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Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by Arainach on Tuesday October 31, 2023 @03:31AM (#38081305)
>My DNA isn't some terrible secret I have to hide in the dark.

.....please get back to us on how that opinion ages once your insurance companies get ahold of the data.

Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by zo1 on Tuesday October 31, 2023 @03:59AM (#38081485)
Not OP, and I agree that research needs to get access to DNA for medicinal, personalization and drug-development research purposes. What I'm more worried about is this sort of data being used to train a neural network that maps genes to physical traits, which would be both a goldmine and Pandora's box.

If I could compare it to something recent, it's the whole Content -> LLM -> Content loop that was created and we're all upset over now to various degrees. Our DNA is the content and up until now has been an opaque black-box with only minor views into it for very specific genetic diseases. Once they open up the box that allows them to get to things like IQ, height, muscle-density, resistance to diseases, fertility, etc, then the human race is in for a wild down-hill ride.

Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by xnorswap on Tuesday October 31, 2023 @04:13AM (#38081569)
Once that happens, it won't be by the backdoor.

Insurance companies will offer a "DNA discount" and ask for DNA directly, and simply charge more to anyone who refuses, and then grade the amount of "discount" based on the risk profile back from the DNA sample.

If you hold out and refuse, you'll simply get lumped in with the riskiest.

People love a "discount".

Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by sergers on Tuesday October 31, 2023 @04:35AM (#38081730)
My household mortgage provider, TD Bank Canada, offered me critical illness/death "insurance" for me and my spouse.

As we were insuring over a million in the mortgage/loc, I guess they have diff requirements.

They sent over their own funded nurse, who collected vitals and blood samples which we signed off them running any number of tests.

I should have checked if any clause for DNA. But that's not needed... Insurance is already all over you now.

Mostly in past was just a quick questionnaire. Then I was use to be sent to Dr for physical.

Now they contracting their own nurses and labs.

They probably already collecting your dna

Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by panta on Tuesday October 31, 2023 @06:02AM (#38082436)
taken to the extreme, if complete data availability allowed to predict the future with enough precision, than everyone would pay an insurance premium corresponding to their insured negative events. In practice insurances wouldn't have any reason to exist. The foundational premise of the insurance concept is that risk is spread across every participant in an equal manner.
Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by clbrmbr on Tuesday October 31, 2023 @06:26AM (#38082616)
Really important comment!

Is having a bad recessive a “pre-existing condition”? Or do genotypes form already legally protected classes?

Clearly we need good lawyers here, or careful regulation, or public medical insurance.

I hope it doesn’t go the way of car insurance.

Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by 0x00_NULL on Wednesday November 01, 2023 @08:13PM (#38107213)
While this is an interesting idea, no doubt, epigenetics casts major doubt on whether knowing the DNA expression at a particular time is diagnostically useful.

Sure. There are some conditions that are purely genetic, but many genes can be switched on and off depending on the environment - or even recoded in the replication process. DNA isn’t as static as we once thought and knowing a person’s DNA is not quite as useful as we imagined.

This isn’t as big of a deal as we imagined. It’s going to take some incredible processing to uncover causal patterns, and a huge amount of experimentation to determine whether they are stable against epigenetic changes. In my opinion, this is quite exciting.

Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by WarOnPrivacy on Tuesday October 31, 2023 @09:05AM (#38084223)
> The foundational premise of the insurance concept is that risk is spread across every participant in an equal manner.

Applying this broad principle to auto insurance, it isn't doing well. Auto ins is ~mandated. Participants are forced to pay for risk pools they aren't part of.

ex: Car repair costs are skyrocketing. Premiums are also skyrocketing, including for people who don't carry collision.

Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by plonk on Wednesday November 01, 2023 @03:53AM (#38095625)
Everyone can make disasters at the wheel though. If you didn’t mandate insurance, there would be victims with no recourse.
Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by WarOnPrivacy on Wednesday November 01, 2023 @09:33AM (#38097960)
Sure. But insurance companies leverage that mandate; they make people who don't choose (or can't afford) collision policies subsidize people that do. With this, the bargain of shared risk is quietly killed and replaced with exploiting the poor (or frugal) to pay for the non-poor (or lavish).
Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by nerdix on Tuesday October 31, 2023 @09:06AM (#38084233)
Why wouldn't insurance have a reason to exist? Even the healthiest people need medical insurance because anyone can experience accidental injury requiring hospitalization and/or on going medical care.
Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by panta on Tuesday October 31, 2023 @09:55AM (#38084863)
Then only insurance for actual accidents would make sense, but even then insurance companies could start analyzing more meticulously the individual probabilities of having accidents: do you have an active lifestyle? you pay a premium; do you practice sports? you pay a premium; travel more than the average human? pay a premium; are you getting older? insurance rate grows exponentially; already had an accident? sorry, you no longer a desirable customer.
Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by everforward on Tuesday October 31, 2023 @03:32PM (#38090241)
This is presuming perfect knowledge; it's a thought experiment. In this hypothetical world, your insurance company does know that in 13 months you're going to get in a car accident that flings a 1.27mm shard of glass into your eye, that it's going to take 27 minutes to complete the surgery that fixes it, that you'll have an infection after that and the first 2 antibiotics won't work but the third one will.

It's basically just pointing out that perfect knowledge makes risk 0, and that insurance doesn't make sense in a world with no risk. At that point the question is basically just whether you distribute medical costs evenly across everyone or let there be winners and losers on those costs.

Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by trimethylpurine on Tuesday October 31, 2023 @06:05AM (#38082460)
In the US at least, according to some quick web searching, discounts must apply to the entire pool of insured. (For medical insurance specifically.)
Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by Ancalagon on Wednesday November 01, 2023 @02:15PM (#38102467)
Man that is so dystopian, and I don't disagree with what you're saying will happen at all.
Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by globular-toast on Tuesday October 31, 2023 @04:14AM (#38081572)
I worked in insurance and they all seem intent on tailoring everyone's insurance policies based on any minutiae they can dig up on them. For example they found out for life insurance that people who live in greener areas live longer, so they were trying to obtain geographical data for "greenness".

I asked them what the end game is. What happens when everyone's insurance policy is exactly tailored to them? What is the point of insurance then? If they get it too right they put themselves out of business. They didn't have a good answer.

Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by charcircuit on Tuesday October 31, 2023 @04:24AM (#38081651)
>What is the point of insurance then?

Protection from unlikely events.

>If they get it too right they put themselves out of business.

No, they don't. Getting it too right just means they are able to more effectively compete on pricing since they know the lowest price they can offer while still making profit.

Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by sa-code on Tuesday October 31, 2023 @04:30AM (#38081686)
The point you missed is that when insurance is hyper tailored to specific people, you are basically paying for your own healthcare and can cut out the middle man
Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by charcircuit on Tuesday October 31, 2023 @04:46AM (#38081833)
That is assuming all health related costs can be predicted 100% correctly. If there is a 1/3rd chance to incur a cost then insurance lets you get away with only paying 1/3rd of the cost.
Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by adastra22 on Tuesday October 31, 2023 @04:52AM (#38081881)
Yes, the is the assumption in this hypothetical.
Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by charcircuit on Tuesday October 31, 2023 @04:57AM (#38081928)
In that hypothetical in the best case the insurance company will never lose money by charging someone less than what they will have paid out to them and they will be able to sell this service to other companies, in the worst case they become essentially a bank.
Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by soco on Tuesday October 31, 2023 @05:01AM (#38081959)
Uh, no. Insurance is paying for unlikely events, as it was said above. Greener area or not, you can still get run over by a car, event for which you definitely didn't pay. Or you house struck by lightning, or any such insurance cases might arise. The green area only affects the probability of such events, thus the tailoring.
Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by globular-toast on Tuesday October 31, 2023 @07:23AM (#38083095)
But my point is by hyper-optimising for individuals it will at some point cross a line where it's not really insurance as you understand it any more. The unlikely event is that the insurance company gets it wrong, for example your house floods in an area that was not predicted to flood for millennia. As the insurance company gets better, the chance of an unlikely event gets smaller. How small can that chance get before you decide to just take the risk yourself?
Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by bossyTeacher on Tuesday October 31, 2023 @06:06AM (#38082467)
insurance <> healthcare

the point of insurance is to cover for unlikely events not expected events (like you needing increase healthcare support as you age)

Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by rurp on Tuesday October 31, 2023 @01:45PM (#38088617)
You don't think that insurance companies will charge a hefty premium for sitting in the middle of that? That's a pretty classic middle man scenario.
Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by petesergeant on Tuesday October 31, 2023 @04:27AM (#38081662)
> If they get it too right they put themselves out of business

What? How is it you think insurance companies make money exactly? And why would getting better at predicting risk stop them doing that?

Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by globular-toast on Tuesday October 31, 2023 @07:17AM (#38083023)
Insurance makes money by ensuring their income (premiums) is greater than their outgoing (payouts).

The value of insurance (and why we pay for their profits) is in spreading risk across populations. They already target particular demographics (when the law allows them to), but I'm talking about targeting individuals.

If the insurance company can predict exactly how much they will be paying out to you in the next 10 years, say, then they just become a glorified savings account with a cost attached (their profit). The value is then essentially telling you how much you need to save. Data companies like 23&Me could then offer this without bothering with the savings account part.

My feeling is people won't accept this and will want actual insurance policies that actually spread risk across populations because people don't want to be told "you need to save twice as much as your neighbour because of your cancer in 15 years time".

Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by nerdix on Tuesday October 31, 2023 @09:17AM (#38084371)
Except accidents happen.

Unless they have a crystal ball and can tell you whether or not you will be involved in an accident leading to serious injury (and the nature of those injuries) then you still need health insurance.

I know a guy who was robbed and shot. Had to have surgery and spent a few weeks in the hospital.

I have a neighbor that was jogging, tripped over a bump in the sidewalk and broke his arm. Few weeks in a cast.

I know plenty of blue collar workers who had on the job injuries that required medical treatment.

Your DNA isn't going to help with that. And in America, a simple 4 hour visit to the ER can result in a multi-thousand dollar bill. And if you're unfortunate enough to need a surgery and a multi-week stay then we're talking 5 figures minimum.

Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by K0balt on Tuesday October 31, 2023 @08:04AM (#38083478)
As insurance risk estimation errors approach zero, the value of having insurance instead of just a medical savings account approaches zero. Rates for higher risk individuals will become prohibitively high and those people will have no choice but to be uninsured. Insurance companies would be essentially only covering black swan events, as individual premiums would match individual health costs with high fidelity.

As a result the incentive to get comprehensive health insurance rather than just disaster insurance would plummet, as an MSA would be more cost effective and you also get to take advantage of better than predicted health outcomes in the form of interest earned and at EOL a potential inheritance gift.

Sounds great, except you jhave to understand that this would mean that society would somehow need to deal with the burden of the least healthy, who would be very unlikely to purchase, or be able to afford, insurance under this scheme. It’s like trying to charge up front for building roads. You just end up with no roads. Socialism (or in the case of insurance,capital funded socialism) is extremely beneficial to society in certain specific verticals.

Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by rurp on Tuesday October 31, 2023 @01:44PM (#38088585)
I expect that marketing, regulation, and accidents will keep insurance companies around indefinitely. The upside of near perfect information seems great, for the insurance companies. They can ensure that the premiums they charge are higher than the expected payout for 100% of their customers. That won't be so good for the folks who need insurance the most though.
Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by adastra22 on Tuesday October 31, 2023 @04:53AM (#38081885)
That was explicitly made illegal under federal law for exactly this reason.
Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by solumunus on Tuesday October 31, 2023 @05:13AM (#38082058)
More efficiently priced insurance would be a good thing. A lot of people seem to be confused about what insurance is.
Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by denton-scratch on Tuesday October 31, 2023 @05:58AM (#38082402)
"Efficiently priced insurance": do you mean so the insurance company can set your premiums based on a more-accurate estimate of your risks?

