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Re:Cellular immunity to SARS-CoV2 found at 6 months in non-h... by goalieca on Monday November 02, 2020 @09:14AM (#24968284)
We've found pre-existing T-cell immunity in many individuals (cross-protection from other coronaviruses?) so even if we don't have long-term perfectly sterilizing immunity, the odds are stacked in favour of this becoming just another winter respiratory disease once some level of herd immunity kicks in.

There is a lot of confusion around herd immunity. Think of it more like an equilibrium state than an elimination state. It is where this virus will end up whether we have a perfectly sterilizing vaccine or not.

https://www.bmj.com/content/370/bmj.m3563

Re:Cellular immunity to SARS-CoV2 found at 6 months in non-h... by mns on Monday November 02, 2020 @11:51AM (#24970135)
> the odds are stacked in favour of this becoming just another winter respiratory disease once some level of herd immunity kicks in.

The thing is, looking at the seasonality of the other strains of coronaviruses, you can see how it kind of looks to what we had this year (only worse as no one was ever infected with this). See Fig. 1 here : https://smw.ch/article/doi/smw.2020.20224

But people do sure like to blame and shame everyone in Europe and the US as if 1 billion people in the Northern hemisphere are somehow all to blame they weren't compliant enough. Viruses will doo what they always did.

Re:Cellular immunity to SARS-CoV2 found at 6 months in non-h... by ttul on Monday November 02, 2020 @12:42PM (#24970769)
Viruses can be stopped. See South Korea, China, and Taiwan for a few examples. Sure, the Chinese approach would not be possible in a democracy. But Taiwan? My friends there continue to live a very free life, yet COVID-19 is nowhere to be seen... Arguably, they are much freer than we are in North America and Europe right now.
Re:Cellular immunity to SARS-CoV2 found at 6 months in non-h... by timr on Monday November 02, 2020 @02:15PM (#24971878)
"Viruses can be stopped. See South Korea, China, and Taiwan for a few examples."

China just had an outbreak of hundreds cases in the Uighur region.

What seems more likely: that China has truly "stopped" the virus, and it just re-appeared, miraculously, in one of the most heavily travel restricted places on earth...or that it's actually spreading in China, and testing isn't catching it?

https://www.bbc.com/news/world-asia-china-54687533

Also, you'll note the following quote in the story linked above:

"Asymptomatic cases are not counted in China's official tally of 85,810 confirmed infections."

As for South Korea, it still has regular outbreaks, including some large ones:

https://apnews.com/article/virus-outbreak-pandemics-india-ar...

Taiwan's success at managing the virus has come ~entirely from strict border controls. Being a tiny island nation certainly helps with this. They still have cases, but so far, they're all amongst travelers:

https://time.com/5905129/taiwan-coronavirus-record/

The overall picture here is that some nations have done better than others at controlling the virus (at considerable expense) but almost nobody can claim to have "stopped" it.

Re:Cellular immunity to SARS-CoV2 found at 6 months in non-h... by GregarianChild on Monday November 02, 2020 @03:01PM (#24972491)
The Time article you cite is simplistic in regards of Taiwan's Covid response. Let me cite what I wrote 5 months ago in https://news.ycombinator.com/item?id=23290800 about Taiwan:

   ----------- 
The country has 23M inhabitants, most of them are clustered in a few densely populated metro areas (Taipei, Kaohsiung, Taichung–Changhua, Taoyuan–Zhongli, Tainan and Hsinchu). Taiwan had many daily flights to/from China, including daily directs from Wuhan (stopped 31 December 2019). Taiwan is one of the world's older countries (median age ~43). Taiwan permitted the docking of the Diamond Princess [2] and allowed passengers to disembark in Keelung (near Taipei), on 31 January, before the ship left for Japan. The ship was subsequently found to have numerous confirmed infections onboard. In reaction, Taiwan's government published the 50 locations where the cruise ship travelers may have visited and asked around 600k citizens who may have been in contact with the tour group to conduct symptom monitoring and self-quarantine if necessary. None were confirmed to have COVID-19 after 14 days had passed. (The only advantage Taiwan had was that facemasks were widely used and even expected on public transport for years.) For all those reasons, Taiwan was at unusually high risk from Covid.

