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Re:Alterations in glutamate and the experience of ego dissol... by joeberon on Thursday May 28, 2020 @05:08AM (#23335100)
Totally anecdotal but LSD made my depression significantly worse than improving it in any way. I had two proper trips and had a seizure kind of thing at the start of the second one due to the overwhelming visuals (not experienced anything like that before or since).

EDIT: to expand, it made me very questioning of my own consciousness and gave me severe and persistent existential dread and fear of death to the point where I felt quite suicidal (which I've _never_ experienced before). I restarted my old anti-depressants which have helped quite a lot but I don't think these feelings will ever truly disappear. Quite honestly it is the one drug I truly regret taking. If you aren't ready to accept what these drugs will show you then it can be a long-lasting and damaging experience, certainly it was for me

Re:Alterations in glutamate and the experience of ego dissol... by crisissolution on Thursday May 28, 2020 @09:17AM (#23336866)
Thanks for sharing, I'd like to add my own experience on LSD and the long-lasting effect of fear-of-death it can result in. I have taken LSD only three times and can't say I enjoyed it very much, but I still wanted to give it a chance. Last time I took a 1/2 of what was recommended for me to see how it goes, and the beginning was pretty enjoyable, I played League of Legends, and the mobs started walking on the wall behind the monitor as if the view was projected on it, it was fun. I used to smoke a lot of weed at that time, and it always had a soothing and calming effect for me - not this time.

Marijuana never caused me any panic, but at the end of the trip, I was barely feeling anything and smoked a joint, what happened next was frightening. I felt an ache at my heart and considered calling the hospital for several hours, but was scared because of intoxication. I could not relax and sit at one place, there was darkening in my eyes, and peripheral vision was gone, and LSD made the feeling of fear massively intense. It felt as if my heart was going to stop just because I was thinking so much that I was dying.

I can only name what helped me then: I started walking short distances telling myself that if I manage to go from point A to point B then I'm fine and it's just a bad drug tripped. It helped, also tasting various flavours and hearing sounds from outside the street helped me focus my attention on something else. After a few hours of walking/tasting/hearing, I noticed my heart pace slowing down and the realisation that I wasn't in any real danger followed next. A terrible feeling that I will never forget. The bad trip lasted about 6 hours, and for the next few days, I felt a sharp pain in my chest.

Re:Alterations in glutamate and the experience of ego dissol... by luckydata on Thursday May 28, 2020 @02:07PM (#23340394)
sounds like your trip was done very sub-optimally. I can't imagine a violent video game being something I would like to be involved while on psilocybin or similar.

read this before trying again: https://en.wikipedia.org/wiki/Set_and_setting

Re:Alterations in glutamate and the experience of ego dissol... by joeberon on Thursday May 28, 2020 @03:30PM (#23341451)
League of Legends is hardly a "violent video game"
Re:Alterations in glutamate and the experience of ego dissol... by bluntfang on Thursday May 28, 2020 @04:17PM (#23342046)
what? you're literally destroying a city and killing hundreds of creatures a game with the goal of destroying the building that allows them to exist. How is that not violent?
Re:Alterations in glutamate and the experience of ego dissol... by tripanon on Thursday May 28, 2020 @02:38PM (#23340775)
As others have noted, set & setting are hugely important as well as staying away from other intoxicants during the experience (unless you are experienced with LSD or in the care of someone to guide you through the trip). It's not surprising that the combination of the video game and weed would have this effect. I personally can't even look at a screen during a trip, it looks too cartoonish and just beyond uninteresting to me.

My personal rules for any LSD trip are: be in the company of others you feel comfortable being sober with (as in no drugs, not even weed or alcohol), be in a safe place or near a safe place you can get back to without much issue if things get overwhelming, relaxing music, lots of fresh fruit on hand. Oh, and make sure anyone you're with is not on any sort of anti-depressant. I've seen some bad mixes with SSRIs and psychedelics (primarily DMT).

You should be ready to go introspective during your trip. If things get overwhelming, lay down, focus on your breath, and remember you're tripping and that you will sober up in a few hours. Let yourself cry if you need to. The worst experiences come when you try to fight it.

Re:Alterations in glutamate and the experience of ego dissol... by amanaplanacanal on Thursday May 28, 2020 @11:55AM (#23338772)
My experiences with psychedelics and cannabis (many decades ago now) were similar in that LSD or psilocybin were terrific on their own, but the addition of cannabis made it extremely unpleasant. I still find cannabis unpleasant now. I found cannabis very enjoyable before trying that combination. My advice for any explorers would be to not smoke cannabis while tripping.
Re:Alterations in glutamate and the experience of ego dissol... by vmception on Thursday May 28, 2020 @02:25PM (#23340597)
I've heard so many anecdotes about how to steer acid trips by mixing with other drugs.

These candy flipping practices seem like a great way to die!

