti-Aging Startup Raises $116M With Bezos Backing by mirekrusin on Thursday October 27, 2016 @09:56PM (#12812367)
It's called life, evolution, it's been like that since day 1 but you sound surprised?

Questions about life's purpose are silly, just like asking "what's the purpose of Mount Blanc?" is silly.

Living longer wouldn't change the notion of "purpose" or anything around it anyway.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by ThomPete on Thursday October 27, 2016 @10:07PM (#12812426)
I think it's safe to say you are missing the point.
Re:Anti-Aging Startup Raises $116M With Bezos Backing by Taek on Friday October 28, 2016 @02:17AM (#12813532)
Well, I can understand how from your perspective it makes sense for you to want to live forever, but from an evolutionary perspective your species is more successful if you die after a while.

If if immortality didn't have negative consequences as severe as stunting an entire species, we'd probably see more species that were capable of immortal individuals. Such species do exist, but not in the Mammal kingdom as far as I'm aware.

But I also think it sets a good guideline. Death improves a species, because it leaves room for more children + more generations (for a given set of resources), which means more opportunity for improvements to evolutionary fitness.

edit: another commenter pointed out something I think is fairly profound. When a group of cells in your body decides to pursue immortality, it's usually cancer. And if you don't address it, it kills you, and them too. Science theoretically has a way to grant our individual cells immortality without causing cancer, but it'd have to be orchestrated carefully.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by ThomPete on Friday October 28, 2016 @06:21AM (#12814540)
You are missing the point. Op claimed that the continuation of adding new life and letting other life die out was important. I am questioning that argument not evolution. Why should i care about the continuation of life for anyone but me.
Re:Anti-Aging Startup Raises $116M With Bezos Backing by solipsism on Thursday October 27, 2016 @10:22PM (#12812525)
You're actually starting a conversation on HN about what the purpose of life is?

Good luck...

Re:Anti-Aging Startup Raises $116M With Bezos Backing by ThomPete on Thursday October 27, 2016 @11:59PM (#12812954)
No. I am asking why I wouldn't want to live forever.
Re:Anti-Aging Startup Raises $116M With Bezos Backing by idra on Friday October 28, 2016 @03:43AM (#12813827)
Because you miss out on death, which is arguably the most important event in our lives.
Re:Anti-Aging Startup Raises $116M With Bezos Backing by ThomPete on Friday October 28, 2016 @06:19AM (#12814527)
Not to me
Re:Anti-Aging Startup Raises $116M With Bezos Backing by enraged_camel on Thursday October 27, 2016 @08:48PM (#12811869)
>>[Death] has a nice way of making space for a newer generation of thinkers. Old prejudices die, new thinkers arrive.

On the other hand, humanity loses out on a tremendous amount of knowledge and experience with each death.

Imagine if Einstein were alive today, for instance. Or Richard Feynman. Or Carl Sagan.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by mehwoot on Friday October 28, 2016 @02:13AM (#12813519)
Planck said "Science advances one funeral at a time", and he was in that exact field...
Re:Anti-Aging Startup Raises $116M With Bezos Backing by dkarapetyan on Thursday October 27, 2016 @09:34PM (#12812257)
Those were lives well lived and a lot of the meaning and wisdom now derived from their lives is because they are gone. Same can not be said for the multitude that just wants more time.
Re:Anti-Aging Startup Raises $116M With Bezos Backing by jnicholasp on Friday October 28, 2016 @12:24AM (#12813085)
All of the meaning and wisdom derived from their lives was because they were alive. Now they aren't, and we don't get any more of their particular genius, and that is a damned shame.

It's also a damned shame that my grandfather, who is precisely nobody on the world stage, but still somebody, and currently in the hospital and I might get a text any minute saying he's dead, is on the brink of exiting the world, joining the hundred billion or so other humans who've ceased to exist for no good reason other than that the blind god Nature doesn't care about anything we care about. What Nature has ordained, she has ordained without reference to meaning or wisdom or the interests of those who live and die within her system, and we will be doing right when we remake her.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by dkarapetyan on Friday October 28, 2016 @02:47PM (#12819403)
Reflection requires pause. It would not be the same if all those people were contemporaries of current modern scientists. In fact I have no clue how much value current scientists are adding or not adding or whether Feynman and friends would still be contributing in any way as you are assuming. The geniuses will appear after some reflection in a hundred years or so. Long after they're all gone.

I'm sorry for your eventual loss but immortality does not appeal to me the way I guess it appeals to others. Cycles in nature don't seem like a disease to me that need curing. Alleviating the pain and suffering of aging is fine and that's what these guys seem to be doing.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by ryuker16 on Friday October 28, 2016 @02:53AM (#12813651)
I'd imagine a society with 200 yr old people would be much wiser and sanely run.
Re:Anti-Aging Startup Raises $116M With Bezos Backing by anexprogrammer on Friday October 28, 2016 @04:51AM (#12814135)
Perhaps. There might be a lot more cynicism and conservatism. Our legislators might not have adjusted to the implications of telephone and tv, let alone apps and online privacy.

