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Re:American darknet vendor and Costa Rican pharmacist charged by CameronNemo on Wednesday August 05, 2020 @10:50PM (#24067710)
Justice is such a poor way to describe what is happening here. I have full empathy with those who have struggled with opioid addiction or lost loved ones to the disease. But the fact is that opioid prescriptions are still being written with too little oversight, too few safeguards, and not enough support for patients. Withstanding such contradiction in treatment of opioid suppliers, the federal government cannot keep treating opioid abuse on the supply side. We need solutions that focus on patient health and wellness. An opioid on its own does not result in overdoses or abuse, and even moderate use can be balanced with a healthy lifestyle. The DOJ does not have the tools, skills, or experience necessary to address the public health crisis that is opioid abuse.
Re:American darknet vendor and Costa Rican pharmacist charged by arcticbull on Thursday August 06, 2020 @02:06AM (#24068505)
This is your regular reminder that Portugal decriminalized all drugs in 2001 and usage did not go up but the health effects and negative societal effects of drug use all but vanished [1]. They went from worst in the EU to among the best in the EU in the decade that followed on pretty much every metric.

Addiction has a huge situational component. 20% of US GIs in Vietnam were addicted to heroin. When they returned home 90% of them stopped using heroin overnight, indefinitely [2].

We're doing this all wrong.

[1] https://www.theguardian.com/news/2017/dec/05/portugals-radic...

[2] https://jamesclear.com/heroin-habits

Re:American darknet vendor and Costa Rican pharmacist charged by Hitton on Thursday August 06, 2020 @05:48AM (#24069500)
They decriminalized usage and possession of drugs for personal use, not dealing the drugs.
Re:American darknet vendor and Costa Rican pharmacist charged by remarkEon on Thursday August 06, 2020 @02:40AM (#24068649)
This is your regular reminder that extrapolating an outcome from a country like Portugal (an outcome we should all be happy about, by the way) to a country like the United States is unwise. I've never been to Portugal, but have friends that live in both Spain and Portugal and I'm pretty envious of the kind of community and shared identity they describe. I image that probably has something to do with the outcome seen there. So, while I think it's possible to decriminalize all drug use in certain contexts, we've tried this experiment in some US cities and it's not resulted in anything anyone could describe as a success.

>Addiction has a huge situational component.

Yes, this is exactly what I'm getting at.

>20% of US GIs in Vietnam were addicted to heroin. When they returned home 90% of them stopped using heroin overnight, indefinitely [2].

This seems to contradict your previous point, no? In Vietnam there was of course zero enforcement, outside of the military (I'm being charitable here for reasons that should be obvious), and they returned home to a country where the drug was illegal.

Edit: very interesting, the negative reaction to this comment. What I said is true, so I can only assume that people who are reacting negatively are doing so because they are projecting a view on me that I do not hold.

Re:American darknet vendor and Costa Rican pharmacist charged by arcticbull on Thursday August 06, 2020 @05:35PM (#24075708)
I think the reason people are reacting negatively to your comment is that:

(1) We have data from 1971 onward, just shy of 50 years, that shows that the "war on drugs" approach used in most of the world has been an abject and total failure. Drug usage remains pervasive, social harms are clear, and we keep throwing people in jail. No progress is made.

(2) A country was doing terribly on every metric, then they made a bold decision that was the opposite of the failed approach everyone else is using.

(3) The results were spectacular.

(4) Your response is "well that'll never work here." This is an implicit endorsement of the failed status quo, and an explicit rejection of evidence in support of an alternative.

> This seems to contradict your previous point, no?

No, it doesn't. It's not at all related to availability or legality of drugs -- drugs are equally available literally everywhere. Nobody in the US who wants to do heroin has any trouble getting heroin, or any other opioids. Accessibility is not the issue. And nobody addicted to heroin goes "oh, well, it's illegal in America, guess I'll stop."

It's evidence to support that we need to end the abject failure of an approach we've squandered 50 years on, and start a new, public health and community support approach to managing addiction. As evidenced by a place it's been overwhelmingly successful.

We literally can't do worse than what we have now, unless you wanted to make drugs mandatory.

Re:American darknet vendor and Costa Rican pharmacist charged by ithkuil on Thursday August 06, 2020 @04:20AM (#24069073)
> and they returned home to a country where the drug was illegal.