Re:Alterations in glutamate and the experience of ego dissol... by spuz on Thursday May 28, 2020 @10:31AM (#23337719)
The process that patients go through when participating in a medical trial of psilocybin is so different than the typical recreational setting that the rest of us experience these drugs. They do everything they can to make sure the patient is well prepared and has the minimum chance of having a bad trip.

However, every time I read about studies into psychedelics, I only ever hear about the upsides and not the potential downsides. I went through a similar experience to you - although not as severe. I had anxiety for about 3 years after my bad trip which luckily gradually reduced over time.

What worries me is that the more these drugs gain credibility in the medical field the more likely it is that depressed kids are going to self-medicate and given the ability of these drugs to multiply the user's existing anxieties, they should be the last people who should be experimenting and self-medicating with them.

Re:Alterations in glutamate and the experience of ego dissol... by PragmaticPulp on Thursday May 28, 2020 @12:15PM (#23339020)
> The process that patients go through when participating in a medical trial of psilocybin is so different than the typical recreational setting that the rest of us experience these drugs. They do everything they can to make sure the patient is well prepared and has the minimum chance of having a bad trip.

Not just this, but they surround the sessions with intense therapy.

They're not just giving people psychedelics and keeping them calm. Look up the MAPS (a foundation for psychedelic research) protocol. People are given a series of intense therapy sessions, only some of which involve psychedelics.

Sadly, many of the studies fail to have an active control group. That is, they aren't comparing therapy + psychedelics to therapy alone. That's a major pitfall in the current research.

And unfortunately, the therapy component of the research is lost in most internet headlines and articles. People are walking away with the impression that psychedelics are inherently anti-depressant compounds, when the reality is that they're being researched as adjuncts to intense therapy.

Re:Alterations in glutamate and the experience of ego dissol... by Trasmatta on Thursday May 28, 2020 @10:38AM (#23337821)
I also had severe, lasting anxiety after a couple of bad trips. I will never use again unless I get the opportunity to do so in a therapeutic setting with trained professionals. There is tremendous potential for good with these substances, but they have some real risks.
Re:Alterations in glutamate and the experience of ego dissol... by specialist on Thursday May 28, 2020 @08:44AM (#23336580)
That's rough. I'm sorry you're struggling with the aftermath.

My own story may be relevant to you. FWIW:

I was really into zen as a kid. Part of my rebellion against Christianity and leaving my church. Once while meditating, I accidentally had a pretty bad trip. (I can describe the actual trip separately.) I was completely unprepared, didn't even know such a thing was possible.

It's kicked my ass ever since.

From what I read (afterwards), others have called that kind of trip ego death, death-rebirth, religious experience.

In buddhist terms, if that was the 2nd stage, I had ZERO interest in experiencing the 3rd stage, much less the 4th stage (aka "enlightenment").

A few months later, I was diagnosed with an acute life threatening disease. I was hospitalized for months, spent a few years recovering.

So the upside to having the living shit scared out of me while meditating was that actual near death real experiences were emotional cake walks. My care providers were like "Who is this kid?!" My family was less amused by my apparent blasé attitude.

Any way. To wrap this up.

We're all going get "there" one way or another. You're gonna die. It's all pointless. Yadda, yadda.

But you can choose to resume your normal life. You cope. You adapt. Fake it, if you have to, like I did. And eventually the habit of day to day living, striving, struggling, smelling the roses will become your new normal. Most of the time.

Just one caveat. Your pharmacology can absolutely change your brain, personality, outlook. Mental well being isn't just happy self-talk. Mind and body are inseparable. So figure out that other stuff too, if needed.

Re:Alterations in glutamate and the experience of ego dissol... by joeberon on Thursday May 28, 2020 @09:22AM (#23336909)
Honestly it was similar for me. I'm not sure if this is related to what you are saying but partly for me the suicidal and fearful thoughts were just from considering how incredibly intense the trip was. The emotions and anxiety and just general rawness of nature felt so clear on the trip that it gave me some kind of PTSD and flashbacks that lasted afterwards, to the point where whenever I thought back to the trip I would crave death instead, and these intrusive thoughts were getting more and more frequent to the point of daily. I remember having many thoughts were I was so scared of even the thought of tripping that I would immediately start to obsess over the idea of being dead instead.

I knew that wasn't ok at all so I ended up going back on my old SSRIs which, unsurprisingly, massively turned down the intensity knob on everything and brought me back to reality.

I think I struggled with the aftermath for about 6 months. At first I thought my anxiety was cured by the trip, but about 2 or 3 months after I started losing touch with reality. I am better now (due entirely to SSRIs) but still struggling with the generalized anxiety disorder I have grappled with for my life so far

Re:Alterations in glutamate and the experience of ego dissol... by elbear on Thursday May 28, 2020 @11:12AM (#23338264)
Consider reading this book to deal with your trauma.[1] It talks about how trauma is stored in the body but also offers a few approaches to healing at the end.

