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Re:Vitamin D Supplementation Improves Cognitive Function: 12... by ve55 on Thursday November 12, 2020 @08:49PM (#25077907)
It's worth noting that vitamin D has a lot of high-confidence but low-effect results going for it, including a lot of strong meta-analysis over many health outcomes. What I mean by this is that it usually seems to conclusively either do something beneficial, but minor, almost nothing in the case of many studies, and in the case of some others, something very beneficial (as we've seen a few of in relation to covid recently).

Although Vitamin D isn't a particularly exciting supplement most of the time, that isn't enough of a reason for us to ignore it, as the proper way to make the decision of taking it or not would be to perform a cost/benefit analysis (as we should with any other supplements, lifestyle changes, etc).

The costs of vitamin D are just about as low as any supplement gets, and can be between $0.01 and $0.05 per day. The non-financial costs such as side effects or potential adverse effects are practically non-existent as well. So I do think that even those that have a healthy bit of skepticism over some results should still consider supplementation - there are a lot of potential benefits even if some are minor, and almost no risks or real costs. The optimal way to supplement is to get a blood test before+after starting supplementation in order to be confident you're taking the correct amount, but this isn't required of course. But I think the cost/benefit analysis is clearly in favor, so I didn't hesitate to add Vitamin D to my list of supplements that I take daily (https://nearcyan.com/supplements/ if curious), along with many others at this point.

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by throwaway5752 on Thursday November 12, 2020 @09:48PM (#25078243)
It is fat soluble. You can develop toxicity, and the effects are not trivial: https://www.mayoclinic.org/healthy-lifestyle/nutrition-and-h...

It seems based on casual reading of research that more people are deficient than not and dosing to toxic levels is unlikely. But it's not a bad idea to do this under the care of a doctor.

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by monetus on Thursday November 12, 2020 @10:24PM (#25078463)
For reference: The level of toxicity listed in your link is 60,000IU per day. Fauci said he takes 10,000IU per day. The bottle I purchased recommends 2,000IU per day.

Get your blood work done people.

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by roel_v on Friday November 13, 2020 @02:18AM (#25079839)
I always see Americans (apologies for making assumptions if you're not) throw around blood testing like it's something trivial and casually done. Here in the Netherlands, it takes a real medical indication and some pushing of a doctor to get any testing done. Alternatively, you use a private testing company that costs 200 to 400 euros for a comprehensive screening. Question to the public in various countries - how easy is it to get preventative tests done where you live, and what does it cost?
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by Honga on Friday November 13, 2020 @02:50AM (#25080042)
The Dutch health care system is allergic to preventative care. It's stunningly hard to try and just get routine things checker/done. As an Australian, having lived in four different countries, I'd say the Dutch system is the odd one out here.
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by arcticbull on Friday November 13, 2020 @05:05AM (#25080807)
More preventive care -- specifically screenings -- isn't always better. Humans are piles of goo, each person is different and totally normal, healthy baseline values are frequently quite different for different people. There is no such thing as a "normal" person.

The negative effects of false positives can easily outweigh the benefits of early screenings. For example, an NHS study shows that PSA antigen testing for prostate cancer is actually net harmful. [1]

Of course this isn't a blanket statement against testing in general, I'm just cautioning you against pre-judging the Dutch system as somehow less effective on the basis of "lack of preventive care" in general based on your personal experiences. It could well be that the other systems you participated in were less effective but attempting to placate anxious humans wanting to feel like they're 'doing something.'

[1] https://www.telegraph.co.uk/news/2020/01/17/prostate-cancer-...

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by noir_lord on Friday November 13, 2020 @05:24AM (#25080894)
UK system is the same.

Amazing when something goes awry, not great at preventing the thing going awry though they have made some good improvements recently (starting with their website debunking bullshit claims and headlines in the press).

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by gnrlst on Friday November 13, 2020 @04:19AM (#25080572)
Italy here: just went to my doctor and said "hey, i should get a blood test since I haven't had one in a couple years"...my doctor said "yes, please do" -> got a prescription and went to the hospital. I think I paid something like 20 euros to do it at a private hospital that is affiliated with the state health program, after I added urine testing and a couple of additional tests to the bloodwork.
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by gopkarthik on Friday November 13, 2020 @03:21AM (#25080226)
In India, Its pretty easy to get various preventative tests done. As for as prices, its cheap enough for engineers but non-trivial sums for a majority of the population.