They also returned to their families and loved ones, trying re-introduce themselves to civil society and many figured out that heroin was not helping (illegal or not)

Re:American darknet vendor and Costa Rican pharmacist charged by remarkEon on Thursday August 06, 2020 @04:24AM (#24069098)
You (and others in this thread) are helping to make my point for me, which is that personal social structures are paramount for killing drug addiction.
Re:American darknet vendor and Costa Rican pharmacist charged by ethanbond on Thursday August 06, 2020 @06:39AM (#24069718)
I don’t think anyone is disputing that some variation of this idea is true. What’s not being stated explicitly is that if it’s true that social connectedness (ambiguously including identity, purpose, etc.) matters, then it’s also true that our current enforcement mechanisms are probably incredibly counterproductive.

Everyone gets the point you’re making, you’re just not following it through to something meaningful and instead supposing it implies something it doesn’t.

Re:American darknet vendor and Costa Rican pharmacist charged by Fjolsvith on Thursday August 06, 2020 @09:39AM (#24070752)
And... that ties nicely in with the defund the police narrative.
Re:American darknet vendor and Costa Rican pharmacist charged by arcticbull on Thursday August 06, 2020 @05:40PM (#24075756)
This has nothing to do with the "defund the police" narrative, Portugal did this 20 years ago.
Re:American darknet vendor and Costa Rican pharmacist charged by Fjolsvith on Friday August 07, 2020 @11:39AM (#24083040)
> then it’s also true that our current enforcement mechanisms are probably incredibly counterproductive.

Fits nicely to me.

Re:American darknet vendor and Costa Rican pharmacist charged by arcticbull on Friday August 07, 2020 @01:09PM (#24084198)
Ah, I see what you meant, I read it as implying that the "defund the police" people were driving the narrative I was referencing, not that the narrative I was referencing happened to fit the "defund the police" one.
Re:American darknet vendor and Costa Rican pharmacist charged by raxxorrax on Thursday August 06, 2020 @04:06AM (#24069001)
That the experience of war made people take more drugs does actually tell something, but I doubt it is favorable towards the argument for stricter enforcement.
Re:American darknet vendor and Costa Rican pharmacist charged by Implicated on Thursday August 06, 2020 @02:44AM (#24068670)
> we've tried this experiment in some US cities and it's not resulted in anything anyone could describe as a success.

We have? Can we get a citation on that?

Re:American darknet vendor and Costa Rican pharmacist charged by remarkEon on Thursday August 06, 2020 @03:19AM (#24068804)
Portland, Oakland, Seattle for starters. Maybe you have a different definition of decriminalization.
Re:American darknet vendor and Costa Rican pharmacist charged by powerslacker on Thursday August 06, 2020 @10:49AM (#24071396)
For Oakland, that's marijuana decriminalization only though. Portugal's decriminalization affected all major street narcotics.
Re:American darknet vendor and Costa Rican pharmacist charged by Implicated on Wednesday August 12, 2020 @12:24PM (#24133640)
Ehh, I lived in Portland - where do you see anything about a decriminalization of all drugs there? I must have missed it.
Re:American darknet vendor and Costa Rican pharmacist charged by aarpmcgee on Thursday August 06, 2020 @12:45PM (#24072703)
Citation?
Re:American darknet vendor and Costa Rican pharmacist charged by 263943736 on Wednesday August 05, 2020 @11:24PM (#24067866)
Opioids are among the best medications for treating severe pain. If we're focusing on patients I'd much rather focus on rehabilitative strategies since the current degree of increased scrutiny is already making accessing adequate medication more difficult for groups like the elderly or people with chronic pain. Even more increased oversight is just going to escalate hesitation among doctors.
Re:American darknet vendor and Costa Rican pharmacist charged by adrianN on Thursday August 06, 2020 @01:47AM (#24068426)
Do you feel like chronic pain patients outside the US don't get adequate treatment? Because where I live opioids are prescribed much less frequently, but I don't think chronic pain patients suffer more than in the US.
Re:American darknet vendor and Costa Rican pharmacist charged by watwut on Thursday August 06, 2020 @06:10AM (#24069603)
> don't think chronic pain patients suffer more than in the US

How would you know who suffers more on average?

Re:American darknet vendor and Costa Rican pharmacist charged by Aerroon on Thursday August 06, 2020 @12:17AM (#24068085)
I wonder where most of the harm is coming from with opioids. Do the opioids themselves cause more harm than society does by making them illegal?

