Don't forget the many, many negative issues SOME people get from nicotine.

I loved nicotine, but it terribly exacerbates my rheumatoid arthritis in my hands, inflames blood vessels in my lower arms (to the point of waking with my arms completely numb in the middle of the night) and gives me terrible heart palpitations that woke me up (if I consumed nicotine a few hours before bed).

I had to get some surgery on my fingers, and the staff seemed relieved to learn I don't smoke. Something about narrowing blood vessels making this kind of operation less successful. Not sure if they were just trying to cheer me up or it's an actual thing :-)

And stomach cancer

https://www.sciencedirect.com/science/article/abs/pii/S00062...

Which is itself a major risk factor for dementia (and strokes)