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Re:The explosion of new coronavirus tests that could help to... by pmoriarty on Saturday July 18, 2020 @01:34AM (#23879271)
The most promising plan I've heard along these lines is detailed in a recent episode of This Week in Virology.[1]

We could have this disease under control by the time school starts by giving everyone (or at least everyone in highly affected areas) tests every day.

This is possible, practical, and affordable.

The technology for fast pregnancy-test style tests for COVID-19 exists right now, and they could cost as little as $1 per test.

The reason these tests aren't being used yet is because of the FDA's misguided requirements for extremely high sensitivity for COVID-19 tests. If these requirements could be relaxed to allow lower-sensitivity tests, then these tests could go out on the market... or, better yet, the government could take over and ensure everyone gets tested with these tests every day for $1 a test.

Even a more limited plan of testing just all schoolkids every day for $1 a test would be way better than what we've got now.

[1] - Starting at about 6'20" in to episode 640: https://www.microbe.tv/twiv/twiv-640/

Re:The explosion of new coronavirus tests that could help to... by ISL on Saturday July 18, 2020 @01:39AM (#23879294)
To put this idea in perspective, there are ~56 million students in the US. To do this daily for an entire school year at $1/test would cost ~1% of the trillion dollars allocated spent in the first relief bill.

Testing and contact tracing is a bargain compared to continuing to pay everyone to stay home. I don't understand why we're not seeing for-real effective contact tracing from our governments yet.

Re:The explosion of new coronavirus tests that could help to... by 082349872349872 on Saturday July 18, 2020 @01:54AM (#23879357)
Some of us are seeing effective contact tracing. The most effective step here, I believe, was requiring at-the-door call-backs to verify numbers given by people going clubbing.

(We're currently running 11/million new cases per day @ 3,2% unemployment. At one point our per capita case rate was much worse than that in the States.)

https://www.lemonde.fr/les-decodeurs/article/2020/03/27/coro...

Re:The explosion of new coronavirus tests that could help to... by ashtonkem on Saturday July 18, 2020 @03:03AM (#23879632)
Preventative measures are often orders of magnitude cheaper than whatever it costs to clean up later.
Re:The explosion of new coronavirus tests that could help to... by fouc on Saturday July 18, 2020 @02:44AM (#23879562)
I would just consider that it's about $30/mo per student. Cheap enough to roll into the tuition costs for most schools I imagine.

Prices would come down fast as this scaled up too

Re:The explosion of new coronavirus tests that could help to... by xienze on Saturday July 18, 2020 @08:16AM (#23880877)
> To put this idea in perspective, there are ~56 million students in the US. To do this daily for an entire school year at $1/test would cost ~1% of the trillion dollars allocated spent in the first relief bill.

Which $1 test currently in production would this be? And as a point of context, there’s been nowhere near the ~10B tests (I assume you’re talking about a 180 day school year) you’re proposing administered _worldwide_. Furthermore, what factory produces and ships 56 million of anything on a daily basis? I’ve said this before but I think HN readers suffer from thinking that everything in the world works like AWS in that you can just spin up unlimited “anything” on a moment’s notice.

Re:The explosion of new coronavirus tests that could help to... by pmoriarty on Saturday July 18, 2020 @11:30AM (#23882032)
"Which $1 test currently in production would this be?"

The technology to make these tests currently exists, but the companies which own the technology have chosen not to put them in to production because the tests aren't sensitive enough to gain FDA approval under current regulations.

If the regulations were relaxed to allow these less sensitive (but perfectly adequate) tests, then they could be put in to production.

So what's necessary for us to get $1 tests is to convince the FDA that these less sensitive tests are adequate for use, which is what the This Week in Virology podcast and the NYT article linked to earlier argue for.

"Furthermore, what factory produces and ships 56 million of anything on a daily basis?"

From the TWiV podcast[1]:

"Take every manufacturing company that knows how to print paper, adapt their tools to print monoclonal antibodies on to those sheets and just start slicing it up and shipping it out. It's as easy as that, I mean, you know, I'm simplifying it a bit, but..."

[1] - from about 32'30" in to the podcast https://www.microbe.tv/twiv/twiv-640/

Re:The explosion of new coronavirus tests that could help to... by perl4ever on Saturday July 18, 2020 @06:41PM (#23885452)
>what factory produces and ships 56 million of anything on a daily basis

Maybe more than one factory would be needed.

The idea that 56 million a day of anything is outside the realm of anything but software might be exaggerated. Global production of microcontrollers, for instance, seems to be around 80 million per day.

https://www.grandviewresearch.com/industry-analysis/microcon...

