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Re:Everything you need to know about Covid-19 vaccines by drukenemo on Thursday July 22, 2021 @12:49AM (#27915485)
I know I’m not addressing the article , but the comment above and many others on this topic. I’m still surprised by the blank check this community generally gives to big pharma and governments, seeing their track records. It’s not that I expect an anti (COVID-19) vaccine attitude, but I would have expected to see here a more questioning tone more regularly, as I see how strongly voiced HN can be with other topics. For example: discussion of their fast development time vs safety, VAERS stats, vaccination of children and pregnant women, real-world efficacy and the fact that these vaccines are under experimental usage up to 2023 or so.

All I’m saying is that I’d expect to see less consensus here on not touching these matters.

Re:Everything you need to know about Covid-19 vaccines by flocial on Thursday July 22, 2021 @01:19AM (#27915643)
The vaccine is now a political issue just like mask wearing and lockdowns or any other aspect of this pandemic. Rational discussions that deviate from the accepted narrative are attacked and suppressed even on HN. Apparently experimental mRNA vaccines, censorship, violation of civil liberties, and other transgressions are fair game during a “pandemic”.
Re:Everything you need to know about Covid-19 vaccines by mattigames on Thursday July 22, 2021 @02:08AM (#27915929)
Rational discussions are created by speaking only with calm rational arguments, instead of inflammatory discourse such as putting the word pandemic between quotes, implying that 4 million deaths by a virus are not enough to be considered a pandemic.
Re:Everything you need to know about Covid-19 vaccines by fsh on Thursday July 22, 2021 @04:20AM (#27916658)
All of these issues have been discussed extensively for months.

According to the mRNA vaccine data I've seen, for adults the benefit of protection against COVID-19 vastly outweighs any observed risks due to the vaccine. This was already the case after the very large phase-3 studies, and much more so after real-world data from hundreds of millions of vaccinations became available. So it should not be surprising that there is a broad consensus that getting the vaccine is a good idea.

Of course the initial studies excluded riskier groups such as pregnant women and children. Now there is some data, but no general consensus between the different countries' regulatory agencies yet.

Overall, I don't see a "blank check" for the pharma companies at all. They had to conduct and publish very large studies before getting even emergency use authorizations for their products.

Re:Everything you need to know about Covid-19 vaccines by ggm on Thursday July 22, 2021 @01:13AM (#27915611)
How many doses worldwide, how many reported incidents. It's that simple. If you think some at-scale public disaster is impending, Can you explain what you think it is, beyond skepticism it might exist and we're not adequately cautious?
Re:Everything you need to know about Covid-19 vaccines by chessmiater on Thursday July 22, 2021 @01:30AM (#27915703)
It's not that simple.

Lead poisoning for example takes years to manifest itself.

So did other drugs which took years until regulators retracted them because they did more harm then good.

Specifically about mRNA vaccines, we know little about the long term effects of the lipid nano particles used in them and there are reasons to be concerned.

Re:Everything you need to know about Covid-19 vaccines by _Microft on Thursday July 22, 2021 @02:06AM (#27915913)
As far as I remember there were never serious adverse effects that did not appear within a few weeks of administration of a vaccine. The mRNA technology is conceptually even a lot simpler than other ways of vaccination. What are you exactly afraid about?
Re:Everything you need to know about Covid-19 vaccines by chessmiater on Thursday July 22, 2021 @02:14AM (#27915959)
Re:Everything you need to know about Covid-19 vaccines by _Microft on Thursday July 22, 2021 @02:37AM (#27916108)
You were alluding to long term effects.

With hundreds of millions of people having received mRNA vaccines by now, we most likely have seen all the short term side effects that there are, except the rarest of them. I would not worry too much about these either.

Re:Everything you need to know about Covid-19 vaccines by adrianN on Thursday July 22, 2021 @01:53AM (#27915836)
What are the reasons to be concerned? To me as a layman the mechanism of action seems very straightforward and not at all concerning.
Re:Everything you need to know about Covid-19 vaccines by chessmiater on Thursday July 22, 2021 @02:09AM (#27915932)
Re:Everything you need to know about Covid-19 vaccines by adrianN on Thursday July 22, 2021 @03:06AM (#27916270)
Thanks! So the main concern seems to be autoimmune disease?

