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Re:Pfizer is testing a pill that, if successful, could cure ... by arcticbull on Monday April 26, 2021 @07:46PM (#26949786)
> ...common cold.

The common cold is a tricky one because it's about 200 different viruses, including rhinoviruses, coronaviruses, RSV and parainfluenza. And a bunch more that haven't been identified yet.

Re:Pfizer is testing a pill that, if successful, could cure ... by sharkweek on Monday April 26, 2021 @08:27PM (#26950142)
My infant daughter just wrapped up a run of about three or so weeks of “a cold.”

After the second week, a handful of Covid tests, and one fever, we took her to the doctor and asked why this cold was lasting so long.

Our pediatrician was like “not cold, colds. She probably had 3-4 viruses back-to-back.”

I had no idea this was a thing - he called them “daycare viruses.”

Re:Pfizer is testing a pill that, if successful, could cure ... by _AzMoo on Monday April 26, 2021 @08:37PM (#26950222)
In 2019 my infant son had a 3-month period where he was sick at varying levels for 100% of the time. We kept thinking it was some kind of resurgence, until an epidemiologist at the hospital explained to us that he just kept getting different viruses from daycare over and over.
Re:Pfizer is testing a pill that, if successful, could cure ... by mixmastamyk on Tuesday April 27, 2021 @01:54AM (#26952488)
The year of sickness, what I call our daycare episode. During that time I heard the GRC podcast about vitamin D3, started taking it, and haven't been sick more than a day or so since.
Re:Pfizer is testing a pill that, if successful, could cure ... by wirrbel on Tuesday April 27, 2021 @03:25AM (#26953073)
I am supplementing vitamin D3 and I still get sick. It is not a silver bullet for immunity.

Probably your kid has by the time you started supplementing just gone through the typically circulating virus strains and thus the viral loads in your kid don't replicate to levels that almost guarantee you being infected when interacting with them (like cuddling, comforting when they cry, etc.).

Re:Pfizer is testing a pill that, if successful, could cure ... by mixmastamyk on Tuesday April 27, 2021 @12:35PM (#26958243)
It's approaching ten years, and yes we have seen just about every strain. It stopped the winter week I started taking it.

As I said I sometimes get sick every few years but one day is typically the maximum. Consider me convinced.

Re:Pfizer is testing a pill that, if successful, could cure ... by cmrdporcupine on Monday April 26, 2021 @09:59PM (#26950967)
Oh boy, welcome to parenthood. Having young children in daycare or school means a constant stream of virus infections for the whole family. I don't remember when it started to trail off, but probably when my youngest got to about 7 or 8.
Re:Pfizer is testing a pill that, if successful, could cure ... by throwaway2037 on Monday April 26, 2021 @11:17PM (#26951585)
I also wonder about this. They say that children who grow up on farms have stronger immune systems because they are exposed to the natural environment more. Weirdly, they also have low incidence of food allergies.

Do children who attend daycare eventually develop a much stronger immune system? (No idea how this could be scientifically measured.) I also wonder about doctor's who work in the emergency room. How are they not constantly sick with some kind of common cold / flu / bronchitis? They must have the immune system of a super hero.

Re:Pfizer is testing a pill that, if successful, could cure ... by skinkestek on Tuesday April 27, 2021 @02:45AM (#26952811)
> They say that children who grow up on farms have stronger immune systems because they are exposed to the natural environment more. Weirdly, they also have low incidence of food allergies.

I have many siblings (more than 9). All of us grew up on an active farm except the youngest one. None have had any food allergies except from my youngest brother.

> I also wonder about doctor's who work in the emergency room. How are they not constantly sick with some kind of common cold / flu / bronchitis?

A colleague of mine told me his wife would eat anything that had expired best before date etc while she was in training, just to build her defenses.

I cannot vouch for this theory but maybe someone else can tell if it is a common tactic.

(I think it sounds weird.)