Re:The explosion of new coronavirus tests that could help to... by acqq on Saturday July 18, 2020 @08:50AM (#23881080)
> Which $1 test currently in production would this be?

It's not about what's "currently in production." It's about what should be a strategic goal to produce the bigger number of tests and use them frequently.

1) The current arguments against the speed tests is that they are not "sensitive" enough. But if one's goal is to do day to day testing and isolating from some environment those that can spread, there's no necessity to detect the RNA leftovers detected by the "sensitive" tests. Rather, the goal is to detect those that are the "powerful spreaders" who in fact have way more instances of virus present in their samples at the moment they are tested. Apparently even the "less sensitive" tests are in fact sensitive enough to catch these who produce a lot of virus. Those who produce a lot of virus have many orders of magnitude more virus RNA present in their samples than those who are in the phase of infection where they aren't so dangerously infective.

Once one accepts that the "ultimate sensitivity" is not necessary, much cheaper tests than those currently used are possible.

2) Even if a single test is still e.g. 20 USD, just stating the goal of having very frequent and regular tests for the sole purpose of protecting a big group of people allows for "pooling" the tests, e.g. testing 20 people together using just one test.

Running the numbers for a university of 1000 people:

1000 / 20 = 50 means only 50 tests per day allow for testing for protection of all 1000 people. Once one batch of 20 is positive, which should not happen every day, additional 20 tests allow for recognizing the one who is the actual carrier. Again, as those that are "dangerous" have many orders of magnitude more virus in the samples, pooling of 20 samples together should be still keep the result detectable enough.

3) Moreover, the test should be less complicated as the one used now: the idea is to test the spit, not to swab the deeps inside of the head.

4) Expensive and slow tests are simply not giving us the possibility to do these "detect early and often" strategies. The really sensitive PCR tests are indeed expensive and aren't as fast as the less expensive can be.

How can the cheap test be made? For example, by designing them to be used the same way the diabetics test their blood sugar levels:

https://www.diabetesaustralia.com.au/blood-glucose-monitorin...

Or even the way the pregnancy tests work:

https://www.123rf.com/photo_107386863_positive-pregnancy-tes...

In short, just new test strips.

Moreover, there are already companies that did some development of such kinds of tests.

It could be done, but it depends on the goals being set.

China successfully used pooling to test the population of 11 million:

https://www.bloomberg.com/news/articles/2020-05-29/how-china...

Re:The explosion of new coronavirus tests that could help to... by CyberDildonics on Saturday July 18, 2020 @03:30PM (#23884102)
The money is barely going to individuals. $35,000 USD per tax payer (at least) has been pushed through. How much went to individuals? A few thousand for the people that got any money at all. The entire base money supply of the US shot up and the ramifications will be felt for decades. Casinos and steak houses received bail outs, the money was never meant to be used wisely.
Re:The explosion of new coronavirus tests that could help to... by vmchale on Saturday July 18, 2020 @08:09AM (#23880839)
> I don't understand why we're not seeing for-real effective contact tracing from our governments yet.

The trump administration does the worst thing possible in any situation.

Re:The explosion of new coronavirus tests that could help to... by dang on Saturday July 18, 2020 @02:51PM (#23883787)
Could you please stop posting unsubstantive comments to Hacker News?

Particularly please don't take HN threads further into political flamewar. Comments like this lead nowhere good.

https://news.ycombinator.com/newsguidelines.html

Re:The explosion of new coronavirus tests that could help to... by adrianN on Saturday July 18, 2020 @02:16AM (#23879447)
Good luck convincing people who refuse to wear a mask to subject themselves to a test every day.
Re:The explosion of new coronavirus tests that could help to... by pmoriarty on Saturday July 18, 2020 @02:28AM (#23879497)
If testing was required to go to work, go to school, enter a restaurant, a bar, or a theater, people would do it.
Re:The explosion of new coronavirus tests that could help to... by adrianN on Saturday July 18, 2020 @02:32AM (#23879508)
Wearing a mask is required for many of these activities are people still refuse.
Re:The explosion of new coronavirus tests that could help to... by fouc on Saturday July 18, 2020 @03:39AM (#23879760)
No mask, no service.. surely businesses can refuse service out of safety concerns
Re:The explosion of new coronavirus tests that could help to... by irrational on Saturday July 18, 2020 @05:31AM (#23880203)
My daughter works a minimum wage job. Her stories about her coworkers are appalling. For instance, a bunch of them went to a crowded rave after work one day and most of them got the virus, but they didn’t say anything and kept showing up for work until one of them became symptomatic and then it came out.