The cases I've mostly heard about seemed to be that people hot addicted to opioids and the only way to keep it going was to break the law. That eventually got them in trouble. For some drugs it does seem like the government trying to protect you from the drugs do more harm than what the drugs themselves do. Are opioids among them?

Re:American darknet vendor and Costa Rican pharmacist charged by neuroma on Thursday August 06, 2020 @03:17AM (#24068798)
Prof Nutt made and published a universal harm scale which accounts for multi dimensional harm of drugs, and potentially allows comparisons to be made between them https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109763/#B29. This work got him sacked from his lead advisory role to the UK govt, as it undermined the policy and caused embarrassment. Nutt still works in Imperial College researching psychedelics as novel therapeutics. The money shot is this https://www.researchgate.net/figure/Overall-weighted-scores-...

A recent article which contextualises the work is here https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109763/

Re:American darknet vendor and Costa Rican pharmacist charged by ethanbond on Thursday August 06, 2020 @06:42AM (#24069738)
Wow this is awesome. I’ve pondered the need for exactly this sort of thing for a while as the obvious desired basis for drug policy. Shouldn’t be surprised the Nutt has done it!

Obviously it’s lossy to reduce something with this much complexity down to a single dimension but it’s still a helpful tool nonetheless.

Re:American darknet vendor and Costa Rican pharmacist charged by beenBoutIT on Thursday August 06, 2020 @01:27AM (#24068350)
They need to let people take whatever they want to take and then educate everyone about how addictive some opiates are.
Re:American darknet vendor and Costa Rican pharmacist charged by raducu on Thursday August 06, 2020 @06:39AM (#24069723)
In the past, I've tried a lot of recreational drugs, including some opioids, and without trying to, I can't see how I could get myself addicted to opioids or benzodiazepines, but I know a LOT of people would.

As far as I remember, only 10% of people who ever used heroin get addicted to it. But that still leaves 10% at a very high risk, because of their neurochemistry and life circumstances.

So I don't think ALL drugs should be legal.

Re:American darknet vendor and Costa Rican pharmacist charged by DanBC on Thursday August 06, 2020 @06:45AM (#24069756)
> Opioids are among the best medications for treating severe pain

> people with chronic pain.

Chronic refers to the length of time the pain exists, it doesn't refer to severity.

Here's what the Royal College of Anaesthetists says about opioids

https://fpm.ac.uk/opioids-aware

> Key Messages

> 1. Opioids are very good analgesics for acute pain and for pain at the end of life but there is little evidence that they are helpful for long term pain.

> 2. A small proportion of people may obtain good pain relief with opioids in the long-term if the dose can be kept low and especially if their use is intermittent (however it is difficult to identify these people at the point of opioid initiation).

> 3. The risk of harm increases substantially at doses above an oral morphine equivalent of 120mg/day, but there is no increased benefit: tapering or stopping high dose opioids needs careful planning and collaboration.

> 4. If a patient has pain that remains severe despite opioid treatment it means they are not working and should be stopped, even if no other treatment is available.

> 5. Chronic pain is very complex and if patients have refractory and disabling symptoms, particularly if they are on high opioid doses, a very detailed assessment of the many emotional influences on their pain experience is essential.

Re:American darknet vendor and Costa Rican pharmacist charged by raverbashing on Thursday August 06, 2020 @02:49AM (#24068699)
Doubt it

Especially as it is prescribed in the US, where drugs get preferred instead of other interventions. "Back pain? Opioids. No PT, no losing weight, just opioids. No, not even NSAIDS, just go for opioids"

Remember that some drug companies pushed for their medication to be in 12h regimens which increased their dependency potential, as opposed to a shorter interval preferred by doctors?

As a personal experience, opioids don't seem to work much for me on many types of pain.

Re:American darknet vendor and Costa Rican pharmacist charged by nipponese on Wednesday August 05, 2020 @11:41PM (#24067938)
Check out therapies targeting sodium channels. I found out through my wife that her company (a major pharma corp) is working on therapeutics that can block voltage to certain sodium channels in the brain to suppress pain.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350027/

