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Re:Vaccine hopes rise as Oxford jab prompts immune response ... by marketingPro on Monday October 26, 2020 @07:45AM (#24895056)
This article reinforces that herd immunity between young healthy people would have been the best solution.

Our old are going to get sick from vaccines, so the young are going to get it anyway. Next year under 50 year olds will line up for their vaccine.

Meanwhile 1.5 years worth of old, obese, and sick people will have died from coronavirus.

Wouldn't it have been better if healthy kids and adults caught it in q2 2020?

(Please no ancedotes of a sick 5 year old child dying from "coronavirus", statistics are necessary when discussing billions)

Re:Vaccine hopes rise as Oxford jab prompts immune response ... by celticninja on Monday October 26, 2020 @08:02AM (#24895173)
Given that immunity from infection is currently questionable your suggestion doesn't make sense. The reason the findings mentioned in this article are important is because the immune response seems to be stronger than that seen in people that have been infected and recovered. So this vaccine would be better at creating herd immunity than just allowing everyone to get infected. At the same time vaccinations will have a reduced impact on people than actually catching the virus would.

There is a difference between the level of illness experienced by those who are vaccinated Vs those who get infected, so more old people will die as a result of infection than would die as a result of vaccination.

So no, it would not be better for healthy adults and kids to get it in Q2 2020. Also how do you propose that you only infect the healthy adults and kids?

Re:Vaccine hopes rise as Oxford jab prompts immune response ... by rimliu on Monday October 26, 2020 @08:07AM (#24895215)
How is immunity from infection questionable? We had 43 million cases and about a dozen or so reinfections. Not sure if confirmed reinfections reach the double digits yet.
Re:Vaccine hopes rise as Oxford jab prompts immune response ... by graeme on Monday October 26, 2020 @08:22AM (#24895337)
So studies of other coronaviruses show immunity lasted 6-12 months. We’re a but early to see mass reinfections.

That said, my guess would be normal reinfections would be less severe, more like a cold. There have been some severe reinfections but any reinfection under six months suggests something atypical in the immune response.

Also SARS-Cov-1 produced a longer immune response so that may happen here.

But lifelong sterilizing immunity seems pretty unlikely based on what we know so far. The vaccines aren’t aiming at sterilizing immunity actually, their goal is to greatly lower the severity of the infection.

Re:Vaccine hopes rise as Oxford jab prompts immune response ... by rimliu on Monday October 26, 2020 @08:51AM (#24895591)
Studies also show that the immunity for original SARS (the close relative) lasts many years.
Re:Vaccine hopes rise as Oxford jab prompts immune response ... by graeme on Monday October 26, 2020 @12:34PM (#24898004)
Yeah that’s what I meant by SARS-Cov-1. But I prob should have gone with the clearer term
Re:Vaccine hopes rise as Oxford jab prompts immune response ... by celticninja on Tuesday October 27, 2020 @08:55AM (#24906917)
Re:Vaccine hopes rise as Oxford jab prompts immune response ... by celticninja on Monday October 26, 2020 @08:31AM (#24895410)
Read the papers on it, antibody tests in people who have previously tested positive for covid have found little or no antibodies in tests taken 3 months after infection. So it appears as if there is a limited/short term immunity after initial infection. The vaccine appears to produce a much stronger immune response, such that antibodies can be identified in tests some time after the vaccination.

You can get limited immunity from the common cold after being infected but you are just as likely to catch it 12 months later anyway. With covid that means we are dealing with it annually, which our health services cannot keep up with.

Re:Vaccine hopes rise as Oxford jab prompts immune response ... by rimliu on Monday October 26, 2020 @08:48AM (#24895566)
There are more immune mechanizms beside antibodies (T-cells, B-cells). For the common cold there are different viruses, so you may get a cold caused by different ones.
Re:Vaccine hopes rise as Oxford jab prompts immune response ... by dtech on Monday October 26, 2020 @10:04AM (#24896258)
antibodies disapear quickly, but the B-memory cells that produce them are still in the body ready to be mobilized.

"Common cold" and "flu" is not 1 virus, but hundreds of different viruses which is why you get them repeatedly. You do build immunity though. It's why children always have a cold and adults a lot less common.

Re:Vaccine hopes rise as Oxford jab prompts immune response ... by celticninja on Tuesday October 27, 2020 @08:55AM (#24906919)
Re:Vaccine hopes rise as Oxford jab prompts immune response ... by cheph on Monday October 26, 2020 @08:10AM (#24895237)
> Given that immunity from infection is currently questionable your suggestion doesn't make sense.

If you can't get immunity from the infection, how will the vaccine work?