Oh, I see. You mean we should be able to run on to 200 don't you? ;)

Re:Anti-Aging Startup Raises $116M With Bezos Backing by ryuker16 on Thursday November 03, 2016 @07:49PM (#12869196)
I suspect some age related conservativism is due to health and looks.
Re:Anti-Aging Startup Raises $116M With Bezos Backing by ancient_kaiser on Friday October 28, 2016 @03:33AM (#12813789)
Yes, that would be lovely, Kaiser Wilhem I would still sit on the throne of Prussia and Rutherford B Hayes would be seeking re-election.
Re:Anti-Aging Startup Raises $116M With Bezos Backing by berntb on Friday October 28, 2016 @04:26AM (#12814010)
This is probably the best pro-death argument -- the social consequences. The rest can be solved.

But in two to seven decades, when they have this problem, I doubt they will see it as a moral choice to kill (/refuse to save) people because a lot of them will be conservative.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by ryuker16 on Thursday November 03, 2016 @07:50PM (#12869206)
If kaiser Wilhelm can hold the throne in a democracy for 100+ years he likely is doing a bang up job
Re:Anti-Aging Startup Raises $116M With Bezos Backing by Pica_soO on Friday October 28, 2016 @06:07PM (#12821174)
I find the idea of a live long prison sentence with immortals funny. That would grow quickly towards infinity.
Re:Anti-Aging Startup Raises $116M With Bezos Backing by atomical on Thursday October 27, 2016 @10:13PM (#12812472)
You sound like a nihilist, except for the part about appearing to have "concern for everyone else."
Re:Anti-Aging Startup Raises $116M With Bezos Backing by solipsism on Thursday October 27, 2016 @10:23PM (#12812526)
You say that like it's an insult. And nihilists don't necessarily not have concern for others.
Re:Anti-Aging Startup Raises $116M With Bezos Backing by Frogolocalypse on Thursday October 27, 2016 @10:33PM (#12812569)
Yes. Nihilist != Narcissist.
Re:Anti-Aging Startup Raises $116M With Bezos Backing by atomical on Friday October 28, 2016 @08:34PM (#12821929)
I am a nihilist.
Re:Anti-Aging Startup Raises $116M With Bezos Backing by nullc on Thursday October 27, 2016 @08:06PM (#12811647)
I've found it helpful to share this with people: http://www.nickbostrom.com/fable/dragon.html
Re:Anti-Aging Startup Raises $116M With Bezos Backing by paulsutter on Thursday October 27, 2016 @08:33PM (#12811785)
> "orators argued that the dragon has its place in the natural order and a moral right to be fed. They said that it was part of the very meaning of being human to end up in the dragon’s stomach. Others still maintained that the dragon was good for the human species because it kept the population size down"
Re:Anti-Aging Startup Raises $116M With Bezos Backing by Taek on Friday October 28, 2016 @02:45AM (#12813626)
The article paints death in a very black and white, good-vs-evil picture, but I hold that it's a much more complex mechanism.

And I don't mean to suggest that we should accept death or not pursue the escape of death, but most species (with some notable exceptions) who have enjoyed evolutionary success have death hardcoded into their genome.

Which suggests to me that over a sufficient timescale (probably dozens to thousands of generations), death is beneficial to a species. Death means that there are more resources available to younger generations, and means that you get more cycles of genetic optimization. That makes the species more successful as a whole.

Humans may find some way to get optimization cycles that don't involve death, but I hold the opinion that if we don't continuously pursue optimization cycles, we'll eventually be out-competed evolutionary by something that does. We have a huge head start, but in the fable, so did the dragon.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by nullc on Friday October 28, 2016 @10:57PM (#12822393)
Something doesn't need to be beneficial to be conserved, being not too harmful is enough. Or even being harmful but pointlessly crosslinked with something essential such that it's hard for evolution to escape the local minima.

More over, human values are not the same as the objectives of evolution, nor should they be.

> but I hold the opinion that if we don't continuously pursue optimization cycles

We can undermine the optimization of evolution just fine, without ending death from aging--

I seem to recall that both of us wear corrective lenses, thus largely excluding the selective pressure for naturally better eyesight that we might otherwise be subjected to. :)

With that in mind, it's something of a false choice that you present: It's not like mankind is subject to the full force of evolutionary pressure with aging and completely free of it without.

Besides, I seem to recall the the rate for accidental death in adults suggests that we'd end up with a roughly 500 year life span even if we completely cured all aging related issues. A lot longer in human terms, but hardly anything for evolution.

