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Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by chrisco255 on Monday December 26, 2022 @05:02AM (#34136277)
This vaccine isn't even effective any more against modern forms of Covid. Covid mutates multiple times per year. And by and large, low income countries have not been "overwhelmed" by Covid.

I'll add, this study is not comprehensive, there could be other risk factors as well, the other vaccines could have issues, majority of the general population has already contracted Covid at least once, etc etc but some people insist on quadrupling down on dubious mRNA treatments with unknown compounding risks for unknown numbers of people. It's the definition of insanity. It might be worth revisiting alternative therapeutic treatments including monoclonal antibodies and antiviral drugs, rather than continue on this ignorant path. Just a thought.

Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by keewee7 on Monday December 26, 2022 @05:19AM (#34136373)
>low income countries have not been "overwhelmed" by Covid

India was completely devastated by COVID-19.

One reason was that India failed to focus their care on actually vulnerable elderly people and they instead had 30-something dudes demanding intensive care and taking up oxygen cylinders for themselves and their families.

Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by ramraj07 on Monday December 26, 2022 @05:38AM (#34136486)
I agree that india bungled their Covid response royally (though not unexpectedly for me) but what evidence do you have that it was all because of 30-somethings hogging the oxygen cylinders.

I myself predicted there will be a run on oxygen concentrators and had one rented for my mom in case. But when delta hit I couldn’t in good conscience keep it and returned it back to the hospital. I know many rich families did not do that and hoarded cylinders and concentrators like this when people were dying. However I’m not convinced that this was the reason for the massive suffering caused in india. It’s just another facet of the cruelty that happened during this time.

Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by fancybouncy on Monday December 26, 2022 @05:33AM (#34136455)
Isn't most of India's population very young (half of it is under 15)? I'm skeptical that the "vulnerable elderly people" had much impact on India's covid story.

Either way, the elderly have already lived their life, isn't it better to focus on the younger people when a choice must be made?

Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by noduerme on Monday December 26, 2022 @06:28AM (#34136775)
If you had two hard drives and had to destroy one, without knowing what was on them, only how much information they each contained... wouldn't you keep the one with more stored in its memory?
Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by Kwpolska on Monday December 26, 2022 @06:45AM (#34136881)
You’re focusing on the memories and experiences of a person, but are completely ignoring the potential to grow, develop, and do things - something that 30-year-olds have, and 90-year-olds pretty much don’t.
Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by noduerme on Monday December 26, 2022 @06:51AM (#34136916)
But it only takes 30 years to make a 30 year old. They're at least 3x more replaceable than 90 year olds.

[edit] also, do things for whom? To what end if not to build experience?

Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by abofh on Monday December 26, 2022 @12:04PM (#34139473)
Alternatively, most 30 year olds have 30 more years to contribute to society. Most 90 year olds do not.
Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by archagon on Monday December 26, 2022 @07:42PM (#34143563)
Why is “ability to contribute to society” a factor in considering who to save? Down that path lies euthanasia of the disabled and mentally ill.
Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by fancybouncy on Wednesday December 28, 2022 @11:50AM (#34162871)
and this is bad how?
Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by headsoup on Monday December 26, 2022 @07:15AM (#34137054)
Yeah it definitely makes sense to sacrifice the children for the elderly, I mean what good are the kids of tomorrow without the old of today.

In other words I'm saying that's a silly analogy

Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by noduerme on Monday December 26, 2022 @07:42AM (#34137212)
>> what good are the kids of tomorrow without the old of today

Worshipping youth in its ignorance and speed while discarding the wisdom of elders is called fascism. The right question would be what can civilization hope to achieve besides a reversion to barbarism and "Lord of the Flies" if it doesn't hold its oldest, most vulnerable and most wise members, and their experience, in the highest regard?

The young have always been proud and disposable. And if they don't die young, they get old. Then maybe they have something more interesting to say.

Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by headsoup on Monday December 26, 2022 @10:51AM (#34138603)
Wow straight to the fascism argument, nice. I fail to see at all how sacrificing the young and healthy for the old and ill is not fascism, but sacrificing the old and ill for the young is? Isn't a component (not all...) of fascism any sacrifice 'for the good of the nation.' Didn't realise it was so specific.

