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Re:AstraZeneca may have provided incomplete efficacy data NIAID by slibhb on Tuesday March 23, 2021 @08:29AM (#26554232)
You trust experts to lie to the public (at the very least through omission) for their own good.

No thanks. Your attitude is a significant part of our current political dysfunction. Public servants have been replaced by self-promoters and technocrats who share nothing except contempt for the man on the street.

Re:AstraZeneca may have provided incomplete efficacy data NIAID by ceejayoz on Tuesday March 23, 2021 @08:34AM (#26554254)
In the tech world, we've got responsible disclosure for security holes. That's essentially what's being proposed here - let AZ have 24h to at least come up with a response. The article includes a line saying "AstraZeneca did not immediately respond to a Reuters request for comment", which sure sounds like "we sent their PR an email, then hit publish an hour later".

We've already seen issues in recent weeks with the blood clots issue, where the initial breathless media coverage gives way to "the regulators took a look and it seems fine, it's about the normal level of them, and the pause probably killed many more than the clots ever did".

Lay people - including reporters - are really bad at teasing apart normal "how the sausage is made" from "there's an actual issue here", especially with anti-vax propagandists ready to leap on anything with even a hint of confusion.

Re:AstraZeneca may have provided incomplete efficacy data NIAID by robbiemitchell on Tuesday March 23, 2021 @09:11AM (#26554542)
> "DSMB externalisations of concerns are deeply unusual for multinational pharma companies and suggest an extraordinary high level of friction between the DSMB and the sponsor,' Citi analysts said in a note."

It sounds like they're not getting the type of collaboration they want from AZ, so they've raised the stakes.

Re:AstraZeneca may have provided incomplete efficacy data NIAID by raverbashing on Tuesday March 23, 2021 @08:55AM (#26554421)
> Lay people - including reporters - are really bad at teasing apart normal "how the sausage is made" from "there's an actual issue here", especially with anti-vax propagandists ready to leap on anything with even a hint of confusion.

Exactly this. Journalists and laypeople are specialists in making mountain out of molehills

But it's said when specialists also do that (with the suspension of the vaccine when the thing it is preventing has a 1000x chance of causing the same problem)

Re:AstraZeneca may have provided incomplete efficacy data NIAID by slibhb on Tuesday March 23, 2021 @08:44AM (#26554341)
Let's make a distinction between "the tech world" and some substance we're injecting into people en masse.

In all likelihood the AstraZeneca vaccine is perfectly fine. But we should have this conversation in public. If people "come to the wrong conclusions," that's fine. It's the price we pay for an open society.

Re:AstraZeneca may have provided incomplete efficacy data NIAID by ceejayoz on Tuesday March 23, 2021 @08:49AM (#26554382)
> Let's make a distinction between "the tech world" and some substance we're injecting into people en masse.

Yes, let's, but let's also factor in "how many people die if we pause vaccinations for several weeks and it turns out not to have been an issue".

Re:AstraZeneca may have provided incomplete efficacy data NIAID by slibhb on Tuesday March 23, 2021 @09:06AM (#26554499)
I have two arguments against this:

1. If there's a serious issue with the vaccine and we kept it quiet, the consequences would be catastrophic. Not only in terms of public health but also in terms of public trust. Even a small chance of this outcome far, far outweighs the number of people who will die due to people wrongly deciding not to get the AZ vaccine.

2. We have a moral obligation to have conversations in public that involve the safety of injecting substances into people. Regardless of "cost benefit analysis," people simply have a right to be privy to these conversations. It's better for things to go worse and respect this right than for things to go better and not respect it.

Re:AstraZeneca may have provided incomplete efficacy data NIAID by petertodd on Tuesday March 23, 2021 @09:57AM (#26555009)
Remember that many public vaccination programs are relying on healthy people taking on risks to protect others. Right now, more people are being harmed by polio vaccinations than by wild polio: https://www.the-scientist.com/news-opinion/polio-vaccination...

I think that is a perfectly acceptable trade-off given the the long-term goal of eliminating polio entirely. I also think it's totally ok to ask people to bravely face a risk to help others (a fairly small one in this case). I even think it can be ok to ask minors, and parents, to take on those risks in some circumstances, and I think polio elimination is one of them. But it's a trade-off that must be done openly, with consent.

Re:AstraZeneca may have provided incomplete efficacy data NIAID by ceejayoz on Tuesday March 23, 2021 @09:09AM (#26554526)
> If there's a serious issue with the vaccine and we kept it quiet, the consequences would be catastrophic.

The issue in question is about efficacy, not some unexpected dangerous drug interaction or side effect.

Somewhat lower than expected efficacy wouldn't be "catastrophic".

Re:AstraZeneca may have provided incomplete efficacy data NIAID by slibhb on Tuesday March 23, 2021 @09:17AM (#26554593)
You expressed concern about anti-vaxxers, correct? If it turns out the AZ vaccine doesn't work very well, that's a boost to them, especially if the conversation occurred in private. Perhaps that will result in more people dying in the long run due to decreased trust in institutions.

When you play this utilitarian game, you can kick the consequences can down the road forever, which is why it's better to think of these arguments in more immediate terms.