[1]: https://www.goodreads.com/book/show/18693771-the-body-keeps-...

Re:Alterations in glutamate and the experience of ego dissol... by specialist on Thursday May 28, 2020 @09:43AM (#23337113)
Damn. I think you've got it worse than I ever did.

I politely ask you to do two things, if you haven't already.

First is to have someone, something in your life that keeps you accountable. Self-reporting is unreliable. My most recent example: I was on bupropion last year. I literally felt no different with or without. But it was harming me. My only clue was my activity monitor. (Apple Watch FTW.)

Second, never accept "No" or "idk", tenaciously seek the answers you need. Someone, somewhere has some of the missing puzzle pieces you need. Doctors (et al) are not omniscient and if they've not seen cases like you before, they couldn't possibly have those answers.

Be well. I hope things get easier for you.

Re:Alterations in glutamate and the experience of ego dissol... by joeberon on Thursday May 28, 2020 @09:47AM (#23337167)
Thank you for the support.

I am sure I have overstated the risk, or maybe that is just my anxiety talking. I never had any actual plans to hurt myself, just overwhelming fear and dread to the point I wished it would end by any means.

Thankfully I have my wife to keep me accountable

Re:Alterations in glutamate and the experience of ego dissol... by josephpmay on Thursday May 28, 2020 @09:55AM (#23337251)
Wait, you accidentally experienced ego death while meditating as a kid!? That's fascinating

If you're willing to share, I would love to hear more. How did you get so deeply into meditation? What was your practice like? What were you doing that got you to such a "bad trip"

Re:Alterations in glutamate and the experience of ego dissol... by specialist on Thursday May 28, 2020 @12:09PM (#23338945)
I don't know that it was ego death, precisely. I just inferred that from comparing the impact on me with what others reported experiencing. I've heard it also called 'epiphany'.

I was just reading books and pondering. Sci fi, Sagan, Fritjof Capra, Taoism, Zen, some Buddhism. I didn't know any one who knew anything about this stuff.

I started meditating because I was struggling, had a lot time, nothing to do, and was trying to psyche myself up to start working again. I hadn't been diagnosed yet, so didn't know my failings were health related. I thought I just had a bad attitude, was being lazy.

I got pretty good at reaching a trance state. I was stuck on the notion of "no thought". Best I could do was let thoughts float away. So I started my notions of mental exercises. Visualize a sphere. Think of a color and try to see it with my mindseye. Imagine the center of my ego was my sternum and not my head, imagine the world from that perspective. Float above my own body.

So I was just doing my thing, pretending to have an out of body experience, and I slipped into a different state. The idea was really simple. It was like being able to actually internalize a trillion. Or like Fritjof's epiphany of seeing all the grains of sand on the beach.

I had the full impact of how big the universe is and how small I am, the briefness of my lifespan.

It terrified me. I reflexively pulled back, popped out of trance. And then I laid on the bed for a long while, trying to figure if I was back in my room, if I was dreaming, what's real or not.

I came out of it very different worldview. That whole ecological, holistic awareness, everything is connected, and other woo-woo descriptions. Popping that ego-centric bubble for just a moment.

Again, I'm just using other people's words for what best matches my experience. "If you meet Buddha on the road, kill him." and all that.

Re:Alterations in glutamate and the experience of ego dissol... by joncrane on Thursday May 28, 2020 @12:15PM (#23339023)
I don't know if this is the same thing, but in my early teens, I terrified myself during meditation because I got to a point where I felt I could "think myself out of existence" if I had continued along the (mental) path I was on.

Not sure if that's the same thing as ego death but it was terrifying.

Re:Alterations in glutamate and the experience of ego dissol... by specialist on Thursday May 28, 2020 @12:22PM (#23339099)
Sounds the same. The Void is terrifying. Whenever my distractions stop working -- Hello Hacker News! -- my mind wanders back and everything seems a lot less real.
Re:Alterations in glutamate and the experience of ego dissol... by elbear on Thursday May 28, 2020 @11:13AM (#23338282)
If you want to delve more into this topic, I recommend this book: https://www.goodreads.com/book/show/25942786-the-mind-illumi...
Re:Alterations in glutamate and the experience of ego dissol... by elbear on Thursday May 28, 2020 @11:14AM (#23338291)
How are you dealing with that experience now? Did it completely put you off meditating?
Re:Alterations in glutamate and the experience of ego dissol... by specialist on Thursday May 28, 2020 @11:48AM (#23338675)
re mediating:

I tried to resume shortly thereafter. FHCRC (always doing experiments) had a doctor working on pain and toxicity. Her angle was mindfulness, mediation, hypnosis. Didn't work on me.

Though I do yoga style relaxation, manage my pains, I've not been able to attain trance state again, much less the next stage.

I think it's because I can't concentrate, focus that way any more. Cuz chemo brain.

