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Re:Mark Cuban is tackling out-of-control drug prices by treis on Tuesday June 07, 2022 @10:44AM (#31655086)
This keeps showing up but it's total bullshit. Cuban wants to take 15% of the transaction for running a web site and processing payment. They're not manufacturing drugs. They're not buying drugs. They're not shipping drugs. They're not doing anything at all besides taking your order and giving it to someone to do all those things.

It's not a charity. It's a profitable business and a very profitable one at that.

Oh yeah, and the prices aren't lower than what you can get using GoodRX.

Re:Mark Cuban is tackling out-of-control drug prices by hwoolery on Tuesday June 07, 2022 @11:23AM (#31655710)
It's not total bullshit - compare Imatinib on GoodRX ($787) vs CostPlus ($14) for 30 tablets. What the company is doing is cutting out the (arbitrary) pharmacy markup. They take a 15% cut and are TRANSPARENT about their price (again, novel in the drug industry). If you followed their company, you'd also notice they have plans to further lower the margin by manufacturing their own drugs, but these things take time.
Re:Mark Cuban is tackling out-of-control drug prices by treis on Tuesday June 07, 2022 @11:45AM (#31656028)
GoodRX shows me $42.54 at Publix vs $19.40 shipped from CostPlus. So yes, some drugs will be cheaper but it's not the magnitude of savings they claim and it's not across the board. Last time this came up I checked a handful and CostPlus was usually slightly more when you include shipping cost.
Re:Mark Cuban is tackling out-of-control drug prices by jeromegv on Tuesday June 07, 2022 @12:10PM (#31656444)
If many drugs are cheaper... what's the complaint then? That it's not as much saving as they say? At the end of the day, the market will speak. If he's cheaper than the market and people start buying from him, then its a net positive for everyone.
Re:Mark Cuban is tackling out-of-control drug prices by bumby on Tuesday June 07, 2022 @12:38PM (#31656875)
I think the complaint is this isn't a new or unique solution, but it already exists through other companies like GoodRx.

Just out of curiosity, I looked at some of the costs for the most prescribed meds. All seemed to within the same price range. Personally, I liked the GoodRx UI better.

Not that what Cuban is doing is "bad" but I don't know that it needs to be characterized as some radical new alternative. That seems more like marketing hype to me but it does a good job of raising awareness.

Re:Mark Cuban is tackling out-of-control drug prices by cudgy on Tuesday June 07, 2022 @08:05PM (#31661611)
If it’s cheaper, why does it have to be a radical alternative? The healthcare system is so screwed up that simple solutions / “low hanging fruit” are available to be implemented. For example, allowing government prescription purchases to be negotiated, which a rational person would deem basic, but it is presented as a draconian act against insurance companies to allow it.
Re:Mark Cuban is tackling out-of-control drug prices by bumby on Tuesday June 07, 2022 @08:36PM (#31661816)
It doesn’t have to be radical to be useful. I think what Cuban is proposing is useful. It’s just not radically better than other options that already exist, so from that perspective calling it unique or novel or radical is mainly marketing hype.
Re:Mark Cuban is tackling out-of-control drug prices by josefresco on Tuesday June 07, 2022 @12:00PM (#31656253)
> but it's not the magnitude of savings they claim

I follow Cuban on Twitter and he retweets people constantly who are saving substantial amounts of money. In their own words the savings are huge. Are you claiming these people are lying or fake?

