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Serotonin is involved in regulating the digestive system so if you take drugs that act on serotonin like LSD or MDMA symptoms like nausea are quite common.
I would say you shouldn't have your first trip unless your mental health is stable, or it is in a therapeutic context.

Once you have some sense of what to expect you can more readily use your judgment as to whether you're in the right headspace. I find it can be quite helpful to mitigate mild/moderate anxiety or depression.

Re:America’s Need for Skilled Immigrants Isn’t Going Away on Wednesday October 24, 2018 @07:08PM (#18297260)
The US is not uniquely diverse, Canada and Australia among other countries have a higher percentage of foreign born population.
Re:Ask HN: Over 60 = no engineering jobs? on Wednesday October 17, 2018 @03:30PM (#18242854)
I worked at an HR tech startup that did recruiting services for a lot of seed/series A companies. Maximum ages for roles were discussed openly and nobody even considered the possibility doing so might be illegal.