The only success I've had is with http://thewayofseeing.com. Focus is like a muscle. I've gotten a bit better. But my best effort is mindfulness.

re coping:

One day at time. Happy to be here. :)

Re:Alterations in glutamate and the experience of ego dissol... by elbear on Friday May 29, 2020 @02:36AM (#23346893)
I'm glad to hear that you're coping and that you found a practice that works for you.

Wish you well and I hope you have a fruitful journey :)

Re:Alterations in glutamate and the experience of ego dissol... by ragle on Thursday May 28, 2020 @02:48PM (#23340884)
Apologies in advance for the wall of text, but this is a topic that has occupied a considerable portion of my attention for nearly 25 years. :)

If any of what I share here is helpful for someone, it will be well worth drifting significantly off topic and perhaps over-sharing my personal experience.

That said, my experience is my own - other people's mileage may vary depending on their background and personal makeup. Trust your intuition (and your doctor / therapist if you have one)!

From your comments below (about being able to notice yourself out of existence), it sounds to me like you experienced both udayabbaya-nana (knowledge of arising and passing away) and bhanga-nana (knowledge of dissolution), as well as the other dukkha-nanas (knowledges of suffering) that follow [1].

It also sounds like you are familiar with the Zen analogs for these Theravada terms - sharing them here mostly for other readers.

These are well-known and understood phenomena, at least in Buddhism. Some modern yogis refer to this territory as the "Dark Night", a term borrowed from St. John of the Cross' work describing the experiences from a mystical Christian perspective[2].

The Atlantic had a good piece on this (touching on some relevant research at Brown) several years back [3].

I went through something similar to what you've described here with meditation, and similar to what many others have described here with psychedelics.

It took years of searching, research and growth for me to process and integrate these experiences and return to both a stable, consistent meditative practice and enjoyable / helpful use of psychedelics, including cannabis (which gave me panic attacks for many, many years).

For anyone who is in similar territory but wishes they could continue exploring: Bhajan / Kirtan [4] (example [5]) and Yoga Asana were both incredibly helpful for me, as was a-melodious chanting of various mantra and stotra.

Coming at the problem as a programmer with some understanding of machine learning - I looked at chanting practices as training data for my own biological neural network. A way to re-wire my relationship with meditation / spiritual practices / ego death.

The transition from my atheistic Buddhist practice to a sort of mystical pluralist practice that integrates many traditions was an interesting one, for sure.

I stopped seeing "god" as an absurd, surely-non-existent (for everyone) personal entity and began recognizing "gods" as undeniably-existing (for me) hybrids of:

* helpful anthropomorphic representations of key truths

* helpful anthropomorphic representations for lawful phenomena

* at the highest level: helpful conceptual placeholders for things that are completely impossible for me to describe

As a former atheist, I slowly became more and more comfortable with this framework. I think this was a combination of having grown up in a religious environment; having mystical experiences, searching for answers and finding documentation (independently arising in many different traditions) that closely mirrored my experiences; and feeling like there was tremendous mind-shaping power in a shared subconscious framework transmitted through trance-inducing chants practiced by millions of people over many centuries.

Like many, I would encounter truths through various mystical experiences and find great relief - only to fall back into unhelpful habitual patterns later. A daily relationship with one's personal Gods (in whatever form they take for you) is a very powerful psychological anchor for remaining tethered to truths discovered through mystical experience.

Lectures by Ram Dass[6], talks by Mooji[7] and dharma talks from many different teachers at Dharma Seed [8] also helped considerably.

I have some conjectures rattling around in my mind about _some_ manifestations of mental illness having _some_ of their roots in the territory of ego death (or close brushes with it). Many of us live in a society where all of our basic needs are met and there is ample time for introspection. Moreover, many of us fill a good deal of our non-introspective free time with music, cinema and television which has been shaped (directly or indirectly) by artists and thinkers under the influence of mind-expanding drugs, leading to further introspection (at least this was the case for me and many of my peers).

That is, I don't think someone necessarily needs to even be a yogi to wander into Dukkha-nana territory. Though, to be sure, the proliferation of superficial "mindfullness" practices will add to the aforementioned dog pile of causes and conditions for initial "spiritual awakenings" (for lack of a better term).

I'd love to share my entire journey and more thoughts on this (including 8 years living and traveling in Asia, trying to find answers). One day!

Lastly: if you find yourself in this territory and things are really bad, there are resources available to you! Check out: https://spiritualcrisisnetwork.uk.

Shenzen Young also has really helpful advice about when it's time to seek help from a medical professional: https://www.youtube.com/watch?v=BQ5B70ac_9M

==

[1] - http://www.buddhanet.net/knowledg.htm

[2](pdf) - http://www.carmelitemonks.org/Vocation/DarkNight-StJohnofthe...

[3] - https://www.theatlantic.com/health/archive/2014/06/the-dark-...