Another perspective would be that the biggest threat to mankinds survival isn't anything evolution is well equip to protect us from-- us killing ourselves with phenomenal weapons and bad policy. Because our bad decisions could wipe our mankind worldwide evolution has no real chance to fabricate less problematic future humans. ... But perhaps humans acting in their own perpetually immortal interest might just behave a little more prudently.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by TeMPOraL on Friday October 28, 2016 @08:56AM (#12815244)
> Humans may find some way to get optimization cycles that don't involve death, but I hold the opinion that if we don't continuously pursue optimization cycles, we'll eventually be out-competed evolutionary by something that does. We have a huge head start, but in the fable, so did the dragon.

I think we're pretty safe. Evolution works really, really slowly. Even the earliest humans recorded optimized their lives much faster than evolution. That's our advantage - a brain that can do the iterations in abstract, many orders of magnitude faster than nature does in matter.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by pointytrees on Thursday October 27, 2016 @11:27PM (#12812783)
At first I thought the article was going to explain why it isn't worth pursuing agelessness, but I'm impressed at how well it wrapped everything up. Great article, thanks.
Re:Anti-Aging Startup Raises $116M With Bezos Backing by Frogolocalypse on Thursday October 27, 2016 @10:32PM (#12812565)
> I want to climb every mountain.

Statistically speaking, anti-aging isn't going to be the defining factor in your mortality, if that's what you want to do with your extended lifetime.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by stickfigure on Friday October 28, 2016 @04:54AM (#12814141)
I'm disappointed that this isn't the top-rated response, because I think it's totally fair. The parent post resonated with me incredibly -- I want to do all the things. Yes, I fully expect to die in a motorcycle accident far from modern health care. I'm ok with that. I suspect the parent would agree.

"I f*cked up spectacularly" is an acceptable way to go. "I watched a lot of TV" is not. 80 years is not long enough to attempt all the spectacular things.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by pointytrees on Thursday October 27, 2016 @11:17PM (#12812749)
Hah, yea, good point. Honestly though, I live in northern California, and I have climbed a good handful of the 10k peaks around here, but there are just so many more I have not had the time to visit. So many parts of the Pacific Crest Trail that I havn't been able to hike. And that's just stuff in a 2 hour drive. I've climbed a few dozen of the Tahoe peaks, but there are so many more to do. Over the past few years, I've probably gotten to a mountain top once every 4 weeks. Some months I go every weekend, other months I get busy with other things. I never want to do Everest. But, there are some 14k in Denver that might be fun. Believe me, I'll hike more trails and mountains than most people, but there are just so many hikes, and not enough weekends.
Re:Anti-Aging Startup Raises $116M With Bezos Backing by Frogolocalypse on Thursday October 27, 2016 @11:24PM (#12812775)
Re:Anti-Aging Startup Raises $116M With Bezos Backing by BjoernKW on Thursday October 27, 2016 @07:36PM (#12811444)
Not enough time? Perhaps, but forever is a long time. Quite possibly it's exactly our limited time that has us achieve great things. If you have all the time in the world why bother starting that business or learning that new skill today? Might as well start tomorrow ...

I also find it at least a bit disturbing that WoW is so high on that list. Then again, if you have all the time in the world ...

Re:Anti-Aging Startup Raises $116M With Bezos Backing by xixixao on Thursday October 27, 2016 @07:53PM (#12811564)
Also, no one is trying for immortality. You will still die, just not from standard health decline. Hack, why not at least try and see what happens, going back to normal dying will be easy (depending on the cure, but most likely).
Re:Anti-Aging Startup Raises $116M With Bezos Backing by BjoernKW on Friday October 28, 2016 @03:27AM (#12813775)
> going back to normal dying will be easy

Depending on the solution, normal dying might indeed be impossible. I remember a piece of dystopian fiction (I think it was an Outer Limits episode) where characters couldn't even kill themselves anymore because nanobots would instantly repair any damage.

Not that this scenario is extremely likely but there might be ramifications we can't think about yet. Immortality after all isn't a particularly well-trodden path.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by TeMPOraL on Friday October 28, 2016 @08:59AM (#12815264)
[Spoiler alert for Black Mirror]

Black Mirror's "White Christmas" covered a similar theme with uploaded consciousness, where the victim obviously couldn't self-terminate in any way.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by pointytrees on Thursday October 27, 2016 @11:36PM (#12812821)
The items were not listed in order. I've had a couple spins of playing WoW and DotA, and often times the reason I quit are because there are so many other things I want to do. I work full time, I have a rental property, I have a small business (with my wife), 1 dog, 3 cats, no kids yet, but soon hopefully. We get outdoors, go camping, visit family. Probably getting into sailing next summer. Life's great. Don't get me wrong. But, dang. With "forever" I could get so much done. I'm also fairly patient, and conservative, so with time on my side, the safest investments will pay off well. But, then again, if you have time to work, why not jump into the risky investments. If you lose everything, you can just rebuild. Maybe a hybrid of both approaches. However, if death were cured, then money, investing, and finance would probably change quite radically as well.

