Overhead and parallelization limitations become a serious issue then. Frameworks like PySpark take your Python code and are able to distribute it better, but it's still (relatively) very slow and clunky. Or they can limit what you can do to a DSL (often SQL), but you can't to much serious data work without UDFs, where again Python comes in. There are tricks but you can never really avoid the limitations of the Python interpreter.
It gets worse because Python doesn't expose you to memory management. This initially is an advantage, but later on causes bloat.
Python is an incredibly easy interface over these native libraries, but has a lot of runtime costs.
If using C++20 onwards, then it is relatively easy to have similar high level abstractions, one just needs to let go of Cisms that many insist in using.
Here Rust has clearly an advantage that it doesn't allow for copy-paste of C like code.
Naturally D and Swift with their safety and C++ interop, would be an option as well.
It also means that many people use Python while they don't understand that what part of the code is actually fast. They mix Python code with wrappers to native libraries, and sometimes the Python code slows down the overall work substantially and people don't know that fault is there. E.g use Python Maths with the mix of Numpy math bindings, while they can do it with Numpy alone.
Any other ecosystem is able to plug into the same underlying native libraries, or even call them directly in case of being the same language.
In a way it is kind of interesting the performance pressure that is going on Python world, otherwise CPython folks would never reconsider changing their stance on performance.