[4] - https://en.wikipedia.org/wiki/Kirtan

[5] - https://www.youtube.com/watch?v=YBso7TPtvJU

[6] - https://beherenownetwork.com/category/ram-dass/

[7] - https://podcasts.apple.com/us/podcast/satsang-with-mooji/id1...

[8] - https://dharmaseed.org/talks/

Re:Alterations in glutamate and the experience of ego dissol... by specialist on Thursday May 28, 2020 @06:42PM (#23343829)
Thank you for your thoughtful reply. I'll chew thru those links.
Re:Alterations in glutamate and the experience of ego dissol... by moreaccountspls on Thursday May 28, 2020 @10:00AM (#23337290)
I'd be interested in hearing about the actual experience.
Re:Alterations in glutamate and the experience of ego dissol... by shlant on Thursday May 28, 2020 @09:03AM (#23336744)
I wonder if some have a genetic predisposition to bad reactions to psychedelics. My best friend had an LSD reaction similar to yours (increasingly intense hallucinations until falling on the ground and starting to seize). His brother had a bad experience with psilocybin and jumped out a window. I believe a second brother also had a bad experience.

Makes me even more concerned when people talk about psychedelics as a low risk self-treatment for various illnesses. I myself have had a bad trip which resulted in years of anxiety and panic attacks (although after having done psychedelics many times before).

Re:Alterations in glutamate and the experience of ego dissol... by joeberon on Thursday May 28, 2020 @09:13AM (#23336833)
Yeah I think that the psychological harm, much like some other drugs, can be underrated. Another example of a drug people see as harmless is cannabis, which can reliably give people (including myself) intense anxiety and panic attacks. It is conjecture on my part but I can't think that it is healthy for your mind to subject yourself to intense feelings of anxiety.

These days I steer clear of all drugs except for my SSRIs and alcohol, the latter being basically the only recreational drug I've taken that seems to not put me at some level of psychological turbulence.

Re:Alterations in glutamate and the experience of ego dissol... by saiya-jin on Thursday May 28, 2020 @09:45AM (#23337143)
Powerful psychoactive substances shouldn't be taken by people who are not mentally 'balanced', meaning just fine, happy with themselves or similar.

I know its easy to say in hindsight, many of us tried those things when we didn't think about it, and it worked better for some and less for others.

I think the old set & setting has some proper meaning here and can vastly bootstrap the incoming experience. Having a calm, even soothing environment, no negative outside influences like badly tripping / drug rejecting friends who can drag anybody down to mud. If one is really unsure, have some friend 'spotting' for you and drag you back and calm down if bad trip comes. If one is in bad mental place, just don't do it, it ain't alcohol which can be taken almost on any mood.

Personally, I've never had a profound trip unless alone, relaxing on the bed with nice music in the background, but that worked for my specific personality.

Re:Alterations in glutamate and the experience of ego dissol... by Trasmatta on Thursday May 28, 2020 @10:45AM (#23337897)
> Powerful psychoactive substances shouldn't be taken by people who are not mentally 'balanced', meaning just fine, happy with themselves or similar.

Agreed, but part of the problem is that they're often framed by their proponents as a miracle drug that can cure you of depression, anxiety, and fear of death. So people with those problems will often self medicate with them.

And for some people, it totally works. But it can backfire tremendously, and actually worsen those problems. There's a psychonaut meme that there's "no such thing as a bad trip, just a difficult one", but that's absolutely untrue.

I think psychedelics have incredible therapeutic potential, though, and I'm looking forward to a world where they are legal, well tested and researched, and usable in safe environments with trained and compassionate professionals.

Re:Alterations in glutamate and the experience of ego dissol... by anonzzzz on Thursday May 28, 2020 @03:07PM (#23341102)
I would say you shouldn't have your first trip unless your mental health is stable, or it is in a therapeutic context.

Once you have some sense of what to expect you can more readily use your judgment as to whether you're in the right headspace. I find it can be quite helpful to mitigate mild/moderate anxiety or depression.

Re:Alterations in glutamate and the experience of ego dissol... by shlant on Saturday May 30, 2020 @12:34AM (#23358506)
"Powerful psychoactive substances shouldn't be taken by people who are not mentally 'balanced', meaning just fine, happy with themselves or similar."

But therein lies the crux of this kind of reasoning: those kinds of requirements are vague and highly subjective - what does "mentally balanced" entail? who determines that?

It would require a high level of self-awareness and even then, some woundings/mental illnesses may not be apparent until some sort of traumatic event (such as a bad trip). It's incredibly difficult to know ahead of time what kind of reaction someone is going to have to such powerful mind-altering substances and IMO although the advice of "set and setting" is important, it in no way will prevent all possible issues from happening.

