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Re:Person carrying bacteria resistant to antibiotics of last... by janvidar on Thursday May 26, 2016 @06:21PM (#11782159)
This was precisely addressed by Sir Alexander Fleming's 1945 Nobel Prize speech:

“But I would like to sound one note of warning. Penicillin is to all intents and purposes non-poisonous so there is no need to worry about giving an overdose and poisoning the patient. There may be a danger, though, in underdosage. It is not difficult to make microbes resistant to penicillin in the laboratory by exposing them to concentrations not sufficient to kill them, and the same thing has occasionally happened in the body. The time may come when penicillin can be bought by anyone in the shops. Then there is the danger that the ignorant man may easily underdose himself and by exposing his microbes to non-lethal quantities of the drug make them resistant. Here is a hypothetical illustration. Mr. X. has a sore throat. He buys some penicillin and gives himself, not enough to kill the streptococci but enough to educate them to resist penicillin. He then infects his wife. Mrs. X gets pneumonia and is treated with penicillin. As the streptococci are now resistant to penicillin the treatment fails. Mrs. X dies. Who is primarily responsible for Mrs. X’s death? Why Mr. X whose negligent use of penicillin changed the nature of the microbe. Moral: If you use penicillin, use enough.”

Edit: Fleming's full Nobel lecture: http://www.nobelprize.org/nobel_prizes/medicine/laureates/19...

Re:Person carrying bacteria resistant to antibiotics of last... by Florin_Andrei on Thursday May 26, 2016 @06:38PM (#11782251)
It's amazing how long ago this issue was understood. And yet not much was done meanwhile, on a global scale, to address it.
Re:Person carrying bacteria resistant to antibiotics of last... by caf on Thursday May 26, 2016 @08:54PM (#11783082)
Every time I've filled a script for antibiotics, they have been accompanied by very prominent written warnings that you must complete the full prescribed course. Often reiterated verbally by the pharmacist.
Re:Person carrying bacteria resistant to antibiotics of last... by stephengillie on Thursday May 26, 2016 @09:31PM (#11783249)
But has the warning ever said why you should complete the course? I always assumed (until recently) this was to prevent reinfection, not resistance.

Stern warnings with no information about possible consequences is heavily lambasted in movies, yet we repeat this behavior with medicine and expect different results.

If you tell someone not to do something and don't tell them why not, and the consequences aren't otherwise clear, expect them to do what you said not to do.

Re:Person carrying bacteria resistant to antibiotics of last... by SkyMarshal on Thursday May 26, 2016 @10:44PM (#11783530)
Was going to say the same thing. My doctors have always told me to finish the prescription, but never once why.

My mother was a nurse so she always reminded me of the critical missing reason why, and I've always dutifully finished all antibiotics prescriptions as a result.

But that was a simple thing the doctors writing the prescription should have been doing themselves, and an apparent systemic failure of the medical profession to account for messy human psychology in a critical procedure.

Re:Person carrying bacteria resistant to antibiotics of last... by caf on Thursday May 26, 2016 @11:23PM (#11783691)
It astonishes me that people would be prepared to acquiesce to authority when a doctor tells them to ingest these drugs that they really know very little about, but draw the line at accepting the advice about taking the whole course of drugs.
Re:Person carrying bacteria resistant to antibiotics of last... by goldenkey on Friday May 27, 2016 @02:36AM (#11784299)
Most doctors dont have the types of antibiotics memorized by heart either unless they work in a specialty or ER. There are cell wall destroyers, folic acid synthesis interruptors, protein synthesis disruptors, etc. [1]

Gone are the days where a doctor should be taken at his judgment 100% as if medicine is a black box enigma. The average HNer would be wise to google about their conditions and drugs they consume. A doctor can only remember so much - they are primarily valuable for their experience in hueristic diagnosis -- not for knowing everything medical and everything pharmacutical. It is wise to relinquish some responsibility to a professional but not all.

Most of medicine aside from surgical methods can be understood by a mildly intelligent person who cares enough, because of wikipedia and google, everything except actual experience is very accessible.

I dont see how your astonishment is anything other than misinformed hyperbole.

[1] https://upload.wikimedia.org/wikipedia/commons/8/87/Antibiot...