As an example here's a list of all the tests, prices that a diagnostic center chain in South India provides https://appointments.aarthiscan.com/#/city/Bangalore/select-... https://aarthiscan.com/test-package/preventive-health-checku...

The test for Vitamin D is about 16EUR and comprehensive blood screening starts at 18EUR

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by WhiteSage on Friday November 13, 2020 @03:09AM (#25080148)
In Spain you go to your healthcare doctor and ask, and they will usually grant you the blood test, but it depends on them. I never had any issues though.
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by tecleandor on Friday November 13, 2020 @05:38AM (#25080969)
Yep, expect for this weird COVID-19 year, were it's advised to no overload the health system, usually you would only need to see your GP and tell him/her "it's been a while since last check up" or "I'm feeling weird/tired/not sleeping well" and usually they would begin by a basic blood test.
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by the-dude on Friday November 13, 2020 @04:25AM (#25080604)
This is not accurate : although I will not deny Dutch doctors are weary of preventive testing, it depends on your doctor.

My current doctor agrees to get my blood tested quite easily ( I don't have very serious issues ). It is not expensive either. When symptoms improved, we agreed let's test again, see where we are.

My previous doctor however, was very adverse. I left him because of this.

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by reader_mode on Friday November 13, 2020 @03:10AM (#25080154)
I think 200-400 euros once per year (hell it doesn't even need to be that often if you're young) should be acceptable on NL standard of living, here in Croatia if you get a private life insurance plan (around the same amount/year) they include some yearly tests + general checkup and cover up to 200 EUR tests in partner clinics.
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by Fnoord on Friday November 13, 2020 @02:25AM (#25079887)
"A real medical indication." This is anecdotal, but I just told my doctor (GP) my symptoms, that I am vegan and hence don't eat milk products. I was also on quitting smoking. Got a reference for blood test and smoking cessation (Zyban). I don't remember if smoking cessation was insured, but the rest all was. Going to your GP is free (via mandatory insurance) in The Netherlands. I got my vitamin D and B12 checked among other things.
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by shadowprofile77 on Friday November 13, 2020 @04:38AM (#25080670)
Where I live, you can get just about any blood test you want or heard of done at a days notice (excepting clinically conditional time rubrics for the sake of test accuracy, ie: waiting a couple weeks+ after possible HIV exposure to get an HIV test, that kind of thing) at any one of dozens of private laboratories for extremely reasonable costs. Complete blood profiles go for a little over the equivalent of 25 dollars US and most typical tests are not far below or just above that figure. Exotic tests can get more expensive but rarely exceed a price equivalent to 200 dollars for truly unusual things like specialized checking for exotic tropical diseases.

Socialized health is also available here but with the usual pushing and prodding necessary for anything outside the most basic, routine preventative tests, and slow at that. Advanced countries with socialized healthcare offer wonderful advantages for medical catastrophes and sufferers of chronic illnesses that would be hard to privately insure against, but when it comes to preventative discretionary healthcare, my impression is that they can be awfully bureaucratic (I used to live in Canada).

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by lultimouomo on Friday November 13, 2020 @02:38AM (#25079977)
If you are taking vitamin D supplementation, your physician will surely prescribe you periodic testing, at the very least if you ask for it. But since I have a private testing point just beside my office, I go there without doctor prescription; last time it cost me 17€ to get my vitamin D checked. This is in Italy.
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by blub on Friday November 13, 2020 @02:56AM (#25080077)
In Germany you have to pay (35-40 EUR) for your blood test to check for deficiency even if you were previously found deficient and must re-check after supplementing. My doctor also doesn't give a fuck and never asked me to re-test.
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by _pmf_ on Friday November 13, 2020 @03:13AM (#25080181)
Same in Germany. Even when paying privately (despite being in the common healthcare), I've had problems getting an appointment.

It's sad, because a full blood profile (including hormones) has such huge cost to benefit ratio in avoiding completely unnecessary speculative wild goose chases.

