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Re:SARS-CoV-2 positivity rates associated with circulating V... by jimmyswimmy on Saturday September 19, 2020 @08:35AM (#24527001)
I'd be interested to see the results broken out by racial group. There is evidence that blacks do not metabolize vitamin D the same way that whites do, and the standard test for vitamin D concentration does not measure its bioavailability accurately. This could strongly affect the results depending on the racial distribution of participants. In other words this effect could reduce the significance of the results.

Here's a popular article on the topic. https://www.npr.org/sections/health-shots/2013/11/20/2463933... though there's plenty of research articles available.

The difference is that the test evaluated 25(OH)D concentration, and not 1,25(OH)D which is the useful (metabolized) compound. There is currently no standard test for the latter, which is why they didn't do it. Though I would prefer to see those results, it would be easier at the present time to parameterize the study by racial group to reduce or eliminate this effect.

That said it would be nice if we could all just take a nice cheap vitamin for this. Caveat: I am not in life sciences.

Edit. They do show a figure which breaks out the relationship by race. https://journals.plos.org/plosone/article/figure?id=10.1371/... and it is much stronger for African Americans. Perhaps my hypothesis was incorrect.

Re:SARS-CoV-2 positivity rates associated with circulating V... by kenjackson on Saturday September 19, 2020 @11:10AM (#24527901)
BTW, as someone who is Black — I didn’t find a single thing in your post racist. It talked about race, but not in a way to oppress or demean any group. At least that was my take.
Re:SARS-CoV-2 positivity rates associated with circulating V... by asveikau on Saturday September 19, 2020 @12:22PM (#24528528)
I'm a white dude, so obviously I can't speak for black people and it's not typically appropriate for me to get super offended about this on your behalf, but personally there's something so jarring to me when people use "blacks" as a plural noun. I think by prior experience, when I hear it put that way it subconsciously primes me to expect the person speaking is angry and racist. I've just heard so many people say it that way in agitated tones.

Then again, I've also definitely heard older people talk that way and they don't seem to mean harm or be angry.

Re:SARS-CoV-2 positivity rates associated with circulating V... by crispyporkbites on Saturday September 19, 2020 @01:22PM (#24529008)
It’s not a racist post obviously- but it is false to group people into the American race definitions in a scientific discussion, because it doesn’t hold true and has been debunked a long time ago as a genetic definition.

It can apply from a socio economic angle, but that applies only in America or a country that uses American racial profiles for systemic racism.

Edit: Aware this is a controversial viewpoint in non-scientific communities, so here's some interesting comments from Wikipedia on the subject:

> Modern scholarship regards race as a social construct, an identity which is assigned based on rules made by society.[2] While partially based on physical similarities within groups, race does not have an inherent physical or biological meaning.[1][3][4]

> Social conceptions and groupings of races have varied over time, often involving folk taxonomies that define essential types of individuals based on perceived traits.[5] Today, scientists consider such biological essentialism obsolete,[6] and generally discourage racial explanations for collective differentiation in both physical and behavioral traits.[7][8][9][10][11]

> Even though there is a broad scientific agreement that essentialist and typological conceptualizations of race are untenable,[12][13][14][15][16][17] scientists around the world continue to conceptualize race in widely differing ways.[18] While some researchers continue to use the concept of race to make distinctions among fuzzy sets of traits or observable differences in behavior, others in the scientific community suggest that the idea of race is inherently naive[7] or simplistic.[19] Still others argue that, among humans, race has no taxonomic significance because all living humans belong to the same subspecies, Homo sapiens sapiens.[20][21]

Re:SARS-CoV-2 positivity rates associated with circulating V... by umanwizard on Saturday September 19, 2020 @01:27PM (#24529054)
I’ve gotten blood tests done where the normal range for various parameters was listed as being different for different racial groups.

If there is no correlation between genes and “American race definitions”, how is this possible?