You're putting the wrong lens on this. My argument is that we are to deliberately harm the young to possibly protect the old and ill (which in this case isn't so as the vaccines don't guarantee prevention), rather than leaving them alone in the hope of protecting the old and ill as-is. Not 'let the old die for the young.'

Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by joshuahedlund on Monday December 26, 2022 @07:26AM (#34137112)
When you have 1.4 billion people, even a lower proportion of older folks is a huge number. Including a lot lost “only” in their 50’s and 60’s.
Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by chrisco255 on Monday December 26, 2022 @05:51AM (#34136558)
India suffered a 28% increase in excessive deaths from 2020-2021:

https://www.medrxiv.org/content/10.1101/2021.09.30.21264376v...

In line with many first world countries: https://ourworldindata.org/grapher/excess-deaths-cumulative-...

Notably, sub-Saharan Africa did not suffer greatly from Covid.

Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by noduerme on Monday December 26, 2022 @06:49AM (#34136900)
>> Notably, sub-Saharan Africa did not suffer greatly from Covid.

Neither did China. How stunning. It must be due to their fantastic public health systems.

Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by headsoup on Monday December 26, 2022 @07:14AM (#34137043)
Ah, it's a conspiracy when these countries 'do well' but everything you are told in the West is true huh?
Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by noduerme on Monday December 26, 2022 @07:33AM (#34137158)
Even if everything stated in western journalism were complete lies, I don't see how that would make the reporting out of autocratic dictatorships any truer.
Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by DiogenesKynikos on Monday December 26, 2022 @09:20AM (#34137767)
Do you know anyone in China? Just ask them what life was like for most of zero-CoVID. Most people didn't even know a single person who had gotten infected.

You don't have to arbitrarily trust some authority. Everyone in the country could see from their own experience that spread of the virus really was being effectively controlled.

Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by headsoup on Monday December 26, 2022 @10:55AM (#34138658)
Depends if you believe everything that comes out of a dictatorship is a lie. How untrue is it? We know it's under-reported, but who do you trust to find the truth?

The question is, do you think it is easier or harder to spot the lies of Western journalism, and what problems does that cause in forming a base to judge others?

Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by noduerme on Monday December 26, 2022 @02:34PM (#34140970)
Pointing at flaws in Western journalism is a red herring. Using it as a whataboutist talking point is a favorite these days of dictatorships and their apologists.

No, it's not 'the question' whether it's easier or harder to spot the 'lies' of Western journalism. That has no bearing whatsoever on the obvious, cut and dry reason for the underreporting of covid deaths in China.

But it is worth pointing out that, unlike the "news" propaganda organs of dictatorships, Western journalism is in no sense a monolith that speaks with one voice. Not even mainstream media in the US speaks with one voice (because yes, Fox is the MSM too). So while it may require a bit more sophistication to pick out truths, it is at least not a one-sided distortion of history in favor of the rulers.

Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by headsoup on Monday December 26, 2022 @08:45PM (#34144012)
Pointing out flaws is a red herring?

No, finding the flaws in western journalism takes more effort because it's not as obvious. Which means the rulers can get away with propoganda and manipulation much more easily than one who provides a direct, complete and obvious propoganda.

I think people would be wise to be equally critical of left and right MSM, not just assume they aren't propoganda because they are on different 'sides' (hint, they're not really)

Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by noduerme on Monday December 26, 2022 @09:54PM (#34144481)
It's a red herring because this article is about reported statistics from country to country. When the media in one relatively free country skews statistics, that is generally reported by opposition media in the same country and in other free countries abroad. Certainly it's right to point out that some "free" media has skewed statistics or parroted an establishment line about covid, and pointing it out is exactly what a free press is for. And if you read news from alternative and European and Latin American outlets as well, you can spot the biases of some MSM reporting in the US. But what is a red herring is pointing out MSM bias in the same breath as Chinese propaganda, presenting it in a context by which it is somehow meant to excuse the total top-down censorship of an unfree press. The attempt to draw draw that equivalence is the favorite tactic of dictatorships. It's not just a matter of detecting lies, but of exposing truth. For instance, the lab leak hypothesis would never have even been mentioned in an unfree press; to simply know that your government is lying via press manipulation only tells you that you don't know anything. It doesn't tell you what they're hiding from you. Yet the American press has shown itself free enough to expose these things, giving one the opportunity to determine what may or may not be true. That opportunity simply doesn't exist in the Chinese media ecosystem.
Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by DiogenesKynikos on Monday December 26, 2022 @09:16AM (#34137747)
China didn't suffer greatly (until now) because it didn't allow the virus to spread.

