Also Intel and ARM themselves specify the C intrinsics for their architectures so they're the same across MSVC, GCC and Clang, it's not like the wild west of other compiler extensions.
What makes intrinsics really interesting is that you can use wrapper libraries such as our Highway, then the code actually is portable and efficient.
The other big general issue is memory aliasing. If you're working on 8-bit data then C says that means it aliases everything and it's going to deoptimize your other memory accesses. Conversely if you're freely switching types like SIMD tends to do, that's against the aliasing rules.
Which brings us to the most "more effort" of assembly - no variables or inline functions, only registers and macros. Which is okay for self-contained functions a hundred lines or so, but less so with heavily templated multi-thousand line files of deeply intertwined macros nested 4 levels deep. Being able to write an inlined function that has no side effects felt a thousand lines away reduces mental effort by a lot, as does not having to redo register allocation across a thousand lines because you now need another temporary register for a short section of code, or even think about it much in the first place to still get near-optimal performance on modern CPUs.
Why 'much less effort' though? Intrinsics are on the same abstraction level as an equivalent sequence of assembly instructions aren't they? And they only target one specific ISA anyway and are not portable between CPU architectures, so the difference between coding in intrinsics and assembly doesn't seem all that big. Also I wonder if MSVC and GCC/Clang intrinsics are fully compatible to each other, compiler compatibility might be another reason to use assembly.