> Overall, the robust inflammatory milieu induced by LNPs, combined with presentation of the vaccine-derived peptides/protein outside of antigen-presenting cells, might cause tissue damage and exacerbate side effects. Since self-antigen presentation in an inflammatory environment has been linked to autoimmune disease development (Charles A Janeway et al., 2001), this merits further investigation, albeit not detected here.

Because short term inflammation is, as far as I know, not a big deal and somewhat desirable for vaccinations? It is my understanding that we intentionally mix in inflammatory substances ("adjuvants") with normal vaccines to kick the immune system into action?

Re:Everything you need to know about Covid-19 vaccines by ghoward on Thursday July 22, 2021 @01:17AM (#27915633)
That's just it: we are not adequately cautious. Who knows what the long-term side effects of the vaccines will be?

The fact that those concerns are hand-waved away makes me more concerned. I mean, I don't trust Big Pharma, but at the very least, the FDA stood in their way. This time, the FDA gave them a pass called "Emergency Use Authorization," and that worries me.

Re:Everything you need to know about Covid-19 vaccines by zarzavat on Thursday July 22, 2021 @01:21AM (#27915655)
Covid has long term effects too, seemingly much more than vaccines. Were this not the case then yes the calculus for younger people would be very different. But it seems that everybody benefits.
Re:Everything you need to know about Covid-19 vaccines by ghoward on Thursday July 22, 2021 @01:50AM (#27915827)
You can only make that judgment for yourself. Assuming that your judgment works for everyone is highly presumptuous.

For myself, I see less risk in going the route where I may not even get COVID at all and risk actually getting it, rather than having a 100% chance of injecting myself with a vaccine that I don't trust.

Re:Everything you need to know about Covid-19 vaccines by CorrectHorseBat on Thursday July 22, 2021 @02:49AM (#27916183)
I don't know how you you calculated that risk, but right now the numbers are so overwhelmingly in favor of the vaccines that even with a 1% chance of getting COVID-19 getting the vaccine you don't trust is safer than getting the virus you should trust even less. And unless you live in one of the few countries that have contained COVID-19 (for now), the chance of getting COVID-19 is a lot higher than that.

If you've already had COVID-19 you could argue the numbers become less clear.

Re:Everything you need to know about Covid-19 vaccines by ghoward on Thursday July 22, 2021 @10:27AM (#27919260)
You say that right now, the numbers are overwhelmingly in favor of vaccines. I disagree, but even if you're right, that's only right now. Until we know more about their long-term effects, we don't know. I'm in the age group that has higher risk of blood clots from the vaccines.

Also, according to some estimates, 60-90% of people have had COVID, so I could have had it.

Re:Everything you need to know about Covid-19 vaccines by CorrectHorseBat on Thursday July 22, 2021 @03:30PM (#27923144)
> You say that right now, the numbers are overwhelmingly in favor of vaccines. I disagree, but even if you're right,

How can you possibly disagree with that? There is a several orders of magnitude difference. Data for the USA: there are 6,207 reports of people dying after getting the vaccine (of which only a few have a plausible causal relationship between getting the vaccine and death) [1], while there are 607,289 registered COVID-19 deaths [2] (and yes, the excess deaths do agree with that number [3]). There are exactly three confirmed vaccine deaths in the USA, from TTS due to the J&J vaccine.

> Until we know more about their long-term effects, we don't know

I agree, so we should act on basis of the data we have right now. And that data says overwhelmingly says getting a vaccine is much safer than getting COVID-19 on the short and mid long-term. There is nothing that points to that on the long term suddenly the vaccines will be worse than the virus.

> I'm in the age group that has higher risk of blood clots from the vaccines.

There is no evidence that the Pfizer and Moderna vaccines increase the risk of blood cloths. On the other hand, there is plenty of evidence that COVID-19 does.

[1] https://www.cdc.gov/coronavirus/2019-ncov/vaccines/safety/ad... [2] https://covid.cdc.gov/covid-data-tracker/?CDC_AA_refVal=http... [3] https://www.cdc.gov/nchs/nvss/vsrr/covid19/excess_deaths.htm

Re:Everything you need to know about Covid-19 vaccines by ghoward on Thursday July 22, 2021 @04:55PM (#27924201)
We should not act just on the basis of data we know now. We should also follow the Precautionary Principle.