Yet, no lockdown.

No country managed the disease better than Taiwan. We should learn from Taiwan. See [1] for an analysis of Taiwan's response from early March 2020.

It is interesting to reflect upon why most countries ignored Taiwan. The World Health Organization's locking out Taiwan on China's request is probably one reason. Is it the only one?

[1] C. Y. Wang, C. Y. Ng, R. H. Brook, Response to COVID-19 in Taiwan: Big Data Analytics, New Technology, and Proactive Testing. https://pubmed.ncbi.nlm.nih.gov/32125371/

[2] https://en.wikipedia.org/wiki/Diamond_Princess_(ship)

Re:Cellular immunity to SARS-CoV2 found at 6 months in non-h... by timr on Monday November 02, 2020 @03:10PM (#24972610)
Regardless of what you think of the response, facts from now trump facts from five months ago. The point of citing the Time article was to show that they continue to have imported cases on a regular basis (fact), and that they prevent these from spreading by strict border controls (fact), not to provide commentary on the quality of their overall response.

Taiwan is a tiny island, with relatively little international travel (compared to the US, China, etc). If they have no cases internally, and they seal the borders before those cases are introduced, then almost nothing else matters. Small, isolated, island countries can do this -- but even then (i.e. New Zealand) one mistake will mean rapid endemic spread. So sure, as long as Taiwan continues to effectively isolate itself from the outside world, they can probably carry on. But they're not going to: they're already talking about re-establishing travel with the rest of Asia.

It's virtually impossible for a country like the US to do the same thing Taiwan did. Even if we could seal the borders like Taiwan, our population is about 13 times larger, we have large land borders with other countries, and a proportionally large number of expatriate residents with right-of-return. Even with our bans on international travelers, the US has had 6.6 million foreign arrivals in 2020 [1]. Effectively 25% of the entire population of Taiwan has arrived in the US in 2020. And that's just non-citizens.

[1] https://www.trade.gov/visitor-arrivals-program-i-94-data

Re:Cellular immunity to SARS-CoV2 found at 6 months in non-h... by pessimizer on Monday November 02, 2020 @02:04PM (#24971766)
And New Zealand. And somehow Australia just reported their first day with no new cases in 6 months.
Re:Cellular immunity to SARS-CoV2 found at 6 months in non-h... by kgc on Monday November 02, 2020 @07:29PM (#24975061)
Both New Zealand and Australia performed strict lockdowns. The US/Europe is unlikely to be able to achieve the same level of compliance needed to make those successful.
Re:Cellular immunity to SARS-CoV2 found at 6 months in non-h... by kgc on Monday November 02, 2020 @07:28PM (#24975053)
South Korea's approach was different from China's and relied heavily on widespread testing.
Re:Cellular immunity to SARS-CoV2 found at 6 months in non-h... by bobthepanda on Tuesday November 03, 2020 @11:54AM (#24981363)
Where did they say it was the same?
Re:Cellular immunity to SARS-CoV2 found at 6 months in non-h... by mensetmanusman on Monday November 02, 2020 @02:07PM (#24971797)
Depends on time scale, suppose for argument no vaccine works, then these countries just have to have massive border control and limit travel massively as they are now.

There is no ‘they are much freer’ argument in the diverse states, because people are dealing with this thing in a huge diversity of ways. Some people have exactly the same life, but they wear a mask, no big deal...