Re:Mark Cuban is tackling out-of-control drug prices by gameshot911 on Tuesday June 07, 2022 @12:11PM (#31656461)
People likely are saving a ton of money, but they were also probably not utilizing the most optimal solution out there previously (e.g. buying through their insurance vs. GoodRX).
Re:Mark Cuban is tackling out-of-control drug prices by josefresco on Tuesday June 07, 2022 @12:30PM (#31656755)
Right, so this is a big win for awareness. I've heard of GoodRX a few times but never looked into it because I have decent insurance. It took Mark's new venture, and his marketing efforts (via Twitter) for me to realize "this was a thing".
Re:Mark Cuban is tackling out-of-control drug prices by treis on Tuesday June 07, 2022 @12:57PM (#31657152)
Sure, but it's not getting rid of middlemen or making anything more efficient. It's just another actor sliding into the market to make a bunch of money exploiting the broken drug market.
Re:Mark Cuban is tackling out-of-control drug prices by toomuchtodo on Tuesday June 07, 2022 @05:03PM (#31660031)
It saves pharma consumers money between now and when US healthcare is “fixed” (whatever that looks like), which could still take a long time. As the starfish parable goes, it matters to these people. I encourage you to recognize that reduction in suffering and economic hardship in the short term.
Re:Mark Cuban is tackling out-of-control drug prices by rnk on Wednesday June 08, 2022 @03:40AM (#31664444)
Yeah, I really disagree with the person above you, @treis. This saves people money. It's not stealing from them, it's saving them money. This is a valuable and good thing. This gives attention to the fact that they can pay much less.
Re:Mark Cuban is tackling out-of-control drug prices by treis on Wednesday June 08, 2022 @09:53AM (#31667369)
The people doing valuable work are Truepill that's actually doing the heavy lifting of fulfillment. Cuban is slapping his name on a white label solution, taking 15% for his trouble, and acting like he's solving the US health care system. In reality, he's just another middleman inflating prices.
Re:Mark Cuban is tackling out-of-control drug prices by sushid on Wednesday June 08, 2022 @01:38AM (#31663660)
How is not a net good? Are you saying that a 50% saving is not significant enough reduction in cost? Certainly this is a step in the right direction? I get that Cuban putting his name on an existing project is kind of annoying but it's certainly good PR for the company, right?
Re:Mark Cuban is tackling out-of-control drug prices by Pigalowda on Tuesday June 07, 2022 @12:34PM (#31656823)
Even though it’s not for every drug it’s still a helpful tool/product and not mutually exclusive of GoodRx
Re:Mark Cuban is tackling out-of-control drug prices by cripblip on Wednesday June 08, 2022 @04:32AM (#31664731)
Sounds like it could be replaced with rsync and a cronjob?
Re:Mark Cuban is tackling out-of-control drug prices by bergenty on Wednesday June 08, 2022 @02:59AM (#31664221)
How do you know it’s only “some” drugs that are cheaper?
Re:Mark Cuban is tackling out-of-control drug prices by lelandfe on Wednesday June 08, 2022 @09:21AM (#31666919)
1. You're comparing 400mg on GoodRx vs 100mg on CostPlus. Changing to 400mg takes CostPlus to $40

2. Scroll down on GoodRx. $787 is the price from CVS; other pharmacies like Rite Aid offer it at ~$114.

Obviously still a jump! Just not a $700 one.

Re:Mark Cuban is tackling out-of-control drug prices by daniel-cussen on Tuesday June 07, 2022 @02:29PM (#31658301)
Yeah they're basically a lubricant for competition.
Re:Mark Cuban is tackling out-of-control drug prices by bko on Tuesday June 07, 2022 @11:51AM (#31656102)
The reaction to his company is weird. It's not a charity, and I don't think he claims its a charity. We have plenty of charities the deal with healthcare and plenty of non-profit hospitals. Doesn't really do much in the grand scheme of things. He wants to lower price the same way Bezos wants to lower price. Your margin is my opportunity.

Why do you have this reaction to just this particular business? Do you have it for other businesses? Like a low-cost supermarket opens up and you're upset that they're not really growing their own food? At this point, I would applaud any competition in the US health care space, especially if it adds transparency.

Re:Mark Cuban is tackling out-of-control drug prices by klvino on Tuesday June 07, 2022 @12:03PM (#31656311)
Objective analysis. Cuban, Musk, and others have developed fandoms yielding coverage that portrays them as 'saints' (an overly positive light). With fandoms comes some degree of polarization as non-fans present their counter-points.

Cuban found there is margin that can be squeezed in the pharma market due to being a high margin product with inefficient distribution. He moved on a revenue opportunity, plain and simple.

Re:Mark Cuban is tackling out-of-control drug prices by s1artibartfast on Tuesday June 07, 2022 @01:39PM (#31657703)
Fans seem to exaggerate a mild good into a great good, but the anti-fans take a mild good and claim it is a great evil.

The end result is the anti-fans come off delusional and out of touch with reality.

