How much work can you really get done going via airplane? How much time do you waste going through security and how well can you work crammed into a tiny seat?
Sometimes taking it a bit slower is also good for your health.
Europeans think that 100km is a long way while Americans think that 100 years is a long time.
In daytime, there are a few options with only one change, but you'll sit in a train for 8 hours or so, which may not be your thing.
In general, https://seat61.com/ has good tips.
But for distances up to 4-5 hours by train, especially if the connection is direct, it is better to take the train. While the flight time may be much shorter, the need to get to/from the airport (which tend to be far away from the city itself, if only because of noise issues) and to be at the airport 2 hours before departure will consume a lot of time.
Train stations, OTOH, are usually located fairly close to the city center, if not squarely in it, for historical reasons (most important railway links were built prior to 1870, when the cities were much smaller than today).
They could do like the USA does and make flying such a time-consuming pain in the ass that it's rarely worth it for trips under 5 hours.