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by ps2fats on Friday November 13, 2020 @02:43AM (#25080003)
I understand why this is the way it is (cost-savings), but this needs to change. It has been shown that preventative screening can be very cost effective as opposed to reactive treatment.
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by rocgf on Friday November 13, 2020 @04:52AM (#25080739)
Roughly the same in the UK, at least in my experience.

In Romania, getting blood work is very common, even for trivial things. A few years back it was also very cheap, about 20-30 euros for the basics.

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by Darmody on Friday November 13, 2020 @07:01AM (#25081367)
To be fair, that's not cheap for Romania. Most people can afford it, yes, but that doesn't mean it's cheap.
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by rocgf on Friday November 13, 2020 @09:39AM (#25082603)
Agreed, it's not very cheap for Romania, but the ratio between salaries and blood test prices is better than in other Western countries, assuming prices have not changed significantly in the past few years.
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by Darmody on Saturday November 14, 2020 @06:56AM (#25091770)
I don't know if the ratio is better. In Spain wages are way higher and blood tests are free. And after reading some comments here it doesn't look that expensive in other countries compared to their median wages.

I know Romania pretty well and I'd say they have Romanian wages and European prices on almost everything.

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by im3w1l on Friday November 13, 2020 @10:14AM (#25083070)
When I was in the US they did a full test on me as a matter of routine. Here in Sweden they stare at me like I'm crazy when I ask if I could maybe get something tested.
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by ImperviousPandi on Friday November 13, 2020 @06:30AM (#25081223)
A few tips from living in the Netherlands

1. Find a different huisarts, one that specializes in expats. Check on google maps reviews. I found a great one that will give me referrals whenever I ask. 2. Go to that doctor and tell them you've been tired and want to check nutrition levels.

We found a local huisarts that does walk-ins in the mornings which makes it much easier.

My partner went and said he was having stomach pains and that we recently went vegan, that was enough to get a referral for a blood test.

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by faeyanpiraat on Friday November 13, 2020 @03:05AM (#25080124)
In Hungary you can get it done anytime for like 10 euros.

More complex screenings can cost between 30-100 euros.

Or get it all for free if your doctor prescribes it. It is quite easy, you just have to be a bit lucky to have a doctor who actually want to go trough the investigation about your health issues.

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by httpsterio on Friday November 13, 2020 @06:22AM (#25081188)
I have free health care through my university here in Finland and my doctor writes me any test I can back up sufficiently. If I want to go the private route, a basic blood panel with minerals and vitamins is somewhere around 100 euros. Not cheap but definitely doable.
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by distant_hat on Friday November 13, 2020 @04:30AM (#25080631)
In India, I can get almost any blood test with no requirement to get a prescription. The phlebotomist will even come home to collect the blood sample. The prices are fairly reasonable and most tests will be under $20.
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by toshk on Friday November 13, 2020 @03:39AM (#25080346)
You can get an extensive screening for around 120 here in Amsterdam. Probably more expensive if I go through official doctor and have to pay it with eigen risico (first few 100 euros of healthcare you pay yourself).
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by roel_v on Friday November 13, 2020 @04:11AM (#25080527)
Where is that? I only looked online, I haven't found anything online that cheap that includes vitamin/mineral levels + hormones.
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by toshk on Monday November 23, 2020 @05:09AM (#25185205)
Did it at https://www.yourlabs.nl/, current price is 189. But you are right, hormones is a seperate test
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by MLpractitioner on Friday November 13, 2020 @05:13AM (#25080844)
Can you share the location please? Very interested
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by toshk on Monday November 23, 2020 @05:09AM (#25185207)
Did it at https://www.yourlabs.nl/, current price is 189. But you are right, hormones is a seperate test
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by ignasl on Friday November 13, 2020 @06:49AM (#25081308)
If your car breaks you would spend 400 eur in an instant without even thinking. If you feel something is off or to do this comprehensive biochemical tests every 3 or 5 years is not that expensive.
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by eloff on Thursday November 12, 2020 @10:39PM (#25078548)
There's an expert that specializes in vitamin D toxicity cases and regularly posts here. She sees cases at less than the 10000IU daily dose Fauci takes.