Re:Cellular immunity to SARS-CoV2 found at 6 months in non-h... by garmaine on Monday November 02, 2020 @12:06PM (#24970347)
Except there are populous, prosperous countries (e.g. Taiwan) which have kept the virus 100% in check and eliminated it from community spread. I do blame other countries for not doing enough.
Re:Cellular immunity to SARS-CoV2 found at 6 months in non-h... by pessimizer on Monday November 02, 2020 @02:05PM (#24971784)
This is a great argument for why surgeons shouldn't wash their hands. Things will happen when they happen.
Re:Cellular immunity to SARS-CoV2 found at 6 months in non-h... by WildParser on Monday November 02, 2020 @10:27AM (#24969085)
Yeah, the mathematics around herd immunity are often misused.

People seem to always assume independent identical random variables. Corona Virus are seasonal - infections highly locally clustered.

The spreading might refuse to follow slow brownian motion of the herd. If e.g. an aircondition blasts an entire room of people with bad air, how much do herd effects really help?

Does the term "herd immunity" make sense for a seasonal virus at all?

Re:Cellular immunity to SARS-CoV2 found at 6 months in non-h... by maxerickson on Monday November 02, 2020 @10:31AM (#24969139)
Does the term "herd immunity" make sense for a seasonal virus at all?

Yes. For instance, one of the benefits of widespread flu vaccination is that it slows the rate that the virus spreads at. Herd immunity is just the threshold where enough people have immunity that the spread diminishes. That we don't necessarily reach the threshold doesn't make the lesser effect useless.

Re:Cellular immunity to SARS-CoV2 found at 6 months in non-h... by cies on Monday November 02, 2020 @10:41AM (#24969274)
> Herd immunity is just the threshold where enough people have immunity that the spread diminishes.

So herd immunity is not about immunity. Quite a misnomer then! Always thought herd immunity protected those still vulnerable, but according to you it merely means the vulnerable may merely be having a few more healthy hours falling sick non the less.

Re:Cellular immunity to SARS-CoV2 found at 6 months in non-h... by usrusr on Monday November 02, 2020 @11:37AM (#24969954)
It is about immunity, just not about the individual. It means that if the virus spreads to a non-immune individual from the outside the spread inside the herd will eventually stop (but we don't know when). It can still reach an arbitrary number of non-immune individuals, but given infinite time and an infinite herd, it will eventually stop.

Low level zero friction school physics analogy: think of a ball rolling onto an inclined plane. If the plane is angled upwards the ball will slow down and eventually stop rolling further upwards, if the plane is angled downwards it will just continue accelerating forever. But in the upwards case no place on the plane is truly safe from getting reached by the ball, because speed and angle is not specified. Herd immunity means that the slope is upwards, but the velocity would still be an open-ended random distribution.

A more accurate model for virus spread would replace momentum with dice rolls and slope with success thresholds, but that's just more difficult to imagine (unless your biography contains a phase of obsessing over p&p rpg rules).

Re:Cellular immunity to SARS-CoV2 found at 6 months in non-h... by enkid on Monday November 02, 2020 @10:55AM (#24969445)
With more individuals having immunity, it's likely the disease won't reach as many individuals who are vulnerable because they lack immunity and have underlying medical conditions. It's the level when outbreaks can stay localized instead of spreading to everyone.
Re:Cellular immunity to SARS-CoV2 found at 6 months in non-h... by xorcist on Monday November 02, 2020 @06:41PM (#24974771)
A good friend of mine has done a lot of research on infectious diseases.

An individual has immunity when the immune response is triggered. By definition. It was very confusing to me at first before I caught on to the meaning of the term.

It makes sense when you think about it. Can you "get" the virus a second time? Of course of can. That doesn't contradict the fact that you have some level of "immunity".

After all, the immune response is a big part of what most of us feel when getting sick.