Re:AstraZeneca may have provided incomplete efficacy data NIAID by ceejayoz on Tuesday March 23, 2021 @09:34AM (#26554764)
> it's better to think of these arguments in more immediate terms

Absolutely! That's why I said it has to include:

> "how many people die if we pause vaccinations for several weeks and it turns out not to have been an issue"

as a consideration.

Re:AstraZeneca may have provided incomplete efficacy data NIAID by slibhb on Tuesday March 23, 2021 @09:48AM (#26554913)
That's not "in more immediate terms". It involves peering into the future and it implies the belief that we can perform a cost benefit analysis and therefore remove the moral and political elements from decision making.

When I say immediate, I'm talking about this:

> 2. We have a moral obligation to have conversations in public that involve the safety of injecting substances into people. Regardless of "cost benefit analysis," people simply have a right to be privy to these conversations. It's better for things to go worse and respect this right than for things to go better and not respect it.

I would rather have more people die in an open society than less people die in a closed one.

Re:AstraZeneca may have provided incomplete efficacy data NIAID by yostrovs on Tuesday March 23, 2021 @08:44AM (#26554338)
The reason there's so much skepticism of public health authorities is because they repeatedly mislead the public. Right now, for example, Dr Fauci tells people who have been vaccinated to wear two masks. That's because he wants the unvaccinated to keep wearing theirs, lest they see others without masks. But it's nonsense and lay people know it. So they see this and think Fauci is mad, deceptive, or something else that can't be a reason to trust him. And that's how public health figures lose the trust of the public and create millions of skeptics of vaccines, masks, social distancing, etc.
Re:AstraZeneca may have provided incomplete efficacy data NIAID by ceejayoz on Tuesday March 23, 2021 @08:48AM (#26554369)
No, the double masking recommendation comes from studies performed that demonstrate a better fit, especially with the cloth masks that are in widespread use.

https://www.cdc.gov/mmwr/volumes/70/wr/mm7007e1.htm

Don't get mad at Fauci over a personal lack of information.

Re:AstraZeneca may have provided incomplete efficacy data NIAID by peytn on Tuesday March 23, 2021 @09:15AM (#26554575)
From that article:

> The findings of these simulations should neither be generalized to the effectiveness of all medical procedure masks or cloths masks nor interpreted as being representative of the effectiveness of these masks when worn in real-world settings.

I think complaints are justified when CDC officials turn around and do exactly what their report says not to do: interpret the findings as being representative of real-world settings. A year in and with trillions spent, our evidentiary standard should be higher.

Re:AstraZeneca may have provided incomplete efficacy data NIAID by ceejayoz on Tuesday March 23, 2021 @09:24AM (#26554657)
How, exactly, are you proposing we get the data on "real-world settings" without trying out the approach that's been lab-validated? Barring evidence in the "this might be dangerous" direction, those lab results certainly appear to support recommending people adopt the practice.

Turning this sort of CYA language that's standard in medical research into a scary gotcha is exactly the sort of propaganda the anti-vax folks engage in all the time.

Re:AstraZeneca may have provided incomplete efficacy data NIAID by peytn on Tuesday March 23, 2021 @09:40AM (#26554818)
I believe clinical trials are the gold-standard mechanism by which specific questions about interventions may be answered. I’m not pointing out a “scary gotcha.” I’m pointing out an omission identified in the linked work.
Re:AstraZeneca may have provided incomplete efficacy data NIAID by ceejayoz on Tuesday March 23, 2021 @09:57AM (#26555024)
Lab confirmation of double masking can be performed in an afternoon. A clinical trial is going to take tens of thousands of self-reporting "I wore two" people for months or longer, plus difficulties with all sorts of confounding variables.

I'm very comfortable with a tentative recommendation based on the lab data for a non-dangerous intervention. If we get observational data a year from now confirming it, even better.

Re:AstraZeneca may have provided incomplete efficacy data NIAID by peytn on Tuesday March 30, 2021 @07:50PM (#26641983)
Then you are more comfortable than I with unreviewed reports from government scientists a year into a declared state of emergency. That’s okay.
[dead]
Re:AstraZeneca may have provided incomplete efficacy data NIAID by ceejayoz on Tuesday March 23, 2021 @09:13AM (#26554562)
Because while we have conclusive data that states "the vaccine will keep you out of the hospital", we do not yet have the data that lets us conclusively say "you can't get and spread the virus if you're vaccinated".

Israel's data thus far looks promising (https://www.reuters.com/article/health-coronavirus-israel-va...), but they're being careful because they don't yet know for certain.

Again, "I don't know the answer" isn't the same as "there is no answer".

Re:AstraZeneca may have provided incomplete efficacy data NIAID by Neil44 on Tuesday March 23, 2021 @09:13AM (#26554560)
I don't think experts are lying to the public, I think they have questions and it's correct they should ask them. But you can do that with a phone call or an email. When you make a press release you're not asking a question you're making a statement. And the statement the media makes and then the statement the public choose to hear are beyond your control. To use the old analogy, there are consequences to yelling fire in a crowded theater.
Re:AstraZeneca may have provided incomplete efficacy data NIAID by nerdbaggy on Tuesday March 23, 2021 @08:45AM (#26554347)
The pharmaceutical company is littered with corruption and kickbacks. Look at any pharmaceutical company on Wikipedia