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Re:Eating fewer calories can ward off ageing by L_226 on Tuesday January 02, 2024 @03:30AM (#38839430)
I encourage everyone I discuss healthspan with to read the Blueprint protocol docs from Bryan Johnson (founder of Braintree/Venmo)[0]. He hired a team of specialists to make him as healthy as possible - it is his full time job to be a "professional rejuvenation athlete".

Part of his protocol is caloric restriction coupled with very specific exercise and intermittent fasting. According to his published health data he is extremely healthy! His YT channel [1] is also pretty interesting, if mildly cult-like.

[0] - https://protocol.bryanjohnson.com/ [1] - https://www.youtube.com/@BryanJohnson/videos

Re:Eating fewer calories can ward off ageing by Icko on Tuesday January 02, 2024 @03:38AM (#38839474)
I can't get a read on this guy. I have strong bullshit feelings, but I'm not 100% sure.

1. He seems to have an awful lot of referral links - $60 for a bottle of olive oil? 2. He has not posted why is his regime like that - e.g. "Here is a paper about iron deficiencies, so I'm taking an iron supplement". 3. 90% of his website is "look at how dense my bones are", "look at how healthy my liver is" - bro I just wanted to see the actual regime, and you can't even post that.

Re:Eating fewer calories can ward off ageing by gloryjulio on Tuesday January 02, 2024 @04:39AM (#38839831)
> $60 for a bottle of olive oil?

Looks like just another scam artist to sell stuff

Re:Eating fewer calories can ward off ageing by joenot443 on Tuesday January 02, 2024 @05:53AM (#38840309)
With a very, very short amount of research you'd find he has a pretty seasoned track record, having sold Venmo's parent company to PayPal for $800m in 2013. Not exactly the drop-shipping repackaged olive oil salesman you're painting him to be.

Personally, I try not to throw out accusations about people when I'm this unfamiliar with their background. I'd encourage you to consider a similar habit :)

Re:Eating fewer calories can ward off ageing by pcstl on Tuesday January 02, 2024 @06:01AM (#38840351)
So he's a successful businessman.

How does that background translate to any kind of scientific competence? Because his website is heavy on the buzzwords and the Silicon Valley "glorious future"-talk and remarkably light on anything resembling responsible science.

He clearly doesn't want to advance knowledge about longevity, he wants to be the world's top longevity marketer and salesman. It's just a business long shot to him. And yes, that is perfectly congruent with his background.

Re:Eating fewer calories can ward off ageing by gloryjulio on Tuesday January 02, 2024 @07:03AM (#38840751)
Like taking nutritional advice from a successful entrepreneur, and startup advice from doctors?

It seems that Jobs is way more successful than him. Should we follow his fruit diet?

Re:Eating fewer calories can ward off ageing by wouldbecouldbe on Tuesday January 02, 2024 @04:40AM (#38839845)
I don't think he needs te money tbh
Re:Eating fewer calories can ward off ageing by pcstl on Tuesday January 02, 2024 @04:50AM (#38839918)
As an entrepreneur myself, I can tell you that "needing the money" stops being a significant motivation after a while, or at least takes a back seat to the thrill of just getting people to buy the thing.
Re:Eating fewer calories can ward off ageing by gloryjulio on Tuesday January 02, 2024 @05:19AM (#38840106)
Well a lot of the scam artists are rich. It's not like they have stopped scamming
Re:Eating fewer calories can ward off ageing by tomalaci on Tuesday January 02, 2024 @04:17AM (#38839704)
It is on https://protocol.bryanjohnson.com site. For example, his fitness routine: https://protocol.bryanjohnson.com/#fitness

Personally, I have taken few things from his routine and double-checked it with other sources and more importantly found much cheaper products/things locally than the ones that are advertised (even though, most of them are fine anyways such as in Skincare he uses standard Cerave stuff).

Do note that this is -one- guy trying basically everything that seems plausible. It would likely result in frequently switching up things that are not researched well.

Re:Eating fewer calories can ward off ageing by pcstl on Tuesday January 02, 2024 @04:47AM (#38839905)
The issue is that he never explains why he does particular stuff, what specific results particular stuff he tried had, what worked and especially what didn't.

His website is full of "look at my amazing results!", which makes for good marketing talk but does not good science make and is not good nor helpful for people who are trying to separate what works from what doesn't - but is great for Mr. Johnson' budding supplement business's baseline.

Re:Eating fewer calories can ward off ageing by JumpCrisscross on Tuesday January 02, 2024 @04:23AM (#38839741)
> I have taken few things from his routine

Any you feel comfortable sharing?

Re:Eating fewer calories can ward off ageing by radu_floricica on Tuesday January 02, 2024 @05:31AM (#38840181)
I knoooow, it was exactly my feeling. He has a lot of referral links... but over half of them are out of stock. If he gave a shit about making money he'd have updated the links.

Overall I think he's legit, but also weird. It could be "rich guy weird" or "on the spectrum weird", doesn't really matter. Either way, I'm mostly taking him seriously now, with caveats.