Re:Mark Cuban is tackling out-of-control drug prices by skinnymuch on Wednesday June 08, 2022 @07:23AM (#31665769)
Isn’t that how the fans seem too? I’m not sure that’s always true either. All that tunnel and loop stuff by Musk and Boring company are pretty awful.
Re:Mark Cuban is tackling out-of-control drug prices by s1artibartfast on Wednesday June 08, 2022 @01:29PM (#31670930)
Fans can certainly do the inverse with a mild evil and exaggerating it into a great good, I just don't think it is the case with Cuban's option for low price drugs. It is hard to follow the mental gymnastics that twist people getting a cheaper option to buy drugs into evil, even if it isn't perfect. The worst possible outcome is the drugs aren't cheap and people don't buy them. No harm, no foul.

Regarding Musk's loop and Boring company, I would also consider those a mild good. Hyped to high hell, but I don't see how that ever becomes bad.

What is awful about cheaper all electric tunneling rigs? If if meets some of the claims, then cool, if it doesn't, then it is neutral.

I am honestly curious why you think it is pretty awful?

Re:Mark Cuban is tackling out-of-control drug prices by skinnymuch on Thursday June 09, 2022 @03:45PM (#31685864)
Hm I don’t know about tunneling rigs. I assume that’s one of their own made things for their tunnels? A search only shows a couple of things about that and it appears to be all internal stuff. Nothing for the public or to be sold to businesses.

One major issue with their rigs would be the future impact of their tiny tunneling. They tunnel such small holes that make the actual end products weak. Their Vegas tunnel are so small. God forbid there’s an emergency while there’s a lot of traffic. Good chance lives will be lost.

Vs the amount of results for their main product they’ve done and sold that isn’t a blow torch: the Vegas loop. That’s what I was talking about. It seems to be an awful idea that is widely seen as a disappointment now. Their LA plan was by far much stupider. They were trying to do a tiny fraction of the traffic that an electric underground metro could do while being much less energy efficient since trains are more efficient than a lot of cars.

There’s a boatload of issues that make the tunnel awful and nothing more than a way to push Teslas more. All I can find are negative takes of the Vegas loop. I can’t add anything others aren’t saying.

It’s hard for me to see how the entire thing isn’t a scam to push Tesla. It’s mine boggling that this isn’t getting the same treatment as Morbius the film (intense loud continuous mockery). Then I remember the insane amount of fans and the push to keep everything Elon positive.

Re:Mark Cuban is tackling out-of-control drug prices by conductr on Tuesday June 07, 2022 @11:16AM (#31655613)
I've done work in this industry. Negotiating wholesale contracts and contracts directly with manufactures as well as all the other middle men. In theory alone, Cuban's strategy should/could work. However, what I've seen is there is a market price equilibrium effect in place such than any middle man who is best positioned, will inflate the price towards that market price. So what will happen is, in a world where it's only the manufacturers and Cuban, the manufacturers will get to absorb all the profit of the current middlemen and Cuban keeps his 15% and the price to consumers remains. Or, continues upwards seeking that equilibrium point. For generics, there may be some competition and the market of manufacturers will naturally consolidate until the generic is only available from a single manufacturer. In many instances, this already occurs, the manufacturer has a Brand then when IP is open and competition imminent, they release the first Generic at a price that makes other manufactures hesitant to ramp up production thus maintaining a complete monopoly for that specific drug.

And then you realize this is simply how capitalism is designed to work. People in the business of healthcare always try to dream up these complicated business models and because the other complicated business models inflate prices and their new and better business model is going to save the world. It almost never happens or works. Capitalism and the set of basic economic laws win every time.

The only real solution I could dream up is to implement price control. Where the consumer's cost is some function of the manufacturer's cost. Where the function/regulators should discourage price gouging and encourage manufacturing efficiencies. Unnecessary costs like mass advertising campaigns should be banned and the R&D side of the business should be separated from the the sales side. I personally wish all the IP generated in medicine was somehow publicly owned; either through purchase, initial funding, or... IDK I just think it would benefit all by having the scientific side of medicine unrestrained from IP.