Re:Pfizer is testing a pill that, if successful, could cure ... by wirrbel on Tuesday April 27, 2021 @03:40AM (#26953147)
> A colleague of mine told me his wife would eat anything that had expired best before date etc while she was in training, just to build her defenses.

I lived for 5 years in a college dorm sharing bathroom/toilet and a communal kitchen with 14 other students. I am not quite sure it built up my immune system. I managed to get the swine flu back then, too.

This reminds me of another dorm story, a friend of a roommate always washed his hands when he came of the bus and visited. And I distinctly remember how we all felt that this was somewhat weird, obsessional, when in retrospect it just feels prudent and I don't really think he showed signs of pathological obsession. Its interesting how standards change.

As to eating stuff past expiry date: my wife tends to stockpile yogurt and dairy products in our fridge, not that uncommon that they were past their date. Turns out, since they are pasteurised they are often still good weeks after their best-before date. I actually don't think there is much in them to train your immune system (unless they are spoiled and I don't think fungal toxins is something you voluntarily want to put in your body).

Re:Pfizer is testing a pill that, if successful, could cure ... by arcticbull on Tuesday April 27, 2021 @12:11PM (#26957898)
Best-before dates aren't meaningful.

> Contrary to popular impression, the current system of food product dating isn’t really designed to help us figure out when something from the fridge has passed the line from edible to inedible.

> For now, food companies are not required to use a uniform system to determine which type of date to list on their food product, how to determine the date to list or even if they need to list a date on their product at all. [1]

[1] https://theconversation.com/how-do-food-manufacturers-pick-t...

Re:Pfizer is testing a pill that, if successful, could cure ... by arcticbull on Tuesday April 27, 2021 @01:15AM (#26952281)
Children who grow up with dogs and cats are also less likely to have allergies and asthma. [1] Lovable little filth monsters drag in all sorts of stuff, I guess haha.

[1] https://www.webmd.com/allergies/news/20180716/can-dogs-keep-...

Re:Pfizer is testing a pill that, if successful, could cure ... by BenjiWiebe on Tuesday April 27, 2021 @01:35PM (#26959003)
Sadly pets and farms still aren't a cure all. I grew up/live on a farm with cows, cats, and usually a dog. I've got a lot of environmental allergies and a few food ones, and my day to day symptoms can be pretty bad, especially this time of year. Oh well, who knows how much worse I'd be if I hadn't grown up on a farm.
Re:Pfizer is testing a pill that, if successful, could cure ... by mattowen_uk on Tuesday April 27, 2021 @07:16AM (#26954429)
> Do children who attend daycare eventually develop a much stronger immune system?

I would say so, yes. Your body remembers what viruses it's already fought, and will remain primed (for a significant time) to fight it again. Kids exposed to lots of illnesses when young, should end up with a more robust immune system in adulthood.

This is why chicken pox parties are a thing.

Re:Pfizer is testing a pill that, if successful, could cure ... by sharkweek on Monday April 26, 2021 @10:18PM (#26951111)
Yeah, we have a toddler right now too, and if I’m estimating, during the months of October - February over the last three years I would guess I’m at least a little sick half the time.
Re:Pfizer is testing a pill that, if successful, could cure ... by cmrdporcupine on Monday April 26, 2021 @10:32PM (#26951246)
The one that shocked me was rotavirus. At the time my kids were little it wasn't part of the regular vaccination regimen here in Ontario yet, was optional and our doctor didn't tell us about it. The kids both got it at the same; wasn't a huge deal for my son who was still breastfeeding, just had some diarrhea. But my daughter is three years older and couldn't keep food down for many days and lost a few pounds was very unwell. Awful.
Re:Pfizer is testing a pill that, if successful, could cure ... by antod on Tuesday April 27, 2021 @12:54AM (#26952148)
Both our kids had stints in an isolation ward being fed/hydrated through a tube with rotavirus at ages around 3-4. They couldn't even hold down small amounts of water for days. I could see how it kills so many kids in developing countries without access to that.
Re:Pfizer is testing a pill that, if successful, could cure ... by cortesoft on Monday April 26, 2021 @08:56PM (#26950394)
Yeah, it is pretty nuts how sick kids get in daycare, although our pediatrician says it is training their immune system. She said that for kids not in daycare, the same thing happens once they hit kindergarten.