An ounce of prevention is worth a pound of cure. If you keep the virus out of the country, you don't need great hospitals.

Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by chmars on Monday December 26, 2022 @07:33AM (#34137159)
Sub-Saharan Africa has of course also suffered greatly from SARS-CoV-2, they just have not the means to count their cases. SARS-CoV-2 does not behave differently in Africa than in other regions of the world, especially not in low-vaccination (or even no-vaccination) countries.

«Rather than an ‹African paradox,› the far simpler explanation is that COVID-19 has affected African countries just as the virus has everywhere else, but has gone undocumented.»

https://www.bu.edu/sph/news/articles/2022/morgue-data-reveal...

In countries with a younger population, less deaths from acute COVID-19 are expected, although the number of additional direct deaths from COVID-19 is still substantial. The disease burden burden, i.e., morbidity, also remains high, maybe even more given the sub-par health infrastructure.

Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by chrisco255 on Monday December 26, 2022 @10:15AM (#34138227)
> Sub-Saharan Africa has of course also suffered greatly from SARS-CoV-2, they just have not the means to count their cases.

Of course they do. If they suffered dramatically from Covid, it would be documented, just as it was for Ebola, Malaria, etc.

> SARS-CoV-2 does not behave differently in Africa than in other regions of the world, especially not in low-vaccination (or even no-vaccination) countries.

The statistics for Covid are all over the map with regards to vaccine status [2].

Some countries with high mRNA distributions did well (Canada, Australia). Some countries with high mRNA distributions did not do well (Brazil, US, Russia, Italy, Cuba). Some countries with low mRNA distribution did well (sub-Saharan Africa, Haiti, DR, Jamaica, Egypt, Papa New Guinea) [1][2].

> In countries with a younger population, less deaths from acute COVID-19 are expected, although the number of additional direct deaths from COVID-19 is still substantial.

A lot of these countries are showing 50-100 excessive deaths per 100K. That's on par with a bad flu season. Sub-saharan Africa has suffered far worse disease outbreaks than Covid. And unlike Covid, diseases like Malaria affect children [3].

[1] https://ourworldindata.org/covid-vaccinations#what-share-of-... [2] https://ourworldindata.org/grapher/excess-deaths-cumulative-... [3] https://ourworldindata.org/malaria-introduction

Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by chiefalchemist on Monday December 26, 2022 @06:59AM (#34136962)
It sounds more like India was devestated by selfishness and misguided priorities. Covid just happened to be there to take the blame.
Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by tsimionescu on Monday December 26, 2022 @05:28AM (#34136422)
I'm not sure about the monoclonal antibody treatments, but antivirals have much much worse side-effects than vaccinating the entire population, even if we did have one that worked on Covid-19 (which, unlike vaccines, we don't).

By and large, the Covid-19 mRNA vaccines have probably been some of the most extraordinary accomplishments in medicine, with unthinkably low risks given the speed with which they were developed. We took a gamble, but the magnitude of evidence we now have that they are safe is incredible, they are up there with some of the most common OTC medicine.

Fortunately, the vaccines still seem to offer some protection to make sure that vaccinated people are less likely to have a severe form of Covid-19.

[dead]
Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by fabian2k on Monday December 26, 2022 @06:35AM (#34136822)
The mRNA vaccines drastically reduce severe disease and death in elderly people, it's a really strong and easily observed effect. And they were developed in record time compared to any previous vaccine, so that is certainly a very impressive accomplishment.

Against earlier variants of the virus the vaccines were also very impressive in preventing infections. Far higher than the 50% minimum standard that was set when the development started.

Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by jinpa_zangpo on Monday December 26, 2022 @07:05AM (#34137001)
I'm willing to believe the mRNA vaccines have "saved a lot of lives" but there is a study that I haven't yet seen and I'd like to see: compare the number of deaths per hundred thousand in 2022 between the vaccinated and unvaccinated broken down into ten year age groups. 2022 because it's the year that the omicron strain has dominated. My hypothesis is that there will be no significant difference below 60 and an advantage for the vaccinated above 60, but that's just my guess and I'd like to see this very simple study done.
Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by headsoup on Monday December 26, 2022 @07:18AM (#34137072)
Curiously they mostly stopped reporting on that this year.

Below 50's were never even close to high risk and as soon as it was known (which was very) the vaccines didn't prevent spread they should have immediately been halted for all low risk age groups.

Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by chezelenkoooo on Monday December 26, 2022 @08:20AM (#34137398)
Did you try googling?

The chance of death is low for those up to 50. But vaccines even further reduce that.

https://www.google.com/amp/s/www.scientificamerican.com/arti...

Here's another one with a bit more of a specific breakdown

https://www.google.com/url?sa=t&source=web&rct=j&url=https:/...

Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by headsoup on Monday December 26, 2022 @10:45AM (#34138531)
Ooh yes, googling, the way to get the true and correct data first time, every time.

Unfortunately at this point there is no way to see if the vaccines have actually saved lives because a) they don't stop the virus or its spread, it is not confirmed that the vaccines haven't caused significantly more covid infections by being leaky (look up 'Leaky Vaccines,'[1] or OAS (original antigenic sin)) and they have encouraged high risk behaviour in the false belief the vaccines provide sufficient protection. I mean I don't even see any ads or posters around any more advising on hygiene improvements like not shaking hands, getting out in the sun, eating healthily, look after the weak and elderly, etc. People just take the vaccine as their safety blanket and worse, are signing their kids up for it when they were never a risk vector (until mid-covid the 'science' changed on that).

If you can point me to a study that conclusively shows vaccines absolutely saved lives over the longer term (that aren't based on models full of positive assumptions on efficacy and effectiveness), I'm happy to read it.

[1] example: https://boriquagato.substack.com/p/theres-something-antigeni...

Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by DiogenesKynikos on Monday December 26, 2022 @09:40AM (#34137919)
Exactly the sort of analysis you're describing was done in Hong Kong this year: [0].

The results are clear: the rate of severe or fatal cases was many times higher for unvaccinated people in all age groups.

For people aged 20-59, three doses (of either mRNA or inactivated virus vaccines) reduced the chance of severe or fatal disease by nearly 99%. Efficacy actually drops with age: for >80-year-olds, there's only a 97% reduction in risk (though because the starting risk is much higher, they get a larger overall benefit).

This was with Omicron, by the way. In an unprotected population, Omicron is still very destructive.

0. "Vaccine effectiveness of one, two, and three doses of BNT162b2 and CoronaVac against COVID-19 in Hong Kong: a population-based observational study", The Lancet Infectious Diseases, July 2022: https://doi.org/10.1016/S1473-3099(22)00345-0

Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by briandon on Monday December 26, 2022 @10:13AM (#34138213)
News from Christmas Eve (Dec 24), Google Translated:

  There were 39 new deaths in Hong Kong today, of which 
  37 died in public hospitals and 2 were reported by 
  public mortuaries. 

  There are 37 newly reported deaths of patients infected 
  with the new coronavirus, including 23 males and 14 
  females, aged between 50 and 104 years old. 

  Among the newly reported deceased patients, 14 were 
  from institutions. 

  As for vaccination, 5 had no injection information, 3 
  received 4 left injections, 25 received 3 left 
  injections, 2 received 2 left injections, and 2 
  received 1 left injection.
Source: 原文網址: 疫情|增21,362宗確診 三兒童情況危殆 七日平均死亡人數突破40 | 香港01 https://www.hk01.com/article/850466

Of the 39 deceased, all of whom were 50+ and 14 of whom were care home residents, only 5 were unvaccinated, 3 had received 4 shots, and 33 of the 39 had received at least 2 shots. That matches or exceeds the vaccination rate for their age demographics.

Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by DiogenesKynikos on Monday December 26, 2022 @10:18AM (#34138249)
Without knowing the rate of vaccination in the population (particularly in the elderly population), the data you gave means nothing. Just to illustrate the point, in a fully vaccinated population, every person who dies will be vaccinated.

