Thanks.
> Perhaps providing more frequent diet breaks for athletes as they become leaner could improve fat loss efficiency, lean body mass retention, and mitigate fat loss plateaus. For example, beginning the initial phases of contest prep using a 4:1 ratio of diet: diet break, then moving to 3:1, then 2:1, and finally 1:1 may be more opti- mal than simply using a set ratio for the entire duration of the preparation; however, we can only speculate.
https://www.researchgate.net/publication/339949771_Effective...
Of course, at some point the leptin system breaks down, probably due to desensitized receptors. But in a negative calorie state, you can take advantage of your leptin sensitivity.
UD 2.0 by Lyle McDonald is a good basic program that is built off the premise of carb cycling (and the effects on leptin and insulin).
it's called a refeed and bodybuilders have been doing it for decades to drop fat while maintaining muscle mass, you don't need leptin injections
some recent studies have backed up the bro science as well
>The researchers reported that 19 participants in the continuous diet group completed the study and lost an average of 9.1 kg furthermore, 17 participants in the intermittent diet group completed the study and lost an average of 14.1 kg (4).Hence, the authors concluded that greater weight and fat loss was achieved in the intermittent diet group (4)