These vaccines are still experimental. I am not going to take any one of them until at least they are not and companies accept liability for them.

On top of that, trying to shame people into taking the vaccines, as I see so many doing, is authoritarian. It does not lead to a good place.

This is my line in the sand against authoritarianism. It turns out that my line is against being forced to be part of an experiment. Where's yours?

Re:Everything you need to know about Covid-19 vaccines by _Microft on Thursday July 22, 2021 @01:59AM (#27915870)
With communicable diseases, your decision does not only affect you yourself but the rest of society as well. So we are actually making a decision for everyone with that.
Re:Everything you need to know about Covid-19 vaccines by ghoward on Thursday July 22, 2021 @10:32AM (#27919327)
One of the greatest lies of this COVID saga is that everyone is responsible for everyone else's health. We are not. The vulnerable are responsible for their own health and should take measures to protect themselves, not expect everyone else to do it for them.
Re:Everything you need to know about Covid-19 vaccines by _Microft on Thursday July 22, 2021 @01:57PM (#27922127)
Always Has Been

You have always been responsible not only for your own safety but also for the safety of your contacts/co-workers/environment. If you think otherwise, you might want to reflect about communicable diseases/STDs/traffic/gun safety/work place safety/you name it in general and it should become glaringly obvious. Covid safety is not different. For now, the required measures are more severe but it is not true that it is a special in regard of having to look out for others.

Re:Everything you need to know about Covid-19 vaccines by ghoward on Thursday July 22, 2021 @04:50PM (#27924154)
COVID safety is different because the measures we are being forced to do is actually affecting our ability to live.
Re:Everything you need to know about Covid-19 vaccines by vkou on Thursday July 22, 2021 @01:54AM (#27915841)
> You can only make that judgment for yourself. Assuming that your judgment works for everyone is highly presumptuous.

Yet people who refuse to get vaccinated seem to have no problem making this judgement for other people that they are likely to spread COVID to, when they fall ill.

Re:Everything you need to know about Covid-19 vaccines by ghoward on Thursday July 22, 2021 @10:34AM (#27919345)
When I fall ill, I quarantine. I do not just "spread" it to others.

Other than that, I'm not responsible for the health of other people. They are responsible for their own health.

Re:Everything you need to know about Covid-19 vaccines by vkou on Thursday July 22, 2021 @01:57PM (#27922124)
Covid also spreads asymptomatically, and for a lot of people, days 1-14 of it can feel a lot like a common cold. You need to take preventable measures to not be a potential spreader. Those measures are... Getting vaccinated.

Unless you are living in a spacesuit, you shedding viral particles into common spaces does make you responsible for the health of other people.

Re:Everything you need to know about Covid-19 vaccines by ghoward on Thursday July 22, 2021 @04:51PM (#27924170)
If people are vulnerable, they are responsible for taking precautions. If I am sick, even with the "common cold," I quarantine.
Re:Everything you need to know about Covid-19 vaccines by mistermann on Thursday July 22, 2021 @01:18AM (#27915638)
Is the reporting of incidents to VAERS truly simple?

More generally, there's an entire field devoted to such matters: epistemology.

Re:Everything you need to know about Covid-19 vaccines by kmos17 on Thursday July 22, 2021 @10:28AM (#27919282)
The blank check has a lot of research available to back it up, and the fact that vaccines are the most successful medical advance in human history having wiped out entire diseases like polio that had horrific consequences. There is also the non-negligible 600k deaths in the US alone directly due to covid with none attributable to the vaccine so far and a very clear decrease in hospitalization and deaths in vaccinated populations.

What is mind boggling is the callousness of people questioning vaccination because they think their personal risk is low when so many have died, and a belief in some unproven hypothetical risk when so many facts are weighing in favor of vaccination.

Re:Everything you need to know about Covid-19 vaccines by colechristensen on Thursday July 22, 2021 @01:23AM (#27915665)
It became a political issue.

People seem to have a problem with overcompensating for issues they align with positively.