FWIW, I'm pro-capitalism but don't feel it should be universal. Healthcare deserves a universal approach with a goal of maximizing access and thus affordability. And, I say that having personally built a decent career on the business end of healthcare that would likely evaporate if healthcare was truly "fixed" and I would completely accept that fate for the greater good.

Re:Mark Cuban is tackling out-of-control drug prices by bumby on Tuesday June 07, 2022 @12:44PM (#31656980)
Take this honest question in the spirit it was intended because I agree with everything you posted and appreciate both your candor and ethical stance.

You mentioned "access" and "affordability" but there is a third leg of healthcare in terms of "quality". How do you see your proposed approach affecting healthcare quality?

For example, does public-owned R&D lower incentives to generate new treatments? Or, conversely, does it raise incentives for higher quality drugs for underserved (and unprofitable) diseases?

Re:Mark Cuban is tackling out-of-control drug prices by conductr on Tuesday June 07, 2022 @01:13PM (#31657355)
Yeah, great questions actually. Not sure I have a fully formed model I'm putting forth so just going to speak in generalities.

> How do you see your proposed approach affecting healthcare quality?

In the business end of healthcare, quality is just a base assumption. You (Okay most) would never make a business decision that erodes quality and clinicians are trying to improve quality all the time. The companies I've worked for have entire departments named simply "Quality" with significant budgets/headcount. That said, from an economic standpoint, it just needs to be a part of that formula. The current real thing that comes to mind is CMS (Medicare) issues quality scores to hospitals (star ratings) and their reimbursements go down if their quality score dips. It also helps folks "shop" providers as the star rating is public information.

> does public-owned R&D lower incentives to generate new treatments?

I don't think it has to. Scientist want to do science. If funded, I believe they will. I'm more concerned with what science we're ignoring because it has no obvious GTM strategy, link to some ROI, &/ random business objective.

> Or, conversely, does it raise incentives for higher quality drugs for underserved (and unprofitable) diseases?

I think it does, or can. Because I think it opens the field for more exploration. I've never been very close to how pharma R&D is performed, but my understanding is it's rather narrow. For example, "we want to solve X because we can make $Y". Once we solve X, we can do X.a, X.b, X.c, etc. It doesn't matter that they could make the world a better place by solving Z and perhaps that's what the scientist would rather be doing.

I'd certainly entertain counter-arguements, this is just Sim City brain at work on hypothetical realities.

Re:Mark Cuban is tackling out-of-control drug prices by s1artibartfast on Tuesday June 07, 2022 @01:57PM (#31657937)
>I think it does, or can. Because I think it opens the field for more exploration.

I somewhat disagree. I think the best solution is for payers (single or not) to set prices based on quality adjusted life years (QALY). This is done in some single payer markets and makes a lot of sense as it couples incentives with impact.

While cooperate Pharma pays most of R&D costs, Fundamental (extremely early) research is usually still publicly funded through academia. This is where the possible solutions to Z come from.

The "problem" is that R&D spend can have more impact (lives saved) on mainstream diseases than rare diseases. Public-funding/ownership doesn't solve this fundamental issue. You can direct funding to rare diseases by decree, but you are still saving fewer lives than you would otherwise.

Re:Mark Cuban is tackling out-of-control drug prices by conductr on Tuesday June 07, 2022 @02:28PM (#31658295)
Either approach would be an improvement to current format. My only issue, and I'm rather layman on this, is I don't think academia creates solutions. They generate ideas and the pharma has to figure out all the parts to manufacture/commercialize it. I'd think that process could be more seamless. Right now, I think academia may touch on Z but if there's no $ it just dies in academia and that's a shame.

I also tend to agree that we should be solving problems that affect folks the most and factoring for the magnitude of the issue which is what QALY seems to do to gauge impact, so I like that idea. However, in doing so, I expect you're casting a larger net and bound to stumble on something that serves a smaller market as a byproduct of the R&D. In the current reality, the byproduct would get shelved and never commercialized because it had no ROI, which is also a shame.

Re:Mark Cuban is tackling out-of-control drug prices by wantsanagent on Tuesday June 07, 2022 @12:02PM (#31656292)
"the market of manufacturers will naturally consolidate until the generic is only available from a single manufacturer."

