Typically the Ethernet shield is also only alibi-insulated from the device's ground. Sometimes not at all. (Personally it's always funny to me to see the fat 1kV/1nF capacitor from the shield to the device ground and then the metal of the socket is just bunched up with basically no clearance against the metal case or something like that). This can of course be avoided by simply using unshielded cable.
It takes an awful lot of power to smash through these multiple layers of insulation and bypass all the capacitors, at least if the PSU is properly designed (specifically, clearance between the various power / ground domains).
In contrast, Ethernet transformers are tiny small little things.
We don't notice them on larger wires as the wear is infinitesimal, but in a CPU where the wire diameters are in the micron scale and below there is likely a maximum lifetime of usage before the whole system becomes inoperable.
Might be 500 years of continual usage, might be 50, I don't know and I don't think anyone has done a long-term study on how long a CPU can be continuously operated before it fails, but the risk is there.
If we are talking about 1970s and '80s machines, they tend to run pretty hot, related to the PSU technology. Things like electrolytic capacitors "don't like this" and may contribute to cascading failures. PSU failures are apt to fry some chips, some of which may be hard to come by. So, better keep them cool = off.
If you consider machines from the 2000s retro, continuous run, avoiding the stresses caused by system start, may help keeping them alive. (I've a MacPro running since 2008, with no failures, apart from failing 3rd party ECC DDR3 RAM. Some of this RAM has even failed twice, the RAM originally shipped by Apple is still fine, though. This machine has only been ever off, when I've been on vacation.) – Machines from the 1990s and early 2000s are pretty much the same, but typically suffer from poor capacitors and/or batteries. So…?