Re:American darknet vendor and Costa Rican pharmacist charged by solinent on Wednesday August 05, 2020 @11:29PM (#24067887)
Opioids don't aid in recovery though--they're not a band-aid, they're simply a veneer. They can prevent recovery since they delays][ physical rehabilitation. I honestly think cannabis is a much better solution long-term, but good luck transitioning an opiate user to cannabis.
Re:American darknet vendor and Costa Rican pharmacist charged by 263943736 on Wednesday August 05, 2020 @11:41PM (#24067939)
Not being in crippling pain is usually considered a good thing. Sure, some things like a broken arm can probably get by with weed and yes some people respond exceptionally well to weed but there is a night and day difference between the two when it comes to treating most forms of severe pain such as what people with significant spinal trauma experience or what the elderly often (for any number of reasons ultimately relating to age) experience.
Re:American darknet vendor and Costa Rican pharmacist charged by solinent on Wednesday August 05, 2020 @11:48PM (#24067963)
I agree (it's meaningless though, I'm just pointing out the obvious above, I'm not an expert here) for acute injury it makes sense to use opioids in severe cases like you mention, however, I think we still need to find the best strains and cultivate them for pain use, we've only scratched the surface with cannabis, it's a big genus. Weed ain't what it used to be.

For chronic cases, I think chronic makes a lot of sense.

Pain helps you get moving. Opioid's don't. Too much pain is debilitating. Surely we can find a formula here (a very very large one).

Cannabis never removes all the pain. I think that's the main feature here.

Re:American darknet vendor and Costa Rican pharmacist charged by jimkleiber on Wednesday August 05, 2020 @11:43PM (#24067949)
Your comment reminds me of an episode of Joe Rogan with Johann Hari [1], talking about what really causes addiction and the failures of the "war on drugs."

He states, "The opposite of addiction is not sobriety, the opposite of addiction is connection." (18:08)

The former U.S. surgeon general, Vivek Murthy, declared loneliness an epidemic, and just wrote a book on it [2].

I believe the biggest challenge we face in the United States centers on emotional health. How do we feel? Whom do we trust? Who do we think loves us? How do we rebuild trust? How do we apologize and forgive? How do we grieve?

I watched a 60 Minutes episode talking about some of the pharma reps trying to convince doctors to prescribe more opioids [3]. One rep, Alec Burlakoff, had this interchange with the interviewer:

> Bill Whitaker: You're preying on these people-- > Alec Burlakoff: Yeah, because they're desperate. They'll try anything. And they may get relief from Subsys initially, But we all know what's gonna happen. We know. We've been doin' this long enough. We know how it ends. > Bill Whitaker: And that is? > Alec Burlakoff: It ends in addiction, withdrawal, pain, suffering, and even death. > Bill Whitaker: And you didn't care about that? > Alec Burlakoff: Back then, I was numb to that.

This reminds me that while I often think that the people who feel disconnected are the ones using the opioids, very often the ones selling them also feel disconnected. How did this man get so numb to selling products that he knew were causing so much pain and suffering to others? How did he get so numb in life in general? More importantly, how do we help him feel more alive?

I agree, I don't think the Department of Justice, especially with a focus on punishment rather than rehabilitation, can lift us out of this hole. I believe it will require a focus on emotional health, on repairing relationships, on helping us feel less distant, more close, to our friends, family, neighbors, and fellow Americans.

[1]: https://www.youtube.com/watch?v=CDpjvFn4wgM [2]: https://www.amazon.com/Together-Connection-Performance-Great... [3]: https://www.cbsnews.com/news/opioid-epidemic-pharmaceutical-...

Re:American darknet vendor and Costa Rican pharmacist charged by peteretep on Wednesday August 05, 2020 @11:51PM (#24067974)
> Johann Hari

A man whose professional experience is journalist and has no science, medical, public health, or psychotherapy background... and he’s trying to sell a book.

Is this too harsh a take? Is there a reason I should be taking his opinion seriously?

Re:American darknet vendor and Costa Rican pharmacist charged by stordoff on Thursday August 06, 2020 @12:44AM (#24068183)
Also a known plagiarist[1] and someone who has had his book's presentation of mental health/healthcare challenged[2]. It's an interesting (albeit I think too sweeping) opinion, but using him as a source just makes me question it.

[1] https://en.wikipedia.org/wiki/Johann_Hari#Plagiarism

[2] https://www.theguardian.com/science/brain-flapping/2018/jan/...

Re:American darknet vendor and Costa Rican pharmacist charged by jimkleiber on Thursday August 06, 2020 @01:21AM (#24068325)
I didn't know about the plagiarism or the editing of his critics' Wikipedia pages to portray them in a more negative light. I find the plagiarism to be concerning for trusting what he has done, and yet I think in this case, I would find fabrication worse than quoting someone from another conversation. About the Wiki edits, I see it as petty and yet not detracting too much from what I quoted, but again, maybe I'm just sticking to it because I like the argument he made, unwilling to dig deeper.