That's called a monopoly. And while it is a natural tendency it's also a point of regulation. By preventing monopoly you keep the desirable part of capitalism (competition) without having to enforce less palatable anti-capitalist measures like direct price controls.

Re:Mark Cuban is tackling out-of-control drug prices by conductr on Tuesday June 07, 2022 @01:29PM (#31657560)
Agree and I believe I called it an effective monopoly following that quote.

But, it's simply not regulated today. You'd have a hard time proving they are pricing in this way as a means to hold the monopoly. They could point to their margins and say, "plenty of room for competition" but meanwhile you can't force other manufacturers to ramp up production without even fatter margins. They'd need margin + market share to break even.

It usually only when the market is very large, manufacturing is not complex, or when the original manufacturer is still charging a lot for generic (sometimes only a bit lower than Brand). That another manufacturer will ramp up production. Often times, even manufacturing a generic drug requires steep initial investment and can be risky.

Even for generics with multiple manufactures, "multiple" might be only a handful. When you compare that fact, to the pricing trends they follow, it then is an effective oligopoly. And while I don't believe it to be the case, the pricing trends I've seen sure do look like collusion. My experience is it's more like an indirect collusion, where company A employs folks that have worked for competitors A, B, and C. So when they hear "through the grapevine" that company B is going to increase prices 10% next quarter, suddenly everyone is increasing prices 10% next quarter (give or take). [This I've witnessed myself a number of times]

Re:Mark Cuban is tackling out-of-control drug prices by specialist on Wednesday June 08, 2022 @10:56AM (#31668267)
Side question: I had some vague notion that Cuban was getting into the mfg side. Like maybe white labeling specific drugs he bought from existing mfgs, possibly even generic. Like Amazon Basic, but for drugs.

Which is how I assumed Amazon was going to enter the pharma space. But what do I know?

Any way, would such a move much change your analysis?

PS: I distinguish market capitalism and corporatism. One is pro competition, the other is utterly opposed to it.

Re:Mark Cuban is tackling out-of-control drug prices by conductr on Thursday June 09, 2022 @01:08AM (#31677751)
The white label approach is exactly the case I hypothesized (world with only manufacturers and Cuban), so no change there. I believe it's called "white label DTP direct to patient". This is picking up steam in the industry. It could certainly work and could compete against the status-quo for a time; but as it scales in market share, I anticipate the economic forces I described to eventually occur.

If he begins manufacturing the products, I'm not sure how that works. But I believe there's a lot of regulations and issues around manufacturer-to-patient sales. Tides could be turning, my experience in this part of healthcare is a few years old now. In theory, I suppose Cuban could stand up a separate legal entity for manufacturing where he sells to his pharmacy legal entity at some low price to avoid the economic forces I described.

Re:Mark Cuban is tackling out-of-control drug prices by specialist on Thursday June 09, 2022 @08:48AM (#31680562)
> exactly the case I hypothesized

Sorry, I misread. Further, OC explicitly says "Truepill is a white-labelled pharmacy e-commerce platform that MCCPDC".

I should have read more closely. I think part of my confusion is from not seeing (or maybe not recognizing) any examples on costplusdrugs.com.

Regardless, your points about retail price equilibrium still stands.

The choices remain "hollywood accounting" (fraud) and price controls. I continue to hope there's a third option. Not for any moral reason. But rather to avoid the inevitable omgherd libertarian backlash about the authoritarian governmental depriving corporations their god given right to further impoverish sick people. Something like changing the market incentives from fee-for-service to rewarding wellness (eg capitation). But I have yet to imagine how that could work for pharma.

Anyhoo. Thanks for humoring my grasping at straws.

Re:Mark Cuban is tackling out-of-control drug prices by TuringNYC on Tuesday June 07, 2022 @01:23PM (#31657485)
>> This keeps showing up but it's total bullshit. Cuban wants to take 15% of the transaction for running a web site and processing payment.

If he saves the consumer a lot of money, does it really matter if he takes 15% of the txn? Secondly, dont people/companies deserve to be paid for value they add?