My point is, the minimum wage workers at many of these businesses could not care less whether you are following mask rules or not.

Re:The explosion of new coronavirus tests that could help to... by ForHackernews on Saturday July 18, 2020 @06:36AM (#23880426)
Many minimum-wage workers desperately need that income (maybe not middle-class teens working summer jobs) so it's unsurprising that they'll come to work sick.
Re:The explosion of new coronavirus tests that could help to... by bolasanibk on Saturday July 18, 2020 @03:45AM (#23879785)
It's not always that simple: French bus driver attacked over mask rules dies [https://www.cnn.com/2020/07/11/europe/france-philippe-mongui...]
Re:The explosion of new coronavirus tests that could help to... by ashtonkem on Saturday July 18, 2020 @12:52PM (#23882717)
I mean, murders also illegal. The legality of enforcing a mask order is easy, the process of actually enforcing that rule might not be.
Re:The explosion of new coronavirus tests that could help to... by dvdbloc on Saturday July 18, 2020 @04:30AM (#23879987)
Can confirm that every day in Seattle I am seeing customers not wearing masks and businesses serving them without issue even though they are not allowed to.
Re:The explosion of new coronavirus tests that could help to... by Fjolsvith on Saturday July 18, 2020 @09:39AM (#23881328)
When you own a business, the customer is always right.
Re:The explosion of new coronavirus tests that could help to... by ashtonkem on Saturday July 18, 2020 @12:55PM (#23882750)
I’ve noticed that opinion always comes from people who don’t deal with customers directly.
Re:The explosion of new coronavirus tests that could help to... by Fjolsvith on Saturday July 18, 2020 @04:47PM (#23884716)
I own a business, and while a customer might not be right, I always treat them like they are right. Thus, the saying.

So, you now cannot say "always" in that statement, because I deal with customers daily.

Re:The explosion of new coronavirus tests that could help to... by johncearls on Saturday July 18, 2020 @03:24PM (#23884051)
Here we go. Let's jump from convincing to requiring. This is the difference between freedom and tyranny, and the fact so many Americans are ready to make that jump is outrageous.
Re:The explosion of new coronavirus tests that could help to... by lern_too_spel on Saturday July 18, 2020 @04:12PM (#23884446)
Schools already require proof of vaccination and antibody testing. Workplaces already have dress codes. Conflating mandatory testing or mask wearing with tyranny is why we're losing.
Re:The explosion of new coronavirus tests that could help to... by chrisco255 on Saturday July 18, 2020 @02:37AM (#23879533)
There's arguments to be said that this is a violation of ADA and grounds for massive lawsuits.

See: https://www.workplacefairness.org/medical-privacy-workplace#...

Also, just as a personal aside...I will gladly join massive, maskless protests to underscore that I will never accept medical testing as a condition of engaging in society. This is a completely unacceptable violation of civil liberties.

Re:The explosion of new coronavirus tests that could help to... by Zanni on Saturday July 18, 2020 @02:51AM (#23879593)
I assume you're referring to "Section 4. Can my employer require me to take medical tests in order to keep my job?"

But that section explicitly states, "... unless they are related to your job and necessary for the conduct of your employer's business.

I think there's a pretty strong case that the health and safety of fellow employees and/or customers during a pandemic qualifies.

Re:The explosion of new coronavirus tests that could help to... by chrisco255 on Saturday July 18, 2020 @02:58AM (#23879617)
Yeah, no. There is no clause in the Constitution that says "except in a pandemic". We've had far worse pandemics than Covid-19, from tuberculosis to smallpox to Spanish flu, and no such provision was ever required. So if you want to get an amendment to the Constitution, start collecting signatures.
Re:The explosion of new coronavirus tests that could help to... by bosswipe on Saturday July 18, 2020 @03:12AM (#23879660)
The constitution doesn't say you have to wear pants either but it's still required. In any case the workplace link you cited is not in the constitution it's the disability law.
Re:The explosion of new coronavirus tests that could help to... by lps41 on Saturday July 18, 2020 @06:45AM (#23880455)
Sorry, but you are wrong.

This would no more violate the ADA than random drug testing (legal) or requiring temperature checks, which some employers are already doing to protect against COVID-19.

Also, the ADA is not a constitutional amendment, so even if there is a potential conflict with ADA, Congress could easily address that in a new bill without needing to pass a new constitutional amendment.