I love thinking about this concept. I hope that over the next 20 years, they figure out how to extend life to 125 years, so that then in the following 20-40 years they can extend life indefinitely. Here's to hoping.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by nickpinkston on Thursday October 27, 2016 @07:44PM (#12811494)
I'm unsure if anyone who thinks "there's just not enough time" is the kind of person who would sit around because of their immortality.
Re:Anti-Aging Startup Raises $116M With Bezos Backing by TeMPOraL on Friday October 28, 2016 @09:01AM (#12815275)
I disagree. I believe that a big reason kids are so good at learning and trying things is that they haven't yet internalized the concept of "not enough time" - there's always shitloads of time; if not today, then tomorrow. If not this summer, then next summer. When you don't have to worry about running out of time, you don't mind blowing it on learning stuff.
Re:Anti-Aging Startup Raises $116M With Bezos Backing by BjoernKW on Friday October 28, 2016 @03:34AM (#12813795)
There's the rub. The feeling of "There's just not enough time." precisely stems from the fact that our time is limited. If that's no longer given that feeling might disappear from humanity entirely, which in turn could lead to stagnation and ultimately - and ironically - to mankind dying out.
Re:Anti-Aging Startup Raises $116M With Bezos Backing by ctack on Friday October 28, 2016 @06:32AM (#12814575)
The guy on the farm next door is happy killing leopards which threaten his sheep. Leopards are endangered. He doesn't care, in his world view there have always been many Leopards.

He has his reasons for wanting to kill leopards, but eventually humans are going to kill them all and that can't be right.

Like you, I'm excited by the idea of living longer, but it's selfish. For the world it would be better if we lived even shorter. You'd have a faster churn of ideas. Think of ignorant people consuming ivory or rhino horn out of ignorance. This ignorant generation is going to wipe out these animals outside zoos and tiny protected reserves. Their children would likely be more educated and likely not follow the ignorant behaviour of their parents. But the parents(we) live too long.

I'm sure there is an analogue in my appetite for beef and the destruction of the Amazon or my desire to own and drive a fossil fuel driven vehicle.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by anabis on Thursday October 27, 2016 @09:41PM (#12812291)
You can probably exhaust trails, mountains, biomes.

But probably not human created stuff like raids and video games, because new ones will be made. Well languages maybe, because of consolidation.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by elorant on Thursday October 27, 2016 @08:05PM (#12811633)
As long as everyone else lives forever. Otherwise you're in for a very depressing ride.
Re:Anti-Aging Startup Raises $116M With Bezos Backing by jnicholasp on Friday October 28, 2016 @12:33AM (#12813117)
That is, unless you get yourself a time-traveling space ship and dedicate yourself to the engrossing project of personally insulting every single being in the universe, in alphabetical order.

http://www.hhgproject.org/entries/wowbagger.html (That site sucks to read, btw. White text on black background, ugh.)

Re:Anti-Aging Startup Raises $116M With Bezos Backing by LargeCompanies on Thursday October 27, 2016 @09:13PM (#12812098)
Like the movie the green mile you may not want to live forever when everyone you love dies and that cycle continues over and over. Emotionally you might wish you too followed the cycle of life all those you love were following.
Re:Anti-Aging Startup Raises $116M With Bezos Backing by cko on Friday October 28, 2016 @09:42AM (#12815659)
But don't you ever get weary? Like "oh, this again. I've seen this before, in a slightly different form. This too shall pass."

I've felt this way since I was 20, and I haven't seen much.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by pointytrees on Friday October 28, 2016 @12:13PM (#12817554)
I'm in my mid 30's. There are a few hikes that I do repeatedly. One to a peak, one to a riverbed. I've done them dozens of time. Sitting by the rushing water, no cars, no people, no industrial sounds, trees everywhere. Rejuvenates me every time.

Yea, there are typically trees, bushes, rocks and dirt on every trail. But, they're different. Even the same trail changes over time. Trees fall, views change. Sometimes you see a deer. Sometimes you find a crazy looking flower, or bug, or plant. Sometimes it's just exhilarating to hike quickly and elevate your heartrate in the crisp cold mountain air.

I know what you're saying though. I have been on a trail, where it was the first time on that trail, and I though, geez, same ol' same ol'. But, I quickly forgot that a few minutes later as I left the highway, and got deeper in the wilderness.

I love it. As I mentioned earlier, I work a full time. Sitting at a desk. So, these times on the trail are so refreshing.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by megablast on Thursday October 27, 2016 @10:53PM (#12812660)
Do you want to all that with a depleted body and will?
Re:Anti-Aging Startup Raises $116M With Bezos Backing by pointytrees on Thursday October 27, 2016 @11:42PM (#12812853)
Obviously, I'd like to maintain my body and will. When I was in Maryland for a year, my landlady was 104 years old, and quite sharp. Her daughter was 80 and crazy spry. Every day my landlady would be out on the porch, cleaning and organizing. She couldn't run around, and she was probably past the point where I'd enjoy spending eternity, but the point is that her bloodline was amazing. I could certainly spend an eternity with the health that her 80 year old daughter had. She could pick up her grandson, and get around the yard just fine.