Re:SARS-CoV-2 positivity rates associated with circulating V... by crispyporkbites on Saturday September 19, 2020 @01:46PM (#24529181)
Re:SARS-CoV-2 positivity rates associated with circulating V... by umanwizard on Saturday September 19, 2020 @03:22PM (#24529818)
I’m aware that race is not a strictly defined category, and that racial classification is arbitrary to a large extent. However, this doesn’t answer my question.
Re:SARS-CoV-2 positivity rates associated with circulating V... by crispyporkbites on Saturday September 19, 2020 @03:42PM (#24529911)
It demonstrates the logical fallacy - if it's an arbitrary classification, as you say, how can those blood test groupings be accurate? They can, at best, be arbitrary
Re:SARS-CoV-2 positivity rates associated with circulating V... by umanwizard on Saturday September 19, 2020 @07:51PM (#24531052)
“Arbitrary” doesn’t mean “uniformly random”. Even though the lines are blurred, there is still a strong correlation between being considered part of a particular racial classification in the US and having certain genes.
Re:SARS-CoV-2 positivity rates associated with circulating V... by hajimemash on Saturday September 19, 2020 @07:32PM (#24530978)
Thanks for the interesting first link. Now I understand your earlier comment
Re:SARS-CoV-2 positivity rates associated with circulating V... by brmgb on Saturday September 19, 2020 @11:24AM (#24528028)
That's because you are American. As a foreigner, I find the idea that you can label a group as "black" and imagine it to be both descriptive and homegenous enough to see meaningful genetic variations relative to another group labeled as "white" somewhat funny and verging on racism (but then again I have been conditioned from childhood to see the word race applied to humans as something deeply racist whereas it is seen as completely innocuous in an American cultural context).
Re:SARS-CoV-2 positivity rates associated with circulating V... by microcolonel on Saturday September 19, 2020 @11:30AM (#24528077)
> I find the idea that you can label a group as "black" and imagine it to be both descriptive and homegenous enough...

No, the whole distinction of black is dark skin colour, which is a proxy for skin melanin, which is (far as I'm aware) the primary factor determining vitamin D production from sun exposure (which is not directly useful in the body, but is the form that is often measured).

Also, because of the effect on vitamin D production from sun exposure, there is some evidence that other aspects of how vitamin D is handled by the body are different for people with darker skin, maybe because their ancestors got more than enough of it.

This isn't even about social categories “Black” and “White”, it is literally about the direct correlates of skin colour.

Re:SARS-CoV-2 positivity rates associated with circulating V... by kipchak on Saturday September 19, 2020 @11:53AM (#24528276)
>This isn't even about social categories “Black” and “White”, it is literally about the direct correlates of skin colour. To expand upon this according to an ONS study "Blacks" in England and whales had a 1.9 times higher rate of dying compared to "Whites" after socioeconomic controls, while Pakistani and Bangladeshi ethnic groups were 1.6 times more likely.[1] This makes sense if you figure lighter skin was a evolved trait for those in latitudes that got less sun. [2]

[1] https://www.ons.gov.uk/peoplepopulationandcommunity/birthsde...

[2]https://www.pnas.org/content/107/Supplement_2/8962

Re:SARS-CoV-2 positivity rates associated with circulating V... by secondcoming on Saturday September 19, 2020 @12:31PM (#24528585)
Whales?
Re:SARS-CoV-2 positivity rates associated with circulating V... by Bud on Saturday September 19, 2020 @12:42PM (#24528672)
Let's assume that was just a particularly hilarious typo for "Wales".
Re:SARS-CoV-2 positivity rates associated with circulating V... by kipchak on Saturday September 19, 2020 @07:29PM (#24530965)
Indeed, though thinking about it people living in "whales" would probably have low vitamin D levels as well.
Re:SARS-CoV-2 positivity rates associated with circulating V... by umanwizard on Saturday September 19, 2020 @07:57PM (#24531074)
I spent about 3 seconds wondering why in the world you were talking about whale vitamin-D levels, and thinking it was vaguely offensive that you were comparing ethnic/racial groups of humans to marine mammals.

Then I remembered that Wales exists :)

Re:SARS-CoV-2 positivity rates associated with circulating V... by singemonkey on Saturday September 19, 2020 @11:39AM (#24528160)
I mean, black and dark skin colour are overlapping sets, but the word black doesn't define everyone with dark(er) skin.

If you mean darker skin (darker than what???) then use that term.

Accuracy is important.

Re:SARS-CoV-2 positivity rates associated with circulating V... by jt2190 on Saturday September 19, 2020 @12:28PM (#24528567)
Just a note that they are estimating race using zip code. I’m not sure you’d want to draw any conclusions from that.

> To analyze race/ethnicity, patient data were linked to estimated race/ethnicity proportions reported by zip code in the 2018 5-year American Community Survey (ACS)

Re:SARS-CoV-2 positivity rates associated with circulating V... by bXVsbGVy on Saturday September 19, 2020 @10:14AM (#24527562)
Does it means that those studies that says most people of color in northern hemisphere are vitamin-D deficient not that strongly substantiated?

I though people of color produces less vitamin D due the skin pigmentation that filters light in UVB spectrum.