On the second point, I think it would be hard to find a book talking about mental health/healthcare that weren't challenged, but I could be wildly wrong on this. I just get the impression that there are many many takes on mental health, especially coming from a variety of fields—psychology, psychiatry, neuroscience, social work, sociology, criminology, etc.—and that I personally believe we still have a lot to learn in this space.

I agree the opinion is probably too sweeping, as I like to qualify most of my statements and some people, especially authors and politicians, often exaggerate theirs.

> Your comment reminds me of an episode of Joe Rogan with Johann Hari [1], talking about what really causes addiction and the failures of the "war on drugs."

I guess I'm a bit confused at such pushback on Hari, but maybe by putting "really" in my statement, with such confidence in the statement, I invited such a challenge.

Re:American darknet vendor and Costa Rican pharmacist charged by jimkleiber on Thursday August 06, 2020 @12:38AM (#24068161)
I mean, you don't have to take his opinion seriously, or more importantly, as a final answer to the issue of addiction.

I personally don't think that just because he's a journalist without those backgrounds, that he's not capable of learning and presenting truth in those spaces—I see a lot of value in journalistic skills of investigation and interdisciplinary exploration. That being said, it doesn't necessarily mean he's right or that he's not exaggerating or oversimplifying.

I found the podcast episode to be quite compelling to get me more interested in looking up other sources to see whether they agree with him, or if they differ, and in which ways. Even you posting this, questioning his credibility, inspired me to search a bit of what people with more experience in directly related scientific fields have said. Some have questioned whether the studies done with rats extrapolate to humans, some have questioned his seeming disapproval of antidepressants, and more.

I guess it just depends on who and what you trust to give you the truth about this issue. I found the interview illuminating, but that doesn't mean you would or should.

Re:American darknet vendor and Costa Rican pharmacist charged by nonissue on Thursday August 06, 2020 @02:39AM (#24068646)
I don't know anything about him, but based on his wikipedia article, I wouldn't put any stock at all in his journalistic skills. https://en.wikipedia.org/wiki/Johann_Hari
Re:American darknet vendor and Costa Rican pharmacist charged by jimkleiber on Friday August 07, 2020 @01:11AM (#24078573)
That's OK. Admittedly, if I had read that before, I may have seen his work more skeptically but I would still probably have engaged. With a lot of journalists reporting on science, if I can, I try to dig deeper into the studies they quote and go to the primary sources. Other times I probably just judge what they're saying based on my gut and intuition, trying to take shortcuts and hoping it's right :-)
Re:American darknet vendor and Costa Rican pharmacist charged by moneywoes on Thursday August 06, 2020 @02:04AM (#24068497)
Thank you for bringing that up. I often forget to validate sources prior to looking at their viewpoint.
Re:American darknet vendor and Costa Rican pharmacist charged by jimkleiber on Friday August 07, 2020 @12:58AM (#24078498)
I'm not sure if you were being sarcastic (or ironic?), as I think about HN being a platform where we present our viewpoints with few of our identities able to be validated. However, I can see value in both.
Re:American darknet vendor and Costa Rican pharmacist charged by ghthor on Wednesday August 05, 2020 @11:58PM (#24067994)
Because it's a novel opinion, and novel opinions are what a good scientist needs to make major breakthroughs. I sure people were saying the same things about Galileo as there were of the women from Alexandria before him, etc.
Re:American darknet vendor and Costa Rican pharmacist charged by jimkleiber on Thursday August 06, 2020 @12:41AM (#24068173)
I like this, as scientists need hypotheses to test and often those can come from non-scientists. I wonder how many of our scientific discoveries have come from suggestions (or bold statements) from people in other fields. Sure, many may prove to be false, but I like how you've framed it as a novel opinion that could spur further research into a topic.

What is science, if not a never-ending quest to learn more about the universe?

Re:American darknet vendor and Costa Rican pharmacist charged by Donthatme on Thursday August 06, 2020 @06:44AM (#24069750)
> I like this, as scientists need hypotheses to test and often those can come from non-scientists.

Bold claim, or tortured use of often.

> I wonder how many of our scientific discoveries have come from suggestions (or bold statements) from people in other fields.

