News for hackers. Stuff that matters.
Re:Administering immunotherapy in the morning seems to matte... by _qua on Sunday June 08, 2025 @08:42PM (#44220461)
Move fast and break things in human medicine means unethical researchers maim and kill people, often marginalized people. Nazis, Japanese experimenting on prisoners, Tuskegee airmen syphilis experiments, Cincinnati radiation experiments and many others stand as testament to what ambitious unethical scientists will do to further their knowledge and career. Thus we have strict guardrails that slow down how we do things.
Re:Administering immunotherapy in the morning seems to matte... by xvector on Sunday June 08, 2025 @10:10PM (#44220908)
I am close with a few folks in medical research and the broken nature of the system and sheer amount of red tape has broken their dreams. It is impossible to get anything done.

There is a difference between "reasonable guardrails" and suffocating progress until it's nearly impossible barring Herculean efforts by multibillion dollar entities. It cannot be understated how badly the current bureaucracy has destroyed medical progress.

We are seeing the same problem with nuclear overregulation result in worse outcomes and more deaths for people globally.

There is real suffering and a human cost, measurable in lives, to slowing down progress - just as there is one for reckless progress.

Re:Administering immunotherapy in the morning seems to matte... by _qua on Sunday June 08, 2025 @10:17PM (#44220936)
I don’t disagree but the guy below you wants to grow human shells and try head transplants.
Re:Administering immunotherapy in the morning seems to matte... by tomcam on Monday June 09, 2025 @12:00AM (#44221324)
Transplant a few heads and suddenly you never get invited to another Christmas party
Re:Administering immunotherapy in the morning seems to matte... by tough on Monday June 09, 2025 @07:08AM (#44223221)
Re:Administering immunotherapy in the morning seems to matte... by tomcam on Wednesday June 11, 2025 @11:41AM (#44248817)
I maybe wouldn’t put this on my LinkedIn
Re:Administering immunotherapy in the morning seems to matte... by short_sells_poo on Monday June 09, 2025 @06:47AM (#44223078)
This is why we can't have nice things. I don't (mostly) doubt that poster's good intentions, but it takes only a few people with undirected ideas and flexible morals or empathy to necessitate strict rules around medical research.
Re:Administering immunotherapy in the morning seems to matte... by lofaszvanitt on Monday June 09, 2025 @08:13AM (#44223677)
good! old, dinosaur like systems need to be forgotten already.
Re:Administering immunotherapy in the morning seems to matte... by echelon on Sunday June 08, 2025 @08:57PM (#44220536)
We've been able to clone mammals for 30 years and haven't acted on it. We're still toying with molecular systems beyond the limit of detection.

Clone humans. Cut off their brain stem during development. Turn off cephalization signals for good measure. Scale it up to industrial scale.

Research problems solved.

We'd have every study at our fingertips. We'd have organs and tissue and blood for everyone.

We could possibly even do whole head transplants and cure all non-blood, non-brain cancers.

But we're playing in the sand.

Re:Administering immunotherapy in the morning seems to matte... by cannonpr on Sunday June 08, 2025 @10:12PM (#44220922)
You might be surprised at how little of the body still functions without brain function, well, some bits of the brain, including basic homeostasis and immune system function.
Re:Administering immunotherapy in the morning seems to matte... by echelon on Monday June 09, 2025 @03:44AM (#44222263)
We're not at all trying.

If you toss out the old rule book and provide unlimited funding, it can be made to work.

Re:Administering immunotherapy in the morning seems to matte... by darkwater on Monday June 09, 2025 @05:35AM (#44222738)
Yeah, sure. There are probably going to be only a few tens of thousands "unknown unknowns" side-effects but hey, who cares? We will figure them out, we are out of the stone age cave now!
Re:Administering immunotherapy in the morning seems to matte... by nothrabannosir on Monday June 09, 2025 @03:02AM (#44222041)
This comment, more than any other, has sold me on the value of red tape in medical research.
Re:Administering immunotherapy in the morning seems to matte... by echelon on Monday June 09, 2025 @03:42AM (#44222250)
Our genome is a machine, from the nucleotides to the packing, to the enzyme activity, to the metabolic flux.

Our bodies are bigger machines made of lots of little machines.

Our minds or conscious egos or "souls" are the neurotransmitter and activation activity of the connectome and all of its cells and synaptic weights and metabolic activity. They're our lived experiences for as long as our brains can function. Minds experience and produce wonderful things.

If you divorce the body from the mind, there is no "person". Just a very complicated machine. A very valuable machine full of parts.

A human body in a vegetative state is not a person. It's a dormant machine. People may have emotional attachment to that vestige, but it is no longer capable of being a person. It is not a person.

We use brain dead humans for organ transplant all the time. If you understand the premise, then it isn't that far-fetched that we might grow vegetative humans in a lab for medical use and research.

Bodies that never have brains can never become persons. They're no different from plants.

Re:Administering immunotherapy in the morning seems to matte... by willguest on Monday June 09, 2025 @04:46AM (#44222512)
My guess is that you're either a dev or an orthopaedic surgeon, well-versed in managing the machinistic aspects of systems, but with little motivation to go beyond them.

There is decent experimental evidence to demonstrate that we are more than gene expression and the machine analogy you insist on is not a good one for understanding biological systems - see work by Michael Levin, as example.

There is a wider paradigmatic shift underway that moves from thinking about parts to processes. This refocus on relations rather than objects is very important and, for biological systems, points to a fundamentally social/collective aspect to their nature.

The machine metaphor also fails when you can no longer explain how the machine works. This is true in many areas of medicine (e.g. anasthesia) and, while we continue to believe (sometimes with enormous zeal) in the concepts that helped us in the past, we cling to them at the cost of building better understanding.

What you say isn't "wrong", but it is too limited to be a useful guide in asking new questions about things like immunotherapy treatments.