Re:SARS-CoV-2 positivity rates associated with circulating V... by tzs on Saturday September 19, 2020 @11:09AM (#24527899)
Skin pigmentation does affect vitamin D production.

There are a few stages between production of vitamin D and the delivery of useful vitamin D to the places where it is needed. The form produced by the skin is not the form needed, so it has to be transformed.

The usual test measures vitamin D levels at a particular stage, and then we infer that if the levels are normal at that stage, they will be normal at the final stage too.

The problem seems to be that this was calibrated based on the levels in light skinned people, and it is starting to look like the relative levels at the different stages are different in darker skinned people.

Think of it not as a dark skinned person's skin produces less than a light skinned person's skin, but rather the light skinned person's skin produces more than the dark skinned person's skin. Their bodies both need the same amount of the final form, and both are able to convert enough to that form, and don't bother converting much more than they need. The result is that the light skinned person has more leftover pre-conversion form. The test measures that pre-conversion form.

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Re:SARS-CoV-2 positivity rates associated with circulating V... by bXVsbGVy on Saturday September 19, 2020 @10:20AM (#24527612)
I think using black is fine, nyt choose the capitalized Black:

https://www.nytimes.com/2020/07/05/insider/capitalized-black...

Re:SARS-CoV-2 positivity rates associated with circulating V... by plorg on Saturday September 19, 2020 @10:32AM (#24527676)
Black as adjective, sure. Black as a noun, I should think not.
Re:SARS-CoV-2 positivity rates associated with circulating V... by ceejayoz on Saturday September 19, 2020 @10:30AM (#24527665)
The NYT usually pairs “Black” with “people”. “Black people” and “blacks” read a little differently.
Re:SARS-CoV-2 positivity rates associated with circulating V... by celticninja on Saturday September 19, 2020 @10:35AM (#24527686)
Yup, black people and white people still recognises their shared humanity. The use of blacks and whites is divisive.
Re:SARS-CoV-2 positivity rates associated with circulating V... by celticninja on Saturday September 19, 2020 @10:32AM (#24527677)
Black is fine, 'the blacks' or 'the whites' is not. If you are describing someone it is fine to denote their skin colour. It is not fine to encompass a whole group as 'blacks', does this include mixed race people, does it include all BAME groups?
Re:SARS-CoV-2 positivity rates associated with circulating V... by jjcon on Saturday September 19, 2020 @10:45AM (#24527751)
Not everyone here speaks English as a first language (including me). To me that sort of language policing just seems petty. We all know the point being made.
Re:SARS-CoV-2 positivity rates associated with circulating V... by ceejayoz on Saturday September 19, 2020 @10:50AM (#24527787)
“Didn’t know that, thanks for the info” is also a possible approach here for someone speaking English as a second language.
Re:SARS-CoV-2 positivity rates associated with circulating V... by jjcon on Saturday September 19, 2020 @10:51AM (#24527800)
Or they can reply like I did and say quit distracting the conversation with petty language policing
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Re:SARS-CoV-2 positivity rates associated with circulating V... by jjcon on Saturday September 19, 2020 @10:53AM (#24527810)
Please stop calling everything racist - that sort of flamewar is against hn rules and is not in the spirit of cordial conversation
Re:SARS-CoV-2 positivity rates associated with circulating V... by bXVsbGVy on Saturday September 19, 2020 @11:03AM (#24527866)
I see your point. And think this controversy could be avoided if OP chosen more neutral words. But I don't think OP was willfully racist.

The most adequate terminology is still in dispute and most people don't follow this discussion closely. Also it varies from country to country.

For instance, in my country, the "n-work" used to be accepted while "black" was pejorative. But recently, a new line of though emerged: those who think we should adopt the NA convention.

To avoid any controversy, I would had chosen other words:

    s/racial/skin color/
    s/black/dark skinned people/
    s/black/fairer skinned people/
OP probably tried to be consistent with the papers they cited.
Re:SARS-CoV-2 positivity rates associated with circulating V... by umanwizard on Saturday September 19, 2020 @11:15AM (#24527943)
But black people and “dark-skinned people” don’t mean the same thing. Black people specifically means people whose ancestors are from sub-Saharan Africa. There are other people with dark skin whose genetics are completely different, for example in India or Australia.
Re:SARS-CoV-2 positivity rates associated with circulating V... by celticninja on Saturday September 19, 2020 @11:20AM (#24527992)
Does 'blacks' somehow do a better job of defining an ethnic group? Or is it again a catch all term for non-white?
Re:SARS-CoV-2 positivity rates associated with circulating V... by umanwizard on Saturday September 19, 2020 @11:22AM (#24528009)
No, “blacks” is not a catch-all term for non-white. Again, it means people whose ancestors are from sub-Saharan Africa. In fact, in the US it is usually even more specific than that, since the vast majority of black Americans’ ancestors are from West Africa specifically.

