Yes.

An Inspector-General is in charge of inspecting and auditing, as the name would suggest. That requires being impartial in absolute terms, because you must be able to call out problems no matter how inconvenient they are.

Being in a position of power means an inevitable accrual of reputation and influence, and 22 straight years of accrual is ridiculous. Her excessively long tenure is also unusual; the longest-serving Inspector-General besides her served for 8 years, shortest being 2 years not counting acting IGs, average is about 4 years each IG not counting her 22 year tenure.

So yes, I support her termination because her long tenure lends me no confidence she can perform her duties ethically anymore. There must be a regular changing of the incumbent to head off the office being bought or otherwise corrupted. There are millions of other D.C. bureaucrats to replace her with, and even more Americans overall. There is no reason to keep her specifically for this long and I daresay that the lack of a term limit for this office has to be an oversight.