The biggest caveat being, of course, that it's a study with a sample size of 1. A very in-depth study, but the applicability is limited. For example if you look at the list of supplements, there are quite a few which are obviously there because he's a vegan.

This is also related to why his protocol isn't explained in detail - it's ongoing and result-based. He may try something, see if it works, and stick it in the protocol. Supporting studies are useless for this modus operandi - he's not trying to convince you that particular supplement is good for you. All he's doing is risk-benefit calculations for his particular case. Which means that yes, he'll have a bunch of stuff which maybe work for everybody, or maybe work for him, or maybe random noise just made them look like they work for him but are actually useless. Or worse, stuff which can be actively harmful, but he was lucky or just very healthy otherwise and didn't see the damage.

Re:Eating fewer calories can ward off ageing by pcstl on Tuesday January 02, 2024 @06:07AM (#38840381)
I'd agree with you if it weren't for all the cultish red flags present here.

This is clearly a man who wants a cult-like mentality to form around him.

If he were just going ridiculously in-depth with his self-research and being open and honest about this, I'd actually admire him a lot, but it's all the grandiose talk about "Zeroth principles thinking" and "Aligning with what the 25th century would want" together with implying his detractors must be weak, scared and lacking in self-control that turns me off heavily.

Re:Eating fewer calories can ward off ageing by amval on Tuesday January 02, 2024 @04:17AM (#38839708)
I encourage everyone to ignore Bryan Johnson, whose not-so-secret goal is to sell supplements to gullible people and has nothing to do with actual science.
Re:Eating fewer calories can ward off ageing by paul7986 on Tuesday January 02, 2024 @03:43AM (#38839508)
In the ABC interview I linked to below he looks really weird no matter how much bright light they shine on him for the interview (lighting is everything). He doesn't look healthy to me!

https://www.youtube.com/watch?v=kw2H_j81_50&t=75s

Re:Eating fewer calories can ward off ageing by unsupp0rted on Tuesday January 02, 2024 @03:58AM (#38839583)
He does look strange- it's mainly his hair I think. It looks fake and alters his whole look. His body is outwardly in great shape.
Re:Eating fewer calories can ward off ageing by gnicholas on Tuesday January 02, 2024 @04:17AM (#38839709)
Yeah, my thought was hair (looks like implants, but what do I know) and manicured brows. And then the skin that looks like it doesn't see much sun, so it's undamaged but also a bit pallid/grey.
Re:Eating fewer calories can ward off ageing by irjustin on Tuesday January 02, 2024 @04:37AM (#38839818)
Kind of reminds me of Data.
Re:Eating fewer calories can ward off ageing by joncrocks on Tuesday January 02, 2024 @04:45AM (#38839887)
I believe he dyes it. This could make the colour look a little off.
Re:Eating fewer calories can ward off ageing by steve1977 on Tuesday January 02, 2024 @04:02AM (#38839620)
He looks a bit like Data from Star Trek TNG
Re:Eating fewer calories can ward off ageing by amoss on Tuesday January 02, 2024 @04:50AM (#38839919)
Leaning hard into what would the 25th century value, but on limited data.
Re:Eating fewer calories can ward off ageing by paul7986 on Tuesday January 02, 2024 @06:09AM (#38840399)
I agree yet these older pics he looks so different and normal ..his look changed substantially

https://www.google.com/imgres?imgurl=https%3A%2F%2Fnetstorag...

Re:Eating fewer calories can ward off ageing by tomalaci on Tuesday January 02, 2024 @04:03AM (#38839628)
He frequently renews his skin through rather extensive skincare. In health terms, ideal skin has no sun damage or micro-scars/exterior damage and, therefore, is not surprising that he does look like some sort of vampire. I mean, the guy even transfuses blood from his kid.
Re:Eating fewer calories can ward off ageing by JumpCrisscross on Tuesday January 02, 2024 @04:38AM (#38839825)
> frequently renews his skin through rather extensive skincare

What is he doing?

Re:Eating fewer calories can ward off ageing by tomalaci on Tuesday January 02, 2024 @04:54AM (#38839947)
https://protocol.bryanjohnson.com/#skin-health

For non-invasive skincare he does daily face-wash, moisturizing creams (face and body), application of creams containing Vitamin C, E, B3 and more. Personally, it is enough to apply some moisturizer (for face and body) and UV-protective cream. If you want really smooth/clean face then you can look into getting some retinol/retinoid - the stronger the better the effect as long as your skin can tolerate (so requires experimentation). Stick to proven brands such as Cerave, Eucerin and few other big ones.

For more invasive procedures he does microneedle and laser procedures. Both operate on principle of basically causing controlled damage on the skin to force your body to repair it. I used to have some stretch marks that were repaired using CO2 laser. Before trying to do any of this - consult your local dermatologist if you have something that bothers you on the skin, however. These procedures can be costly, requires after-care and obviously should be performed by certified professionals.

He also does microbotox injections to clear any pores. In my opinion this is now veering off more to cosmetic enhancement with fillers and the like.