First few months of daycare, constant colds. Then COVID hit and we took the kids out of daycare, no colds for months. Back at daycare, colds started right away.

It has mostly stopped for my five year old. She gets a normal amount of colds now (a few per year), but our two year old is still a constant cold machine.

Re:Pfizer is testing a pill that, if successful, could cure ... by wirrbel on Tuesday April 27, 2021 @03:42AM (#26953156)
For us it mostly stopped at age 3 (starting daycare at 2). Of course our daughter still gets sick now and then but fairly low-frequent. First year was rough though.
Re:Pfizer is testing a pill that, if successful, could cure ... by throwaway2037 on Monday April 26, 2021 @11:14PM (#26951564)
I'm sorry to hear about your daughter's illness. I hope she has recovered well.

Did the doctor's test for respiratory syncytial virus (RSV)? I only learned about that illness recently. Interestingly, there have been multiple, failed attempts to build a vaccine. It is one of the last statistically significant childhood viral illnesses without a vaccine in highly developed nations. I wonder if an mRNA solution can be found after the COVID crisis is over. I sincerely hope so.

Ref: https://en.wikipedia.org/wiki/Respiratory_syncytial_virus

Re:Pfizer is testing a pill that, if successful, could cure ... by kristofferR on Monday April 26, 2021 @07:57PM (#26949891)
"The most commonly implicated virus [in the common cold] is a rhinovirus (30–80%). Other commonly implicated viruses include human coronaviruses (≈ 15%), influenza viruses (10–15%), adenoviruses (5%)." [1]

So yeah, this wouldn't be a cure for common cold. Maybe it could be a pill people could take with a 10-20% chance of curing it, if they're lucky.

[1]https://en.wikipedia.org/wiki/Common_cold#Viruses

Re:Pfizer is testing a pill that, if successful, could cure ... by tempestn on Monday April 26, 2021 @10:12PM (#26951072)
Are you assuming that this antiviral only works on coronaviruses? Maybe that's not the case.
Re:Pfizer is testing a pill that, if successful, could cure ... by kristofferR on Tuesday April 27, 2021 @06:02AM (#26953976)
The article was pretty clear about that in my view, yes.

> Pfizer is keeping schtum about the detail of the lab tests it has completed but says it has demonstrated “potent in vitro antiviral activity against SARS-CoV-2”, as well as activity against other coronaviruses, raising the prospect of a cure for the common cold as well as future pandemic threats.

Re:Pfizer is testing a pill that, if successful, could cure ... by arcticbull on Tuesday April 27, 2021 @01:17AM (#26952300)
Yeah its a good question; my understanding is that unlike antibiotics, broad-spectrum antivirals don't really exist. [1]

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103698/

Re:Pfizer is testing a pill that, if successful, could cure ... by kuprel on Monday April 26, 2021 @07:48PM (#26949809)
200 pills then
Re:Pfizer is testing a pill that, if successful, could cure ... by sp332 on Monday April 26, 2021 @11:27PM (#26951652)
That would be fine if we combined it with expanded rapid testing. Spit in a tube, get a pill that cures your specific virus.
Re:Pfizer is testing a pill that, if successful, could cure ... by MengerSponge on Monday April 26, 2021 @09:27PM (#26950675)
We've found that you can safely take approximately 28 pills per day. You'll be through this innovative course in just under 7 days!
Re:Pfizer is testing a pill that, if successful, could cure ... by Dylan16807 on Tuesday April 27, 2021 @05:55AM (#26953927)
So you can immediately cure 1/7 of patients, and if we analyze what strains are in the area we can rapidly get that above 90%? Sounds good.