A lot of academic fields are fairly siloed from others. One example is presentations at a conference from a subfield that is just slightly oblique from yours is hard to follow because they use different jargon than you. It is getting a little better with some emphasis on interdisciplinary research.

> Sure, many may prove to be false, but I like how you've framed it as a novel opinion that could spur further research into a topic.

From my experience with being blasted by spam ideas just because my contact information is in a university's physics directory, a lot of/most 'novel opinion' is noise.

Re:American darknet vendor and Costa Rican pharmacist charged by jimkleiber on Friday August 07, 2020 @12:54AM (#24078478)
> Bold claim, or tortured use of often.

Fair point, it may not be that often.

> A lot of academic fields are fairly siloed from others. One example is presentations at a conference from a subfield that is just slightly oblique from yours is hard to follow because they use different jargon than you. It is getting a little better with some emphasis on interdisciplinary research.

True, jargon and other aspects can draw divisions really fast. I left the electrical and computer engineering department at my university to pursue international studies because it was interdisciplinary and I could basically build my own major from economics, intl business, anthropology, political science, and other areas. So I'm probably biased towards interdisciplinary stuff and maybe see more of it than there may be.

> From my experience with being blasted by spam ideas just because my contact information is in a university's physics directory, a lot of/most 'novel opinion' is noise.

I can only imagine how many novel theories of the universe you receive and how few have relevance. I still think sometimes we can see patterns in the odd/wrong suggestions they provide and come to hypotheses about things, but maybe more so in some fields than others, and maybe much less directly than I had postulated.

Anyway, really appreciate the back and forth dialogue :-)

Re:American darknet vendor and Costa Rican pharmacist charged by peteretep on Thursday August 06, 2020 @01:28AM (#24068355)
> novel opinions are what a good scientist needs to make major breakthroughs

I wonder how frequently those opinions come from journalists trying to hawk books on fairly facile premisses tho

Re:American darknet vendor and Costa Rican pharmacist charged by jimkleiber on Friday August 07, 2020 @01:04AM (#24078532)
Hard to know...partially because I feel a bit embarrassed to admit, but I don't feel 100% confident I understand what "facile premises" means.

What do you mean by it?

Re:American darknet vendor and Costa Rican pharmacist charged by sva_ on Thursday August 06, 2020 @12:25AM (#24068109)
> How did this man get so numb to selling products that he knew were causing so much pain and suffering to others?

If I had to take a guess, his income as the vice president of sales probably helped with that.

Re:American darknet vendor and Costa Rican pharmacist charged by jimkleiber on Thursday August 06, 2020 @12:56AM (#24068242)
Yeah, I can imagine he faced many money/moral tradeoffs in his career, as do many of us, and perhaps he became more and more numb over time as he kept choosing the money, the whole boiling frog theory (if I used that correctly).

I guess I still see it as an issue of how connected he felt to himself and other people. I know plenty of people right now, who, if they were offered his salary to do the same job, would never do it. And others who were probably in a field like that and quit because it was getting too much, or maybe even became whistleblowers.

Makes me also think about how some of us can become workaholics to avoid pain in our lives, or crave lots of money to cover up for fears of not having or being enough.

Re:American darknet vendor and Costa Rican pharmacist charged by ohbleek on Thursday August 06, 2020 @01:16AM (#24068304)
I very much appreciate the way you’ve discussed these topics in this thread. You definitely have a tendency to give people the benefit of the doubt and I don’t think that quality is inherently faulty. I do think we have to recognize that some actions may require a certain level of sociopathic behavior and that sociopathy is very real.
Re:American darknet vendor and Costa Rican pharmacist charged by jimkleiber on Thursday August 06, 2020 @01:33AM (#24068382)
And I appreciate you saying this! I sometimes feel guilty for how I communicate on HN, being maybe a bit more emotional or colorful than other comments, but perhaps that's just me being self-conscious. So thank you.

I guess with sociopathy, even if they are behaviors that are very difficult or impossible for a person to change (something I strongly doubt in most cases), I'm still curious as to what brought a person to that stage.

This reminds me of one of the speeches that has touched my heart the most—"Love Your Enemies" by Martin Luther King, Jr.[1]—where he discusses how he strives to love a person, even if he doesn't like how they behave. I see sociopathy similarly—if the person can't change, I may remove myself as much as I can from their behaviors, but still wish them well. I don't know if it will help them change, but it sure helps me feel better :-)

[1]: https://www.youtube.com/watch?v=522wcqUlS0Y

edit added link

Re:American darknet vendor and Costa Rican pharmacist charged by malux85 on Thursday August 06, 2020 @03:52AM (#24068951)
> How did he get so numb in life in general?