My US-specific experience is that customers are squeezed for a pound of flesh. These often come at the worst time, when you are sick, possibly really really sick. For example, you're deathly ill, on line at CSV, and you're arguing about a $200 mystery co-pay for a prescription you cant wait days for. Luckily for me as a SWE, I can afford $200 mystery charges. For some it could mean death.

Any way to create transparency of pricing is really important, and could lead to live and death moments. I dont think we should dismiss these lightly.

Re:Mark Cuban is tackling out-of-control drug prices by lcall on Tuesday June 07, 2022 @11:02AM (#31655388)
From one of those prior discussions, a related nonprofit effort to lower prices of drugs that are sometimes in short supply or overpriced, where the founding Utah hospital system has joined with other hospital systems, has a solid, long-term reputation (and good personal experience--their intake agreement to get a blood sample drawn totaled 2 reasonable pages, where the next-nearest hospital came out at 11) and have generally done friendly good work for a long time as far as I can tell.

Wikipedia said (lightly shortened): "Civica Rx is a nonprofit generic drug company founded in 2018 by national philanthropies and leading U.S. health systems[1] to reduce and prevent drug shortages in the United States and the price spikes that can accompany them. .... While serving 55 health systems and 1,500 hospitals (or 1/3 of all licensed U.S. hospital beds), Civica also supplies the U.S. Department of Veterans Affairs, the U.S. Department of Defense, and “340B” hospitals caring for vulnerable patients in some of the country’s most underserved areas. As of January 2022, Civica provided nearly 70 million vials of essential medicines, enough to treat over 26 million patients across the United States. These numbers continue to grow as Civica moves from a start-up to a well-established societal asset, serving more patients every day. Most recently, eleven of Civica's 55+ medications are being used to help COVID-19 patients, including neuromuscular blocking agents, sedation agents and pain management medications for patients on ventilators." Etc. ( https://en.wikipedia.org/wiki/Civica_Rx )

https://www.fiercehealthcare.com/hospitals-health-systems/dr... (thanks to pottertheotter in another HN link/discussion about Mark Cuban, below)

https://civicarx.org/

Other prior discussion: https://news.ycombinator.com/item?id=25932233 ("The Mark Cuban Cost Plus Drug Company" about which I don't know anything more.)

Re:Mark Cuban is tackling out-of-control drug prices by antman on Wednesday June 08, 2022 @04:58AM (#31664858)
Thw whole article is about reducing costs through "simplification" and "removing the middleman". If anyone else thinks that laws,disttibution oligoololies and lobbies are not the problem, they can go build a drug factory and see if that works out. Drugs are produced cheaply and can be distributed cheaply from other countries in the US tomorrow.
Re:Mark Cuban is tackling out-of-control drug prices by silisili on Tuesday June 07, 2022 @12:08PM (#31656405)
I appreciate you calling out some, let's call them un-nicities, that aren't usually spelled out when this comes out.

All of that said, I don't think that makes the idea BS. The company is able to save many people money on prescriptions, which is a good thing. That Cuban or his company makes money on the way shouldn't bother us in the least (unless/until we ever get single payer).

Re:Mark Cuban is tackling out-of-control drug prices by pete_nic on Tuesday June 07, 2022 @12:20PM (#31656585)
>Opening in 2022, our state-of-the-art Texas manufacturing site will manufacture products to address drug shortages and price gouging

[1] Their website says they will start manufacturing drugs this year

[1] https://www.markcubancostplusdrugcompany.com/

Re:Mark Cuban is tackling out-of-control drug prices by adave on Wednesday June 08, 2022 @03:17AM (#31664303)
Are you hating just to hate,I just looked up a prescription that is for adhd/depression generic variant and its $399 at GeniusRx minimum and $15 shipped at Cost Plus. They must be doing something right and a lot better than someone commenting on their buisness model whereas you dont even know other pharmacies inefficiencies/model.
Re:Mark Cuban is tackling out-of-control drug prices by eachro on Tuesday June 07, 2022 @03:01PM (#31658670)
It might take a while but the free market should correct this if that take rate is in fact too high.
Re:Mark Cuban is tackling out-of-control drug prices by qiskit on Tuesday June 07, 2022 @11:39AM (#31655948)
>This keeps showing up but it's total bullshit.

Because it's probably paid advertising. Almost every article is paid advertising.