Re:Person carrying bacteria resistant to antibiotics of last... by jasonkostempski on Thursday May 26, 2016 @11:48PM (#11783779)
People will take all kinds of advice when they're trying to feel better but once they feel good, they want to get back to partying ASAP and the doctor says no drinking while taking antibiotics.
Re:Person carrying bacteria resistant to antibiotics of last... by Patient0 on Friday May 27, 2016 @03:34AM (#11784467)
The no drinking thing is actually a bit of a mythconception - e.g. Penicillin is safe to take while drinking. http://www.abc.net.au/science/articles/2005/06/02/1380836.ht...
Re:Person carrying bacteria resistant to antibiotics of last... by s_kilk on Friday May 27, 2016 @04:16AM (#11784611)
TL;DR - In the early days of penicillin, it was used to treat various STDs. Doctors strongly advised their patients that alcohol was not to be consumed while taking the anti-biotics, not because there was a chemical interaction between the medicine and the infection, but to lower the odds of the patient getting wheeled one night and re-infecting themselves.
Re:Person carrying bacteria resistant to antibiotics of last... by dwaltrip on Friday May 27, 2016 @02:45AM (#11784325)
Nonetheless, that's the way it is. Processes should adapt to humans, not vice versa.

For the most part, of course. Cultural evolution does occur, however it's unpredictable and not something that can be easily forced.

Re:Person carrying bacteria resistant to antibiotics of last... by neilc on Friday May 27, 2016 @06:05AM (#11784965)
I think another factor is just intuition: taking medicine when you feel ill makes sense, but continuing to take the medication for several days after you feel completely recovered seems intuitively wrong to a lot of people.
Re:Person carrying bacteria resistant to antibiotics of last... by awqrre on Thursday May 26, 2016 @09:41PM (#11783306)
I always assumed that it was to completely kill it and that resistance was a side effect of not killing it...
Re:Person carrying bacteria resistant to antibiotics of last... by beambot on Thursday May 26, 2016 @10:09PM (#11783411)
Yep, you're intelligent enough to make the correct assumption. Unfortunately, I presume many others are not and could really use a little extra education by the pharmacist dispensing meds -- so they also understand the why.
Re:Person carrying bacteria resistant to antibiotics of last... by ddt_Osprey on Thursday May 26, 2016 @10:16PM (#11783438)
Meanwhile, here's me over here, thinking throughout my youth that it was advice to prevent the painful, avoidable side effects withdrawal symptoms.

Stepping down off a high dosage in halves is the exact same strategy used to ease people out of addiction.

As a kid, I thought anti-biotics were this far-out medicine, so strong and hazardous that coming down off them was something you had to do carefully.

Re:Person carrying bacteria resistant to antibiotics of last... by eru on Friday May 27, 2016 @12:08AM (#11783851)
A reasonable hypothesis for a kid. Though, if you ever take any antibiotics, they usually don't taper off the dose at the end, do they?
Re:Person carrying bacteria resistant to antibiotics of last... by awqrre on Friday May 27, 2016 @07:19PM (#11789751)
Not the ones that I've encountered... they used the same dose at the same intervals for the whole period of time... maybe to keep a lethal level in your system the whole time.
Re:Person carrying bacteria resistant to antibiotics of last... by ddt_Osprey on Saturday May 28, 2016 @10:15PM (#11794482)
I definitely remember receiving blister packs, decorated with directions and pill groupings that started with 2 pills, at high intervals like every 6 hours, then tapered to 2 pills every 12 hours toward the end of the first week, then 1 pill every 12 hours for the remainder of the pack, and included strict instructions to use the whole thing.

I got strep throat a few times as a kid. I don't have perfect recall about the details of what I had to take and when or why, though. But I do remember having to vary dosage.

Re:Person carrying bacteria resistant to antibiotics of last... by eru on Friday May 27, 2016 @07:55PM (#11789917)
Yes, exactly. And a smart kid might notice that. :)
Re:Person carrying bacteria resistant to antibiotics of last... by Cyph0n on Friday May 27, 2016 @06:11AM (#11784989)
Exactly this. If it's so vital that we finish the dose, why don't you make a bigger deal out of it? I feel that doctors simply don't care enough. Is there any other explanation?
Re:Person carrying bacteria resistant to antibiotics of last... by junto on Saturday May 28, 2016 @06:01PM (#11793766)
This is actually typical bad parenting or poor management. Whilst orders without explanation work in the army through absolute discipline, it doesn't work very well with people who haven't been conditioned to it.

Given an instruction when you don't understand the "why" is highly ineffective. As seen by your experience with your doctor.

There is also a further problem in that antibiotics treat not just you, but prevent infection in the wider population. People in general find it hard to think about the wider impact, which is something we see every day with regards to the world wide population's regards to the impact of their own pollution. It's why we recycle but then drive SUVs.

