Another issue is the, albeit anecdotal, inaccuracy of LSD concentration in black market products. If you are aiming for a 100 ug dose, and blotters marketed as 100 ug can range from 50-150 ug, its quite hard to do proper dosage. Darknet markets have however probably improved the situation with accountability and reviews from customer.

Also, the pharmaceutical effect of any given amount depends on body weight and various other factors. So the exact amount needed for a particular trip level is different from person to person.

75-125 is an actual trip. Anything less than that you're not going to get the full psychedelic experience. We can debate the effects of microdosing, but 100-150ug has been a gold standard for decades for a reason.

I don’t disagree! :) I think you’d find the graphs in the tripsafe link interesting - they show a relationship of starting dose size and rampup vs. lasting benefits. Also some statistics of how many participants felt high anxiety per starting dose. The most significant lasting benefits seemed to come from initially low and then escalating doses. iow it seems like a small dose allows people to process better. Open more up? Be swept less away by the experience and work more within their personal selves’ substance and experience?

I mean first off that is only in comparison to a dosage schedule of the reverse amount.

I'm just arguing that it would make more sense to start at 80-110-140-170 etc because below that is placebo.