Re:The explosion of new coronavirus tests that could help to... by ashtonkem on Saturday July 18, 2020 @03:09AM (#23879653)
I’m sorry, but you’re just not right.

The Supreme Court has repeatedly held that the government has a pretty wide reaching authority when it comes to fighting disease. If the federal government can quarantine entire towns and force vaccines, they can similarly force you to be tested.

Re:The explosion of new coronavirus tests that could help to... by chrisco255 on Saturday July 18, 2020 @03:18AM (#23879683)
No, they haven't. There's no such precedent in U.S. history.

They can't quarantine towns from the federal level. Not in the least. A state might be able to, because the 10th amendment is a thing, but Federal government cannot. And neither state nor federal government can force vaccines because it violates the 4th amendment. You don't get to search my body for diseases and use them to discriminate against me. Sorry. Furthermore, Roe v. Wade was argued on the basis of a right to privacy that's implicit. So no, I'm right on this.

Re:The explosion of new coronavirus tests that could help to... by sfblah on Saturday July 18, 2020 @03:43AM (#23879772)
https://www.politico.com/news/magazine/2020/05/15/national-q...

I mean, you’re entitled to your opinion, but at least some people disagree.

Edit: and, your claim that there is no such precedent is a flat out lie.

Re:The explosion of new coronavirus tests that could help to... by irrational on Saturday July 18, 2020 @05:34AM (#23880221)
No such precedent? George Washington forced vaccinated his entire army from smallpox. There is precedence from the very start of the country.

I am so embarrassed on your behalf.

Re:The explosion of new coronavirus tests that could help to... by bernie_simon on Saturday July 18, 2020 @03:49PM (#23884266)
Wikipedia says Jenner first demonstrated the smallpox vaccine in 1796. The revolutionary war ended in 1783.
Re:The explosion of new coronavirus tests that could help to... by irrational on Saturday July 18, 2020 @03:55PM (#23884311)
According to a tiny bit of research, it was a crude form of smallpox vaccination, yet still a vaccination.
Re:The explosion of new coronavirus tests that could help to... by ashtonkem on Saturday July 18, 2020 @04:44PM (#23884683)
Inoculation, technically.
Re:The explosion of new coronavirus tests that could help to... by EliRivers on Saturday July 18, 2020 @05:49AM (#23880273)
From an outside viewpoint, this is an interesting demonstration of a failure mode of the US social and political system.

Of all the hills to die on, "not wearing a safety mask" [0] is one of the more batshit crazy, but in a nation where the people have decided that "schoolchildren being slaughtered in their classrooms" is an acceptable price to pay for free and easy firearms, I guess it's not surprising that "people dying horribly, gasping for breath as their lungs fail" is an acceptable price for not wearing a safety mask.

[0] This poster's particular hill isn't the mask, but it is for some, and if I'm doing "batshit crazy", there it is.

Re:The explosion of new coronavirus tests that could help to... by Fjolsvith on Saturday July 18, 2020 @09:47AM (#23881359)
> in a nation where the people have decided that "schoolchildren being slaughtered in their classrooms" is an acceptable price to pay

There hasn't been a single death in California from Coronavirus for any child, period. In the US, there've been about 20 deaths, nationwide, of children from COVID.

Re:The explosion of new coronavirus tests that could help to... by ashtonkem on Saturday July 18, 2020 @12:55PM (#23882753)
They’re making a comparison between our inaction on school shootings to our inaction on COVID. You’ve completely missed their point.
Re:The explosion of new coronavirus tests that could help to... by Fjolsvith on Saturday July 18, 2020 @04:46PM (#23884701)
Oh. I get it. They're really shutting schools in the US down because of school shootings. That makes sense.
Re:The explosion of new coronavirus tests that could help to... by perl4ever on Saturday July 18, 2020 @06:46PM (#23885474)
I think you probably agree with the original commenter that school shootings have killed more than the coronavirus (within the age group). They are saying, if people don't really care about the former, it's not surprising they don't care about the latter, which has killed fewer people. Are you really disagreeing with what they said or just the tone?
Re:The explosion of new coronavirus tests that could help to... by EliRivers on Sunday July 19, 2020 @02:34PM (#23891350)
You know, I actually think you've got a point to make and I can see the shape of it, but you're so inept at expressing yourself that you come across as either completely misunderstanding or just plain wrong. I guess this is still an insulting thing to say, but at least it's not wrapped in snark or passive-aggression.
Re:The explosion of new coronavirus tests that could help to... by ashtonkem on Saturday July 18, 2020 @06:46PM (#23885473)
I genuinely can’t tell if you’re making a bad argument, or if you still don’t get it.
Re:The explosion of new coronavirus tests that could help to... by EliRivers on Saturday July 18, 2020 @09:56AM (#23881398)
Read the whole comment before jumping in. I said the people have decided that schoolchildren being slaughtered in their classrooms is an acceptable price to pay for free and easy firearms.
Re:The explosion of new coronavirus tests that could help to... by ashtonkem on Saturday July 18, 2020 @06:48PM (#23885485)
It’s peak HN that you’re getting downvoted for explaining your own comment.
Re:The explosion of new coronavirus tests that could help to... by Fjolsvith on Saturday July 18, 2020 @04:55PM (#23884774)
> "people dying horribly, gasping for breath as their lungs fail" is an acceptable price