I would be hesitant to go above 4000IU daily without monitoring blood levels every six months or so.

Its winter here in Canada, I'm taking 3000IU per day. I drop that to 1000IU in the summer. I'm not a doctor, not recommending you do the same. Just sharing.

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by nerbert on Thursday November 12, 2020 @11:25PM (#25078863)
Obvious warning but there's a lot of name dropping and I'm not sure what leads people to think Fauci 1) takes 10kUI or 6kUI per day 2) that it's the right dose for them 3) that they can make conclusions on what to do with their health based on a forum.

Get your blood checked, get recommendation from a doctor... before supercharging your blood with calcium & other fun stuff...

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by monetus on Thursday November 12, 2020 @11:48PM (#25078992)
The 10,000 number is hearsay I overheard as a family member listened to this english nurse who professed to taking 5,000 himself. - https://youtube.com/user/Campbellteaching

I imagine someone reading this may not have healthcare coverage, but bloodwork can be cheap! Save up! Please be cautious

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by ardy42 on Friday November 13, 2020 @12:02AM (#25079066)
> I would be hesitant to go above 4000IU daily without monitoring blood levels every six months or so.

I did that for a little while (though the nurse practitioner at my work clinic wasn't too keen on signing off on non-medically indicated blood tests). IIRC, I was supplementing at 5000IU a day and after a few months wound up with a higher blood level than I was comfortable with, based on the ranges that came with the tests. After that, I reduced down to 2000IU a day or less.

I've been much less into supplements in general, but I only take 2000IU irregularly now.

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by mattmanser on Friday November 13, 2020 @03:58AM (#25080462)
Her post about someone with serious health problems with over-dosing vit d (in this case, just 5,000 UI):

https://www.devaboone.com/post/vitamin-d-part-2-shannon-s-st...

Her post about vit d in general:

https://www.devaboone.com/post/vitamin-d-part-1-back-to-basi...

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by raverbashing on Friday November 13, 2020 @05:53AM (#25081039)
> 5000 international units (IUs) daily. Five years later

Five years. Of 5000 IUs per day

Five years. Of more than 10x the EU RDA (and maybe 5x more than the US RDA, still)

But please tell me again how easy it is to overdose

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by mattmanser on Friday November 13, 2020 @03:37PM (#25087172)
I admit I didn't make that clear, the point was 5k UI is not healthy to take long term. But you build a supplement regime around it, and then just keep taking it for years. That's how easy it is.

And in another thread a guy was saying his daily D3 was 20,000 IU a day as if it was perfectly normal.

I was found to be extremely deficient in a blood test and personally been prescribed 10k UI, or maybe even 50k I can't remember, but it was a weekly tablet for only 6 weeks.

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by jmnicolas on Friday November 13, 2020 @03:21AM (#25080227)
Just sharing too: I was taking 3000IU per day like you and noticed really positive changes to my mood and general wellness by increasing to 9k (my pills are 3k each).

But since seeing the alarming articles on HN I reduced a bit, and I'm thinking of getting my blood tested.

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by wavegeek on Friday November 13, 2020 @05:21AM (#25080882)
Yes I read that report and was not convinced. One anecdote. Not in a peer reviewed journal etc.

If you do take Vitamin D, variant D3 is by far best, and it may be wise to take vitamin K2 as well to avoid calcium metabolism issues (calcification).

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by neuronic on Friday November 13, 2020 @08:26AM (#25081889)
The problem is TIME. Taking 10,000 IU for a medium amount of time will very very likely be fine.

But due to fat solubility and therefore slow build up in the body, you are increasingly growing towards toxic levels over a long time.

The body can only regulate vitamin D before synthesis, after sunlight exposure. But if you take already-synthesized vitamin D, that regulation won't kick in and you're free to get hypervitaminosis.

Time in combination with individual biology are what brings issues here. Get blood work done (it cost me 30€ in Germany but was combined with 2 other tests).