Re:Alterations in glutamate and the experience of ego dissol... by joncrane on Thursday May 28, 2020 @12:08PM (#23338929)
It's a paradox, isn't it? What person in their right mind, who's perfectly balanced and stable, would willingly ingest powerful reality-altering substances?
Re:Alterations in glutamate and the experience of ego dissol... by elbear on Thursday May 28, 2020 @11:06AM (#23338181)
I believe it's more about your psychology at the time but also your past trauma that determines how you react to it. Experience with meditation should help with any weird moments too.
Re:Alterations in glutamate and the experience of ego dissol... by shlant on Friday May 29, 2020 @07:32AM (#23348724)
I hear what you are saying, but I'm not just talking about generalized "bad trips" similar to my own - I'm referring to people who's physical bodies have extreme reactions (such as seizures) that seem to be outside the norm (although probably not as rare as most think).
Re:Alterations in glutamate and the experience of ego dissol... by luckydata on Thursday May 28, 2020 @02:11PM (#23340432)
the "jumped out of a window" part seems suspect. It's a common anti-LSD propaganda trope but as far as I know it happened only once provably. It's so strange that your best friend would have been the second case of that.

IMHO psychedelics get a bad rap because they are used by people that haven't done even the bare minimum reading and preparation to have an optimal experience. It's not difficult to do, and once you are in the right place, with the right environment and mindset, it's very easy to use the altered mental state to do productive work on your own psyche.

A hammer is a useful tool as long as you don't hit yourself in the forehead with it.

Re:Alterations in glutamate and the experience of ego dissol... by shlant on Friday May 29, 2020 @07:39AM (#23348766)
sounds like you have a bit of a pro psychedelic bias here and are minimizing people's experiences. This isn't just some story I heard, this is a person that I know and who I witnessed struggle to heal from literal broken bones over years.

"as far as I know it happened only once provably" = "I haven't heard of it, so it must not exist or be a lie". Pretty unproductive perspective to have...

I find your kind of flippant "well they just didn't do it right" approach a very common defense of various forms of dogma. Maybe you should consider that mind-altering substances can have consequences for even those who approach them in the most responsible way possible.

Re:Alterations in glutamate and the experience of ego dissol... by 01100011 on Thursday May 28, 2020 @06:56AM (#23335853)
Similar experience taking LSD(or whatever was on the blotter) when I was a kid. I've done psychedelics since and enjoyed it, but that was my third experience and it was decades before I tried again.
Re:Alterations in glutamate and the experience of ego dissol... by PoachedSausage on Thursday May 28, 2020 @07:56AM (#23336230)
That is what puts me off trying LSD. It seems that unless you live in the Bay area and are friends with certain organic chemists, your chances of getting good quality, real LSD are slim. However, mushrooms are quite easy to grow.
Re:Alterations in glutamate and the experience of ego dissol... by Tenoke on Thursday May 28, 2020 @08:12AM (#23336326)
>It seems that unless you live in the Bay area and are friends with certain organic chemists, your chances of getting good quality, real LSD are slim.

Definitely not true. LSD is one of the purest recreational drugs you can buy. If it's LSD it's 'good' LSD. Occasionally dox or nbome are sold as LSD but even that is relatively rare. Also you can just order it online.

Re:Alterations in glutamate and the experience of ego dissol... by vmception on Thursday May 28, 2020 @02:29PM (#23340647)
I think nbombs are being mixed with LSD

You gotta test. Don't dismiss the need to test.

Re:Alterations in glutamate and the experience of ego dissol... by blaser-waffle on Thursday May 28, 2020 @09:27AM (#23336961)
"Just order it online" make it sound like it's Amazon. In practice you're going to need BTC, a VPN, and several other safeguards.
Re:Alterations in glutamate and the experience of ego dissol... by vmception on Thursday May 28, 2020 @02:28PM (#23340631)
Empire is just like Amazon

There was a time "just using Amazon" meant a whole setup that was not ubiquitous. People also are passionate about making darknet seem like a scary place, I've seen many askreddit threads about the "scariest thing you've seen on darknet" with anything to the contrary losing consensus very quickly. Found that odd and contrived.

Re:Alterations in glutamate and the experience of ego dissol... by tayo42 on Thursday May 28, 2020 @06:00PM (#23343314)
A lot of regularly repeated things you must do don't even seem based on evidence. Like the bible everyone says to follow suggests all these overcomplicated things, it comes off as written by pretend lawyers.
Re:Alterations in glutamate and the experience of ego dissol... by Tenoke on Thursday May 28, 2020 @10:24AM (#23337625)
You don't need a VPN and in most (western) countries getting btc is now trivial.

Not as easy as amazon of course but often easier than depositing money in a poker site for example.

And that's not even mentioning that you can just legally order 1p-lsd on the clearnet the same way you'd order anything (though the UK, Germany and a few others have clamped down on it a bit).

Re:Alterations in glutamate and the experience of ego dissol... by joeberon on Thursday May 28, 2020 @08:03AM (#23336269)
That isn't true here in the UK at least, it is easy and quite cheap to get real LSD. Also it's pretty easy to test too
Re:Alterations in glutamate and the experience of ego dissol... by PoachedSausage on Thursday May 28, 2020 @08:10AM (#23336303)
I guess I haven't been that motivated to really look for it, so maybe I'm wrong about availability here.
Re:Alterations in glutamate and the experience of ego dissol... by jdc on Thursday May 28, 2020 @08:00AM (#23336253)
[...] you're chances of getting good quality, real LSD are slim

How do you figure?