This happens with vaccines, masks, racial, gender, identity, environmental, etc. basically any issue that brings up strong feelings in people tends to go into a religious fanaticism (chips all in, this is absolutely right with no question, anyone not in on the groupthink is the enemy)

Re:Everything you need to know about Covid-19 vaccines by swader999 on Thursday July 22, 2021 @01:30AM (#27915701)
I'm most worried about the vaccine passport. Show us your papers! Seems like it could be the start of a social credit system for the west.
Re:Everything you need to know about Covid-19 vaccines by vkou on Thursday July 22, 2021 @01:42AM (#27915779)
We already have a social credit system, it's called the credit system and a criminal background check.

We also already subject immigrants to medical inspections and forced vaccinations.

Re:Everything you need to know about Covid-19 vaccines by mindslight on Thursday July 22, 2021 @01:43AM (#27915790)
What do you think Equifax, LexisNexis, criminal background checks, person-search websites, and automated account termination are? "Social credit" only seems like some foreign concept because it was coined describing a foreign society - it's more difficult to look inwards at what already exists.
Re:Everything you need to know about Covid-19 vaccines by swader999 on Thursday July 22, 2021 @01:54AM (#27915843)
You don't have to do those for day to day living, attending school, getting on a plane, most employment, entering a grocery store, a pub or daycare for your kid. These will have to be scanned to work and will be able to be turned off. USA seems to be slow rolling towards it but look at France and UK just this week. Life ending fines, 6 month jail time if you enter one of these places without it. No exemptions for those that aquired natural immunity either.
Re:Everything you need to know about Covid-19 vaccines by sofixa on Thursday July 22, 2021 @08:09AM (#27917916)
> ut look at France and UK just this week. Life ending fines, 6 month jail time if you enter one of these places without it. No exemptions for those that aquired natural immunity either

You are wrong, you need a valid digital certificate which can come from 1) two doses and 14 days; 2) negative PCR less than 73hrs; 3) certificate you had covid (in some cases a vaccine dose is required on top). Considering people have had Covid multiple times, a generic exemption for them might be too broad.

Re:Everything you need to know about Covid-19 vaccines by swader999 on Thursday July 22, 2021 @10:40AM (#27919431)
Thanks for the details. The idea that you have to have your pass scanned to enter all these venues is still insane.
Re:Everything you need to know about Covid-19 vaccines by mindslight on Thursday July 22, 2021 @11:14AM (#27919848)
The idea that you should expect to be searched to enter concerts and sporting events is more insane. And yet that's just been the new normal for the past 15 years.

The biggest issue is whether businesses can use your personal information for purposes other than checking vaccination status.

Some of the European systems I've read about seem to discourage that, and the GDPR would also seem to prohibit it. But there's no willpower for such laws in the US, so we'd inevitably end up with the synergy of government and corporate power, like everything else. For instance, half the surveillance systems I listed in my other comment rely on abusing government-mandated identifiers.

Re:Everything you need to know about Covid-19 vaccines by raxxorrax on Thursday July 22, 2021 @05:44PM (#27924730)
Yeah, but that new normal isn't really desirable in itself...
Re:Everything you need to know about Covid-19 vaccines by mindslight on Friday July 23, 2021 @12:46AM (#27927309)
I never said that it was, which was apparent from my characterization of "insane". I was merely pointing out that framing vaccination requirements as some sort of watershed totalitarianism is ridiculous. We get far less specific benefit from other intrusions. For example, spending the political energy putting surveillance valley out of business would go much further for freedom's sake.
Re:Everything you need to know about Covid-19 vaccines by mindslight on Thursday July 22, 2021 @03:07AM (#27916276)
Three of your own examples (day to day living, attending school, most employment) actually do require subjecting yourself to control by the systems I listed. Furthermore, all of the examples you listed make you subject to observation.

The only way to be able to escape this is to be independently wealthy, which with the way our economy is designed is only ever possible for a minority of people. I agree that vaccine requirements are part of ever-creeping totalitarian control, regardless of apparent prudence, but to frame it as some sort of not-yet-here watershed moment is either uninformed or disingenuous.

Re:Everything you need to know about Covid-19 vaccines by swader999 on Thursday July 22, 2021 @10:37AM (#27919382)
Creeping totalitarian control is a decent way to describe this.
Re:Everything you need to know about Covid-19 vaccines by Santosh83 on Thursday July 22, 2021 @01:09AM (#27915594)
People are strongly voiced and logical until their very life (or way of life) is on the table (or even just the whipped up perception of it being so). Then they retreat into a shell of conformity and xenophobia. We see this over and over again.