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by im3w1l on Friday November 13, 2020 @10:18AM (#25083119)
On the one hand yes you could take it for a short time, but on the other why take excessive doses at all and risk falling into a bad habit? When there are lower doses that are both effective and safe?
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by 29athrowaway on Thursday November 12, 2020 @10:48PM (#25078622)
From "The Big Vitamin D Mistake" by Dimitrios T. Papadimitriou (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541280/)

> This could lead to a recommendation of 1000 IU for children <1 year on enriched formula and 1500 IU for breastfed children older than 6 months, 3000 IU for children >1 year of age, and around 8000 IU for young adults and thereafter. Actions are urgently needed to protect the global population from vitamin D deficiency.

Then, a person that consumed from 8000 IU to 12000 IU per day and had kidney damage due to high calcium levels in his blood.

https://www.webmd.com/vitamins-and-supplements/news/20190408...

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by code51 on Friday November 13, 2020 @03:30AM (#25080283)
What about D3K2 supplementation (adding in K2 supplementation) to counter these high levels of calcium?
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by tgsovlerkhgsel on Friday November 13, 2020 @04:24AM (#25080600)
Source for the Fauci claim? I've seen a claim of 6000 (not sourced properly), the RDA is 600, I couldn't find even a dubious source for 10000 and all decent sources didn't give a dose at all.

Given that 10000 is considered more than the maximum safe amount by many health authorities, I doubt Fauci would say he's taking that much even if he did.

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by sharedfrog on Friday November 13, 2020 @08:58AM (#25082145)
The Big Vitamin D Mistake: https://pubmed.ncbi.nlm.nih.gov/28768407/

> A statistical error in the estimation of the recommended dietary allowance (RDA) for vitamin D was recently discovered; in a correct analysis of the data used by the Institute of Medicine, it was found that 8895 IU/d was needed for 97.5% of individuals to achieve values ≥50 nmol/L.

> This could lead to a recommendation of 1000 IU for children <1 year on enriched formula and 1500 IU for breastfed children older than 6 months, 3000 IU for children >1 year of age, and around 8000 IU for young adults and thereafter.

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by draugadrotten on Friday November 13, 2020 @05:08AM (#25080820)
> Fauci said he takes 10,000IU per day.

Source please?

I find Fauci said 6,000IU

https://vitamindwiki.com/Dr.+Fauci+takes+6%2C000+IU+of+Vitam...

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by collyw on Friday November 13, 2020 @05:05AM (#25080808)
What is IU compared to micrograms? (Is it international units? My girlfriend mentioned this measure to me this morning when I gave her a vitamin tabled measured in micrograms, I don't know much about it).
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by swebs on Friday November 13, 2020 @06:36AM (#25081253)
It depends on the vitamin. 1 microgram of vitamin D is 40 IU.
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by raverbashing on Friday November 13, 2020 @02:19AM (#25079845)
The fear of Vit D overdose is funny if it wasn't tragic and possibly a factor in Covid mortality

- In Winter (especially USA/Canada/Europe) most people are deficient. Even more so the older and less active you are

- Read the labels and do basic math. A lethal dose of common OTC medicine is not that hard to obtain as well, are you going to ask a doctor how many Tylenols to take or are you going to read the label?

- Sure, if you're insecure go to the doctor and get it checked. But don't be surprised if consultations and lab exams are backed up at the moment.

- Vit D is fat soluble. Yeah you don't need to keep cranking high doses every day, the buffer lasts long. In fact for some people 10kIU should be good for a week. Review your dose, test your levels if you're taking a high dose for a long time.

In all those "Vit D overdose" stories there's someone doing something blatantly stupid for a long time OR (for the benefit of the doubt) they might have some other unknown problem or contributing factor.

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by hu3 on Thursday November 12, 2020 @10:25PM (#25078468)
> Taking 60,000 international units (IU) a day of vitamin D for several months has been shown to cause toxicity. This level is many times higher than the U.S. Recommended Dietary Allowance (RDA) for most adults of 600 IU of vitamin D a day.

Well of course, drinking 100x times the recommended amount of water would be even worse.

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by throwaway5752 on Thursday November 12, 2020 @10:50PM (#25078635)
A 50,000 IU pill is smaller than a pinto bean. I'm not saying to not take vitamin D, but it can be overdosed with serious negative side effects and the best way to not do that is to consult your physician.
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by radu_floricica on Friday November 13, 2020 @03:08AM (#25080142)
Where did you find 50k pills? I'd like to get some...