I cited a study that does a rigorous statistical analysis.

Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by briandon on Monday December 26, 2022 @10:24AM (#34138294)
See https://www.covidvaccine.gov.hk/en/dashboard Scroll to "Vaccine Doses Administered (Age Group)" Click on "Population with 2nd Vaccine Dose" (under "Metrics")

Yes, you've linked a study.

I've shared a typical daily report of covid-attributed deaths and the victims' levels of vaccination and, as I told you, the vaccination levels of those who die of covid are as high or higher than the rates for their age groups.

Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by Faark on Monday December 26, 2022 @11:01AM (#34138734)
I'm sure it will be quite easy for you to find data points indicating vaccines are bad. The reason i will nonetheless simply disregard your conclusions and stick to what to me seems to be the scientific consensus is, that it is very hard to actually overcome biases (like motivated reasoning) and the scientific process is the best we have to overcome those.

In other words, please link a study. Or something else i can trust actually wants to get at the bottom of this, not win some argument.

Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by briandon on Monday December 26, 2022 @11:15AM (#34138903)
In recent years, you may have noticed that the scientific consensus around covid, starting at the beginning with lab leak vs. "seafood market" and continuing on to the present moment, changes frequently and drastically. Sometimes accompanied by revelations of fraud and dishonesty on the part of trusted public servants and domain experts. Congratulations to you on staving off psychological whiplash amidst all of the consensus-flipping.

If your response to being shown government-announced covid deaths with details of the vaccination levels of the deceased (available on a daily basis from that and other news outlets) and, for comparison, age-bracketed vaccination levels reported by the same government is that you want to be shown a study, then I suspect what you truly want is reassurance or reaffirmation of your current set of beliefs rather than a grasp of what's currently going on.

Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by Faark on Monday December 26, 2022 @03:44PM (#34141661)
Ofc consensus changes. Based on new data. That's how it is supposed to work.

> If your response to being shown government-announced covid deaths [..]

Well, that's what you are trying to promote. That you linked some raw data, not a conclusion-statement from this government, is all i need to know. I'm not calling you a liar. I just assume there to be another angle you might be missing (the motivated reasoning part), but this is something for experts in the respective area. And if not, it will change consensus accordingly. Unless, ofc, you believe in some grad conspiracy of all the governments all around the world. I don't.

Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by shagie on Monday December 26, 2022 @03:22PM (#34141429)
I would also contend that it is necessary to check which vaccines are being administered. The different vaccines have different effectiveness.
Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by gjm11 on Monday December 26, 2022 @08:22AM (#34137407)
Isn't Paxlovid an antiviral that works pretty well on Covid-19?

(I agree with the rest of what you say.)

Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by noduerme on Monday December 26, 2022 @06:40AM (#34136848)
The AZ vax is not an mRNA vaccine. In fact the entire point of this article is that the adenovirus vehicle in the AZ vax is the culprit.

When all is said and done, the mRNA vaccines (Pfizer, Moderna) saved a lot of lives. Moreover they showed that the technology is safe and viable, so expect to see a lot more of that type of in-body, self assembling vaccine for everything from influenza to cancer in the next decade. Of course any formula can have unwanted side effects, whether it's generated in your body or not, but doing nothing and waiting to see how a virus treats you isn't safe, either. You could get pretty fucked up either way, but you're less likely to get fucked up from the vax, and less likely to get fucked up from covid if you had the vax. There's risk in everything. Do the math and take the route with best survival rate. In this case, even the AZ vax was a clear winner over getting covid unvaccinated in 2021.

Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by Amezarak on Monday December 26, 2022 @09:30AM (#34137833)
This is probably, more-or-less true statistically, on a population level.

On a real-life level, things can be different. As I would have expected given my age and health profile, my pre-vaccine Covid case was extremely mild, practically asymptomatic. I would not have even thought I was sick if it wasn't for other members of my household being very sick, and then both of us testing positive.

On the other hand, after my first vaccine dose, I got extremely ill and then had a mild stroke. I deeply regret getting the vaccine. I feel very strongly there was no real point since I'd already had Covid. I just did it because of the mandates. The whole ordeal has soured me a lot on the whole issue.

Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by threatofrain on Monday December 26, 2022 @06:55AM (#34136941)
It would be helpful if you made specific citations for empirical work. This isn't the kind of question that is benefitted by reasoning from first principles.
Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by dennis_jeeves1 on Monday December 26, 2022 @09:59AM (#34138081)
>It would be helpful if you made specific citations for empirical work.

Are personal observations be good enough, or will they be dismissed as mere anecdotes?

Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by rajman187 on Monday December 26, 2022 @07:00AM (#34136964)
This makes no sense, the AstraZeneca vaccine isn’t an mRNA formulation but rather a vector vaccine (genetic material from the COVID-19 virus is placed in a modified version of a different virus—the vector—which gets into your cells and delivers genetic material that gives your body’s cells instructions to make copies of the S protein).

The mRNA vaccines worked to improve immunity and reduce the effects once infected; and to your point about mutations, the mRNA encoding the spike can be modified accordingly as this is a very quick and scalable method of delivery.

Given the hundreds of millions of people that have received mRNA vaccines I think generally we have an understanding of their safety.

The only insanity I see is people still now trying to deny vaccine efficacy, either as government conspiracy theories or through poor scientific understanding.

Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by headsoup on Monday December 26, 2022 @07:08AM (#34137015)
No, we don't have an understanding of their safety. Have you not noticed how most of the data is not even reported on now and near all previous studies stopped at three months? Even the study on interrupted menstrual cycles stopped at three months with 27% of participants still experiencing an interrupted cycle.
Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by rajman187 on Monday December 26, 2022 @07:43AM (#34137218)
> Have you not noticed how most of the data is not even reported on now and near all previous studies stopped at three months?

No, I haven’t noticed this. Do you mean reported in the media? I was never looking there for safety trial results. Do you mean in journals? Then that’s the just wrong—as is the claim that they stop at 3 months. You can look up phase 4 trials, for instance [0]:

> In addition to the standard ongoing (phase 4) trials, people who took part in the phase 3 trials of approved vaccines are continuing to be followed up (up to 2 years after their second dose) to collect more data – for example on safety, asymptomatic infection, and how long protection from the vaccines lasts.

Even the original BioNTech(Pfizer) clinical trial reports it’s methodology of surveying serious side effects for up to 6 months after second dose, which makes it a 7+ month study overall [1]

[0] https://www.bhf.org.uk/informationsupport/heart-matters-maga...

[1] https://www.nejm.org/doi/10.1056/NEJMoa2034577

Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by headsoup on Monday December 26, 2022 @11:32AM (#34139124)
I mean the UK stopped reporting vaxxed vs unvaxxed back in May and I believe they've also stopped or reduced reporting on birth rates. There are other reports that have stopped but I'd have to go digging to grab them again.

That Pfizer trial ended at 3.5 months because 97% of the control group got vaccinated.

Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by sneak on Monday December 26, 2022 @07:05AM (#34136998)
> Given the hundreds of millions of people that have received mRNA vaccines I think generally we have an understanding of their safety.

The conclusion does not follow from the premise.

Five months following a covid infection in which I had 4-6 weeks of neurological deficit, I received the bivalent mRNA booster, which seemed to somehow reactivate the neurological issues for a few days or a week. Doctors told me this is not uncommon.

These are not "safe" in the same way we mean that MSG or acetaminophen are "safe".

Corners were necessarily cut in the trials of these during development to accelerate time to market. They saved lives, the gamble paid off. But the trial protocols are in place for a reason and we do not fully understand these drugs as yet.

Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by rajman187 on Monday December 26, 2022 @07:30AM (#34137148)
The post I replied to stated

> dubious mRNA treatments with unknown compounding risks for unknown numbers of people

If that was the case, after 100s of millions of doses given out shouldn’t these have surfaced in sufficient numbers?

Sorry about your condition, but there’s nothing there that suggests it is related to the mRNA formulation; you could just as easily experienced the same with a viral vector formulation or even without any booster (long covid, if that’s what you had, is not without relapses)

Development corners were not cut, that’s the point of the mRNA formulation, it is incredibly faster than conventional methods to create a brand new product. I assume what you meant was the regulatory requirements for safety, which yes were accelerated and reduced because of the emergency use case. Two years ago. Those trials are tests on large populations , phase 3 being the largest then phase 4 a post-marketing surveillance period [0].