Similarly, white people or “whites” usually refers to people whose ancestors are from Europe, even though there are other people with light skin tones throughout the world (especially Asian or Native American people in high latitudes).

Not really sure what point you’re making.

Re:SARS-CoV-2 positivity rates associated with circulating V... by celticninja on Saturday September 19, 2020 @11:19AM (#24527980)
>. And think this controversy could be avoided if OP chosen more neutral words. But I don't think OP was willfully racist

I agree entirely and said so in my initial comment. As I say elsewhere it was really to inform OP rather than berate them.

Re:SARS-CoV-2 positivity rates associated with circulating V... by sokoloff on Saturday September 19, 2020 @11:07AM (#24527884)
> in my country, the [n-word] used to be accepted while black was seems as pejorative.

I’m presuming you mean “negro” rather than a 6-letter word starting with “ni”?!

Re:SARS-CoV-2 positivity rates associated with circulating V... by celticninja on Saturday September 19, 2020 @11:12AM (#24527916)
None of the papers cited in the thread above use the specific terms 'blacks' or 'whites' so I'm pretty happy placing the responsibility for this on OP.
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Re:SARS-CoV-2 positivity rates associated with circulating V... by beervirus on Saturday September 19, 2020 @09:26AM (#24527267)
Facts can’t be racist.
Re:SARS-CoV-2 positivity rates associated with circulating V... by jacobwilliamroy on Saturday September 19, 2020 @11:16AM (#24527948)
Researchers can be racist. Statisticians can be racist. Publishers can be racist. Just because something bears the shape of truth, does not make it true.
Re:SARS-CoV-2 positivity rates associated with circulating V... by beervirus on Saturday September 19, 2020 @02:30PM (#24529491)
Facts can’t be racist though.
Re:SARS-CoV-2 positivity rates associated with circulating V... by singemonkey on Saturday September 19, 2020 @12:01PM (#24528351)
> Facts can’t be racist.

As long as they actually are facts, then yes this is true.

However, the presentation and choice of which facts to use can be racist, I'm sure you'll agree with me on that.

Re:SARS-CoV-2 positivity rates associated with circulating V... by ineedasername on Saturday September 19, 2020 @10:24AM (#24527630)
This is meant for the person making accusations of racism, not @beevirus, but this is where I can reply and I think it's important to do so even to dead comments given the "racism" accusation.

@Kednicma asked for evidence: A basic google search finds it. [0][1][2][3]. They complain of downvotes & karma lost: Those may very well come from the desire of many in this community to take basic research steps before leveling very serious accusations.

There is no reason to jump to "racism" so quickly merely because a biological difference is asserted between people of different ethnic backgrounds. Ethnicity is intertwined with genetic background, and it's not up for dispute whether or not genetics influence biology, it's practically axiomatic within the concept of genetics.

I acknowledge that research finding biological differences between ethnic groups can be ammunition for racists, but that must not be the automatic assumption, especially in this community where it violates the community guidelines to jump first to an uncharitable negative interpretation of someone's comments.

[0] https://americanbonehealth.org/nutrition/african-americans-n...

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894250/

[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954269/

[3] https://web.musc.edu/about/news-center/2019/06/20/vitamin-d-...

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Re:SARS-CoV-2 positivity rates associated with circulating V... by tzs on Saturday September 19, 2020 @11:19AM (#24527973)
> vitamin D levels are experimentally low in African-Americans and Hispano-Americans. Occum's Razor begs us to justify why this isn't a race-poverty correlation, yet another indication that our society is systematically disenfranchising folks based on skin color and country of origin. With better diet might come better vitamin D blood levels

You are kind of missing the point, which is that the test used for vitamin D levels is not directly measuring the levels of the kind of vitamin D actually needed. It is measuring a different kind of vitamin D, and then we infer the levels of the other kind from that.

This inference is based on data for light skinned people, and it appears that it is not valid for dark skinned people. It underestimates the amount of the needed kind of vitamin D for them.

This may lead to widespread misdiagnoses of vitamin D deficiencies in African-Americans who in fact have fine levels of the kind of vitamin D that is actually needed.