The whole point of insurance is (or was) pooled risk. The more the insurance company knows about my risk (even risks I don't know about), the less point there is in me buying insurance; I may as well just put my premiums into a private sinking fund.

Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by SantalBlush on Tuesday October 31, 2023 @06:20AM (#38082580)
Exactly. If an insurance company has perfect knowledge of each individual's risk and charges accordingly, it ceases to be insurance.
Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by solumunus on Saturday November 04, 2023 @12:13PM (#38142395)
So even if your insurance worked out cheaper you would now see it as not worth buying because it’s too accurately priced? Literally what are any of you talking about, this is crazy talk. You buy insurance to hedge against risk, that’s it, if the cost accurately represents the risk then that’s a good thing. If you have unlimited money then it’s always financially better to not buy insurance, that’s correct right now… People don’t have unlimited money to spend on massive, unexpected acute financial obligations, that’s why people buy insurance… ITT: people not even understanding why they’re spending money on insurance every month, this is mind blowing to me.
Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by adhesive_wombat on Tuesday October 31, 2023 @06:08AM (#38082485)
People in the UK should take note of this thread: this is what the private health industry dearly, dearly wants for you too. Treasure what you have while you still have it.
Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by dkural on Wednesday November 01, 2023 @12:54AM (#38094714)
UK has done the largest sequencing project on Earth, the UK BioBank, and shares the data with both academia and private companies to do drug discovery. NHS is also chronically underfunded.
Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by adhesive_wombat on Wednesday November 01, 2023 @04:45AM (#38095889)
But as no one (yet) needs private health insurance, and very few people have it, it is not (yet) a societal worry that the data will be used to "offer a choice" to people based on genetic misfortune (the choice is bankruptcy or death).

> NHS is also chronically underfunded.

That's very much by ideological design. A recent ex-health minister even co-wrote a book which contained this:

> Our ambition should be to break down the barriers between private & public provision, in effect denationalising the provision of health care in Britain.

Notably he became health minister after this, not before, so the appointment says a lot about what the Party has in mind.

If you look at the graph of waiting times, his tenure is from 2012-2018, and the party is in place from 2010 and quickly has the knives out to ruin the then-recent improvement. https://www.statista.com/chart/27447/nhs-hospital-waiting-ti...

The latest squeeze on "efficiency" (dragging this back into technology) is throwing AI (read: more consultancy contracts) at it.

Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by luma on Tuesday October 31, 2023 @06:31AM (#38082657)
This sort of thing has been illegal in the US since 2008. You’re talking hypotheticals that have already been addressed by legislation.
Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by varjag on Tuesday October 31, 2023 @06:56AM (#38082855)
Man were the old times amazing. Mandatory seatbelts, smoking bans and this. Things that would be impossible to legislate in 2020s.
Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by salawat on Tuesday October 31, 2023 @12:48PM (#38087725)
Note: Compliance departments in insurance companies are basically intended to facilitate by rote presentations of trainings to check off that list item as a required business operation.

Actual teeth to bite back or remidiate non-compliant activity of a company that the executives have decided to file under the "fuck it, nobody's looking" risk heading are basically not there.

Point being, just because the law is on the books doesn't mean it isn't being elided at every opportunity. You have been warned.

Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by Arainach on Tuesday October 31, 2023 @08:01PM (#38092973)
I have not done extensive research, but I suspect this is as effective as banning the government from data collection, with the result that the government pays companies to do that and it's somehow legal that way.
Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by delfinom on Tuesday October 31, 2023 @06:51AM (#38082814)
The Genetic Information Nondiscrimination Act (GINA) of 2008 already forbids them from doing anything.

>GINA prohibits health insurers from discrimination based on the genetic information of enrollees. Specifically, health insurers may not use genetic information to determine if someone is eligible for insurance or to make coverage, underwriting or premium-setting decisions.

Re:Drugmakers Are Set to Pay 23andMe Millions to Access Cons... by solardev on Tuesday October 31, 2023 @07:42AM (#38083276)
The American insurance model is stupid and needs to go away, regardless of my DNA.