Part of the whole agelessness thing is that some of the mechanics of how our cells breakdown and begin to fail would need to be cured. At which point, our bones, and muscles, if cured of that deterioration, would lead to curing death, but it would also lead to the ability to maintain your health and body. As long as you continue to exercise, and eat well, you'd probably have a body similar to an average fit modern 40 year old I'd expect. Or somewhere between the crazy metabolism of 20 year olds, and the deterioration of 70 year olds.

I don't know any of the science though, so just speculating based on what I've read, and my opinions.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by nostrademons on Thursday October 27, 2016 @07:48PM (#12811526)
I dunno. Constraints give us meaning. They're what force us to make choices, and it's choices and opportunity costs that let us define who we are at people. If we lived forever, we wouldn't have to make any hard choices - we'd just do it all. And paradoxically, being able to do it all means that none of it means anything.

It's like playing a game with all the cheats on. Sure, they let you "win" super easily, but because it was super easy, it stops being fun.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by aaron-lebo on Thursday October 27, 2016 @07:58PM (#12811588)
Anti-aging doesn't prevent death.

You could still just as easily get hit by a car when you are 90 and look 20. Or 1000 and look 20, assuming that's even possible. What's really interesting is if people could actually prolong their lifespan indefinitely but we have the same limited bodies. Then you'll see people trying really hard to say alive to comical effect.

I think Aronofsky's The Fountain is a really great outlook on death. It is a disease and like any disease we may as well try hard to defeat it. Doesn't mean it isn't very natural.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by nostrademons on Thursday October 27, 2016 @08:06PM (#12811639)
That seems even more meaningless though, to make the moment of your death random rather than mostly-predictable. I mean, it'd suck to live my life like I had a million years and then get hit by a bus tomorrow.
Re:Anti-Aging Startup Raises $116M With Bezos Backing by aaron-lebo on Thursday October 27, 2016 @08:10PM (#12811665)
A teenager got hit and killed by a car today. Probably seemed pretty random to them. What's the difference?

Hell, if age couldn't kill you, then you could chose your death, which is less random than a heart attack or stroke.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by inimino on Friday October 28, 2016 @03:41AM (#12813815)
I'm not sure that was the outlook that film advocated.
Re:Anti-Aging Startup Raises $116M With Bezos Backing by forthefuture on Thursday October 27, 2016 @08:00PM (#12811595)
It might be unthinkable to someone in the future that we could experience the universe meaningfully in 100 years.

I tend to see human-lifespan rationalizations as simple fatalism. It's okay to think you'd get bored after a million years, but dooming every living human to die because you'd be bored is kind of insane if you think about it.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by aaron-lebo on Thursday October 27, 2016 @08:05PM (#12811636)
> I tend to see human-lifespan rationalizations as simple fatalism.

But you are very mortal and you are at most a few decades old. Your perspective would probably change drastically in your third century or millenia.

It makes conjecture like this as good as worthless because as mortals we do not have the ability to see it from another perspective.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by forthefuture on Thursday October 27, 2016 @08:09PM (#12811660)
> Your perspective would probably change drastically in your third century or millenia.

I'd rather have that opportunity than not.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by pointytrees on Thursday October 27, 2016 @11:43PM (#12812859)
I wholeheartedly agree.
Re:Anti-Aging Startup Raises $116M With Bezos Backing by pdonis on Friday October 28, 2016 @12:06AM (#12812989)
> If we lived forever, we wouldn't have to make any hard choices

No, if we lived forever, we would have to make a lot more hard choices, because we would have so much more time to be exposed to them.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by dcposch on Thursday October 27, 2016 @07:23PM (#12811363)
Not just death, but the gradual loss of physical and mental capabilities you used to have.

That feels scarier to me.

Imagine you could chose to die on your 75th birthday, but in return keep your full 20-something health until then. I'd do it right away.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by scandox on Thursday October 27, 2016 @07:58PM (#12811586)
Why are we so afraid of change of different experiences? Aging is not hell. It may teach us humility. It may give us the opportunity to question our priorities.

Ultimately all the human race will die. Over a short or a long span only learning will matter.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by aaron-lebo on Thursday October 27, 2016 @08:09PM (#12811656)
Have you seen people needlessly suffer in old age? Stooped backs, sore joints, limited abilities, dementia.

On the contrary, talking to my 82-year old professor who is sharper than most college kids but has constant health problems and I wish we could beat aging.