Re:Alterations in glutamate and the experience of ego dissol... by PoachedSausage on Thursday May 28, 2020 @08:07AM (#23336290)
It is not that popular as a drug and there can't be that many people world-wide capable of producing it.
Re:Alterations in glutamate and the experience of ego dissol... by moreaccountspls on Thursday May 28, 2020 @08:33AM (#23336477)
Nah, it's an extremely popular drug and right now it's probably more available than any time since the sixties.
Re:Alterations in glutamate and the experience of ego dissol... by breakyerself on Thursday May 28, 2020 @08:49AM (#23336609)
I don't reccomend LSD to anyone. My last time taking it was devastating. Traumatic hallucinations and delusions during the trip and I had anxiety and uncomfortable tactile sensations that took more than a year to dissipate.
Re:Alterations in glutamate and the experience of ego dissol... by joeberon on Thursday May 28, 2020 @09:16AM (#23336859)
I also suffered from intense tactile sensations throughout the trip that lingered for a few months afterwards. I've always had oversensitivity to touch on THC-heavy cannabis strains but I experienced strong synesthesia on LSD which translated to a few months where feelings of anxiety were directly coupled to my sense of touch in my right index finger and thumb
Re:Alterations in glutamate and the experience of ego dissol... by Trasmatta on Thursday May 28, 2020 @10:46AM (#23337917)
I've had a very similar experience with my hands. I believe it's a symptom of Depersonalization.
Re:Alterations in glutamate and the experience of ego dissol... by raducu on Thursday May 28, 2020 @09:59AM (#23337280)
If you used to be on SSRIs and they worked, then LSD doesn't sound like a good match.

I regret not taking psychedelics, but I hallucinated from a large dosage of hashish and had visual disturbances for a couple of days after, so I figured it's better to not mess with other psychedelics.

I also got a bad panic attack from a moderate dosage of stimulants(bad idea mixing them) and I could not drink coffee for 2 years, or I would get a panic attack just from the coffee -- it all went away eventually and I can drink coffee without a panick attack now (though it does seem to cause joint pain so I try to avoid it).

Re:Alterations in glutamate and the experience of ego dissol... by joeberon on Thursday May 28, 2020 @10:19AM (#23337548)
>If you used to be on SSRIs and they worked, then LSD doesn't sound like a good match.

Well honestly I had thought that LSD could be great for anxiety and depression under the right set and setting. Since I was very sure I could have a great setting (which I could) I thought that my chances of a bad trip were very minimal. Unfortunately I think I just didn't pay enough attention to the "set" part

Re:Alterations in glutamate and the experience of ego dissol... by PragmaticPulp on Thursday May 28, 2020 @11:59AM (#23338809)
> If you used to be on SSRIs and they worked, then LSD doesn't sound like a good match

Do you have any evidence at all to support this claim?

LSD isn't inherently an anti-depressant. The research around psychedelics involves many sessions of intense therapy with LSD used in some sessions to help facilitate the therapy.

Researchers aren't just dosing people with psychedelics and walking away. The drug itself isn't doing the heavy lifting of addressing the problems.

Re:Alterations in glutamate and the experience of ego dissol... by raducu on Thursday May 28, 2020 @12:39PM (#23339353)
I have absolutely no evidence, just my reasoning that if you are depressed and SSRIs work, there must be something wrong with those serotonin networks and SSRIs working mean some balance was restored; LSD will just blast the same networks.

I was not under the impression that OP did LSD in a therapeutical setting.

Re:Alterations in glutamate and the experience of ego dissol... by joncrane on Thursday May 28, 2020 @12:09PM (#23338948)
>though it does seem to cause joint pain

Wait, you get this, too? I have searched for answers to this and gotten nothing. I have long suspected that my coffee habits correspond to my joint pain, but I have associated it with many other things in a search for truth. Can you elaborate?

Re:Alterations in glutamate and the experience of ego dissol... by raducu on Thursday May 28, 2020 @12:33PM (#23339266)
It is just an observation that I made, the research seems to be mixed.

My joint pain started a couple of years ago (early 30s), with really bad pain in my thumb joint after some exertion, X-ray or MRI showed I had some inflammation and excessive liquid, the pain went away after one month or so; then I got pain on the outside of my elbows (perhaps from incorrect posture and lifting my toddler all the time); I originally thought it had to do with my nicotine usage, but I quit for some good months and nothing happened, on the contrary, I started using more coffee and my pain got worse.

I don't think the coffee is 100% responsible, rather that it exacerbates some underlying condition; but so far it is pretty dramatic -- after quitting coffee for a couple of days, my pain is almost gone -- and that happened for too many times to be just a coincidence(though it could).

