You really have to build a meteor app from the ground up, so it is hard for established tech companies to get into Meteor when they already have spent years coding on another stack.
As new startups who use Meteor grow you will see those large-scale projects come about.
This is pretty much my experience as someone who started working on a project where the lead dev had decided to use Meteor and then quit leaving a wonky prototype with "reactive data", poor performance and missing functionality.
Now, some would say "it's not Meteors fault the UI wasn't made well!" and then I'd reply "sure, but if Meteor didn't encourage (and it seems, require) tight coupling of the data access and presentation layers, then maybe we wouldn't have spent the last 3 weeks rebuilding the entire app from the ground up just to add some missing functionality and fix UI bugs".
Honestly, I really can't figure out the lack criticism I see of Meteor around here. All these comments to congratulate on an arbitrary step in version number? I see other articles of accomplishment with a fraction of the positive encouragement and many times the criticisms. Is there a silent majority, or did I spend the last few months being underwhelmed by Meteor because I'm missing something?
Meteor embodies, for me, a tool that makes things 'easy', rather than one that makes things 'simple'.
http://www.infoq.com/presentations/Simple-Made-Easy
Anyways, that's just one developers experience and opinion, take if for whatever you feel it's worth.
It is much simpler dealing with Meteor's API's then working with documentation from 3 or 4 different frameworks that you need to accomplish the same kind of stuff Meteor does.
Meteor gives you a set of clean coherent APIS to work with to get stuff done.
Because if you started a small project in something else, it is not easy to change it to Metero later.
What he said was quite clear.
Does it have to use Node.js on the server can the client side framework work with any server side JSON service?
It is very possible to use other client side frameworks such as Angular or Polymer, rather than just using Meteor's Blaze UI engine. However I find that Blaze's Template<--Helper<--Data<--Event system is extremely easy to understand and reason about.
Edit: Actually, they do seem to have a decoupled version of the Blaze UI that you could use just for your reactive DOM code and hook into a REST API. You just won't get any of the server-dependent features like full-stack automated data synchronization, hot-reload, live CSS injection, or Meteor's build chain. You just get a simple reactive template/helper/events system. http://meteor.github.io/blaze/
Meteor spans both the front-end and back-end to offer a seamless API experience when building your application.
Src: http://www.jesus.org/early-church-history/the-apostle-paul/h...
https://www.youtube.com/watch?v=cJbGNpmE7f0&t=8m30s
Hundreds isn't really exactly "webscale", but I'm sure they'll iron it out, or it could have just been the application that was at fault. It's one data point however on how meteor scales.
Scaling low-latency data synchronization is a challenge for scalability for sure! We are gradually building better and better drivers with persistence to MongoDB.
The scalability can vary greatly depending on your application's data schema, usage patterns and amount of writes.
If you watch the mentioned talk carefully, the speaker describes a collaboration tool with log replay with a lot of actions and running from a single box.
edit: posted too soon they talk about it here https://meteorhacks.com/does-meteor-scale.html
I'm not sure you'd use it to build the infrastructure of your startup on. Or a content heavy site. But I see building tools like for managing a lot of developer instances, internal tools for config, etc to possibly be pretty sweet for this.
Since it seems like everyone wants to think of themselves as doing something huge, I'm sure the answer can't be 'no' to the second question — but I don't see any examples of significant projects being built on the platform. Actually, with that in mind, what happened to the gallery of projects built on top of Meteor? Perhaps I'm missing it.
All that being said, congratulations on reaching 1.0. There's clearly a lot of great energy and thought that went in to the project.
edit: The videos on the site weren't obvious to me at first, but after finding them I think this one is a good counterpoint: https://www.youtube.com/watch?v=QzhtQzAX_6k