Re:Vaccine hopes rise as Oxford jab prompts immune response ... by regularfry on Monday October 26, 2020 @08:17AM (#24895290)
We don't know if it does yet. We know it causes an immune response. We don't know if that stops you from catching it, and we don't know if it stops you from being infectious. It tips the scales in that direction, and all we really need is for it to be effective enough to drop R0 low enough that coupling it with reasonable restrictions makes the virus go away, which is why it's worth pursuing, but that's a different goal to ensuring you can't catch it at all.
Re:Vaccine hopes rise as Oxford jab prompts immune response ... by jmull on Monday October 26, 2020 @09:14AM (#24895790)
> Wouldn't it have been better if healthy kids and adults caught it in q2 2020?

No.

We have one population. There's no way to segment it to allow people at low risk to catch the virus without also allowing people at high risk to get it.

How do you think it could work otherwise?

Re:Vaccine hopes rise as Oxford jab prompts immune response ... by glotgizmo on Monday October 26, 2020 @07:53AM (#24895116)
(In the UK) Young healthy adults and kids live with old/unhealthy/frail parents due to the enormous financial difficulty of leaving home.
Re:Vaccine hopes rise as Oxford jab prompts immune response ... by jedimastert on Monday October 26, 2020 @08:21AM (#24895317)
And in the US too
Re:Vaccine hopes rise as Oxford jab prompts immune response ... by lazzurs on Monday October 26, 2020 @08:05AM (#24895200)
It’s super easy to make those decisions as an abstract mathematical problem. It is another when someone puts your family in front of you and asks you to roll the dice.

As an abstract mathematical problem if somehow herd immunity could be achieved without a vaccine then it sounds like a fine idea. The fact is that immunity after infection does not last long enough to achieve significant enough immunity to get to a useful herd immunity. This of course is what all the medical experts understand which is why Europe is going through lockdowns and Putin has been hiding in a bunker. There have been strict lockdowns in China and most other major governments have taken some sort of similar response, even Sweden eventually. There is almost nothing all of these governments have ever agreed on so universally.

Don’t expect a reply justifying my comment on HN with robust data, I have better things to do with my time like play in a park.

Re:Vaccine hopes rise as Oxford jab prompts immune response ... by gnfargbl on Monday October 26, 2020 @09:03AM (#24895688)
That option was apparently actively considered by the UK Government's scientific advisory group, but rejected on the basis that it would not actually be possible to prevent transmission from less-vulnerable groups to more-vulnerable groups. Reference: https://archive.is/43ir5
Re:Vaccine hopes rise as Oxford jab prompts immune response ... by LatteLazy on Monday October 26, 2020 @08:03AM (#24895185)
Why would old people get sick from the vaccine?

If we let everyone get it in Q2 2020, millions would have died when we ran out of ventilators.

Re:Vaccine hopes rise as Oxford jab prompts immune response ... by toolz on Monday October 26, 2020 @08:21AM (#24895319)
The implication that we even slowed the trajectory isn't well established. It's likely, but not proven. Let's not get ahead of ourselves by pretending there's evidence millions would have died when there's not even a strong correlation between mandates (as defined by the Oxford stringency index database) and reduced death.

and nowhere that I'm aware of came close to running out of ventilators. New York, one of the hardest hit places in the world may have used a third of their available ventilators. They used around 1/2 of the ventilators they reported available to them in 2015 so it wasn't even close to being the limiting factor in healthcare.

Re:Vaccine hopes rise as Oxford jab prompts immune response ... by umanwizard on Monday October 26, 2020 @08:27AM (#24895377)
> If we let everyone get it in Q2 2020, millions would have died when we ran out of ventilators.

How do you explain countries like Belarus, Serbia and Sweden, or parts of the US like South Dakota, where no or very lax measures were taken but what you describe didn’t happen?

In fact, is there any evidence that this happened anywhere, or is it all just conjecture based on modeling?

Re:Vaccine hopes rise as Oxford jab prompts immune response ... by LatteLazy on Monday October 26, 2020 @08:56AM (#24895642)
Last I checked Sweden had 110k cases and 5.5k dead. That's an almost exactly 5% fatality rate. Compare that to neighbouring Denmark with 40k cases and 700 dead gives you a 1.75% fatality rate.

Seems to me that there is good basic evidence right there for Sweden's approach being much more deadly.

We can argue back and forth about the relative value of freedom vs lives or whether Denmark will ultimately have as many dead etc. But right now, it seems that controlling numbers saves lives...

https://www.google.com/search?q=sweden+covid+deaths&rlz=1C1G...