Ever heard of big tobacco? I got lots of relatives that died like that after enjoying cigarettes all their life. It is not surprising.

But, when you consider that the second amendment is an inalienable right, one has to wonder how to separate children from their guns.

"Parents, please don't send your child to school with their gun."

Re:The explosion of new coronavirus tests that could help to... by selimthegrim on Saturday July 18, 2020 @11:27AM (#23882005)
Mayhe they didn’t die but this Kawasaki like complication is a thing
Re:The explosion of new coronavirus tests that could help to... by johncearls on Saturday July 18, 2020 @03:25PM (#23884065)
You are not alone, no matter what the downvotes say.
Re:The explosion of new coronavirus tests that could help to... by ttul on Saturday July 18, 2020 @02:20AM (#23879461)
Everyone must listen to TWIV. It’s actually the best podcast on any topic, let alone virology.
Re:The explosion of new coronavirus tests that could help to... by est31 on Saturday July 18, 2020 @04:10AM (#23879894)
For those who don't like videos, Michael Mina has also made an op-ed in the NYT (mentioned in the TWIV episode linked): https://www.nytimes.com/2020/07/03/opinion/coronavirus-tests...
Re:The explosion of new coronavirus tests that could help to... by manicdee on Saturday July 18, 2020 @02:52PM (#23883798)
Tests aren’t going to stop the virus.

Self-isolation, social distancing, proper hygiene are going to slow the virus down. To implement those properly requires paying low-income workers to stay home.

A vaccine will stop the virus, but we don’t have one yet. It looks like it will be a year or more for a vaccine to be available.

Re:The explosion of new coronavirus tests that could help to... by irrational on Saturday July 18, 2020 @05:27AM (#23880182)
How would the testing once a day happen? Would people take the tests at home and self report? Would everyone have to go to a central location?
Re:The explosion of new coronavirus tests that could help to... by iso947 on Saturday July 18, 2020 @05:32AM (#23880208)
With a “pee on stick” test you’d do it every day before heading out and be trusted to self report of positive (presumably you’d then do a better lab based test which could return within 24 hours to confirm the case)
Re:The explosion of new coronavirus tests that could help to... by irrational on Saturday July 18, 2020 @01:05PM (#23882843)
Are there lab tests that return in 24 hours? Two of my kids recently got lab tested (thankfully both negative) in 2 different states and both took 72 hours to get results back.
Re:The explosion of new coronavirus tests that could help to... by pmoriarty on Saturday July 18, 2020 @01:47PM (#23883175)
Here are some references to quick COVID-19 tests:

"Blood test detects positive COVID-19 result in 20 minutes" - https://medicalxpress.com/news/2020-07-blood-positive-covid-...

"Fresno health clinic offering rapid COVID-19 tests that give results in minutes" - https://abc30.com/fresno-county-coronavirus-covid-19-everyda...

"15-minute COVID-19 test proves accurate at confirming infection" - https://www.upi.com/Health_News/2020/05/08/15-minute-COVID-1...

"New rapid COVID-19 test approved by FDA, results in as little as 15 minutes" - https://www.msn.com/en-us/health/video/new-rapid-covid-19-te...

"A new COVID-19 test can return results in 5 minutes" - https://www.theverge.com/2020/3/28/21197944/coronavirus-test...

Re:The explosion of new coronavirus tests that could help to... by irrational on Saturday July 18, 2020 @02:29PM (#23883590)
So, it is possible, but maybe not practical since at least 2 states are not doing quick tests yet?
Re:The explosion of new coronavirus tests that could help to... by ntsplnkv2 on Saturday July 18, 2020 @08:47AM (#23881066)
That requires an actual functional government.

This is never happening with Trump.