Re:Cellular immunity to SARS-CoV2 found at 6 months in non-h... by maxerickson on Monday November 02, 2020 @11:45AM (#24970051)
Yes, herd immunity does not prevent a given individual from becoming infected, it's a group measurement. Of course, as the rate of spread diminishes, the likelihood of a given individual becoming infected does go down.
Re:Cellular immunity to SARS-CoV2 found at 6 months in non-h... by singemonkey on Monday November 02, 2020 @10:54AM (#24969440)
You probably shouldn't rely on some random HN poster for your definition of what herd immunity means. It's a well defined term in the epidemiological field, and definitions are readily available via sites such as Wikipedia and search engines.
Re:Cellular immunity to SARS-CoV2 found at 6 months in non-h... by WildParser on Monday November 02, 2020 @11:00AM (#24969506)
Hm. For a seasonal virus what would the definition of "diminishing" be?
Re:Cellular immunity to SARS-CoV2 found at 6 months in non-h... by skj on Monday November 02, 2020 @12:53PM (#24970905)
It's a new virus each time. Each time, it diminishes to zero.
Re:Cellular immunity to SARS-CoV2 found at 6 months in non-h... by espresso_enigma on Monday November 02, 2020 @02:30PM (#24972060)
> just another winter respiratory disease

Yeah, but this one can cause lasting cardiovascular and nervous system damage in a significant number of people, in addition to permanent lung damage. It's not just another respiratory disease.

Re:Cellular immunity to SARS-CoV2 found at 6 months in non-h... by goalieca on Monday November 02, 2020 @03:32PM (#24972875)
post-viral fatigue syndrome, myocarditis, and other complications are actually very common complications for viruses. Pneumonia is miserable and can take a long time to recover from.

https://www.sciencedirect.com/topics/medicine-and-dentistry/...

>In the UK, where it is (often incorrectly) known as ME (myalgic encephalomyelitis), 150 000 people are said to be affected. Other terms used for the condition are postviral fatigue syndrome (PVFS) and chronic fatigue and immune dysfunction syndrome (CFIDS). Symptoms may begin suddenly, sometimes after an acute viral infection, and commonly include incapacitating and persistent fatigue, muscle aches, joint pains, weakness after exercise, headaches, swollen glands, digestive disorders, inability to concentrate, memory loss, recurring minor infections or low-grade fevers, depression, an increasing sense of being unable to function, sleep disturbance, light sensitivity, food intolerance and environmental allergies.

https://www.mayoclinic.org/diseases-conditions/myocarditis/s...

> Viruses. Many viruses are commonly associated with myocarditis, including the viruses that cause the common cold (adenovirus); COVID-19; hepatitis B and C; parvovirus, which causes a mild rash, usually in children (fifth disease); and herpes simplex virus.

Re:Cellular immunity to SARS-CoV2 found at 6 months in non-h... by ljf on Monday November 02, 2020 @04:01PM (#24973295)
The WHO is suggesting that in the UK we have as many people with long covid as have died from it, so talking about 60k - far far higher than we for new ME cases each year.

Also the 'new' symptoms the long covid sufferers face are often very different to the initial illness - my wifes heart function was impacted hugely, only just starting to recover 7 months later.

What is good is that unlike ME, it appears many of the long covid sufferers are recovering, it just takes a long time, similar to SARs - where as for many ME is a life long condition. So I wouldn't draw to many parallels just yet until we know more.

Re:Cellular immunity to SARS-CoV2 found at 6 months in non-h... by ACow_Adonis on Monday November 02, 2020 @02:40PM (#24972194)
Do you (or anyone else) have scientific numbers, sources and/or comparisons for:

a) quantification and definition of lasting cardiovascular/ nervous system damage

b) quantification of a significant number of people

c) comparisons to rates comparable to other respiratory diseases (like influenza strains or the bird flu strains etc. )

Understand I ask this not as a coronavirus skeptic, but as a science-literacy proponent who hasn't yet read any reliable source or study for the claim you're making.