Re:Vaccine hopes rise as Oxford jab prompts immune response ... by ghufran_syed on Monday October 26, 2020 @09:09AM (#24895746)
Comparing the case fatality rates makes no sense unless you have the same ability to get a test in both countries. If one country were to test everyone, including asymptomatic people, then their CFR would be lower than a country with more limited testing, simply because the denominator would include those large number of minimally symptomatic or asymptomatic patients that would be missed in the other country.

Also, the CFR is likely intrinsic to the virus, modified slightly by patient population and type of medical care available (both of the latter are probably very similar between the two countries). So any differences in CFR between the two countries mostly reflects the testing issue.

If you do want to compare the two countries, then compare the per capita death rate from covid (assuming everyone who dies in both countries actually gets a covid test - that might not be the case for old people who die at home, where even in developed countries, their primary doctor will just issue a death certificate saying “old age” or “heart attack” in the absence of any information to the contrary. )

Re:Vaccine hopes rise as Oxford jab prompts immune response ... by turing_complete on Monday October 26, 2020 @06:47PM (#24902404)
Wow, that is just classic lying with statistics.

1. You cannot just rely on how many sick people happen to be tested. Every single serology study implies a IFR of well under one percent. I am willing to bet that it will end up between 0.1 and 0.6 % for any developed country.

2. You cherrypick your data if you compare Sweden with Denmark or Germany and not with France or the UK.

My hypothesis is that countries that protect the elderly, and especially nursing homes, well have much fewer deaths. In every country this is were the deaths are concentrated.

Re:Vaccine hopes rise as Oxford jab prompts immune response ... by disgruntledphd2 on Monday October 26, 2020 @08:55AM (#24895625)
Probably too early to tell about South Dakota, to be honest. Let's see what things look like in a few months.
Re:Vaccine hopes rise as Oxford jab prompts immune response ... by mav3rick on Monday October 26, 2020 @08:11AM (#24895241)
Not supporting the OP's assertions, but vaccines have some timid / less potent form of the virus.
Re:Vaccine hopes rise as Oxford jab prompts immune response ... by roman030 on Monday October 26, 2020 @08:16AM (#24895282)
Imagine throwing your phone at the wall and it shatters into 1000 pieces. Now try calling someone with one of these pieces.
Re:Vaccine hopes rise as Oxford jab prompts immune response ... by ourcat on Monday October 26, 2020 @08:21AM (#24895321)
A certain amount of 'reactogenicity' is expected with most vaccines. ie: "expected" adverse reactions.
Re:Vaccine hopes rise as Oxford jab prompts immune response ... by LatteLazy on Monday October 26, 2020 @09:03AM (#24895689)
Thanks, I guess people do get mild flu after the flu vaccine so it would make sense for it to be the same.
Re:Vaccine hopes rise as Oxford jab prompts immune response ... by henearkr on Monday October 26, 2020 @07:53AM (#24895117)
This is a virus with bad long-term effects on the body.

Not a good idea to catch it just to get immune.

Re:Vaccine hopes rise as Oxford jab prompts immune response ... by cheph on Monday October 26, 2020 @08:08AM (#24895221)
> This is a virus with bad long-term effects on the body.

In what percentage of people who get COVID-19 are there bad long-term effects? What other conditions did the people get bad long term effects have? How does these numbers compare with other diseases?

Would appreciate citations.

Re:Vaccine hopes rise as Oxford jab prompts immune response ... by henearkr on Monday October 26, 2020 @08:12AM (#24895251)
Damage to the heart, the brain, even for mild or asymptotic cases. My references are previous posts on HN or on phys.org as you can easily search it.

As you said there are scarce data yet, but the risks are scary. In these conditions, it's obvious one should avoid relying on a herd immunity induced by the virus.

Re:Vaccine hopes rise as Oxford jab prompts immune response ... by cheph on Monday October 26, 2020 @08:15AM (#24895275)
> My references are previous posts on HN or on phys.org as you can easily search it.

And you could cite a claim you are making. Without numbers it is hard to say if this is a good basis for decisions.

Re:Vaccine hopes rise as Oxford jab prompts immune response ... by henearkr on Monday October 26, 2020 @08:23AM (#24895345)
The statistics are in the making, and researchers discover more illness mechanisms each day.

As I said, we are in the presence of a huge risk and there is no "reassuring numbers" anywhere to counterbalance that.

As one reference on the risks I'm speaking of, here is an article about the action of the virus on the nerve cells:

https://www.scientificamerican.com/article/what-we-know-so-f...

By the way, between "relying on virus-induced herd immunity" and just keeping safe with mask and waiting for the vaccine to come, why the rush to get the virus??