Re:Eating fewer calories can ward off ageing by gniv on Tuesday January 02, 2024 @04:35AM (#38839812)
Is there somebody as dedicated to healthspan as him, but who does not ostensibly sell anything?
Re:Eating fewer calories can ward off ageing by AlexSneedMiller on Wednesday January 03, 2024 @11:00PM (#38862838)
He does sell a product, but that product is very optional and seems like it could be valuable for those who really like his free stuff (podcast and free newsletter)
Re:Eating fewer calories can ward off ageing by pcstl on Tuesday January 02, 2024 @04:45AM (#38839892)
On my hand, I encourage everyone I know who is interested in longevity to stick to actual scientific research and stay away from Mr. Johnson as much as possible. There are more red flags around this man than in the entire People's Republic of China. Let's make a small, non-exhaustive list of them:

1. First of all is that he talks significantly more about the supposed results of his program than he does about why his program is like that or even what does his actual program consist in. You will notice that nowhere at all is the actual "program" explained or even described in its entirety. As has been mentioned, all of his content is about "wow, look how amazingly strong I am" or "wow, look at my amazing metabolism" but none of it is actionable content beyond telling people to buy his shit.

2. Speaking of "telling people to buy his shit", once you get beyond the amazingly extensive wall of "wow, look how amazing my results are", his website looks remarkably like every single other unproven supplement peddler out there. I am looking at his website right now as I write this and the number of supplements he sells himself has, in fact increased greatly. He has gone from the $60 olive oil which was his original product to a branded line of spreads, drink mixes, and whatever else to the point that he's starting to look a lot like the Liver King (https://www.youtube.com/watch?v=BKpmAGZQetc), if more "creepy 50 year-old trying to look like a teenager" than Liver King's "creepy 50 year-old trying to look like a jacked piece of salami"

3. While I admire Mr. Johnson's willingness to self-test unproven treatments supposedly in order to figure out if they actually work for himself, his website is remarkably light on warnings on which treatments are actually unproven and which might actually carry some level of danger. The amount of warning on unproven and unlicensed therapies in his website amounts to a single footnote very well hidden under a gigantic wall of "wow, look how amazing my test results are and how impressive my wall of supplements is!"

4. Speaking of his test results, early on Mr. Johnson actually used to talk about challenges, things that went wrong or even just "not so great". As time went on, it's all rah-rah "look at how amazing I am! My measurements are better than an Olympic athlete!!". And while I truly do hope Mr. Johnson's (unexplained, just-so) protocol is just that great, it does seem a lot like peddling his olive oil and whatever else would suffer if he were to say that anything he did was anything beyond perfect.

5. Oh god, the "philosophy" parts. I really want to talk as little as possible about this one, because it's all vapid bullshit and even talking too much about it helps it spread - in fact Mr. Johnson is well-known for actively courting Twitter drama as a way to strengthen his brand. (It should be a well-known fact by any human being living in the 21st century that controversy will make grifters stronger in the short run). His rant on how he is somehow going from "First Principles thinking" to "Zeroth principle thinking", which is "the base of genius" can compete with anything written by any "motivational guru" who talks about "quantum healing" to large audiences... Including a part where he says that anyone who doubts him and his protocol must be weak, miserable, scared of being left behind, afraid of change, and lacking self-control. Wow.

6. Now, let's look at what all this high-minded philosophical talk builds up to. Well, it seems that somehow Mr. Johnson's protocol will help you resist "corporate profiteering at your detriment" and also stop us from "destroying the biosphere" by "aligning us with what the 25th century would value". Huh. Ok, seems pretty great. How can we get there, Mr. Johnson?

    It would have been hard to predict the books that would be written with the introduction of the printing press; or what the internet would enable. The same principle applies to what the human race can become when paired with the torrid wave of technological and scientific progress. We can take baby steps as we work on stretching our imaginations: 

    Week 1: drink the Green Giant (GG) daily.
    Week 2: GG + Super Veggie (SV) daily.
    Week 3: GG + SV + Nutty Pudding (NP) daily.
    Week 4: GG + SV + NP + supplements daily.
Oh, ok, we just need to buy his shit.

I rest my case.

Re:Eating fewer calories can ward off ageing by kuhewa on Tuesday January 02, 2024 @05:20AM (#38840109)
I would skip him and go to Peter Attia, who I have my nitpicks with, but he also has a research team, and is transparent about the whys
Re:Eating fewer calories can ward off ageing by 2716057 on Tuesday January 02, 2024 @05:35AM (#38840210)
Remember to watch a Berkshire Hathaway shareholder meeting after Johnson to learn how nonagenarians actually eat ;)
Re:Eating fewer calories can ward off ageing by robin-whg on Tuesday January 02, 2024 @10:05AM (#38842377)
The caloric restriction and the low body fat percentage resulting from it is not maintainable without the use of steroids. The body doesn't produce enough testosterone, which, among other things, means you'll feel tired all the time, have no motivation and no sex drive. But if I recall correctly, he's transparent about his steroid use.