Re:Cellular immunity to SARS-CoV2 found at 6 months in non-h... by ljf on Monday November 02, 2020 @03:33PM (#24972892)
I'm putting the kids to bed so don't have time to dig out any figures of interest, but my wife caught covid back in March, was OK but pretty ill, but then moved into the long covid phase and was wiped out. Heart rate all over the place and terrible numbness and loads of other rubbish. A full body scan showed issues with her heart function back in August, which is only just starting to recover now, a 'low ejection fraction' and other bits I forget. Latest scans show improved function but nothing like she should see at her age or fitness. This time last year she was lifting 47kg in the gym and working out 4 days a week.

The long term studies showing what you are asking are only just starting to show results - but everything we see so far shows that this is causing more issues, in more people than flu.

Also of note, a partner of my wife's friend got covid (positive test) back in April with only light symptoms. Just got it again (tested again) and is very ill this time - had to go to hospital but wasn't kept in. So immunity might not be what we think.

Re:Cellular immunity to SARS-CoV2 found at 6 months in non-h... by ACow_Adonis on Monday November 02, 2020 @03:55PM (#24973206)
I realise covid is highly politicised right now, but give me the benefit of the doubt. I said I'm not a covid skeptic and I meant it. In its current form it's more virulent than the flu (albeit with a different distribution of mortality outcomes). And of course we have to deal with the general additional affect of immunity (or lack thereof) in the general populace.

But it's possible to seek out new information on covid, and also to seek to stop spreading disinformation on it, while still accepting its serious nature.

Re:Cellular immunity to SARS-CoV2 found at 6 months in non-h... by ljf on Monday November 02, 2020 @04:06PM (#24973349)
I've not yet seen a lot of good research released due to it being so new.

It felt like we spent 3 months trying to convince doctors here that long covid was even a thing, then another couple helping them understand how they can help people like my wife and it is only that last couple of months that there has been a mobilisation of research and interest in this area, so good quality information is currently hard to find.

CoverScan.com moved quite early - https://coverscan.com/news-%26-updates - have done some great work and are starting to release info - my wife was part of the trial. I'm sure there are others, but these things take time.

I'm sure that we will have loads of useful data points next year, but right now even the collection of the data has been poor to understand anything other than just 'deaths' and in some countries 'recoveries' (which was generally just a measure of those that were ill enough to be hospitalised)

Re:Cellular immunity to SARS-CoV2 found at 6 months in non-h... by ACow_Adonis on Monday November 02, 2020 @11:31PM (#24976307)
No, indeed, neither have I. And it may or may not be coming or true, i don't know :) That's why I keep asking to see the evidence when I keep seeing someone making the claim: I actually want to see it if it exists or if they're just repeating the news stories.

To me, it's not the position that Covid has long term effects that's incredulous, because we know that a proportion of a lot of viral infections can develop into longer term complications and effects. But it's the idea/observation that the longer term effects are both comparatively worse than other viruses, and splitting the quantumn of those effects into a "general covid effect" (that is to say, the probability of the effect for a given case of covid), and those of a "general pandemic effect" (that is to say, the population-size effect of having all these infections happening at once due to a relatively vulnerable population with little immunity, in contrast to some of the older/other viruses).

But I admit myself a little more than disturbed how every time I ask to see comparable figures/studies to see how we have knowledge of long-term effects of a virus that's only been around for the short-term, and claims that are usually made without any reference to the viruses to which covid needs to be compared, that I generally get hit by a quick wave of downvotes.

Re:Cellular immunity to SARS-CoV2 found at 6 months in non-h... by ljf on Tuesday November 03, 2020 @02:33AM (#24977312)
Fair enough, give it time. On the inverse - SARs which this seems to be similar in some ways to (though more transmissible and less deadly) is well known to have a wide range of long term effects on a proportion of those that get ill with it.

Come join some of the long covid reddit, Facebook, slack or other groups if you want to research first hand - there are plenty out there!