There is a risk, there is the possibility to wait it over. So why just not do that and wait the safe solution?

Re:Vaccine hopes rise as Oxford jab prompts immune response ... by marketingPro on Monday October 26, 2020 @08:45AM (#24895539)
Suicide, abuse/trauma, avoided medical treatments, drug and alcohol addictions, and depression have all been seen to increase since we first had lockdowns.

There is no safe solution, it's a decision between protecting the 0.5% old, obese, and sick or the 99.5%

Re:Vaccine hopes rise as Oxford jab prompts immune response ... by henearkr on Monday October 26, 2020 @08:53AM (#24895605)
The fact that catching the COVID should be avoided instead of looked for is really obvious.

How to avoid it is the real discussion.

I could avoid it easily until now because everybody wears a mask here.

In some cases or in some countries, this is not possible, or too much people are infected already, and lockdown becomes the best solution.

Nobody is saying that lockdown is the only solution in every case, and absolutely nobody is even thinking that lockdown is making people happy.

Re:Vaccine hopes rise as Oxford jab prompts immune response ... by chimprich on Monday October 26, 2020 @01:18PM (#24898555)
> Suicide, abuse/trauma, [...], drug and alcohol addictions, and depression have all been seen to increase since we first had lockdowns.

Correlation versus causation.

We're in the middle of a major health emergency. Why are you attributing those to the effects of lockdowns, rather than the effects of the pandemic? You don't think that the risk to personal health of a potentially lethal virus, seeing older friends and relatives dying, and worrying about the risk of health systems collapsing are causing any of the above?

In March, someone I know in Italy passed on the virus to his grandfather, who died at home. All the ambulances in the area were tied up for hours. You can imagine the effect on his mental health. I doubt the impact was comparable to the effects of intermittent lockdowns.

Re:Vaccine hopes rise as Oxford jab prompts immune response ... by singemonkey on Monday October 26, 2020 @09:08AM (#24895732)
Please provide evidence for this.

(To avoid misunderstandings, evidence does not mean your unverified opinions).

I'm particularly interested in your methodology for arriving at 0.5%, so a detailed data dump on that from you would be very useful.

Re:Vaccine hopes rise as Oxford jab prompts immune response ... by anoncake on Tuesday October 27, 2020 @05:27PM (#24912130)
The IFR is ~0.6%, the threshold for herd immunity is below 80% according to even the most pessimistic estimates. 80% * 0.6% = 0.5%.
Re:Vaccine hopes rise as Oxford jab prompts immune response ... by anoncake on Monday October 26, 2020 @10:08AM (#24896294)
Exactly. There is scarce data. If after almost a year there is still no evidence of long-term damage, it's reasonable to assume there is none.
Re:Vaccine hopes rise as Oxford jab prompts immune response ... by graeme on Monday October 26, 2020 @08:19AM (#24895306)
We don’t know yet. It’s a gamble.

A uk study suggests 12% have symptoms longer than 30 days. Beyond that, hard to say. We also don’t havea good measure of invisible damage: do survivors have reduced lung function from pneumonia? Damage to endothelium predisposing to pneumonia? Too soon to tell.

About 20% of people are hospitalized.

https://www.bbc.com/news/health-54296223

Re:Vaccine hopes rise as Oxford jab prompts immune response ... by 3np on Monday October 26, 2020 @08:10AM (#24895238)
We don't know. Which is why it's preferred to play it safe, in that regard.
Re:Vaccine hopes rise as Oxford jab prompts immune response ... by rimliu on Monday October 26, 2020 @08:05AM (#24895203)
Nobody knows its long term effect on the body. Especially if you were asymptomatic.
Re:Vaccine hopes rise as Oxford jab prompts immune response ... by feanaro on Monday October 26, 2020 @08:11AM (#24895243)
Your response is phrased in a way that all the meaning lies in the exact definition of what you mean by "knows". There is certainly evidence that there are long-term effects. Example: https://www.medrxiv.org/content/10.1101/2020.10.20.20215863v...
Re:Vaccine hopes rise as Oxford jab prompts immune response ... by henearkr on Monday October 26, 2020 @08:14AM (#24895260)
This huge uncertainty is in favor of avoiding taking the risks, rather than the other way.
Re:Vaccine hopes rise as Oxford jab prompts immune response ... by anoncake on Monday October 26, 2020 @10:09AM (#24896299)
Put another way: Nobody knows of any long term effect on the body.
Re:Vaccine hopes rise as Oxford jab prompts immune response ... by im3w1l on Monday October 26, 2020 @08:54AM (#24895620)
I was considering bug chasing and then isolating. I regret not doing so.