Re:Person carrying bacteria resistant to antibiotics of last... by janwillemb on Monday May 30, 2016 @11:18AM (#11801692)
I just got a course of antibiotics, so I asked why should I finish it (because it said so on the package)? The answer from the lady of the medical staff: otherwise the inflammation would come back.
Re:Person carrying bacteria resistant to antibiotics of last... by perfunctory on Friday May 27, 2016 @02:46AM (#11784330)
Same with me.
Re:Person carrying bacteria resistant to antibiotics of last... by mei0Iesh on Thursday May 26, 2016 @09:23PM (#11783212)
But they don't explain why, and warnings are overdone due to litigation fears, so people will often use their own judgment, and without understanding the concept behind why, they may choose unwisely.

"Take all of the prescribed medication" : "They're just greedy and want to make me buy more"

vs.

"Take all or you'll breed antibiotic-resistant bacteria that cannot be treated and you will die and kill the human race" : "I better follow this prescription"

Re:Person carrying bacteria resistant to antibiotics of last... by caf on Thursday May 26, 2016 @11:21PM (#11783679)
If you're the sort to believe it's just a conspiracy to make you buy unnecessary quantities of drugs, then why wouldn't you also presume that the story about antibiotic-resistant bacteria is also part of the conspiracy?
Re:Person carrying bacteria resistant to antibiotics of last... by TeMPOraL on Friday May 27, 2016 @04:25AM (#11784645)
Because the scale isn't binary here - you don't have only a) people who blindly trust doctors, and b) people who are conspiracy nuts.

Both of them are wrong, btw. Pharma companies are greedy and they do everything they can to make you spend more. Doctors are influenced by them, often very subtly. That is a fact, not a conspiracy. But the fact also is, that doctors save lives and most have noble intentions (despite the meat grinder medical career is). One needs to learn what information belongs more to "greedy companies" category, and what belongs to "life saving science" category. It's no surprise people get confused about this - and that's why you absolutely need to explain to them why they need to finish antibiotics treatments.

Re:Person carrying bacteria resistant to antibiotics of last... by mrob on Friday May 27, 2016 @12:57AM (#11783987)
"What doesn't kill you makes you stronger" is a well known saying. It makes sense that it would apply to bacteria.
Re:Person carrying bacteria resistant to antibiotics of last... by Kristine1975 on Friday May 27, 2016 @01:36AM (#11784106)
>"What doesn't kill you makes you stronger" is a well known saying.

It's from Friedrich Nietzsche's "Twilight of the Idols": "What does not kill me, makes me stronger."

Re:Person carrying bacteria resistant to antibiotics of last... by TeMPOraL on Friday May 27, 2016 @04:20AM (#11784629)
I didn't know that, thanks.

Also, most people don't know that either. Today it's just a saying, that's been repeated by people for decades.

Re:Person carrying bacteria resistant to antibiotics of last... by kbart on Friday May 27, 2016 @08:13AM (#11785462)
"they have been accompanied by very prominent written warnings that you must complete the full prescribed course"

I'm ashamed to admit that the big part of my adult life I didn't know the reason behind that, and always assumed that to be of a kind "you must eat your whole meal" constantly told by grandma. I'm sure I'm not the only one..

Re:Person carrying bacteria resistant to antibiotics of last... by holografix on Friday May 27, 2016 @03:56AM (#11784534)
Oh my god the number of arguments I've had with family and friends, even my girlfriend over this. Why do people think they can stop antibiotics when they "start getting better"?!? It's not a virus ffs
Re:Person carrying bacteria resistant to antibiotics of last... by TeMPOraL on Friday May 27, 2016 @04:18AM (#11784622)
Probably because they have no clue how they work, and they don't have a good mental model of diseases and bacteria. Aka. they don't understand the "why". A bit of explaining would definitely help.

I agree with the observation that telling people to do something without explaining why is stupid and will only lead to disappointment.

Re:Person carrying bacteria resistant to antibiotics of last... by cloudjacker on Thursday May 26, 2016 @09:28PM (#11783238)
yeahhhh I thought it was just because although you feel better you could still be in part of the infection cycle, not because the remaining germs were probably now resistant.
Re:Person carrying bacteria resistant to antibiotics of last... by chatmasta on Thursday May 26, 2016 @09:37PM (#11783282)
For a long time since 1945, many humans have believed a supernatural being created the human race thousands of years ago.

Understanding the process that leads to antibacterial resistance requires understanding evolution. So it's no surprise that much of the world fails to understand it.