Re:Cellular immunity to SARS-CoV2 found at 6 months in non-h... by rusk on Monday November 02, 2020 @03:00PM (#24972489)
I think the burden of proof is on you since you are the one contradicting the prevailing thought. You must “reject the bull hypothesis” as it were. Personally I have seen one case of a 17 y/o with lingering nerve damage covered on national news.
Re:Cellular immunity to SARS-CoV2 found at 6 months in non-h... by zaroth on Monday November 02, 2020 @05:09PM (#24974054)
It is logically impossible to prove a negative. The burden of proof can only possibly be on the people claiming there is an effect.

To put it technically, it is "inappropriate to draw substantive conclusions on the basis of a lack of statistically significant effects." You are not proving the null-hypothesis, you are failing to demonstrate the alternative hypothesis.

Or to put it another way, lack of evidence is not evidence that a thing doesn't exist.

Re:Cellular immunity to SARS-CoV2 found at 6 months in non-h... by rusk on Monday November 02, 2020 @05:56PM (#24974465)
Ehhh but there is evidence? There are plenty of cases. It’s not even reported any more it’s a given.
Re:Cellular immunity to SARS-CoV2 found at 6 months in non-h... by ACow_Adonis on Monday November 02, 2020 @11:38PM (#24976340)
Not even reported any more?

My good man, i propose that outside of news stories focusing on relatively small samples and individual case studies, which generally make no comparison to other virus' comparative effects or mention of the biases inherent in their sample, it is no longer being reported because it has not yet been established.

And the reason for this is nothing conspiratorial or denialist, but just due to the fundamentals of good science: that is to say, it's REALLY REALLY hard to accurately establish the long-term effects of a novel virus that has only been around in the human population for the short-term.

Re:Cellular immunity to SARS-CoV2 found at 6 months in non-h... by rusk on Monday November 09, 2020 @05:13AM (#25033232)
Nicely put. I appreciate you taking the time to be civil. Such a rareity these days. A nice change from being insulted for daring to think different. For what it's worth I have evaluated some of my premises based on our exchange here. Thank you.
Re:Cellular immunity to SARS-CoV2 found at 6 months in non-h... by ACow_Adonis on Monday November 02, 2020 @03:48PM (#24973118)
I fundamentally disagree that I'm conflicting with prevailing thought (at least of medical experts), both because I don't accept that it's prevailing thought, but also because I'm just being proactively and constructively sceptical.

If someone proclaims to know the long term effects of a recent novel virus, that's an interesting claim. then they compare the outcomes to other viruses (or declare its fundamentally different), that's also interesting.

I've seen news articles about specific cases, and alarmist tabloid-esque case studies, but as someone who actually reads medical studies, I don't let media or hand-picked cases set my opinion, because in a pandemic with countless millions infected, and with a disease that disproportionately affects co morbid patients, of course one will find individual reports of bad cases and complications. But the information I asked for is presumably the minimum required for your claim to be justified. And if it is so "prevailing", it would be widespread and easily findable, whereas I have yet to see a single source that has them.

Re:Cellular immunity to SARS-CoV2 found at 6 months in non-h... by Retric on Monday November 02, 2020 @09:57AM (#24968746)
An effective vaccine in the near future is a much better option than natural herd immunity due to the lives lost.

Longer term it gets interesting because young people are at a dramatically lower risk of death and older people will have been exposed several times. So, if things go endemic it’s likely for long term annual deaths to be dramatically lower.

PS: The error bars in what you linked are very wide repressing significant uncertainty around those tests.

Re:Cellular immunity to SARS-CoV2 found at 6 months in non-h... by ethbr0 on Monday November 02, 2020 @10:08AM (#24968860)
As you noted, a vaccine allows us to target immunity, typically by risk profile, as we currently do with common cold viruses.

Herd immunity does not.

So while less virus circulating due to greater population immunity (and therefore lower individual risk of infection) is good, it doesn't help when SARS-CoV-2 does chance into a nursing home.