Most I find anywhere are 5k, and I'm the only one I know that buys them. In a supremajority of cases 50k daily would mean... let's see... about 10 fistfulls of pills. It takes dedication to swallow that much every day.

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by jmnicolas on Friday November 13, 2020 @03:28AM (#25080274)
50k is a one time thing, you shouldn't take this everyday! Read other comments there are articles about the toxicity of 60k per day leading to kidney failures.

I would never take more than 10k daily, and even that might be too much. I really need to have my blood tested.

Here in France when doctors prescribe vitamin D it's a one time thing, say for 3 months. It's in liquid form and comes in a small glass tube.

It's either 50 or 100k.

Here's a picture : https://journaldunenaturopathe.files.wordpress.com/2015/02/i...

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by radu_floricica on Friday November 13, 2020 @05:16AM (#25080863)
I was mostly joking. I rarely take as much - only when I have a bad flu or the beginning of one. And it's included in the yearly checkup: I'm either deficient or, since I started supplementing seriously, normal.
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by prepend on Friday November 13, 2020 @07:35AM (#25081502)
In the US, I was prescribed weekly 50kIU pills. They were the same size as my current 2k doses.

I think it looked something like this [0]. Curiously it was much cheaper than my supplements after insurance and was like $0 or $5.

[0] https://images.app.goo.gl/gVh2XUrbSihcg2HN6

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by numismatex on Thursday November 12, 2020 @11:45PM (#25078976)
taking normal reccommended doses, even getting your levels to average from low takes forever.
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by batushka3 on Friday November 13, 2020 @03:59AM (#25080466)
I've looked up your list and remembered great movie Vitamania. Most striking part was that to people living in space, no suplements are provided except vitamin D. Every other is gained from various food they eat. And the supplement industry is barely regulated and HUUUGE in US.
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by ip26 on Thursday November 12, 2020 @09:41PM (#25078204)
almost no risks or real costs

I worry a little about risk compensation, or whatever the equivalent is for diet. That is to say, if I feel like I'm all set on vitamins & minerals via pills, maybe I don't need to try so hard to eat my fruits & vegetables anymore...

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by ehsankia on Thursday November 12, 2020 @09:51PM (#25078255)
Worth noting that the above mostly talks above Vitamin D specifically, not multivitamins. D is the only one you do not naturally get from food (ignoring fortified food), and it also as mentioned above one of the cheaper ones. Multivitamins are far more expensive in general.
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by abledon on Thursday November 12, 2020 @10:40PM (#25078564)
using a multivitamin daily is considered 'expensive' ?
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by strken on Friday November 13, 2020 @02:43AM (#25080006)
Trying for a rough estimate of the yearly cost of taking a multivitamin daily, I get about $10 USD a year. For the 15% of the global population that live on less than $2 a day, that's around a week's wages. For the 56% that live on $2 - $10 a day, it's slightly more affordable, but still a significant cost.

Now, that's a cheap multivitamin, so it's got about 300IU of vitamin D, which is a pretty small dose. At a guess it's probably cheaping out on some of the other ingredients as well. On the other hand, ingredients bought in bulk and distributed through outlets in the developing world with very low overhead might be more affordable.

EDIT: the numbers for global poverty are probably out of date, but you get the point

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by ehsankia on Friday November 13, 2020 @01:04PM (#25085343)
10-20$ a year, compared to just D which comes down closer to 2-3$ a year. And again considering the other vitamins are much easier to come by. D is usually the ones that's more commonly lacking, especially in northern places.
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by bawolff on Thursday November 12, 2020 @10:13PM (#25078399)
Mushrooms? Salmon? Liver? Eggs? All of these have vit D without being fortified (mushrooms being a bit debatable as to if its fortified)

And its a little misleading not to talk about sunlight - technically that's not a food, but you were kind of implying you couldn't get it from the natural environment.

