Nicotine has been really interesting for Dementia or Alzheimer's so this checks out. The one study I know that is ongoing is mindstudy.org. It's well tolerated, cheap, and widely available.

Not a Doctor but if I had a loved one at-risk or experiencing age-related cognitive impairment, it's probably worth trying rather than waiting for scientific consensus which may take years and will probably be blocked by the FDA so some pharma company can develop patented neuro-nicotine or whatever.

Huberman has also espoused nicotine's benefits, so before someone reading this runs headfirst into a nicotine addiction, please be aware of the withdrawl symptons.

https://www.reddit.com/r/QuittingZyn/

Yes please be careful here folks. Nicotine can also cause anxiety and panic attacks.

don't forget high blood pressure

Don't forget the many, many negative issues SOME people get from nicotine.

I loved nicotine, but it terribly exacerbates my rheumatoid arthritis in my hands, inflames blood vessels in my lower arms (to the point of waking with my arms completely numb in the middle of the night) and gives me terrible heart palpitations that woke me up (if I consumed nicotine a few hours before bed).

I had to get some surgery on my fingers, and the staff seemed relieved to learn I don't smoke. Something about narrowing blood vessels making this kind of operation less successful. Not sure if they were just trying to cheer me up or it's an actual thing :-)

And stomach cancer

https://www.sciencedirect.com/science/article/abs/pii/S00062...

Which is itself a major risk factor for dementia (and strokes)

Very interesting. Though nicotine also has a lot of potential side effects that can make it really counterproductive for the health of an elderly person.