It was 500ug of LSD mixed with probably 6 or 7 drinks of alcohol. Suffered serotonin syndrome for a few days afterwards.

Regardless I’ve heard stories of people having severe long term psychological issues from even relatively light doses, simply because of how their body in particular interacted with the drug.

500ug of LSD isn’t really a standard dose. It’s almost double your typical dose.

I know a guy who took 1000ug. He told me he had side effects / visual glitches for about an entire week

250ug of good acid is still a very high dose! 500ug is more like triple of a typical sane dose. milage may vary i guess but 300ug sent me out of this world

According to Erowid, a "light" dose is 25ug-75ug, a "standard" dose is 50ug-150ug, and a "heavy" dose is 400ug+.

500ug is nuts

It's such a bad idea to combine alcohol with psychedelics. You should lead off with exactly what you took so as not to mislead others.

As I said my experience incurred more risk of severe long term side effects, but those are possible in any circumstance with any psychedelic with even a single, low dose.

The average dose is 25 to 125ug of LSD. So you heavily abused both the drug and alcohol then complain you got a massive hangover.

You ain't right in the head to begin with, my friend. Oh wait, that IS your defining problem.

I was trying to see how far I could go

Well it's generally recommended to "go far" cautiously in several steps otherwise you can severely damage yourself.

Anyhow I expect you to be fairly young so that explains it somewhat. If you're 50 though then it's double weird :)

>You ain't right in the head to begin with, my friend. Oh wait, that IS your defining problem.

That is WAY out of line.

Yeah, up yours too.

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Thank you for telling the story.

To me, it’s interesting to consider the inflammatory aspects – the immunomodulatory effects of LSD and other psychedelics on one hand and alcohol on the other.

It’s well established but little-known that psychedelics have a very significant inflammation-reducing effect which includes drastic reduction of neuroinflammation. (I’m fairly sure that this is a primary reason why they work for depression and anxiety; There’s basically always elevated inflammatory biomarkers with these disorders. Stress is directly causative of neuroimflammation.)

Here’s a really solid review paper from 2017 – today a lot more knowledge has been accumulated: https://www.frontiersin.org/journals/immunology/articles/10....

Alcohol is known to be pro-inflammatory.

I have a hunch that these two disjoint forces on the same physiological systems can have made things worse.

That’s a massive dose and you mixed it with alcohol. That is in no way a responsible way to try out psychedelics. You are right that everyone reacts differently which is why you don’t take a very large dose mixed with other drugs.

Anecdotally, ayuasca quite literally saved my life and helped me tremendously when I was spiraling into a deep depression. Psychedelics when taken responsibly in a controlled environment under supervision can help a lot of people.

> Suffered serotonin syndrome for a few days afterwards.

What sort of physician diagnosed you with Serotonin Syndrome? What symptoms did you describe to them, and what criteria/evidence did they use to arrive there? Were they able to use differential diagnosis to rule out other conditions?

Did you return to the same physician after the symptoms ceased?

Not OP, but the answer is probably what you expected. That being said, as someone prescribed multiple serotenergic drugs concurrently who was knocked on their ass by an errant Vit D dose, the symptoms are pretty obvious (and terrible) and do a good job of convincing one to “not do THAT again”.

I know, right? This is why we must be extra cautious with anyone's claim of disorder or disease, because just because someone thinks they are ill with a particular thing, doesn't mean that they, or even their HCPs have done due diligence -- modern health care is nothing like House or Doc Martin.

In fact, Wikipedia's fatal flaw is that we're forced to take medical claims at face-value when they're made by the subject himself.

Personally, my HCPs are very conservative and reluctant to diagnose -- particularly something they can't treat, and especially adverse, untreatable side effects such as "gynecomastia" or "tardive dyskinesia", etc. (Those could contribute to material grounds for lawsuits!) What physician in their right mind would formally diagnose "Serotonin Syndrome", other than one who's on the payroll of a tort/malpractice attorney?

It's interesting for me to balance a distinct tendency for Somatic Symptom Disorder (also shall never be formally diagnosed) with an impulse for self-knowledge, but an aversion to shitty "treatments" that invariably do more harm than good.

You got serotonin syndrome from LSD?

That is incredibly rare, so rare I can’t find any other documented cases

Edit: did you test it to make sure it was real LSD?

I'm somewhat surprised there's only one comment here asking this.

Yes, it was definitley real. I mixed it with alcohol that’s why.

Did you test it?

Very high doses used to be my jam. I have no real way to tell what the actual dosages were with LSD, but anywhere from 5-10 blotters was pretty typical for me, and had many positive experiences this way. Conversely, my 2 worst experiences were 2 tabs and 1.5, with the second being one of my least fond memories from my life.

I wrote out a lot more detail for this comment, but pruned to just attempt to make these points 1) generalization here is (generally) not very helpful and also 2) I've come to believe "set, setting, & dosage" are typically listed in that order because that is the order of importance.