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by 29athrowaway on Thursday November 12, 2020 @11:05PM (#25078738)
Vitamin D2 + D3 per 100g portion of mushrooms, according to this website from the USDA Agricultural Research Service (https://fdc.nal.usda.gov/)

- Mushrooms, raw: 0.2 µg (7 IU)

- Mushrooms, Chanterelle, raw: 5.3 µg (212 IU)

- Mushrooms, enoki, raw: 0.7 µg (29 IU)

- Mushrooms, maitake, raw: 28.1 µg (1123 IU)

- Mushrooms, morel, raw: 5.1 µg (206 IU)

- Mushrooms, oyster, raw: 0.7 µg (5 IU)

- Mushrooms, portabella, raw: 0.3 µg (10 IU)

- Mushrooms, shiitake, raw: 0.4 µg (18 IU)

- Mushrooms, white, raw: 0.2 µg (7 IU)

As you can see, there are many types of mushrooms and most of them do not have much vitamin D. Some do, but unless you are a mushroom nerd you are getting the wrong kind.

Young adult daily recommended dose = 1000 IU

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by ip26 on Thursday November 12, 2020 @11:29PM (#25078889)
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by 29athrowaway on Thursday November 12, 2020 @11:41PM (#25078943)
267,000 IU after exposing mushrooms to 14 hours of UVB?

Holy cow.

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by BurningFrog on Friday November 13, 2020 @10:46AM (#25083430)
So, much like humans, mushrooms produce vitamin D from sunlight?
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by bawolff on Thursday November 12, 2020 @11:41PM (#25078945)
How much vitamin D is in a mushroom is going to depend more on how they are grown and stored then on the particular species afaik (in particular how much uv radiation it is exposed to).

I believe also that there will be more vitamin D in mushrooms that are irradiated to give them a longer shelf life. I don't think usa is a country where that practise is common, but i believe it is common in some other countries.

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by Scoundreller on Thursday November 12, 2020 @10:57PM (#25078680)
We could fortify beer and Coca Cola with it. While it’ll be on the label, I bet 9/10 people can’t rhyme off what is fortified.

(Around here, it’s salt, milk, flour and cereals that get fortified).

Dunno where fluoride fits, but that too.

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by bgilroy26 on Thursday November 12, 2020 @11:19PM (#25078827)
You belong to an interesting language isolate with whoever wrote this article:

SUNNY VALLI CRAG

http://3.251.20.7/log-details/?log_id=490&y=2009

I was puzzled by your phrase "can't rhyme off". Google returns very few instances that are not related to spontaneous spoken word poetry (which is likely an example of convergent evolution). After poking around a bit, it seemed as though I had heard a similar phrase before "try (to|and) rhyme off" in which 'rhyme' is synonymous with 'to list' as well

Best wishes for yourself, your friends and your family during these uncertain times!

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by keeganpoppen on Friday November 13, 2020 @04:25AM (#25080605)
what a fun phrase. wiktionary says canada: https://en.wiktionary.org/wiki/rhyme_off
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by bgilroy26 on Friday November 13, 2020 @01:15PM (#25085491)
That reminds me of a fun Canadian song that got passed around in the early Kazaa days (I had thought it was a Corky and the Juice Pigs song, but it is hard to attribute based on Google):

T'was the Scots that built this Country

https://www.youtube.com/watch?v=QakAwOhBkbA

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by dashundchen on Friday November 13, 2020 @12:08AM (#25079105)
I'll add that even many non-dairy milks are fortified with Vitamin D - check the label.
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by elric on Friday November 13, 2020 @02:10AM (#25079808)
The way I understand it is that drinks fortified with Vit D are nearly always fortified with D2, whereas the consensus seems to be that D3 is the way to go. Not sure whether that's because D3 is less stable in drinks, or maybe there's another reason to prefer D2 there?
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by ben_w on Friday November 13, 2020 @03:12AM (#25080171)
According to this article D3 is never vegan: https://www.healthline.com/nutrition/vitamin-d2-vs-d3#TOC_TI...

I believe “being vegan” is the point of most milk substitutes.

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by fujiters on Friday November 13, 2020 @04:19AM (#25080574)
Fair point, but D3 can also be derived from lichen, which is vegan.

https://www.vegansociety.com/resources/nutrition-and-health/...