You laden them with paralysing amounts of debt in their late teens, force them into capitalistic servitude for the rest of the life. Make sure they earn only just enough to survive. Make sure they work until they are totally exhausted and you can’t squeeze another dollar of productivity out of them.

Make sure they think the only alternative to this is homelessness/total destitution.

Then don’t give them a legal or ethical option that shows them any future other than the above until they are dead, while their bosses boss gets rich.

Then wonder why they act unethically

Re:American darknet vendor and Costa Rican pharmacist charged by toomuchtodo on Wednesday August 05, 2020 @10:56PM (#24067733)
The DOJ has a hammer. They’re using that hammer in the only way they can (supply side). If you want the demand side fixed, fix it locally (and lobby the federal government for more funds if necessary). The St Petersburg police department (Florida) recently announced they’d hire 25 social workers instead of 25 police officers to address social needs that would’ve previously been handled suboptimally as a police dispatch. There is evidence local efforts can be made when the appetite and will is present.

Having seen opioid addiction up close, I have a hard time not condoning DOJ actions. It’s not perfect, but nothing is.

Re:American darknet vendor and Costa Rican pharmacist charged by njovin on Wednesday August 05, 2020 @11:28PM (#24067879)
As long as the US federal government and the DEA continue their ridiculous war on drugs and refuse to reclassify certain substances despite overwhelming popular and scientific support I fear that any action by regular folks is wasted. It’s clear that higher powers prevail and as long as big pharma keeps funneling money into our “Democratic System” logic and reason will lose out to money and influence.
Re:American darknet vendor and Costa Rican pharmacist charged by KerrickStaley on Wednesday August 05, 2020 @11:59PM (#24067998)
> even moderate use can be balanced with a healthy lifestyle

Genuinely curious: this doesn't really mesh with my understanding. I think opioids are extremely addictive (more so than tobacco or even cocaine or amphetamine) and as a result it's nearly impossible to be a "casual" user (and therefore I don't ever intend to try any opioids). Is there evidence that opioids can be "moderately" used?

Re:American darknet vendor and Costa Rican pharmacist charged by TylerE on Thursday August 06, 2020 @12:20AM (#24068097)
They are extremely addictive. No one disputes that.

The actual drugs here - I’m talking pure, regulated pharmaceutical versions - are pretty benign physiologically. Constipation is about the worst of it.

The combination products (opioid plus something else) are a bit worse - but in those cases it’s the other thing (usually Tylenol) that’s actually hard on your body, especially the liver.

Although it’s much less common these days due to all the regulation, many doctors kept a up successful practices for decades while self medicating heavily.

What gets people killed are either things sold as other things (e.g. heroin laced with fentanyl, which is much stronger) or propel who quit for a while and then go right back to their old dose and OF because their tolerance is gone.

Re:American darknet vendor and Costa Rican pharmacist charged by CerebralCerb on Thursday August 06, 2020 @06:15AM (#24069625)
> Set against a background of assumptions that heroin use is inevitably problematic, there is significant evidence of its controlled use. This paper attempts to draw together the literature on patterns of heroin use which avoid physical and psychological dependence.

https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1360-0443....

This paper is a great read on the topic. Some suggest more than 50% of heroin users are casual users.

Re:American darknet vendor and Costa Rican pharmacist charged by cik2e on Thursday August 06, 2020 @02:12PM (#24073794)
Moderate opioid use is possible if you take long enough breaks to avoid physical dependence. That of course requires the self-discipline to say no to the psychological pull. As far as I recall, I felt some mild withdrawals after about 3 consecutive days of poppy tea use, so the physical dependence does set in pretty quickly. But if you know your boundaries, it’s easy to avoid. I would wager a guess that you could do strong opioids once a week indefinitely without any negative repercussions.
Re:American darknet vendor and Costa Rican pharmacist charged by GordonS on Thursday August 06, 2020 @04:00AM (#24068991)
> as a result it's nearly impossible to be a "casual" user

I wonder about the truth of this. I've done a lot of reading at places like Bluelight (for research and curiosity), and it seems there really are a lot of people who set strict guidelines for their drug use and are able to use opioids periodically without addiction.