Psilocybin for major depression granted Breakthrough Therapy by FDA

Re:Psilocybin for major depression granted Breakthrough Ther... by lm28469 on Tuesday November 26, 2019 @10:02AM (#21638800)

> more akin to a super-placebo, rather than being therapeutic on their own.

As far as I can tell, from my own experience, lsd kind of make you see your own actions/thoughts as an observer[0], it's a very useful tool if you're into introspection. If you're not used to introspection it can be quite unsettling though.

[0] >50ug <400ug, after that you just look a the ceiling and enjoy the lights

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Re:Psilocybin for major depression granted Breakthrough Ther... by senorjazz on Tuesday November 26, 2019 @10:14AM (#21638923)

> >50ug <400ug

That is a huge difference. 400ug is a big dose and 50ug barely noticable.

Anyone reading this without experience going for 400 is going to get knocked for six

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Re:Psilocybin for major depression granted Breakthrough Ther... by lm28469 on Tuesday November 26, 2019 @10:20AM (#21638987)

Ah yeah definitely don't go for 400u for your first time. I assume no one would think "that random dude on HN recommended 400ug" and go for it without more research though. 50-150 is more manageable for a beginner.

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Re:Psilocybin for major depression granted Breakthrough Ther... by AnthonBerg on Tuesday November 26, 2019 @10:36AM (#21639159)

The 150 end of the range as a first time can be manageable for some and can be quite intense for others.

Some research suggests a “30-40 microgram trip first, then a 60-80 microgram before anything larger, then a 120-140 microgram before anything larger, then either stopping there (this was the dosage that resulted in the highest increase in well-being) or doing a 170-240 microgram trip.” — https://tripsafe.org/how-to-take-lsd/#start-small

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Re:Psilocybin for major depression granted Breakthrough Ther... by filleokus on Tuesday November 26, 2019 @11:18AM (#21639593)

Another issue is the, albeit anecdotal, inaccuracy of LSD concentration in black market products. If you are aiming for a 100 ug dose, and blotters marketed as 100 ug can range from 50-150 ug, its quite hard to do proper dosage. Darknet markets have however probably improved the situation with accountability and reviews from customer.

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Re:Psilocybin for major depression granted Breakthrough Ther... by cuspycode on Tuesday November 26, 2019 @01:44PM (#21641298)

Also, the pharmaceutical effect of any given amount depends on body weight and various other factors. So the exact amount needed for a particular trip level is different from person to person.

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Re:Psilocybin for major depression granted Breakthrough Ther... by lmpostor on Tuesday November 26, 2019 @12:17PM (#21640313)

75-125 is an actual trip. Anything less than that you're not going to get the full psychedelic experience. We can debate the effects of microdosing, but 100-150ug has been a gold standard for decades for a reason.

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Re:Psilocybin for major depression granted Breakthrough Ther... by AnthonBerg on Tuesday November 26, 2019 @04:30PM (#21642943)

I don’t disagree! :) I think you’d find the graphs in the tripsafe link interesting - they show a relationship of starting dose size and rampup vs. lasting benefits. Also some statistics of how many participants felt high anxiety per starting dose. The most significant lasting benefits seemed to come from initially low and then escalating doses. iow it seems like a small dose allows people to process better. Open more up? Be swept less away by the experience and work more within their personal selves’ substance and experience?

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Re:Psilocybin for major depression granted Breakthrough Ther... by lmpostor on Wednesday November 27, 2019 @05:24PM (#21652766)

I mean first off that is only in comparison to a dosage schedule of the reverse amount.

I'm just arguing that it would make more sense to start at 80-110-140-170 etc because below that is placebo.

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Re:Psilocybin for major depression granted Breakthrough Ther... by __blockcipher__ on Tuesday November 26, 2019 @12:30PM (#21640454)

Just wanted to mention that 50ug of LSD tartrate is very noticeable. A 100ug tab is a surprisingly strong tab.

Source: have worked directly with LSD crystal in the past. (Unfortunately anecdotes are king when it comes to illicit drugs otherwise I’d be able to cite an actual external source)

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Re:Psilocybin for major depression granted Breakthrough Ther... by refurb on Tuesday November 26, 2019 @04:38PM (#21643016)

lsd kind of make you see your own actions/thoughts as an observer

This is probably the best way to describe the therapeutic value in this situation. Hallucinogens (not just LSD), give you some distance from your headspace. It's not to the degree you feel depersonalized or have an out of body experience, but it allows you to examine your own thoughts without all those underlying assumptions that you hold yourself to subconsciously, every day.

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