Re:Alterations in glutamate and the experience of ego dissol... by blaufast on Thursday May 28, 2020 @10:26AM (#23337654)
Mental disturbances from hashish and psychedelics, while similar symptoms, are completely different internally. I wouldn’t rule out psychedelics based on that experience.
Re:Alterations in glutamate and the experience of ego dissol... by raducu on Thursday May 28, 2020 @12:43PM (#23339411)
It wasn't just "mental" as in anxiety -- those were visual disturbances -- tracers in bright led lights, bright spots in grill patterns (metal or my chess-pattern shirt). The experience just made me think I'm predisposed to HPPD so I thought to play it safe.
Re:Alterations in glutamate and the experience of ego dissol... by dr_dshiv on Thursday May 28, 2020 @05:37AM (#23335310)
Can you share more about the context of the trip? Typically mindset and setting have a big influence. Were you in a safe environment with people you like and trust? Thanks.
Re:Alterations in glutamate and the experience of ego dissol... by joeberon on Thursday May 28, 2020 @05:38AM (#23335324)
Yes, first time was on a canal boat (EDIT: my father-in-law's boat, but he was away) with just my wife. Very safe and secure setting.

Second time was at a very small psytrance festival with my wife and her parents. I trust them completely and they are both very nice, and there were not any scary people about.

Re:Alterations in glutamate and the experience of ego dissol... by PoachedSausage on Thursday May 28, 2020 @06:27AM (#23335656)
Also hoping you move towards recovery and it sounds like you have good people in your life to support that.

I would say that a festival (even small and friendly) is possibly not the ideal place to take psychedelics, unless you're very experienced. If you are particularly prone to paranoia, it can surface with psychedelics (even Cannabis) even in good settings.

Re:Alterations in glutamate and the experience of ego dissol... by joeberon on Thursday May 28, 2020 @06:32AM (#23335690)
I suffer from diagnosed generalised anxiety disorder (GAD). Weirdly that second trip was actually much more relaxed and enjoyable during the trip than the first alone with just my wife on the canal boat, even if I did almost pass out at the start.
Re:Alterations in glutamate and the experience of ego dissol... by PoachedSausage on Thursday May 28, 2020 @07:13AM (#23335950)
Thinking back, your experience of the seizure thing sounds similar to what a friend of mine experienced, not with LSD but MDMA. It is possibly related to the motion sickness and brain poisoning reflex.[0]

[0] https://en.wikipedia.org/wiki/Motion_sickness#Defense_agains...

Re:Alterations in glutamate and the experience of ego dissol... by slfnflctd on Thursday May 28, 2020 @08:00AM (#23336248)
This is what it made me think of as well. My first experience with MDMA started out in the grips of anxiety, trembling and feeling multiple uncomfortable symptoms, afraid I had taken too much. I don't think I was able to even stand or walk for several long minutes.

I went on to have a wonderful & memorable experience, feeling closeness & positivity with every human interaction for hours. The worst part after I got over the initial freakout was coming back down. I've heard people talk about such early-stage freakouts happening on other psychedelics, too, but I don't have much experience there.

Re:Alterations in glutamate and the experience of ego dissol... by anonzzzz on Thursday May 28, 2020 @03:12PM (#23341153)
Serotonin is involved in regulating the digestive system so if you take drugs that act on serotonin like LSD or MDMA symptoms like nausea are quite common.
Re:Alterations in glutamate and the experience of ego dissol... by joeberon on Thursday May 28, 2020 @07:18AM (#23335990)
I did experience motion sickness on LSD so could be related
Re:Alterations in glutamate and the experience of ego dissol... by pwr22 on Thursday May 28, 2020 @05:23AM (#23335177)
Hope your recovery keeps moving in a positive direction :).
Re:Alterations in glutamate and the experience of ego dissol... by joeberon on Thursday May 28, 2020 @05:38AM (#23335326)
Thank you
Re:Alterations in glutamate and the experience of ego dissol... by empath75 on Thursday May 28, 2020 @12:29PM (#23339210)
I don't want to downplay the negative effect it had on you and the difficulty you're having integrating the experience, but it's possible that long term, confronting those thoughts and feelings directly and coming through the other side will end up being better for you.

Everyone has to confront their own mortality eventually.

Re:Alterations in glutamate and the experience of ego dissol... by joeberon on Thursday May 28, 2020 @03:35PM (#23341531)
>confronting those thoughts and feelings directly and coming through the other side will end up being better for you.

I am not sure whether this is actually true, or whether the rumination and pondering will mess me up more

Re:Alterations in glutamate and the experience of ego dissol... by empath75 on Thursday May 28, 2020 @07:14PM (#23344201)
Well, hopefully you can come to some resolution about what it all means. I went through something similar after a bad trip and it made me focus on what’s important to be doing in life with the time I have left.