Unnoticable meaning doesn't have any effect at all, or just no bad side effects?

As in I cannot identify anything wrong with me most of the time while on them.

Just in terms of bad side effects. Hunger was still suppressed. (Might be worse on the higher doses, I'm not on a very high dose.)

Why would that be a 'bad' side effect? Isn't that the whole point of the medication?

Parent is not saying hunger supression is a bad side effect, they just clarify that the difference in noticabeality talked about a few comments up refers to the bad ones - but the good one's remain the same.

I have 2 measurable ones on Zepbound.

My lowest sleeping heart rate is now at least 10 beats higher than before starting (it comes down during the week to about 10 over)

The night after taking the injection my sleep is crap, and the heart rate is 5+ higher again

I have lost 20lbs since mid March with no real effort, and we’re about to do some blood tests for specific cholesterol numbers, which was one of the reasons to try this out.

I’ve been on 15mg (the highest dose) of Zepbound for the past six months. As of right this second I’ve lost 74 pounds since September 2024 when I switched to Zepbound after having a terrible experience with Ozempic/Wegovy and gaining from 260-308.

I notice no ill effects, I just had my three month checkup with the doctor and he thinks I’m good on maintenance mode at max dose, I’ve still got about 34 pounds as my total weight loss goal. Really an ideal case.

For my wife on the other hand she just has constant diarrhea which she blames on the drug, and is only on 5mg. She also gets headaches from the medicine. She’s lost only 20 pounds, even though she needs to lose another 120 or so to be “healthy weight”.

However, before she started taking Zepbound she was only able to walk a few hundred feet at a time, because her back hurt so terribly. The anti inflammatory “side effects” she’s experiencing have massively improved her quality of life, even without huge amounts of weight loss.

I'm on 2.5mg and I just got sulfur burps, which, to me, is the worst side-effect of the lot. I've also gotten terrible diarrhea previously, even on the lowest dose, I've started and stopped it around five times. Hopefully fifth time's the charm, but yes, side-effects very much depend on the person. I have friends on 10mg and 15mg and they're fine.

I'm sorry to hear about your wife's issues with it. My experience was completely the opposite. Since glp-1s slow gastric emptying they've completely ameliorated my IBS-D. It's been marvelous

Below the baseline of individual variance.

Like if your stomach really hated taco bell and you start taking a pill and now you get the same effect from artificial sweeteners you don't care because you're still within what's normal.

That's the level of side effects these things have.

I wouldn’t say unnoticeable, but rather a trade-off that’s fine. My stomach is definitely more sensitive, can’t handle coffee in the morning anymore, etc. It probably depends on the person.

I can tolerate tea quite well. Unseeetened iced tea by the gallon, specifically.

I'm not on any medications, and I've never been able to handle tea in the morning. Green, black, iced, hot, matcha. It always makes me feel nauseated unless I've eaten breakfast first. I always drink black coffee though, without problems.

I am similar. Green tea always makes me feel nauseous on an empty stomach. Tea with milk is normally ok.

That's why the Brits are having it ;-)

This is due to the high concentration of tannin in the tea. It causes stomach problems if you dont have protein in your belly already.

Huh. I’m at a healthy weight but I’m taking retatrutide for IBS and it’s working wonders. Very low dose, though. I originally tried it with semaglutide before the weight loss craze kicked off and the first few days of the week were worse and the latter half of the week was better, so that didn’t make sense for me to stay on.

With all of these long acting GLP's you will get a much smoother experience dosing them 2-3 times/week.

Maybe in the first few weeks, but their half-life is 7 days. You're not doing much besides making a hassle for yourself if your doing that after the first couple of weeks

The amount of "time on" is completely irrelevant. You will reduce peaks and troughs by injecting > once/week, this is a fact.

Yeah, I guess it's worth adding my relatively moderate side effect experience has been dosing 2-3x/week the whole time.

Can you say more about retatrutide for IBS? My IBS is debilitating to the point where I usually refuse to eat food on week-long work trips, because the unplanned emergency toilet trips wreak havoc with my schedule and ability to sit in meetings all day. I'd never heard there was a solution to it.

Sure, and I totally get your issues. I was a damned wedding photographer and I'd only eat towards the very end of the night, and still had a few iffy days.

As I stated, I originally tried semaglutide with no luck. I didn't try tirzepatide. I've been taking a very low dose of retatrutide - about .5mg twice a week. It seemed to be waning in effectiveness a bit so I upped the dose to 2mg/week for now. It's a night and day difference. Most days I go to the bathroom maybe two times, as opposed to the maybe 5-10 times I would need to unmedicated.

To be clear, this isn't an approved use of the medications (and retatrutide isn't approved at all yet, though it pretty clearly will be). However, they slow down gut motility - and as a bonus for your refusing to eat during week-long work trips, they'd probably at least help with that too, in terms of hunger.