Re:Person carrying bacteria resistant to antibiotics of last... by industriousthou on Thursday May 26, 2016 @09:56PM (#11783367)
Even creationists usually understand that microevolution happens.
Re:Person carrying bacteria resistant to antibiotics of last... by Jtsummers on Friday May 27, 2016 @08:19AM (#11785489)
In a bizarre conversation with a coworker once, they insisted (and of course they knew because their parents are doctors) that bacteria don't become resistant to anti-biotics, people's bodies do.

Turned out this was a major point of the anti-evolution stance at his church. I've since encountered the same viewpoint from a number of other people, all going to primarily small, ostensibly non-denominational, churches.

Re:Person carrying bacteria resistant to antibiotics of last... by jussij on Friday May 27, 2016 @01:18AM (#11784054)
Surely they believe the microbes were created by god or is that something god left to evolution?
Re:Person carrying bacteria resistant to antibiotics of last... by reitanqild on Friday May 27, 2016 @01:58AM (#11784174)
A lot of us just don't care.

I am happy to base my work on the currently best working scientific models.

My faith is also based on "best practices": what worked well for my parents, grandparents and me and which also happened to help create the western culture we enjoy today.

"Render therefore to Caesar the things which are Caesar's; and to God the things that are God's."

Re:Person carrying bacteria resistant to antibiotics of last... by Symbiote on Friday May 27, 2016 @03:03AM (#11784400)
But you have no evidence that your ancestor's faith worked well.

Probably the opposite, if you look at any conflicts they were involved in, or what social advances were blocked.

Re:Person carrying bacteria resistant to antibiotics of last... by reitanqild on Friday May 27, 2016 @05:49AM (#11784917)
> But you have no evidence that your ancestor's faith worked well.

I am, to a certain degree, that evidence. (Edit: this holds true to some degree even if you look at it from a purely techical POV which makes me smile : )

> Probably the opposite, if you look at any conflicts they were involved in, or what social advances were blocked.

This is meaningless unless you also take into account the advances brought forward because of it.

And, FWIW, you have to cast your net wide and far to find anything real horrific.

This is not to say we are better people than other, but trying to say our faith made us worse than the alternative (warrior tribes as they existed some hundred years ago) seems very wrong.

Re:Person carrying bacteria resistant to antibiotics of last... by tripzilch on Sunday May 29, 2016 @05:35PM (#11798341)
warrior tribes?
Re:Person carrying bacteria resistant to antibiotics of last... by etatoby on Friday May 27, 2016 @07:30AM (#11785269)
Both, of course.

The point of Creationism (the non-laughable variety, at least) is that some transcendental being designed this Universe with all its fundamental laws and specific constants, including Evolution, with the express intent to have us here, now, in the exact shape we are.

It is not something that can be easily refuted, BTW, nor proven. Which is why it's a matter belonging to faith and not science, for now.

Re:Person carrying bacteria resistant to antibiotics of last... by wutbrodo on Saturday May 28, 2016 @03:19PM (#11792977)
> The point of Creationism (the non-laughable variety, at least)

This is a strawman, as it's quite explicitly not what's being discussed in the parent comment, which specified "created....thousands of years ago" (I assume that kind of creationism is what you're referring to as "laughable").

Re:Person carrying bacteria resistant to antibiotics of last... by Styx- on Friday May 27, 2016 @09:11AM (#11785746)
Well yeah, as long as they keep moving the goal posts. The laughable variety you speak of used to be the only variety.
Re:Person carrying bacteria resistant to antibiotics of last... by emerongi on Friday May 27, 2016 @02:17AM (#11784245)
There are religious scientists. Doesn't mean they don't understand science or deny it.

Today's religion is different in many ways. The ones that say that bible is the 100% correct source of truth are the crazy ones.

Re:Person carrying bacteria resistant to antibiotics of last... by TeMPOraL on Friday May 27, 2016 @04:31AM (#11784661)
Yeah, complaining about religious scientists often seems to be an exercise in selectively applying high standards.

There are a lot of atheist scientists that are perfect bayesian reasoners while doing research, but when they step out of the lab they suddenly get as irrational as the rest of the general population. People are way too good at compartmentalizing beliefs.

Re:Person carrying bacteria resistant to antibiotics of last... by brokenmachine on Friday May 27, 2016 @02:49AM (#11784344)
So what percentage of believing what's written in the bible is the threshold of craziness?
Re:Person carrying bacteria resistant to antibiotics of last... by emerongi on Friday May 27, 2016 @04:04AM (#11784562)
The ones who deny science are crazy to me.
Re:Person carrying bacteria resistant to antibiotics of last... by aminorex on Sunday May 29, 2016 @02:00AM (#11795042)
You misspelled "Koran".
Re:Person carrying bacteria resistant to antibiotics of last... by Vraxx on Thursday May 26, 2016 @07:10PM (#11782437)
that's because it doesn't seem to be a technical hurdle, it seems like it's a social issue. We, as a species, haven't proven terribly adept at handling those yet.
Re:Person carrying bacteria resistant to antibiotics of last... by fleitz on Thursday May 26, 2016 @07:18PM (#11782496)
It's actually really easy to handle the problem, you have a few sets of anti-biotics and you rotate through sets every 5 years.