You're right, we shouldn't be afraid of different experiences, but that doesn't also mean that fighting aging is bad. We could apply your arguments to all medical care, but we don't because there's no point in needlessly suffering.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by kilroy123 on Thursday October 27, 2016 @08:12PM (#12811683)
I agree, but I think everyone wants to have that much later in life. For example after your 100. Instead of 60 or whenever.
Re:Anti-Aging Startup Raises $116M With Bezos Backing by a13n on Thursday October 27, 2016 @07:42PM (#12811474)
Sure but if you've maintained your 20-something health until 75, why choose to die? That's just suicide...
Re:Anti-Aging Startup Raises $116M With Bezos Backing by dennisgorelik on Thursday October 27, 2016 @09:37PM (#12812270)
The choice is to live healthy life until 75 and pay the price of death at 75.

If it is possible to live healthy life past 75 - that would be even better.

Unfortunately none of that is possible to accomplish in the timeframe that would benefit us personally.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by banhfun on Friday October 28, 2016 @02:04AM (#12813491)
You should watch Logan's Run.
Re:Anti-Aging Startup Raises $116M With Bezos Backing by nostromo on Thursday October 27, 2016 @07:41PM (#12811472)
It comes from reverence for naturalism. It's similar in that sense to other movements, like anti-GMO, anti-vax, etc.

Tell people you want to cure cancer and you're a hero. Tell people you want to cure age-related decline and eventually death and you're a weirdo extremist.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by eli_gottlieb on Thursday October 27, 2016 @08:33PM (#12811786)
The word "naturalism" means something else.
Re:Anti-Aging Startup Raises $116M With Bezos Backing by bolocker on Thursday October 27, 2016 @07:55PM (#12811571)
"Only mortals have told me that it would suck to live forever." - /r/Showerthoughts

Aubrey De Grey calls it the "pro aging trance"

https://en.wikipedia.org/wiki/Aubrey_de_Grey#Pro-aging_tranc...

Re:Anti-Aging Startup Raises $116M With Bezos Backing by bitJericho on Thursday October 27, 2016 @08:01PM (#12811602)
It's right up there with "money doesn't buy happiness"
Re:Anti-Aging Startup Raises $116M With Bezos Backing by deegles on Thursday October 27, 2016 @07:55PM (#12811573)
I'm excited for ant-aging, not so much for an endless deluge of VC backed treatments/supplements that aren't grounded in science and/or ineffective.

Besides, lifestyle needs to be addressed first. Reduce/eliminate risky behaviors, eat correctly (whatever that may be), and exercise regularly. Then perhaps look into supplements and treatments.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by notgood on Thursday October 27, 2016 @08:20PM (#12811719)
Some vegans die at their 60s of "natural causes", Winston Churchill died at 90 after having smoked all his life and being very fat. Yeah, statistically there is relevance to eat correctly, but its not as dramatic as some like to believe.
Re:Anti-Aging Startup Raises $116M With Bezos Backing by aaron-lebo on Thursday October 27, 2016 @08:30PM (#12811777)
General Montgomery: I neither drink nor smoke and I am 100 percent fit.

Churchill: I drink and smoke and I am 200 percent fit.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by gwern on Thursday October 27, 2016 @07:49PM (#12811533)
Re:Anti-Aging Startup Raises $116M With Bezos Backing by Taek on Thursday October 27, 2016 @07:55PM (#12811572)
I'm not sure how controversial the opinion is, but it's pretty clear to me that immortality is harmful to a species in the vast majority of cases.

Evolution is a constant processes of competition. When members of a species start living longer, the upgrading of their gene pool slows down. The older members maintain their old ideas and ways of life, and they soak up resources that crowd out the younger members.

The environment is constantly changing. Thanks to all the other organisms that are evolving, it's not enough to become the apex predator and then stagnate. Organisms are always finding a new way to take advantage of their environment, which includes the other organisms.

For this reason, I do not think that any single individual will ever be immortal, and probably not even a collective. That would require gaining control of the universe's resources in a way that guarantees they never lose it.

Decentralization is inherent to the functioning of the universe. The speed of light ensures that multiple decisions be made in parallel. Those that make the most self interested decisions will be competitive, and while that often means participating as a group, no biological group that I know of is entirely devoid of selfish behavior among its members.

Immortality is largely incompatible with evolution and competition.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by eli_gottlieb on Thursday October 27, 2016 @08:47PM (#12811856)
>Immortality is largely incompatible with evolution and competition.

That's an incredibly good argument in favor of immortality. "Evolution" and "competition" are not gods. They do not have any moral authority over us. Our entire civilization has been built on the principle of not subjecting ourselves to Darwinian survival-selection.

That aside, you should probably go count ducks in a swamp or do some other ecological fieldwork before talking about the evolutionary fitness of organisms or ecosystems. You sound atrocious at biology.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by Taek on Friday October 28, 2016 @01:55AM (#12813450)
> Our entire civilization has been built on the principle of not subjecting ourselves to Darwinian survival-selection.