[0] https://en.m.wikipedia.org/wiki/Phases_of_clinical_research

Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by shlant on Monday December 26, 2022 @07:57AM (#34137286)
> Corners were necessarily cut in the trials

What "corners" were "cut"? And if your answer is "they were rushed", don't bother replying.

Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by landemva on Monday December 26, 2022 @05:26PM (#34142597)
> following a covid infection ... I received the bivalent mRNA booster

After a real infection you develop anti-bodies. Why then get the vaccine which would be less good protection and have risks?

Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by briandon on Monday December 26, 2022 @10:50AM (#34138596)
By design, the modified spike proteins created in a vaccinated person's cells from mRNA and adenovirus-vector shots remain anchored within the cells but protrude through their cell membranes so that they can be readily "seen" by the person's immune system.

What do you think happens to the cells in question? That they live out the remainder of their lifespans unmolested? They are destroyed.

Much of the promise of safety at the outset rested on the belief that the contents of the vaccine doses would remain localized at the injection site (muscle in the arm in most places afaik, but the jabs are also given to some people in some places in their thighs). For the mRNA covid vaccines, at least, we know that the doses do not stay in the arm but travel throughout the body and even, in some cases, into breast milk. When the data about dissemination of the mRNA shots contents began to raise alarm bells, there was a period where some medical professionals blamed it on a failure to aspirate the needle before injecting and hoped that those who'd been injured had simply been unlucky and the person administering their dose had hit a blood vessel.

We've gone from, at the beginning, recognizing that wide distribution of the mod-spike-producing covid vaccine dose contents throughout the body was dangerous but believing that it wouldn't be an issue (because we're administering into muscle tissue in the arm) to knowing that the dose doesn't stay in the arm but completely forgetting why we hoped that it would stay there in the first place.

Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by rajman187 on Monday December 26, 2022 @10:51PM (#34144892)
I’d like to see some credible sources for your claims, because it seems we’ve done no such thing.

Even if trace amounts are found, they are no longer functional [0]. And it’s important to consider the percent of dosage when looking at biodistribution post injection, not just the amount of lipids [3], so it’s really much less significant amounts found outside the site of injection. Most is taken care of via hepatic clearance.

UTR sequences, which regulate transcription and sub cellular localization, can be tailored for specific cell types [1].

There is no evidence of spike protein toxicity [2]. And while the covid spike protein has potential to cause damage for example to the cells lining the small vessels of the heart following infection, there is no evidence that this is also the case with vaccinations [4]

[0] https://www.ncbi.nlm.nih.gov/books/NBK565969/

[1] https://jamanetwork.com/journals/jamapediatrics/fullarticle/...

[2] https://www.reuters.com/article/factcheck-vaccine-safe-idUSL...

[3] https://medium.com/microbial-instincts/biodistribution-and-s...

[4] https://www.bhf.org.uk/what-we-do/news-from-the-bhf/news-arc...

Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by briandon on Tuesday December 27, 2022 @02:36AM (#34146229)
Simple question: What do you think happens to cells which express the modified spike proteins?

Any answer that is not a variation on "They are destroyed." is incorrect.

You're changing the subject and copy-pasting canned "How to refute spike protein toxicity content online" stuff at me.

Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by rajman187 on Tuesday December 27, 2022 @03:41AM (#34146694)
You have countless cells that are destroyed on a daily basis, something like a million per second. I don’t understand your point obsessing over cells being killed for expressing the spike proteins, it’s less than a drop in the ocean.
Re:Rogue antibody and mystery pathogen behind AstraZeneca bl... by Zigurd on Monday December 26, 2022 @09:26AM (#34137806)
China is currently amidst an explosion of covid cases and deaths. Outside the first tier cities, China is still a low income country. If you look at the excess deaths numbers across nations, you will see that some kept good records, while some did not. The deaths reported through official channels are about 1/3rd of excess deaths. There is plenty of room for official reports to understate deaths, which makes it tempting for incompetent governments to minimize failures.