Furthermore in Hospitals you make people wash their hands (as in you post security gaurds at the hand washing stations and none shall pass a station without washing) and you have separate wards for those with MRSA and those without MRSA.

If you need an antibiotic that is not in rotation, you are hospitalized while everyone makes sure you take your full course.

Doing these things eliminates about 90% of the problem.

Re:Person carrying bacteria resistant to antibiotics of last... by Houshalter on Thursday May 26, 2016 @09:31PM (#11783254)
There are other problems. There are doctors that give antibiotics for obviously viral infections, just to give the patients some assurance.

There are third world countries that don't care and will not follow any of those rules. Also foreign prison systems, particularly in Russia, which breed TB.

Then there are people that are prescribed low doses of antibiotics for things like acne. I imagine that's a huge risk more than all the other things, taking it every single day.

And, as others have mentioned, agriculture uses about 50% of the world's supply of antibiotics IIRC, and that's not really safe.

Re:Person carrying bacteria resistant to antibiotics of last... by Vraxx on Thursday May 26, 2016 @08:19PM (#11782899)
That was precisely my point. What to do isn't the problem, as you pointed out so succinctly, it's really easy to solve this problem technically. What's the issue here? People and businesses they own aren't following the "optimal" plan, thus it is more of a social issue in getting everybody on the same page.
Re:Person carrying bacteria resistant to antibiotics of last... by Swizec on Thursday May 26, 2016 @07:30PM (#11782584)
Doing these things is also expensive in several ways. We have collectively decided that the cost/benefit is not worth it.

It's much easier to make antibiotics prescription only. Which we have. For humans at least.

Re:Person carrying bacteria resistant to antibiotics of last... by Jedd on Thursday May 26, 2016 @07:44PM (#11782670)
> We have collectively decided that the cost/benefit is not worth it.

I don't think the decision has been conscious.

More importantly the costs and benefits haven't been amortised over the life (and impact) of those decisions. Or, if you will, it hasn't been worth it yet. Unfortunately at the point where we can properly assess the enormous cost of these decisions, the opportunity will be long gone.

Re:Person carrying bacteria resistant to antibiotics of last... by jwatte on Thursday May 26, 2016 @11:47PM (#11783776)
It is absolutely conscious. Mainly conscious by politicians and lobbyists, who are high powered but generally fail a science literacy test. And our population, we, are the ones electing them.
Re:Person carrying bacteria resistant to antibiotics of last... by agumonkey on Thursday May 26, 2016 @07:37PM (#11782629)
It's not even blurry or doubtful. Sometimes pioneers have hints that something may or may not... Here, it's crystal clear from the start.
Re:Person carrying bacteria resistant to antibiotics of last... by iamcreasy on Thursday May 26, 2016 @10:12PM (#11783423)
Reminds me of the climate change warning made by one of the researchers from ExxonMobil back in 1981.

When I see something like this I start to question our governing system. Its way to slow and sluggish to react to these kind of events that requires immediate attention.

Re:Person carrying bacteria resistant to antibiotics of last... by seren on Friday May 27, 2016 @04:19AM (#11784624)
The problem is the signal to noise ratio. Every day you have catastrophic predictions from asteroids, super volcanoes, big earthquakes, new ice age, peak oil, loss of ozone layer, loss of biodiversity, solar storms, ... All with dire consequences.

Each of these events would cost a few (hundreds of?) billions to address or mitigate. It requires a super human intelligence to separate the chaff from the wheat. And this is hard to know what is scaremongering, and what is really dangerous.

Re:Person carrying bacteria resistant to antibiotics of last... by iamcreasy on Friday May 27, 2016 @02:15PM (#11787820)
> And this is hard to know what is scaremongering, and what is really dangerous.

Indeed. Also there are increasing evidence that many scientific studies aren't reproducable.

We need a better System to identify 'useful signals' among noises. But in our current socio-economic structure, this topic never comes up as the most important issue. Abraham Lincoln founded National Science Foundation that laid out a solid ground work for this movement, but nobody(correct me if I am wrong) picked it up where he left of and pushed Scientific inquiry as one of our top agenda.