Re:SARS-CoV-2 positivity rates associated with circulating V... by beervirus on Saturday September 19, 2020 @11:07AM (#24527879)
> The top poster used an NPR article which explored the systemic racism of vitamin D tests.

No, it did not explore systemic racism. It explored physiological differences between races.

Re:SARS-CoV-2 positivity rates associated with circulating V... by mperham on Saturday September 19, 2020 @12:04PM (#24528375)
> differences between races.

Race is a social construct, it's not a scientific category. There is only a continuous spectrum of skin tone. If someone is mixed parentage, what "race" are they?

Re:SARS-CoV-2 positivity rates associated with circulating V... by IgorPartola on Saturday September 19, 2020 @12:27PM (#24528557)
Ugh. Look ignoring race is why people of color systematically get worse medical treatment. Look at Sickle Cell Anemia. It is widely documented that people of color whose ancestors were from Africa and sub Sahara are much susceptible to it. This has been studied extensively and all potential confounding factors have been ruled out. Is it racist to study this? Is it racist to use our understanding of genetic research to try to figure out how to treat this particular syndrome?

Race the social construct is a social construct. We are the same species. Period, the end. But differences in genetics and physiology do warrant study because this is how we can find treatments and preventative measures to a multitude of disease.

This is a lot like saying that research that shows that men are more susceptible to heart attacks then women is sexists because gender is a social construct. Gender is a complex topic that evolves with our evolving understanding of wha it means to be human on a philosophical level. But the X chromosome isn’t a social construct and has very direct very tangible effects. You can’t call it a social construct.

In short: when it comes to how we build a society, recognize differences and account for them to bring as much economic opportunity equality to everyone. When it comes to medicine, study everything including genetic differences in order to get the best understanding of the problem at hand. Getting offended doesn’t get us closer to for example a cure for COVID, does it?

Re:SARS-CoV-2 positivity rates associated with circulating V... by hclimente on Saturday September 19, 2020 @01:28PM (#24529056)
This "race is a social construct" meme is something I have been trying to grapple recently.

I think the point is that races are based on a handful of cherry-picked phenotype differences. On the one hand, these characteristics are a decent proxy for human migrations in the past and might map to evolutionary events with clinical implications. On the other hand, another set of genetically conditioned characteristics would be similarly good at that. In an alternate universe, humans might have defined race based on hair color and height, and that would possibly match evolutionary history in another useful way.

Re:SARS-CoV-2 positivity rates associated with circulating V... by IgorPartola on Saturday September 19, 2020 @05:33PM (#24530462)
The episode of Rick and Morty about Unity has a race war based on nipple shape.

But if you want a really interesting thought experiment consider what would happen if other species of humans than sapiens would have survived along us. Would the Declaration of Independence start with “we the people” or “we the sapiens”? Would the myth of Christ be that he died for sins of men or some specific subset of humans?

But really I don’t see much of a problem with race both being a social construct and a biological reality in the sense that we are talking about two related but separate phenomena. Socially, race is a construct. The idea that judging by your skin color or shape of skull we can tell how smart or virtuous you are is bogus. A lot of people have tried to justify science behind it and all of it has not been science. Scientifically we have a number of genetic differences that can be traced between different origins of our genetic trees. Some of these are inconsequential like some people having straight hair and others having curly hair. Others are more impactful like ability to metabolize lactose as adults. Or susceptibility to heart disease or certain cancers. The kicker is that it is easier to tell the public “if you are ethnicity X you might want to get your heart checked out 5 years before another ethnicity because statistically it’s more beneficial that way” than to say the same thing as “if you have genes A, B, and C”. When my doctor tells me that because I am Easter European my cholesterol is more likely to be elevated, I don’t take offense to that.

Having said all that, don’t use “blacks” or “whites” as a damn noun. That isn’t ok.

Re:SARS-CoV-2 positivity rates associated with circulating V... by beervirus on Saturday September 19, 2020 @12:14PM (#24528459)
The lines are blurry, but that doesn't mean they don't exist. Is sickle cell anemia a social construct?
Re:SARS-CoV-2 positivity rates associated with circulating V... by JamesBarney on Saturday September 19, 2020 @12:36PM (#24528628)
I don't really know what a social construct is.

What is a scientific category vs a non-scientific category?

And I don't think every item needs to fall neatly into a category for that category to be useful.

If I say 86% of african americans have a hypersensitivity to warfarin which means that if they were given the same dose as a white person they'd have a much increased risk of stroke.

Clearly in the previous sentence the distinction of ethnicity is useful and the information makes people safer.