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by elric on Friday November 13, 2020 @05:51AM (#25081026)
Cow's milk is also commonly fortified with D2. I'm guessing the vegan argument likely isn't the only reason.
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by BurningFrog on Thursday November 12, 2020 @11:09PM (#25078767)
"Risk compensation", to use your term, is a perfectly rational way to deal with these issues!
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by wavegeek on Friday November 13, 2020 @05:18AM (#25080868)
As with this study the dose used is often quite low, driven by paranoia about overdoses. Other studies have been very short term, had small numbers of subjects and thus would only find very large effects, or used large irregular "bolus" doses which are very bad and no longer used.

I went through one meta-analysis and found only 3 of about 35 studies that were actually useful. So take a close look at the methods section of the paper. You don't just read the abstract, do you? Do you?

Why 600 IU / day is not enough:

1. Meta-analysis that concluded this was faulty due to back statistical analysis and understated need by a large factor Nutrients 2014, 6, 4472-4475; doi:10.3390/nu6104472 "A Statistical Error in the Estimation of the Recommended Dietary Allowance for Vitamin D" by Paul J. Veugelers and John Paul Ekwaru

2. Lactating women who get only the RDA have vitamin D deficient milk. This makes no sense if the RDA is valid

3. When people go out in the sun their bodies produce up to 10,000 IU per day but not more. Why produce all that Vit D if it is not useful?

Sorry I am away from my paper trove so I do not have the cites for 2 and 3.

[dead]
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by marton78 on Friday November 13, 2020 @03:12AM (#25080176)
Not everybody lives at the latitude their skin has evolved for.
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by bsder on Thursday November 12, 2020 @09:48PM (#25078242)
> and almost no risks

This isn't true--especially for Vitamin D. We have several doctors at this point who deal with cases where too much Vitamin D causes Calcium uptake issues and affects cognition and heart function.

Vitamin D is NOT something like Vitamin C. Your body easily dumps excessive Vitamin C so you can take fairly massive doses with no real ill effects.

Your body has a much tougher time excreting Vitamin D--so large doses of Vitamin D can cause issues and accumulate.

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by ve55 on Thursday November 12, 2020 @10:59PM (#25078689)
Yes, this is true and worth mentioning in some cases, as some commenters have noted. Although as far as my knowledge goes, almost all cases of issues are where the patient is taking either an absurd amount (>10x what they should be), or has some other very unusual/absurd health issue. We can only provide disclaimers for so much, but for the sake of completeness, this is worth mentioning and indeed correct.
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by Ragib_Zaman on Thursday November 12, 2020 @11:05PM (#25078734)
Too much Vitamin D without sufficient Vitamin K can lead to high levels of serum calcium that are not absorbed into the bones. One function of Vitamin K is to shuttle calcium into the bones. You can often purchase combined Vitamin D and Vitamin K supplements to avoid those issues.
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by paulsmal on Friday November 13, 2020 @01:25AM (#25079536)
It’s not vitamin D that needs to be excreting but calcium. That’s why some supplements include vitamin K2, allegedly to absorb calcium into bones.
Re:Vitamin D Supplementation Improves Cognitive Function: 12... by cassepipe on Friday November 13, 2020 @04:15AM (#25080556)
"The non-financial costs such as side effects or potential adverse effects are practically non-existent as well."

This not accurate. I remember that there was an article on the front page of Hacker News an article that explain that Vitamin D is actually a hormone and telling the story of woman that had been prescribed high level of supplementation that could not talk anymore. It had something to do with her calcium intake regulated by that hormone. Luckily she was so distressed she stopped taking the supplementation but still it took her six months to get back to to talking normally and a normal hormone concentration level.

EDIT : I found the article : https://news.ycombinator.com/item?id=24261948

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by tgsovlerkhgsel on Friday November 13, 2020 @04:29AM (#25080625)
I assume they were talking about supplementation at normal supplementation levels, not 10x - 100x that.

As someone pointed out below, if you drink 10x-100x the recommended amount of water, you're likely to have adverse effects (almost certainly including death at 100x) too.

Re:Vitamin D Supplementation Improves Cognitive Function: 12... by abainbridge on Friday November 13, 2020 @04:37AM (#25080666)
This case, I think: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3313753/

It looks like she was getting 600,000 IU injections every week for three months. That's 85,714 IU per day. The NHS recommends maintenance does of 400 IU per day, others recommend up to 2000 IU.