I don't believe it's something you can escape. It largely boils down to the idea of infinite wants vs. finite resources. Bostrom and co. like to talk about how there's enough energy in the universe to power 10^XX human lifetimes, but I strongly don't believe that a human is going to be the ultimate lifeform. Already we can see that the average first-world human today uses substantially more energy than the average human 1000 years ago.

Unless we hit a ceiling on complexity (not currently in sight), there will always be people who want access to more energy. Since energy is finite, there will be competition between them for that energy. And that will more or less result in Darwinian survival-of-the-fittest, at least as far as some individuals/groups/organisms/species will be better at getting access to individuals as others.

I guess the other alternative is that we hit an entirely egalitarian society, but I think that's exceedingly unlikely, as it would require everybody to agree 100% to limit their energy consumption to exactly what they've been allocated, and not to try to acquire more.

> That aside, you should probably go count ducks in a swamp or do some other ecological fieldwork before talking about the evolutionary fitness of organisms or ecosystems. You sound atrocious at biology.

I appreciate the criticism, and apologize for the sloppy metaphors. Evolution thus far though has very clearly favored death as the primary means of design. Few species have remained unchanged over the past XX million years, and even fewer are theoretically capable of immortality (barring some sort of medical intervention). Most organisms have aging hardcoded into their genome.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by eli_gottlieb on Friday October 28, 2016 @07:21AM (#12814765)
>I strongly don't believe that a human is going to be the ultimate lifeform.

Once again, you sound atrocious at biology. Using terms like "ultimate lifeform" isn't even real biology, it's anime and video game "biology(tm)". Real-world evolution has no teleology built into it: there's no "ultimateness" to reach towards.

>Evolution thus far though has very clearly favored death as the primary means of design.

Evolution doesn't really favor anything, as such. Death happens because the Second Law of Thermodynamics makes even the most robust systems (and life is really robust, actually) break down eventually.

>I guess the other alternative is that we hit an entirely egalitarian society

So to be clear, you think an "egalitarian society" (your words) is even less likely than human immortality, despite the fact that relatively egalitarian human societies have been observed in, say, Sweden, while immortality has not.

Have you considered that you may be Ebeneezer Scrooge?

Re:Anti-Aging Startup Raises $116M With Bezos Backing by fabrice_d on Thursday October 27, 2016 @07:20PM (#12811341)
Death is not the problem, the agony is.
Re:Anti-Aging Startup Raises $116M With Bezos Backing by a13n on Thursday October 27, 2016 @07:42PM (#12811478)
Thanks for the response, agreed.
Re:Anti-Aging Startup Raises $116M With Bezos Backing by rsync on Friday October 28, 2016 @02:31AM (#12813585)
"Of all the pain points humans experience, you'd think death lies pretty high on the list. Why are people fighting this?"

Imagine a cell in your body that thinks this way.

What would you call that cell ?

It starts with a "c" ...

Re:Anti-Aging Startup Raises $116M With Bezos Backing by TeMPOraL on Friday October 28, 2016 @09:04AM (#12815308)
Thankfully cells aren't sentient.

Also, the cell you mean is not the one that refuses to die, but one that wants to aggressively reproduce.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by sgift on Friday October 28, 2016 @02:43AM (#12813617)
Probably, because they somehow revere age-related death as something more than it is (see all the comments about making space for new generations and so on). Age-related death is simply another sickness or the accumulation of sicknesses that finally overwhelms your body and strikes you down. And like every other sickness, I hope we get rid of it as fast as possible. Unfortunately, it will probably take longer than my lifetime until that happens.
Re:Anti-Aging Startup Raises $116M With Bezos Backing by eli_gottlieb on Thursday October 27, 2016 @08:26PM (#12811755)
>Of all the pain points humans experience, you'd think death lies pretty high on the list. Why are people fighting this?

Because nobody ever seems to go around funding peer-reviewed medical science done in well-controlled labs with large sample sizes to study how to fight aging.

This is not a problem that a startup company can solve. This is a problem for steady, difficult progress over decades. But people go for the sexy headline rather than the eventual working solution.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by jnicholasp on Friday October 28, 2016 @12:38AM (#12813137)
How much steady, difficult progress is currently being made?

This seems like a thing that is being under-funded and under-researched, and more money, and particularly attention, being given to it is a good thing even if you don't think the particular method is likely to be effective.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by eli_gottlieb on Friday October 28, 2016 @07:22AM (#12814772)
>This seems like a thing that is being under-funded and under-researched,

[citation needed]

Re:Anti-Aging Startup Raises $116M With Bezos Backing by Disruptive_Dave on Thursday October 27, 2016 @08:01PM (#12811601)
I absolutely, 100% do not want to extend my life. And for the record, I am quite pleased with my life. I do not fear death, I do not worry about it, it does not concern me. Therefore I do not feel the need to combat it in any way. The good truly does not exist without the bad, life without death, and so on. Walking the path of "controlling" your life and/or death like this seems needy, egotistical, and pretty sad, imo.
Re:Anti-Aging Startup Raises $116M With Bezos Backing by farresito on Thursday October 27, 2016 @08:56PM (#12811940)
You are already extending your life by going to the doctor. What's the difference between that and an anti-aging therapy? How is that even controlling your death? You are going to die one day. It's a fact. How do you want to die? Would you rather die in the worst conditions possible, like it happens to most people nowadays? If you are happy about dying like that, you might as well stop going to the doctor. Fact is, even if you don't realize, we have been 'manipulating' death for a long time. I think what's egotistical is your comment, honestly. You are basically opposing to a therapy which would remove plenty of suffering from the world, starting with reducing the chances of cancer, removing Alzheimer, etc., yet you don't want to remove it because evolution decided that living indefinitely was not advantageous for human survivability, and so we should not touch that. Heck, what's the point of technology if not to improve our daily lives? Should we oppose to all technology?
Re:Anti-Aging Startup Raises $116M With Bezos Backing by JoeAltmaier on Thursday October 27, 2016 @08:06PM (#12811642)
So you plan to end it all tonight? No?

I think, like everyone else, you expect a reasonable lifespan and would fight to achieve that. From there, its just a matter of how much is enough.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by Disruptive_Dave on Thursday October 27, 2016 @08:19PM (#12811714)
I actually don't expect anything. I get what I get, that's all. Expectation is a problem, generally speaking. Actively killing myself is quite different from un-attaching myself to the concept of an expected X number of years on this earth.
Re:Anti-Aging Startup Raises $116M With Bezos Backing by JoeAltmaier on Friday October 28, 2016 @09:58AM (#12815839)
Well, to belabor the point, not walking out into traffic without looking is evidence of self-preserving instincts. Again from there its a matter of degree.

Admittedly I am also of the school of 'be safe as long as it doesn't take too much mental stress'. I'll live as long as I live, given flu shots and careful driving. But I'm not going to obsess about it either.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by Taek on Friday October 28, 2016 @02:51AM (#12813647)
Surely you can respect though that other people feel differently though? Everybody has their own way of life.
Re:Anti-Aging Startup Raises $116M With Bezos Backing by Disruptive_Dave on Friday October 28, 2016 @07:15AM (#12814748)
Of course, 100%. Just giving my personal take here.
Re:Anti-Aging Startup Raises $116M With Bezos Backing by sgift on Friday October 28, 2016 @02:40AM (#12813611)
Let's talk again after you had the "great" experience of waiting in an ER for your end thanks to cancer, if you really do not fear death (or rather do not miss all the things you'd still want to do with your life).
Re:Anti-Aging Startup Raises $116M With Bezos Backing by Disruptive_Dave on Friday October 28, 2016 @07:21AM (#12814764)
Ok, should I text you or something when that happens? You're taking a very black-and-white approach to what I said. I never stated that I wouldn't have the very natural and human urge to continue life or the feeling of missing out on what could have happened, should I find myself at death's door any time soon. What I said is that I try not to attach myself to those feelings. I see absolutely no value in letting a 100% factual eventuality concern my living, breathing moments in any way whatsoever. That doesn't mean I don't eat healthy or avoid obvious paths to an "early" death. It just means I do not think about it (fear, worry, regret, whatever), as this thinking wouldn't be fruitful for me. Is that not understandable, even if you don't agree with this way?
Re:Anti-Aging Startup Raises $116M With Bezos Backing by pkd on Friday October 28, 2016 @12:26AM (#12813092)
I'd love to live longer if I could stay young throughout. Death is not a pain point for me, but old age is. After watching my grandparents slowly lose control over their bodies, I don't wish to go through that same phase.
Re:Anti-Aging Startup Raises $116M With Bezos Backing by anexprogrammer on Friday October 28, 2016 @04:56AM (#12814153)
Some aspects of living longer I'd love to have - more experiences, more knowledge and so forth.

If we achieve this, but don't reduce input, longer life will just mean we live to see the crash. So in order to have long life how can we stop the growth, and ideally reduce, the human population without totalitarian approaches?

Before solving aging we need to solve achieving a genuinely sustainable number for the planet and its biosphere.

Re:Anti-Aging Startup Raises $116M With Bezos Backing by sbuttgereit on Thursday October 27, 2016 @07:43PM (#12811483)
So long as increased longevity also comes with better geriatric health overall, I'm very much on board. A life worth living is not just avoiding death, it's also being able to physically and mentally function properly as well.
Re:Anti-Aging Startup Raises $116M With Bezos Backing by jimjimjim on Friday October 28, 2016 @03:56AM (#12813876)
i think the general idea is:

i want to live forever

i don't really want everyone else doing the same